scholarly journals Fructo-oligosaccharides lower serum lipid levels and suppress high-fat/high-sugar diet-induced inflammation by elevating serum and gut levels of short-chain fatty acids

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051989671
Author(s):  
Renqiang Yu ◽  
Yongxiang Yin ◽  
Minkai Cao ◽  
Danni Ye ◽  
Yinghui Zhang ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Lipid Levels ◽  
High Fat ◽  
Serum Lipid Levels ◽  
Tnf Α

Objective This study aimed to investigate the effects of fructo-oligosaccharides (FOS) on serum lipid levels and to determine the mechanisms underlying these effects and the potential role of inflammation. Methods Male C57BL/6 mice received a normal diet, a high-fat/high-sugar (HFS) diet, or an HFS diet supplemented with 10% FOS for 10 weeks. In vivo intestinal and serum short-chain fatty acid (SCFA) levels were measured by gas chromatography. In vivo serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and malonaldehyde (MDA) were also measured. Lipid accumulation was visualized. Reactive oxygen species (ROS) generation was evaluated and apoptosis was quantified. Results FOS reversed in vivo HFS-induced lipid accumulation in the liver. An HFS diet increased ALT, AST, TC, TG, and LDL serum levels, decreased HDL serum levels, and increased IL-6, TNF-α, 8-OHdG, and MDA levels. These changes were reduced by FOS. FOS also increased intestinal and serum levels of short chain fatty acids (SCFAs). In vitro, SCFAs ameliorated palmitic acid-induced ROS production and apoptosis of HepG2 cells. Conclusion FOS supplementation lowers serum lipid levels and ameliorates HFS-induced inflammation by upregulating SCFAs.

scholarly journals A Study of Serum Lipid Profile Changes in Children with Dengue Haemorrhagic Fever and its Correlation with Severity in a Tertiary Care Hospital

2020 ◽  
Author(s):  
A Prabhuraj ◽  
KS Kumaravel ◽  
V Anu Rekha ◽  
A Nithiyapriya ◽  
P Sampathkumar ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Denv Infection ◽  
Lipid Levels ◽  
Serum Lipid Levels

Introduction: Dengue Virus (DENV) infection now remains as the most rapidly spreading viral disease worldwide. Lower lipid level occurs in critically ill patients with DENV infection and is postulated as an independent predictor of the clinical outcome. Aim: To find the correlation between serum lipid levels and severity in children admitted with various grades of Dengue Haemorrhagic Fever (DHF) and secondarily to correlate serum lipid levels with factors like platelet count and duration of hospital stay. Materials and Methods: This was a prospective descriptive study done in the Paediatric ward from October 2019 to December 2019. Febrile Children with a platelet count of less than 1 lakh/cu.mm and positive for DENV IgM antibodies by Enzyme Linked Immuno Sorbent Assay (ELISA) formed the study group. Demographic details, number of days of fever on admission, duration of stay in hospital and severity grading of DENV infection as per the National guidelines were collected. These children were evaluated with Complete Blood Counts (CBC), fasting lipid profile, X-ray chest and ultrasound abdomen. Mean and standard deviation was used for categorical variables. Chi-square test was used to assess the strength of association between lipids and severity of DENV infections. Pearson correlation coefficient was used to assess R value between length of stay and serum lipid levels. Results: The Total Cholesterol, Low Density Lipoprotein (LDL), Triglyceride and Very Low Density Lipoprotein (VLDL) showed a simple linear decline as the severity grade advanced from grade I to grade IV. However, statistical significance was found only for total cholesterol and LDL with p-values of 0.046 and 0.041 respectively. The distribution of High Density Lipoprotein (HDL) across the grades of severity did not follow any pattern and was randomly distributed. On analysis of Pearson correlation between number of days of hospital stay and lipid profile, statistical significance was observed for LDL alone (p=0.023). Conclusion: The serum levels of total cholesterol and LDL were significantly reduced in severe grades of DHF. Serum levels of total cholesterol and LDL can be used as an economical surrogate marker to predict the severity of DHF at the time of admission.

