scholarly journals Initial clinical results with a fusion prototype for mammography and three-dimensional ultrasound with a standard mammography system and a standard ultrasound probe

2018 ◽  
Vol 59 (12) ◽  
pp. 1406-1413 ◽  
Author(s):  
Julius Emons ◽  
Marius Wunderle ◽  
Arndt Hartmann ◽  
Marcus Radicke ◽  
Claudia Rauh ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Three Dimensional ◽  
Region Of Interest ◽  
Clinical Results ◽  
3D Ultrasound ◽  
Breast Cancer Patients ◽  
Time Saving ◽  
Simultaneous Evaluation ◽  
Patients Experience ◽  
First Time

Background Combinations *Equal contributors. of different imaging techniques in fusion devices appear to be associated with improvements in diagnostic assessment. Purpose The aim of this study was to test the feasibility of using an automated standard three-dimensional (3D) ultrasound (US) device fused with standard mammography for the first time in breast cancer patients. Material and Methods Digital mammograms and 3D automated US images were obtained in 23 patients with highly suspicious breast lesions. A recently developed fusion machine consisting of an ABVS 3D US transducer from an Acuson S2000 machine and a conventional Mammomat Inspiration device (both Siemens Healthcare GmbH, Erlangen, Germany) were used for the purpose. The feasibility of the examinations, imaging coverage, and patients' experience of the procedure were examined. Results In 15 out of 19 patients, the region of interest (ROI) with the tumor marked in the mammogram was visible on US. The examination was experienced positively by the patients, with no unexpected pain or injury. The examination was time-saving and well tolerated. Conclusion In conclusion, we have shown initial clinical feasibility of an US/radiography fusion prototype with good localization and evaluation of the ROIs. The combined examination was well tolerated. The simultaneous evaluation with mammography and US imaging may be able to improve detection and reduce examiner-related variability.

Patient-reported distress screening outcomes in breast cancer.

2015 ◽  
Vol 33 (28_suppl) ◽  
pp. 79-79
Author(s):  
Bridget Smart ◽  
Laura Vallow ◽  
Laeticia Hollant ◽  
Megan Single ◽  
Katherine Gaines ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Ductal Carcinoma ◽  
Clinical Results ◽  
Psychosocial Distress ◽  
Breast Cancer Patients ◽  
Distress Screening ◽  
Breast Radiotherapy ◽  
Patient Reported ◽  
Patients Experience

79 Background: A significant percentage of cancer patients experience psychosocial distress with the highest prevalence observed in breast cancer patients. The importance of psychosocial distress screening and assessment in women with breast cancer has clearly been established. Patients in our clinic are screened for distress. The results were reviewed in an attempt to better understand the psychosocial distress of breast cancer patients undergoing radiotherapy. Methods: Patients treated curatively for breast cancer prospectively completed the 30 question patient reported distress (PRD) survey that also included a linear analog measure of overall distress. The recorded clinical results of the PRD survey were retrospectively assessed in patients receiving breast radiotherapy from June 1, 2013 to February 2, 2015. Results: Completed PRD questionnaires were available on 179 female patients. 21 (12%) were treated for ductal carcinoma in situ and 91 (51%), 35 (20%), and 32 (18%) were treated for invasive carcinoma Stages I, II, and III. 85 (47%) received chemotherapy. Overall distress ranged from 0 to 10, with a median value of 5. Mean distress scores per category ranged from a low of 1.25 to a high of 2.52. Top concerns in descending order of importance were: “How will I feel during treatment” (2.52), “Fatigue” (2.46), “Sleep difficulties” (2.32), “How will I feel about appearance related to treatment” (2.23), & “Pain that affects daily functioning” (2.19). Least distressing symptoms “Spirituality” (1.25), “Housing during treatment” (1.26), “Control of anger” (1.28), “End of life concerns” (1.32), & “Transportation” (1.34). Conclusions: Distress over tumor related issues ranked low among women’s concerns in comparison to distress related to the side effects of therapy concerning treatment related discomfort, fatigue, and changes in appearance, and anxiety. Pain was a significant concern, although in this group of patients receiving definitive, adjuvant or neoadjuvant therapy, this was likely related to treatment associated discomfort rather than from disease progression. These findings highlight the importance of careful patient education and communication of the expected symptoms and effects of therapy.

