scholarly journals A practical self-made device in parathyroid autotransplantation for patients with secondary hyperparathyroidism

2018 ◽  
Vol 47 (1) ◽  
pp. 59-65
Author(s):  
Lei Du ◽  
Xiwei Zhang ◽  
Liang Yan ◽  
Hao Zhang ◽  
Xuefeng Tang ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Parathyroid Tissue ◽  
Serum Levels ◽  
Bone Diseases ◽  
Metabolic Bone Diseases ◽  
Parathyroid Autotransplantation ◽  
Before And After ◽  
Endoscopic Parathyroidectomy

Objective Secondary hyperparathyroidism (sHPT) is one of the most serious complications in patients on long-term hemodialysis. These patients may suffer from metabolic bone diseases, severe atherosclerosis, and undesirable cardiovascular events. Endoscopic parathyroidectomy with autotransplantation is a treatment option for those who do not respond to clinical management. This study aimed to investigate practical use of a self-made device in parathyroid autotransplantation for patients with sHPT, and to compare this device with ordinary surgical scissors. Methods A total of 15 patients with sHPT were treated with endoscopic parathyroidectomy and autotransplantation. Pieces of parathyroid tissue were squeezed in our self-made device and injected into the brachioradialis muscle. Sixteen patients with sHPT who were treated with traditional parathyroid transplantation served as controls. Serum levels of parathyroid hormone, alkaline phosphatase, calcium, phosphorus and intact parathyroid hormone were measured before and after surgery. Results Preoperative symptoms were alleviated, and serum parathyroid hormone and alkaline phosphatase levels, hyperphosphatemia, and hypercalcemia were improved or normalized in all of the patients in both groups. Pathological examinations showed that parathyroid cells remained active. Conclusion Application of our squeezing device is an economic, effective, and safe method in endoscopic parathyroidectomy and autotransplantation for patients with sHPT.

Serum levels of bone alkaline phosphatase measured with a new immunoradiometric assay in patients with metabolic bone diseases

Bone ◽  
1995 ◽  
Vol 16 (3) ◽  
pp. 409
Author(s):  
S. Gonnelli ◽  
C. Cepollaro ◽  
M.S. Campagna ◽  
M.B. Franci ◽  
A. Monaci ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Levels ◽  
Bone Alkaline Phosphatase ◽  
Bone Diseases ◽  
Immunoradiometric Assay ◽  
Metabolic Bone Diseases ◽  
Metabolic Bone

Differences in postexercise serum levels of parathyroid hormone and osteocalcin before and after 6 weeks of endurance training in elderly men

1996 ◽  
Vol 6 (S1) ◽  
pp. 296-296
Author(s):  
E. Zerath ◽  
X. Holy ◽  
P. Douce ◽  
C. Y. Guezennec ◽  
J. C. Chatard
Keyword(s):  
Parathyroid Hormone ◽  
Endurance Training ◽  
Serum Levels ◽  
Elderly Men ◽  
Before And After

scholarly journals Effects of Orai3-Mediated Store-Operated Calcium Entry on Parathyroid Hormone Release in Secondary Hyperparathyroidism

2021 ◽  
Author(s):  
Zhangying Lin ◽  
Shuhao Wang ◽  
Yanxun Han ◽  
Junwei Zhu ◽  
Suwen Bai ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Tumor Development ◽  
Parathyroid Tissue ◽  
Hormone Release ◽  
Common Complication ◽  
Store Operated Calcium Entry ◽  
Serum Pth ◽  
Parathyroid Hormone Release

Abstract Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease, is characterized by elevated parathyroid hormone (PTH) secretion and Hypocalcemia. Orai3 is a highly selective calcium (Ca2+) channel that plays important roles in tumor development, cardiovascular disease, and autoimmune diseases; however, its role in SHPT is unclear. In the present study, RNA sequencing and western blot assays were used to detect the expression levels of Orai3 in parathyroid tissue from patients with SHPT and from individuals without SHPT. Ca2+ imaging was used to detect the effect of Orai3 channels on Ca2+ signaling in parathyroid gland cells. Enzyme-linked immunosorbent assays were used to detect changes in PTH release. Orai3 knockout rats were used to detect the effect of decreased Orai3 expression on serum PTH levels. We found that the expression of Orai3 in parathyroid tissue obtained from patients with SHPT was significantly higher than that in patients without SHPT. Knockdown of Orai3 in parathyroid cells by transfection with Orai3-specific small inhibitor RNA inhibited store-operated Ca2+ entry (SOCE) in parathyroid cells. Inhibition of SOCE or knockdown of Orai3 significantly inhibited PTH release in parathyroid cells. PTH levels in the blood of Orai3 knockout rat were significantly reduced. Therefore, Orai3 expression and Orai3-mediated Ca2+ signaling may be a mechanism underlying PTH release, and Orai3 may play a role in the development of SHPT.

