scholarly journals Effect of large follicle puncture on IVF-ET outcome in patients with unsynchronized follicle maturationcan

2019 ◽  
Vol 47 (5) ◽  
pp. 2056-2066
Author(s):  
Xinrong Wang ◽  
Wenjuan Wang ◽  
Qinglan Qu ◽  
Ning Zhang ◽  
Cuifang Hao ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Pregnancy Outcomes ◽  
Endometrial Thickness ◽  
Multivariate Logistic Regression Analysis ◽  
Clinical Pregnancy ◽  
Control Group ◽  
Large Follicle ◽  
Vitro Fertilization ◽  
Follicular Maturation

Objective This retrospective study was conducted to explore causes of unsynchronized follicular maturation (UFM) and analyze the effects of large follicle puncture on embryo quality and pregnancy outcome. Methods Clinical features and controlled ovulation hyperstimulation (COH) were compared between the puncture group (n = 48) and the control group (n = 2545). We analyzed the COH process with in vitro fertilization during fresh cycle embryo transfer with different clinical pregnancy outcomes. We compared clinical characteristics and COH process of patients in the clinical pregnancy (n = 774) and non-clinical pregnancy (n = 527) groups. Finally, factors related to pregnancy outcomes were analyzed using multivariate logistic regression analysis. Results Age, level of estradiol on down-regulation day, and initial gonadotropin dose were significantly higher in the puncture group than in the control group. We detected significant differences in age, infertility, and body mass index (BMI) between the clinical and non-clinical pregnancy groups. Age, BMI, and endometrial thickness on the day of human chorionic gonadotropin administration were the independent factors influencing pregnancy outcome. Conclusions Patient’s age and level of anti-Müllerian hormone were the main factors causing UFM in patients undergoing COH. Large follicle puncture had no significant effect on pregnancy outcome.

scholarly journals Clinical Outcomes of Sildenafil Application in Patients of Poor Endometrial Development

2021 ◽  
Author(s):  
Meiling Guo ◽  
Jianan Lv ◽  
Hua Xin ◽  
Yuchen Yan ◽  
wei zhou ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Endometrial Thickness ◽  
Hormone Replacement ◽  
Clinical Pregnancy ◽  
Control Group ◽  
Vitro Fertilization ◽  
Biochemical Pregnancy ◽  
Intracytoplasmatic Sperm Injection ◽  
Infertility Patients

Abstract Problem: Does sildenafil have an effect on pregnancy outcomes in patients with poor endometrial development?Methods: This study included 472 infertility patients who underwent in vitro fertilization/intracytoplasmatic sperm injection and frozen-thawed embryo transfer (IVF/ICSI-FET) and suffered from poor endometrial development in the hormone replacement cycle (HRC) from April 2017 to July 2019. The patients were divided into two groups: the sildenafil group(n=88) and the control group(n=384). Endometrial thicknesses and types on endometrial transformation day, as well as pregnancy outcomes after FET (biochemical pregnancy, clinical pregnancy, early abortion, late abortion, and live birth rates) between two groups were analyzed. Results: No significant differences were observed in endometrial thicknesses and types on endometrial transformation day between the sildenafil group and the control group. There were also no statistically significant differences in pregnancy outcomes between the two groups. After adjusting for confounding factors, the application of sildenafil could not improve endometrial thickness and type of the day of endometrial transformation and the growth of endometrial thickness. Moreover, the sildenafil was not closely related to clinical pregnancy outcomes.Conclusions: Sildenafil could not better endometrial development and pregnancy outcomes in patients with poor endometrial development.