Quantification of Tumor Blush of Highly Vascularized Tumors with Slow Feeding System: Representative Use for Giant Pituitary Adenomas

2021 ◽  
Author(s):  
Yoshikazu Ogawa ◽  
Kenichi Sato ◽  
Toshiki Endo ◽  
Teiji Tominaga
Keyword(s):  
Pituitary Adenomas ◽  
Imaging Techniques ◽  
Cone Beam Ct ◽  
Three Dimensional ◽  
Region Of Interest ◽  
Operation Time ◽  
Preoperative Imaging ◽  
Ct Scanner ◽  
Cavernous Sinus Invasion ◽  
Giant Pituitary Adenomas

abstract Background Modern imaging techniques can identify adverse factors for tumor removal such as cavernous sinus invasion before surgery, but surgeries for giant pituitary adenomas often reveal discrepancies between preoperative imaging and intraoperative findings because pituitary adenomas have feeding arteries with narrow diameters. Current imaging methods are not suitable for tumors with not only large vascular beds but also slow arterial filling. Patients and Methods This prospective study recruited 13 male subjects and 9 female subjects with giant pituitary adenomas between November 2011 and 2018. All the patients were investigated with three-dimensional magnetic resonance (MR) imaging, bone image computerized tomography (CT), and digital subtraction angiography (DSA) using a C-arm cone-beam CT scanner with a flat-panel detector and 50% diluted contrast medium. Fine angioarchitecture was evaluated and the tumor blush was quantified using newly developed region of interest (ROI) analysis to establish surgical strategies. Results Seven patients demonstrated no or very faint tumor blushes. In these patients, feeding arteries run centripetally from the surface of the tumor. Fifteen patients showed significant tumor blushes, and the feeding arteries penetrated centrifugally from the inferoposterior pole to the upper pole of the tumor. All the patients were treated according to the angiographic information with successful hemostasis. The patients showed improvement and/or disappearance of the neurologic deficits. The faint and significant blush groups showed significant differences in intraoperative bleeding (p < 0.01) and operation time (p < 0.05). Conclusion Specialized evaluation focused on vascularization is required for successful therapy of giant pituitary adenomas.

Intraoperative 3D ultrasound–guided resection of diffuse low-grade gliomas: radiological and clinical results

2020 ◽  
Vol 132 (2) ◽  
pp. 518-529 ◽  
Author(s):  
Hans Kristian Bø ◽  
Ole Solheim ◽  
Kjell-Arne Kvistad ◽  
Erik Magnus Berntsen ◽  
Sverre Helge Torp ◽  
...  
Keyword(s):  
General Anesthesia ◽  
San Francisco ◽  
Prognostic Score ◽  
Three Dimensional ◽  
Residual Tumor ◽  
Clinical Results ◽  
Extent Of Resection ◽  
3D Ultrasound ◽  
Low Grade ◽  
Postoperative Mri

OBJECTIVEExtent of resection (EOR) and residual tumor volume are linked to prognosis in low-grade glioma (LGG) and there are various methods for facilitating safe maximal resection in such patients. In this prospective study the authors assess radiological and clinical results in consecutive patients with LGG treated with 3D ultrasound (US)–guided resection under general anesthesia.METHODSConsecutive LGGs undergoing primary surgery guided with 3D US between 2008 and 2015 were included. All LGGs were classified according to the WHO 2016 classification system. Pre- and postoperative volumetric assessments were performed, and volumetric results were linked to overall and malignant-free survival. Pre- and postoperative health-related quality of life (HRQoL) was evaluated.RESULTSForty-seven consecutive patients were included. Twenty LGGs (43%) were isocitrate dehydrogenase (IDH)–mutated, 7 (14%) were IDH wild-type, 19 (40%) had both IDH mutation and 1p/19q codeletion, and 1 had IDH mutation and inconclusive 1p/19q status. Median resection grade was 93.4%, with gross-total resection achieved in 14 patients (30%). An additional 24 patients (51%) had small tumor remnants < 10 ml. A more conspicuous tumor border (p = 0.02) and lower University of California San Francisco prognostic score (p = 0.01) were associated with less remnant tumor tissue, and overall survival was significantly better with remnants < 10 ml (p = 0.03). HRQoL was maintained or improved in 86% of patients at 1 month. In both cases with severe permanent deficits, relevant ischemia was present on diffusion-weighted postoperative MRI.CONCLUSIONSThree-dimensional US–guided LGG resections under general anesthesia are safe and HRQoL is preserved in most patients. Effectiveness in terms of EOR appears to be consistent with published studies using other advanced neurosurgical tools. Avoiding intraoperative vascular injury is a key factor for achieving good functional outcome.

scholarly journals The Role of HDlive Technology in Obstetrics and Gynecology, Present and Future

