Differences in Anthropometric Measurements and Serum Lipid Levels between Representative Samples of the United States and South Korean Populations: NHANES and KNHANES 2007 – 2008 and 2009 – 2010 Study

The objective of this study was to analyze the dynamics and differences of changes in obesity-defining parameters such as body mass index (BMI), waist circumference (WC), total cholesterol (TC), tricarboxylic acid (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in representative samples from the US and South Korea in analogous sampling frames comprising the years 2007 - 2008 and 2009 - 2010. Differences in anthropometric parameters and serum lipid levels between specific sampling frames were evaluated using a t-test for unpaired data. Age-dependent changes were analyzed using the GLM technique and the Bonferroni-Dunn post-hock test. Among all subjects, the obesity defined by BMI is cross-correlated with an increase in WC. However, in extremely obese women in the United States, there is a lack of a direct relationship between BMI and WC. There was also a clear correlation between the relative change in WC and serum lipid levels in subjects of different ethnic groups. This study showed that BMI and WC could be interchangeably used to assess the health risks associated with increased serum lipid levels in US and South Korean populations

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Frizzled-related proteins 4 (SFRP4) rs1802073G allele predicts the elevated serum lipid levels during acitretin treatment in psoriatic patients from Hunan, China

PeerJ ◽

10.7717/peerj.4637 ◽

2018 ◽

Vol 6 ◽

pp. e4637 ◽

Cited By ~ 2

Author(s):

Xingchen Zhou ◽

Wu Zhu ◽

Minxue Shen ◽

Yijing He ◽

Cong Peng ◽

...

Keyword(s):

Serum Level ◽

Serum Lipid ◽

Serum Lipids ◽

Elevated Serum ◽

Density Lipoprotein ◽

Serum Triglyceride ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Serum Lipid Levels ◽

Related Proteins

Background Acitretin is a second-generation synthetic retinoid, and is widely used for treating the severe psoriasis vulgaris. However, it should be chosen with caution for its cardiovascular risk, and it is reported that acitretin may increase the serum lipids. The purpose of this study is to investigate the relationship between the Frizzled-related proteins 4 (SFRP4) rs1802073 polymorphism and the changes of serum lipids in Chinese psoriatic patients during the treatment with acitretin. Methods In our study, 100 psoriatic patients were recruited systematically treated with acitretin (30 mg/day) for at least eight weeks. Data of the patients’ demographic and clinical characteristics and the results of serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were collected pre- and post-treatment. Results A total of 84 psoriatic patients were enrolled and divided into three groups by SFRP4 rs1802073 genotypes. The patients who carried with TT genotype had maintained levels of TG and LDL-C after acitretin treatment, while patients with GG/GT genotypes had significantly elevated levels of serum TG and LDL-C compared to the TT genotype (ΔTG%: 27.53 ± 59.13 vs −1.47 ± 37.79, p = 0.026, ΔLDL-C%: 10.62 ± 26.57 vs −1.29 ± 17.07, p = 0.042). The association of rs1802073 with TG and LDL-C profiles remained significant after adjusting for age, gender, and body mass index. Although without significance, the pre-post change in serum level of TC across rs1802073 GG/GT genotypes demonstrated a trend similar to TG and LDL, and the serum level of HDL-C demonstrated a trend opposite to TG, TC and LDL. Conclusions Our results demonstrated that SFRP4 rs1802073 polymorphism was found to be associated with elevated serum lipid levels after acitretin treatment, and it may serve as a genetic marker of safe and precise treatment for individual psoriatic patients.

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Preliminary Analysis of PON3 rs2375003 Polymorphism in Pakistani Patients with Coronary Artery Disease

Folia Biologica ◽

10.3409/fb_67-3.14 ◽

2019 ◽

Vol 67 (3) ◽

pp. 141-148

Author(s):

Maryam Sameem ◽

Muhammad Arshad

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Serum Lipid ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Pakistani Population ◽

Serum Lipid Levels ◽

Genotype Frequencies ◽

Artery Disease

Coronary artery disease (CAD) is an inflammatory heart disease characterized by the narrowing of coronary arteries. Paraoxonase 3 (PON3) is a candidate gene for protection against CAD development as it reduces oxidative stress and lipid peroxidation. The present study aimed to explore the association of PON3 rs2375003 polymorphism with CAD development and serum lipid levels in the Pakistani population. Study subjects included 300 CAD patients and 300 age and sex matched healthy individuals. The genotyping of rs2375003 polymorphism was done using an allele specific polymerase chain reaction and serum lipid levels were determined. In this study, the genotype frequencies of rs2375003 polymorphismin in CAD patients were TT (2%), CT (8%), CC (90%) as compared to TT (3%), CT (6%), CC (91%) in the healthy subjects. No association was observed between rs2375003 polymorphism and CAD risk (p>0.05). The CT genotype of rs2375003 polymorphism marginally increased the risk for CAD development (OR: 1.36; 95% CI 0.72-2.56) by causing a marginal rise in total cholesterol, low density lipoprotein cholesterol and triglyceride levels, and a marginal drop in high density lipoprotein cholesterol levels. The CT genotype of rs2375003 polymorphism and altered lipid levels might act as potential risk factors in the etiology of CAD in the Pakistani population.