Bone alkaline phosphatase measured with a new immunoradiometric assay in patients with metabolic bone diseases

1996 ◽  
Vol 26 (5) ◽  
pp. 391-396 ◽  
Author(s):  
S. Gonnelli ◽  
C. Cepollaro ◽  
A. Montagnani ◽  
G. Monaci ◽  
M. S. Campagna ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Alkaline Phosphatase ◽  
Bone Diseases ◽  
Immunoradiometric Assay ◽  
Metabolic Bone Diseases ◽  
Metabolic Bone

scholarly journals Relationship between anemia and biochemical parameters of mineral bone disorders in chronic kidney disease stages 3-5 pre-dialysis patients

2020 ◽  
Vol 10 (3) ◽  
pp. 187-191
Author(s):  
Shudhanshu Kumar Saha ◽  
Rafi Nazrul Islam ◽  
Muhammad Abdur Rahim ◽  
Sarwar Iqbal
Keyword(s):  
Chronic Kidney Disease ◽  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Kidney Disease ◽  
Biochemical Parameters ◽  
Bone Diseases ◽  
Dialysis Patients ◽  
Bone Disorders ◽  
Metabolic Bone Diseases ◽  
Ckd Stage

Background: Anemia and mineral bone disorders (MBD) accompany chronic kidney disease (CKD) and worsen as CKD progresses. Different biochemical parameters of CKD-MBD have been associated with anemia of CKD but are less well evaluated in low resource settings. In this study, we evaluated the role CKD-MBD disorders as a cause of anemia in CKD non-dialysis patients. Methods: This cross-sectional study recruited 115 patients with CKD who attended outpatient department (OPD) of Nephrology in BIRDEM General Hospital between January and June 2019. Patients, who were on iron, erythropoietin, calcium or vitamin D therapy in any form within the preceding 3 months and patients with known parathyroid disorders, metabolic bone diseases or anemia with definite etiology were excluded. Each patient’s demographic, clinical and biochemical parameters were recorded. Associations between anemia and serum levels of calcium (corrected), phosphate, parathyroid hormone (PTH), 25-hydroxy vitamin D [25(OH)D] and alkaline phosphatase were evaluated. Results: Total patients were 115 including 71 (61.7%) females. Mean age was 57.8 years. Most patients were in CKD stage 4 (43, 37.4%) and 5 (45, 39.1%). Mean duration of diabetes and hypertension were 12.7 and 7.2 years respectively. Mean serum creatinine (mg/dL), hemoglobin (gm/dL), calcium (mg/dL), albumin (gm/L), phosphate (mg/dL), alkaline phosphatase (U/L), PTH (pg/mL) and 25(OH)D (ng/mL) were 3.1, 10.5, 8.7, 37.9, 4.0, 119.1, 211.1 and 15.1 respectively. Hemoglobin in CKD stages 3-5 pre-dialysis patients had positive correlation with calcium and 25(OH)D and negative correlation with phosphate, alkaline phosphatase and PTH. Among these parameters of CKD-MBD, correlation with alkaline phosphatase was significant (r=-0.352, p=0.001) Conclusion: Anemia in CKD patients is multifactorial and this study concludes that CKD-MBD is yet another entity contributing to anemia in such pre-dialysis patients. Birdem Med J 2020; 10(3): 187-191

scholarly journals EFFECT OF FEED ADDITIVE ON MINERAL HOMEOSTASIS OF COWS WITH KETOSIS

2020 ◽  
Vol 21 (1) ◽  
pp. 247-251
Author(s):  
O. Shkilnyk ◽  
I. Petrukh ◽  
D. Ostapiv ◽  
M. Kozak ◽  
V. Vlizlo ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Hormonal Regulation ◽  
Ketone Bodies ◽  
Mineral Metabolism ◽  
Inorganic Phosphorus ◽  
Feed Additives ◽  
Feed Additive ◽  
Total Calcium ◽  
Before And After