2014 ◽  
Vol 8 (3) ◽  
pp. 234-238
Author(s):  
Mihaela Grigore ◽  
Camelia Cojocaru ◽  
Tudor Lazar
Keyword(s):  
Imaging Techniques ◽  
Three Dimensional ◽  
3D Ultrasound ◽  
Early Embryo ◽  
Obstetrics And Gynecology ◽  
Ultrasound Images ◽  
High Definition ◽  
Maternal Bonding ◽  
4D Ultrasound

ABSTRACT Imaging techniques have continually evolved during the last few decades to improve diagnosis in obstetrics and gynecology. Developed more than 15 years ago, three-dimensional (3D) ultrasound has been widely used in clinical practice during the last decade, and its use continues to grow as researchers explore innovative new applications. High definition live (HDlive) ultrasound (US) is a novel ultrasound technology that improves both 3D and four-dimensional (4D) ultrasound images. This technology can mainly be used to study normal and pathologic embryonic and fetal development. HDlive could be important to perinatal research and could provide a better understanding of the development of the early embryo and fetus. Because of the natural pictures of the fetus that it provides, HDlive could be beneficial for increasing the fetal-maternal bonding, an important factor for healthy behavior during the pregnancy. In gynecology, HDlive could be useful in providing a better image of the adnexal pathology or coronal plane of the uterus. Although its advantages need to be further explored, in our opinion, HDlive is an innovative technique and a useful tool with applications both in obstetrics and gynecology. How to cite this article Grigore M, Cojocaru C, Lazar T. The Role of HDlive Technology in Obstetrics and Gynecology, Present and Future. Donald School J Ultrasound Obstet Gynecol 2014;8(3):234-238.

scholarly journals Role of three-dimensional ultrasound in females with obstructed defecation (in comparison with defecography)

2019 ◽  
Vol 51 (1) ◽  
Author(s):  
Mahmoud Abdel Latif ◽  
Magda Shady ◽  
Nahla M. Elawadly ◽  
Waleed M. Thabet
Keyword(s):  
Pelvic Floor Disorders ◽  
Imaging Techniques ◽  
Obstructed Defecation ◽  
Three Dimensional ◽  
3D Ultrasound ◽  
Control Group ◽  
Case Group ◽  
Hiatal Area ◽  
Muscle Attenuation

Abstract Background Growing attention of pelvic floor disorders has led to development of new imaging techniques, with increasing importance of ultrasonography. The 3DUS technique is considered an accessible tool for imaging of the posterior pelvic compartment. The purpose of this study is to highlight the role of 3D ultrasound in evaluation of obstructed defecation in females and comparing the findings with defecography. Results Study included 30 females classified into two groups: (1) 20 patients (case group complaining of obstructed defecation); (2) ten females (control group-normal nulliparous females). All of them were subjected to defecography and 3D ultrasound during resting, squeezing, and straining. Detection rate of rectocele and intussusception with 3D ultrasound was lower than defecography. By US, significant statistical difference between patients and controls in all measurements of levator hiatus, IS, ES, and PRS thickness during straining (P value < 0.001). During straining, cut-off value of 20.75 cm2 for hiatal area gives sensitivity of 100% and specificity of 95% and using ARA, cut-off value of 105° gives sensitivity of 98% and specificity of 90% for differentiation between patients and controls. Conclusion Ultrasound can be considered a complementary test to defecography in investigation of patients with obstructed defecation. Ultrasound can diagnose levator muscle attenuation and avulsion, thickness of IS, ES, PRS, and distensibility of hiatal area.

scholarly journals Novel insights into early life stages of finned octopods (Octopoda: Cirrata)

2021 ◽  
Vol 140 (1) ◽  
Author(s):  
Alexander Ziegler ◽  
Abigail Miller ◽  
Nina Nagelmann
Keyword(s):  
Deep Sea ◽  
Early Life ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
Life Stages ◽  
Early Life Stages ◽  
Egg Capsules ◽  
First Time ◽  
Capsule Size ◽  
Combined Data

AbstractThe finned or dumbo octopods (Octopoda: Cirrata) constitute a cephalopod (Mollusca: Cephalopoda) taxon almost exclusively comprising organisms that inhabit the deep-sea. This renders studying the general biology of adult cirrate specimens a difficult task, but even more so when it comes to gathering knowledge on their early life stages. During his comprehensive research exploits on cephalopod development, the late Sigurd von Boletzky (1942–2020) also sought to shed light on specific adaptations that eggs and embryos of these enigmatic deep-sea octopods might show. Based on his seminal work, the present article sets out to provide additional data on a broad range of early cirrate life stages, including egg capsules without any obvious embryonic stage as well as those containing embryos. These previously unreported specimens obtained from museum collections were analyzed using conventional morphological as well as modern three-dimensional imaging techniques. The present overview includes specimens from four of the five oceans, i.e., the Atlantic, Pacific, Indian, and Southern Ocean. Based on information on cirrate ovum, chorion, and egg capsule size as well as shape gathered from the literature, an attempt is made here for the first time to identify von Boletzky's as well as the specimens introduced here down to at least genus level. The combined data provide novel insights into early life stages of finned octopods, aiming to continue von Boletzky's legacy with regard to developmental research on a still largely enigmatic taxon of extant deep-sea cephalopods.