Does Hypnofertility-Based Nursing Care Affect Cortisol Levels, Fertility Preparedness, and Pregnancy Outcomes in Women Undergoing In Vitro Fertilization? A Randomized Controlled Trial

2020 ◽  
pp. 109980042097691
Author(s):  
Sevcan Fata ◽  
Merlinda Aluş Tokat
Keyword(s):  
In Vitro Fertilization ◽  
Nursing Care ◽  
Pregnancy Outcomes ◽  
Intervention Group ◽  
Control Group ◽  
Pregnancy Test ◽  
Vitro Fertilization ◽  
Randomized Controlled ◽  
Cortisol Levels

This study used Hypnofertility-based interventions to determine whether these interventions would lead to increased fertility preparedness and pregnancy outcomes and decreased cortisol levels in women undergoing In Vitro Fertilization (IVF) treatment. This randomized, controlled, prospective study was conducted from November 2017 through March 2019 in 61 Turkish women with unexplained infertility (intervention group: 30, control group: 31). Hypnofertility-based nursing care included affirmations, visualization, imagination, and relaxation from the first day of treatment until the day of the pregnancy test. The Fertility Preparedness Scale, a saliva sample for cortisol level, and the pregnancy test results were used for data collection. Hypnofertility-based nursing care decreased the cortisol levels of women in the intervention group compared to that in the control group ( p = 0.00). Though fertility preparedness was higher in the intervention group, the difference was not statistically significant ( p = 0.13). Although interventions relieved the women during the treatment process, there was no anticipated effect on pregnancy outcomes ( p = 0.75). Hypnofertility-based nursing care significantly reduce the cortisol levels, suggesting that the intervention helped women relax.

scholarly journals Association between ambient air pollution and in vitro fertilization pregnancy outcomes in Taiyuan: A retrospective study in a heavy polluted city in northern China

2020 ◽  
Author(s):  
Suming Xu ◽  
Chunqing Sun ◽  
Xingyu Bi ◽  
Dan Feng ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Air Pollution ◽  
Air Quality ◽  
Pregnancy Outcomes ◽  
Northern China ◽  
Ambient Air ◽  
Clinical Pregnancy ◽  
Ambient Air Pollution ◽  
Vitro Fertilization ◽  
Biochemical Pregnancy

Abstract BackgroundGlobally, air pollution has a significant impact on human health. However, the effects of air pollution on pregnancy outcomes in patients undergoing in vitro fertilization (IVF) have not been fully understood. In this study, we analyzed the effects of air pollution on IVF pregnancy outcomes in Taiyuan, which is a heavy polluted city in northern China.Methods516 patients who underwent first fresh IVF cycle were enrolled in the retrospective study from January 1, 2015 to May 31, 2020. We collected medical record data from the electronic medical record system and daily average air pollution data from air quality monitoring station. Logistic regression was used to analyze the relationship between six atmospheric pollutants (PM2.5, PM10, O3, NO2, SO2, CO) and air quality index (AQI) and IVF pregnancy outcomes (biochemical pregnancy and clinical pregnancy) in different exposure periods. ResultsThe results indicated that exposure to NO2 was negatively associated with the odds of biochemical pregnancy and clinical pregnancy, whereas exposure to O3 presented positive association. Furthermore, we also found that AQI was negatively associated with IVF pregnancy outcomes. ConclusionsOur findings suggested that exposure to ambient air pollution during any period may have an impact on IVF pregnancy outcomes, and poor air quality is more likely to reduce clinical pregnancy rates.

scholarly journals Uterine Factors Modify the Association Between Embryo Transfer Depth and Clinical Pregnancy: A Retrospective Study in 7849 Fresh Transfer In Vitro Fertilization Cycles

2021 ◽  
Author(s):  
Xiaohua Sun ◽  
Jiali Cai ◽  
Lanlan Liu ◽  
Haixiao Chen ◽  
Xiaoming Jiang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Embryo Transfer ◽  
Endometrial Thickness ◽  
Patient Characteristics ◽  
Blastocyst Stage ◽  
Clinical Pregnancy ◽  
Uterine Contractility ◽  
Vitro Fertilization ◽  
Fresh Transfer