Onion (Allium cepa L.) by-products as source of dietary fiber: physicochemical properties and effect on serum lipid levels in high-fat fed rats

2012 ◽  
Vol 234 (4) ◽  
pp. 617-625 ◽  
Author(s):  
Vanesa Benítez ◽  
Esperanza Mollá ◽  
María A. Martín-Cabrejas ◽  
Yolanda Aguilera ◽  
Francisco J. López-Andréu ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Dietary Fiber ◽  
Allium Cepa ◽  
Serum Lipid ◽  
Lipid Levels ◽  
High Fat ◽  
Serum Lipid Levels ◽  
Allium Cepa L ◽  
By Products

scholarly journals PSV-15 Influence of the temperament of water buffaloes on the serum lipid levels

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 221-222
Author(s):  
Caroline L Francisco ◽  
André M Castilhos ◽  
Daiane C Marques da Silva ◽  
Fabiola Martinez da Silva ◽  
Aline S Aranha ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Repeated Measures ◽  
Serum Lipid ◽  
Fixed Effects ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipid Levels ◽  
Water Buffaloes ◽  
Serum Lipid Levels

Abstract This study evaluated the effect of the temperament of 75 water buffaloes of three genetic groups (GG: Jafarabadi, Mediterranean, and Murrah; n = 25 for each GG) on serum lipid levels. The animals were classified for temperament through the temperament score (TSc) obtained by the mean of the sum of the scores of the entry time into the squeeze chute (1 to 5: 1=greater time spent for entry, and 5=less time spent for entry) and the exit velocity score (1 to 5: 1=lower speed, and 5=higher speed) calculated after the period of adaptation to the feedlot (d0). The animals were categorized into adequate (ADQ; TSc≤3) or excitable (EXC; TSc >3) temperaments. Blood samples were collected from the jugular vein on days -28, 0, and 84, and evaluated for serum levels of total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) using colorimetric enzymatic analyses performed by commercial kits. Data were analyzed using MIXED procedure in SAS, considering the GG, temperament, day, and the resulting interactions as fixed effects. The term day was used for repeated measures in time. Correlations were estimated using the CORR procedure in SAS. There were no interactions for the variables evaluated (P ≥ 0.11). ADQ animals showed lower levels of total cholesterol (65.95 vs 70.96mg/dL for ADQ and EXC, respectively; SEM=2.33; P = 0.04) and LDL (26.74 vs 30.40mg/dL for ADQ and EXC, respectively; SEM=1.57; P = 0.02) than EXC animals. There was no effect of temperament for the triglycerides (P = 0.41), HDL (P = 0.47), and VLDL (P = 0.46). Positive correlations were verified between both the TSc and triglycerides (r=0.32; P < 0.01), and TSc and VLDL (r=0.33; P < 0.01). Tendency for a positive correlation was detected between TSc and LDL (r=0.20; P = 0.09). In conclusion, there are differences in serum lipid levels between water buffalo temperaments which deserves further investigation. Supported by FAPESP (#2018/25939-1; #2014/05473-7).

scholarly journals Frizzled-related proteins 4 (SFRP4) rs1802073G allele predicts the elevated serum lipid levels during acitretin treatment in psoriatic patients from Hunan, China

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4637 ◽  
Author(s):  
Xingchen Zhou ◽  
Wu Zhu ◽  
Minxue Shen ◽  
Yijing He ◽  
Cong Peng ◽  
...  
Keyword(s):  
Serum Level ◽  
Serum Lipid ◽  
Serum Lipids ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Serum Lipid Levels ◽  
Related Proteins

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids. The purpose of this study is to investigate the relationship between the Frizzled-related proteins 4 (SFRP4) rs1802073 polymorphism and the changes of serum lipids in Chinese psoriatic patients during the treatment with acitretin. Methods In our study, 100 psoriatic patients were recruited systematically treated with acitretin (30 mg/day) for at least eight weeks. Data of the patients’ demographic and clinical characteristics and the results of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were collected pre- and post-treatment. Results A total of 84 psoriatic patients were enrolled and divided into three groups by SFRP4 rs1802073 genotypes. The patients who carried with TT genotype had maintained levels of TG and LDL-C after acitretin treatment, while patients with GG/GT genotypes had significantly elevated levels of serum TG and LDL-C compared to the TT genotype (ΔTG%: 27.53 ± 59.13 vs −1.47 ± 37.79, p = 0.026, ΔLDL-C%: 10.62 ± 26.57 vs −1.29 ± 17.07, p = 0.042). The association of rs1802073 with TG and LDL-C profiles remained significant after adjusting for age, gender, and body mass index. Although without significance, the pre-post change in serum level of TC across rs1802073 GG/GT genotypes demonstrated a trend similar to TG and LDL, and the serum level of HDL-C demonstrated a trend opposite to TG, TC and LDL. Conclusions Our results demonstrated that SFRP4 rs1802073 polymorphism was found to be associated with elevated serum lipid levels after acitretin treatment, and it may serve as a genetic marker of safe and precise treatment for individual psoriatic patients.