Mitochondrial Reconstructions Based on Serial Thick Sections and HVEM

1975 ◽  
Vol 33 ◽  
pp. 286-287
Author(s):  
Jerome J. Paulin
Keyword(s):  
Imaging Techniques ◽  
Three Dimensional ◽  
Posterior Pole ◽  
Dimensional Structure ◽  
Stereo Imaging ◽  
Thin Sections ◽  
Anatomical Features ◽  
The Past ◽  
Cellular Components ◽  
Mitochondrial Reticulum

Within the past decade it has become apparent that HVEM offers the biologist a means to explore the three-dimensional structure of cells and/or organelles. Stereo-imaging of thick sections (e.g. 0.25-10 μm) not only reveals anatomical features of cellular components, but also reduces errors of interpretation associated with overlap of structures seen in thick sections. Concomitant with stereo-imaging techniques conventional serial Sectioning methods developed with thin sections have been adopted to serial thick sections (≥ 0.25 μm). Three-dimensional reconstructions of the chondriome of several species of trypanosomatid flagellates have been made from tracings of mitochondrial profiles on cellulose acetate sheets. The sheets are flooded with acetone, gluing them together, and the model sawed from the composite and redrawn.The extensive mitochondrial reticulum can be seen in consecutive thick sections of (0.25 μm thick) Crithidia fasciculata (Figs. 1-2). Profiles of the mitochondrion are distinguishable from the anterior apex of the cell (small arrow, Fig. 1) to the posterior pole (small arrow, Fig. 2).

Semi-automated methods for 3-D reconstruction of macromolecular complexes

1995 ◽  
Vol 53 ◽  
pp. 42-43
Author(s):  
B. Carragher ◽  
M. Whittaker
Keyword(s):  
Three Dimensional ◽  
Time Saving ◽  
Macromolecular Complexes ◽  
Symmetry Properties ◽  
Dimensional Reconstruction ◽  
Experienced Operator ◽  
Projection Images ◽  
The Individual ◽  
Natural Symmetry

Techniques for three-dimensional reconstruction of macromolecular complexes from electron micrographs have been successfully used for many years. These include methods which take advantage of the natural symmetry properties of the structure (for example helical or icosahedral) as well as those that use single axis or other tilting geometries to reconstruct from a set of projection images. These techniques have traditionally relied on a very experienced operator to manually perform the often numerous and time consuming steps required to obtain the final reconstruction. While the guidance and oversight of an experienced and critical operator will always be an essential component of these techniques, recent advances in computer technology, microprocessor controlled microscopes and the availability of high quality CCD cameras have provided the means to automate many of the individual steps.During the acquisition of data automation provides benefits not only in terms of convenience and time saving but also in circumstances where manual procedures limit the quality of the final reconstruction.

Image formation analysis of thick biological specimens using three-dimensional power-spectra of through focus series

1994 ◽  
Vol 52 ◽  
pp. 124-125
Author(s):  
Karen F. Han
Keyword(s):  
Inelastic Scattering ◽  
Imaging Techniques ◽  
Mass Density ◽  
Relative Proportion ◽  
Three Dimensional ◽  
Power Spectra ◽  
Image Formation ◽  
Energy Filtering ◽  
Ewald Sphere ◽  
Nonlinear Imaging

The primary focus in our laboratory is the study of higher order chromatin structure using three dimensional electron microscope tomography. Three dimensional tomography involves the deconstruction of an object by combining multiple projection views of the object at different tilt angles, image intensities are not always accurate representations of the projected object mass density, due to the effects of electron-specimen interactions and microscope lens aberrations. Therefore, an understanding of the mechanism of image formation is important for interpreting the images. The image formation for thick biological specimens has been analyzed by using both energy filtering and Ewald sphere constructions. Surprisingly, there is a significant amount of coherent transfer for our thick specimens. The relative amount of coherent transfer is correlated with the relative proportion of elastically scattered electrons using electron energy loss spectoscopy and imaging techniques.Electron-specimen interactions include single and multiple, elastic and inelastic scattering. Multiple and inelastic scattering events give rise to nonlinear imaging effects which complicates the interpretation of collected images.

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