Abstract The embryo position is supposed to affect implantation following embryo transfer. However, embryo dislodging caused by uterine contraction may occurred after transfer. The retrospective study was to investigated whether the factors associated with uterine contractility, such as endometrial thickness and progesterone elevation, affect the association between embryo position and implantation. A total of 7849 fresh transfer cycles on conventional stimulation in a single IVF centre during the period 2013–2015 was reviewed. Patients were categorized according to quartiles of embryo-fundus distance (≤9, 9.1-11, 11.1-14, ≥1.4 mm, respectively). Adjusted for confounding factors, the odds ratio (OR) (95%CI) for clinical pregnancy was 0.90 (0.79-1.02), 0.86 (0.74-0.99) and 0.70 (0.60-0.82) respectively in quartiles 2 through 4, comparing with quartile 1. However, ORs were significantly increased when endometrial thickness was < 8 mm. The ORs comparing quartiles 2 through 4 with quartile 1 increased 1.96 (95%: 1.33-2.90), 1.20 (95%: 0.78-1.87) and 1.98 (95%: 1.20-3.26) fold respectively in cycles with an endometrial thickness < 8 mm than in cycles with a normal endometrial thickness (8-11 mm). Elevated progesterone on the day of hCG and blastocyst stage transfer reduced the ORs. Our data suggested an interaction between patient characteristics and embryo transfer techniques.

scholarly journals Luaran Transfer Embrio Simpan Beku pada Pasien Endometriosis Pasca Operasi dan Non Endometriosis yang Menjalani IVF di Klinik Permata Hati RSUP Dr. Sardjito

2020 ◽  
Vol 7 (2) ◽  
pp. 108
Author(s):  
Rina Fatmawati ◽  
Shofwal Widad ◽  
Agung Dewanto
Keyword(s):  
In Vitro Fertilization ◽  
Success Rate ◽  
Embryo Transfer ◽  
Pregnancy Outcomes ◽  
Clinical Pregnancy ◽  
Frozen Embryo Transfer ◽  
Research Subjects ◽  
Vitro Fertilization ◽  
Biochemical Pregnancy

Background: Endometriosis is a chronic condition that is influenced by the hormone estrogen which affects women of childbearing age, and is associated with pelvic pain and infertility. In Vitro Fertilization (IVF) is currently the most efficient assisted reproductive technology and its high success rate is often done for infertility therapy in women associated with endometriosisObjective: The aim of this study is to determine whether postoperative endometriosis affected pregnancy outcomes in patients underwent frozen embryo transfer in IVF / ICSI programs.Method: This Research is done with a retrospective cohort design. The data was taken from medical records, research subjects who met the inclusion and exclusion criteria. The research data was collected, processed and analyzed using SPSS 23. Univariate, bivariate and multivariate data analysis was carried out to determine the effect between variablesResult: There were 458 research subjects in this study. Endometriosis patients were 119 subjects (26%). 57 subjects were categorized as minimum-mild endometriosis (47.9%) and moderate-severe subjects as many as 62 subjects (52.1%). The biochemical pregnancy rate (36.31%) and clinical pregnancy (29.4%) in patients with endometriosis was slightly higher than in non-endometriosis. But statistically it did not affect success rate of achieving biochemical (p = 0.428; RR 0.89; 95% CI: 0.71-1.24) and clinical pregnancy (p = 0.535; RR 0.883; 95% CI: 0.63- 1.22). The rate of miscarriage in postoperative endometriosis patients was higher than non-endometriosis patients (88.6% vs 80.7%) but was not statistically significant (p = 0.294; RR 1.69; 95% CI: 0.61-4.67) . Biochemical and clinical pregnancies were significantly affected by age, infertility, endometrial thickness, embryo age and embryo quality. The incidence of miscarriage was affected by the ovarian stimulation protocol.Conclusion: Endometriosis post operative statistically has no effect on pregnancy outcomes in the IVF / ICSI cycle with frozen embryo transfer compared with another cause of infertility .Keywords:Endometriosis, In Vitro Fertilization, Clinical pregnancy, biochemical pregnancy, miscarriage

scholarly journals The Effect of Endometrial Thickness on Pregnancy Outcomes in In Vitro Fertilization Cycles

2018 ◽  
Vol 2 (3) ◽  
pp. 101-106
Author(s):  
Emre BAŞER ◽  
Runa ÖZELÇİ ◽  
Oya ALDEMİR ◽  
Taylan ONAT ◽  
Serdar DİLBAZ ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Outcomes ◽  
Endometrial Thickness ◽  
Vitro Fertilization

scholarly journals Progesterone levels predict pregnancy outcome in individuals with fallopian tube associated infertility