scholarly journals Effects of Fermented Sargassum thunbergii on Platelet Aggregation and Serum Lipid Levels in Obese Rat induced by High Fat Diet

2015 ◽  
Vol 25 (4) ◽  
pp. 456-462 ◽  
Author(s):  
Jihyeon Cheon ◽  
Juyeong Lee ◽  
Jihye Kim ◽  
Mi-Hwa Park ◽  
Sang-Hyeon Lee ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
High Fat Diet ◽  
Serum Lipid ◽  
Lipid Levels ◽  
High Fat ◽  
Sargassum Thunbergii ◽  
Serum Lipid Levels

scholarly journals Differences in Anthropometric Measurements and Serum Lipid Levels between Representative Samples of the United States and South Korean Populations: NHANES and KNHANES 2007 – 2008 and 2009 – 2010 Study

2021 ◽  
pp. 1-9
Author(s):  
Ryszard Tomasiuk ◽  
◽  
Igor Z Zubrzycki ◽  
Magdalena Wiacek ◽  
◽  
...  
Keyword(s):  
United States ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
The United States ◽  
Lipoprotein Cholesterol ◽  
Clear Correlation ◽  
Lipid Levels ◽  
South Korean ◽  
Serum Lipid Levels ◽  
Representative Samples

The objective of this study was to analyze the dynamics and differences of changes in obesity-defining parameters such as body mass index (BMI), waist circumference (WC), total cholesterol (TC), tricarboxylic acid (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in representative samples from the US and South Korea in analogous sampling frames comprising the years 2007 - 2008 and 2009 - 2010. Differences in anthropometric parameters and serum lipid levels between specific sampling frames were evaluated using a t-test for unpaired data. Age-dependent changes were analyzed using the GLM technique and the Bonferroni-Dunn post-hock test. Among all subjects, the obesity defined by BMI is cross-correlated with an increase in WC. However, in extremely obese women in the United States, there is a lack of a direct relationship between BMI and WC. There was also a clear correlation between the relative change in WC and serum lipid levels in subjects of different ethnic groups. This study showed that BMI and WC could be interchangeably used to assess the health risks associated with increased serum lipid levels in US and South Korean populations

scholarly journals Preliminary Analysis of PON3 rs2375003 Polymorphism in Pakistani Patients with Coronary Artery Disease

2019 ◽  
Vol 67 (3) ◽  
pp. 141-148
Author(s):  
Maryam Sameem ◽  
Muhammad Arshad
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Pakistani Population ◽  
Serum Lipid Levels ◽  
Genotype Frequencies ◽  
Artery Disease

Coronary artery disease (CAD) is an inflammatory heart disease characterized by the narrowing of coronary arteries. Paraoxonase 3 (PON3) is a candidate gene for protection against CAD development as it reduces oxidative stress and lipid peroxidation. The present study aimed to explore the association of PON3 rs2375003 polymorphism with CAD development and serum lipid levels in the Pakistani population. Study subjects included 300 CAD patients and 300 age and sex matched healthy individuals. The genotyping of rs2375003 polymorphism was done using an allele specific polymerase chain reaction and serum lipid levels were determined. In this study, the genotype frequencies of rs2375003 polymorphismin in CAD patients were TT (2%), CT (8%), CC (90%) as compared to TT (3%), CT (6%), CC (91%) in the healthy subjects. No association was observed between rs2375003 polymorphism and CAD risk (p>0.05). The CT genotype of rs2375003 polymorphism marginally increased the risk for CAD development (OR: 1.36; 95% CI 0.72-2.56) by causing a marginal rise in total cholesterol, low density lipoprotein cholesterol and triglyceride levels, and a marginal drop in high density lipoprotein cholesterol levels. The CT genotype of rs2375003 polymorphism and altered lipid levels might act as potential risk factors in the etiology of CAD in the Pakistani population.

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