The article describes the study of mineral metabolism in patients with cow ketosis and during feeding of our developed feed additive, which includes crushed hop cones, vitamin E and protected from cleavage in the rumen amino acids ˗ methionine, choline and carnitine. In the blood of cows with ketosis, before and after the use of feed additives studied the content of total calcium and inorganic phosphorus, alkaline phosphatase activity, determined the ratio of alkaline phosphatase and total calcium, the concentration of thyroid hormones (parathyroid hormone) and thyroid, thyroid also the amount of ketone bodies in the urine and β-hydroxybutyrate in the blood. It was found that twenty days of feeding cows with ketosis, feed additives leads to a decrease in ketonuria and ketonemia, as well as the normalization of mineral metabolism. At the end of the experiment, the content of total calcium and inorganic phosphorus in the blood of cows increased, the activity of alkaline phosphatase and the ratio of ALP / Ca decreased. The normalization of mineral metabolism in cows was also evidenced by its balanced hormonal regulation. The concentration of parathyroid hormone decreased in the blood plasma and calcitonin increased. According to the results of research, it is established that our proposed feed additive contributes to the normalization of mineral metabolism, and can also be used for prevention and in the complex treatment of cows with ketosis.

Relationship of Vitamin D Deficiency and Intraoperative Parathyroid Hormone Elevation in Completion and Total Thyroidectomy

2019 ◽  
Vol 160 (4) ◽  
pp. 612-615 ◽  
Author(s):  
Bradley R. Lawson ◽  
Andrew M. Hinson ◽  
Jacob C. Lucas ◽  
Donald L. Bodenner ◽  
Brendan C. Stack
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Total Thyroidectomy ◽  
Vitamin D Deficiency ◽  
Case Series ◽  
Hormone Levels ◽  
Parathyroid Autotransplantation ◽  
Vitamin D Levels ◽  
Intraoperative Parathyroid Hormone

Objective To quantify how frequently intraoperative parathyroid hormone levels increase during thyroid surgery and to explore a possible relationship between secondary hyperparathyroidism due to vitamin D deficiency and elevation in intraoperative parathyroid hormone. Study Design Case series with chart review. Setting Tertiary academic center. Subjects and Methods A total of 428 consecutive patients undergoing completion and total thyroidectomy by the senior author over a 7-year period were included for analysis. All patients had baseline and postexcision intraoperative parathyroid hormone levels as well as vitamin D levels from the same laboratory. Institute of Medicine criteria were employed for vitamin D stratification (>30, normal; 20-29.9, insufficient; <20, deficient) . Other data analyzed include sex, age, neck dissection status, and parathyroid autotransplantation. Results A total of 118 patients (27.6%) had an intraoperative parathyroid hormone elevation above baseline. Patients with vitamin D deficiency were significantly more likely to experience hormone elevation ( P = .04). When parathyroid hormone rose, it did so by a mean 32.1 pg/mL. Patients with vitamin D deficiency demonstrated significantly larger hormone increases ( P = .03). Conclusion Elevation in intraoperative parathyroid hormone levels above baseline after completion and total thyroidectomy occurs in over one-fourth of cases and is significantly associated with vitamin D deficiency. This study is the first to report this observation. We hypothesize that vitamin D deficiency in these patients may create a subclinical secondary hyperparathyroidism that leads to intraoperative parathyroid hormone elevation when the glands are manipulated. Additional studies will be needed to explore this physiologic mechanism and its clinical significance.

Serum levels of procollagen type 1 carboxy-terminal extension peptide in metabolic bone diseases

1992 ◽  
Vol 17 ◽  
pp. 228
Author(s):  
P. Nardi ◽  
S. Gonnelli ◽  
E. Maioli ◽  
D. Agnusdei ◽  
M.B. Franci ◽  
...  
Keyword(s):  
Serum Levels ◽  
Bone Diseases ◽  
Metabolic Bone Diseases ◽  
Procollagen Type ◽  
Metabolic Bone ◽  
Carboxy Terminal

Serum parathyroid hormone and alkaline phosphatase as predictors of calcium requirements after total parathyroidectomy for hypocalcemia in secondary hyperparathyroidism

Head & Neck ◽  
2017 ◽  
Vol 40 (2) ◽  
pp. 324-329 ◽  
Author(s):  
Pingjiang Ge ◽  
Shuangxin Liu ◽  
Xiaoli Sheng ◽  
Sijia Li ◽  
Mimi Xu ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Secondary Hyperparathyroidism ◽  
Total Parathyroidectomy ◽  
Serum Parathyroid Hormone

Serum levels of carboxyterminal propeptide of type I procollagen in healthy children from 1 st year of life to adulthood and in metabolic bone diseases

1992 ◽  
Vol 151 (10) ◽  
pp. 764-768 ◽  
Author(s):  
G. Saggese ◽  
S. Bertelloni ◽  
G. I. Baroncelli ◽  
G. Di Nero
Keyword(s):  
Serum Levels ◽  
Bone Diseases ◽  
Type I ◽  
Healthy Children ◽  
Metabolic Bone Diseases ◽  
Type I Procollagen ◽  
Metabolic Bone
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