2020 ◽  
Author(s):  
Wenjia BO ◽  
Ning Zhang
Keyword(s):  
Fallopian Tube ◽  
Clinical Data ◽  
Pregnancy Outcomes ◽  
Birth Rate ◽  
Fertilization Rate ◽  
Clinical Pregnancy ◽  
Vitro Fertilization ◽  
Group 3 ◽  
Group 2

Abstract Background: To investigate the predictive value of human chorionic gonadotropin(HCG) and progesterone(P) levels on pregnancy outcomes in patients receiving in vitro fertilization(IVF) due to simple fallopian tube factors. METHODS:We retrospectively analyzed the clinical data of 854 cycles from the simple fallopian tube factor IVF fresh embryo transfer.The clinical data of 854 cycles from January 2010 to December 2018 was divided into 7 groups according to the P level on HCG day.Live birth rates(LBR) and observe trends were calculated. The receiver operating characteristic(ROC) curve was established to determine the optimal cutoff value for P, which was used to further divide the data into 3 groups: Group 1 (P ≦ 1.0 ng/ml), Group 2 (1.0 ng/ml ≤ P ≤ 1.25 ng/ml), and Group 3 (P≥1.25ng/ml). We then compared the ovulation results and clinical outcomes between the 3 groups. RESULTS There were no significant differences in age, infertility years, Gonadotropin(Gn)dosage, Gn days, Luteinizing hormone(LH) level on HCG day, 2pronuclear(2PN) fertilization rate, clinical pregnancy rate(CPR), LBR, full-term birth rate, and preterm birth rate among the three groups, but body mass index （BMI）(P = 0.001), basal LH (P = 0.034), estrogen peak (P = 0.000), number of eggs obtained (P = 0.000) were significantly different. CONCLUSION The level of P level on HCG day does not affect the CPR and LBR after IVF. However, P levels between 1.0-1.25ng/ml may lead to good clinical pregnancy outcomes.

Impact of thawing-loading interval of frozen embryo on pregnancy outcome: retrospective analysis

2021 ◽  
Vol 20 (5) ◽  
pp. 5-11
Author(s):  
A.M. Abbas ◽  
◽  
A.H.A. Hakim ◽  
H.A. Bayoumy ◽  
W.M. Abuelghar ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Pregnancy Outcome ◽  
Embryo Transfer ◽  
Odds Ratio ◽  
Adjusted Odds Ratio ◽  
Clinical Pregnancy ◽  
The Other ◽  
P Value ◽  
Vitro Fertilization

Embryo transfer is a critical final step in the in vitro fertilization (IVF) cycle. Much attention has been paid to standardizing the procedures of embryo transfer to improve pregnancy outcome. Objective. To identify the impact of embryo thawing-loading interval (the time interval passing from thawing to loading of frozen embryo into the catheter) on pregnancy outcome. Results. The study was divided into quartiles according to thawing-loading interval in minutes (G I: <60; G II: 60–119; G III: 120–239; G IV: 240 and above). Numerical variables are presented as median and interquartile range, and inter-group differences are compared using the Mann-Whitney U test. Categorical variables are presented as numbers and percentages, and differences are compared using the chi-square test for trend. After adjustment for the age of women, time of previous failed ICSI (Intracytoplasmic sperm injection) trials, number and maturity of transferred embryos, a thawing-loading interval between 60–119 minutes (adjusted odds ratio = 2.222, 95% CI = 1.370 to 3.603, p-value = 0.001) or between 120–239 minutes (adjusted odds ratio = 1.924, 95% CI = 1.172 to 3.161, p-value = 0.010) was independently associated with increased probability of clinical pregnancy compared with a thawing-loading interval of <60 minutes. On the other hand, a thawing-loading interval of ≥240 minutes significantly decreased the probability of clinical pregnancy (adjusted odds ratio = 0.378, 95% CI 0.215 to 0.664, p-value = 0.001). Conclusion. After adjusting for potential confounders, this analysis found that a thawing-loading interval between 60–239 minutes was independently associated with better pregnancy outcomes compared with a thawing-loading interval of <60 minutes. On the other hand, a thawing-loading interval of ≥240 minutes was significantly associated with a worse outcome. Key words: embryo transfer, IVF (in vitro fertilization), frozen embryo, thawing-loading interval

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