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Association between SLC44A4-NOTCH4 SNPs and serum lipid levels in the Chinese Han and Maonan ethnic groups

Nutrition & Metabolism ◽

10.1186/s12986-020-00533-0 ◽

2020 ◽

Vol 17 (1) ◽

Author(s):

Peng-Fei Zheng ◽

Rui-Xing Yin ◽

Yao-Zong Guan ◽

Bi-Liu Wei ◽

Chun-Xiao Liu ◽

...

Keyword(s):

Ethnic Groups ◽

Serum Lipid ◽

Density Lipoprotein ◽

Notch Receptor ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Serum Lipid Levels ◽

Genotype Frequencies ◽

The Relationship ◽

Lipid Parameters

Abstract Background The current research was to assess the relationship of the solute carrier family 44 member 4 (SLC44A4) rs577272, notch receptor 4 (NOTCH4) rs3134931 SNPs and serum lipid levels in the Han and Maonan ethnic groups. Methods The genetic makeup of the SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs in 2467 unrelated subjects (Han, 1254; Maonan,1213) was obtained by using polymerase chain reaction and restriction fragment length polymorphism technique, combined with gel electrophoresis, and confirmed by direct sequencing. Results The genotype frequencies of SLC44A4 rs577272 and NOTCH4 rs3134931 SNPs were different between Han and Maonan populations (P < 0.05); respectively. The SLC44A4 rs577272 SNP was associated with total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) levels in Maonan group. The NOTCH4 rs3134931 SNP was associated with triglyceride (TG) in Han; and TG and low-density lipoprotein cholesterol (LDL-C) levels in Maonan groups (P < 0.025–0.001). Stratified analysis according to gender showed that the SLC44A4 rs577272 SNP was associated with TC and HDL-C in Han and Maonan females; TC in Maonan males, meanwhile, the NOTCH4 rs3134931 SNP was associated with TG and HDL-C in Han males; TG in Han females; TG and LDL-C in Maonan males; and TG, HDL-C and LDL-C in Maonan females. Linkage disequilibrium analysis showed that the most common haplotype was rs577272G-rs3134931A (> 50%) in both Han and Maonan groups. The haplotype of rs577272G-rs3134931A was associated with TG and HDL-C in Han; and TC, TG and HDL-C in Maonan ethnic groups. Conclusions These results suggest that the relationship among SLC44A4 rs577272, NOTCH4 rs3134931 SNPs and serum lipid parameters may vary depending on the gender and/or ethnicity/race in some populations. Haplotypes could explain more changes in serum lipid parameters than any single SNP alone particularly for TC, TG and HDL-C.

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Association of theKLF14rs4731702 SNP and Serum Lipid Levels in the Guangxi Mulao and Han Populations

BioMed Research International ◽

10.1155/2013/231515 ◽

2013 ◽

Vol 2013 ◽

pp. 1-13 ◽

Cited By ~ 6

Author(s):

Ping Huang ◽

Rui-Xing Yin ◽

Ke-Ke Huang ◽

Xiao-Na Zeng ◽

Tao Guo ◽

...

Keyword(s):

Ethnic Groups ◽

Serum Lipid ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Apo B ◽

Serum Lipid Levels ◽

Environmental Interactions ◽

Lipid Parameters

The objective of the present study was to detect the association of the rs4731702 single nucleotide polymorphism (SNP) and serum lipid levels in the Guangxi Mulao and Han populations. A total of 727 subjects of Mulao and 740 subjects of Han Chinese were included. Serum low-density lipoprotein cholesterol (LDL-C) and apolipoprotein (Apo) B levels were higher in Mulao than in Han (P<0.05). The T allele carriers had higher serum LDL-C and ApoAI levels in Mulao, whereas they had lower high-density lipoprotein cholesterol (HDL-C) levels and ratio of ApoAI to ApoB in Han (P<0.05) than the T allele noncarriers. Subgroup analyses showed that the T allele carriers had higher HDL-C, LDL-C, and ApoAI levels in Mulao males and lower ApoAI levels and ratio of ApoAI to ApoB in Han males than the T allele noncarriers. The subjects with TT genotype in Han females also had higher total cholesterol, LDL-C, ApoAI, and ApoB levels than the subjects with CT or CC genotype. Serum lipid parameters were also correlated with several environmental factors in both ethnic groups. The differences in the association ofKLF14rs4731702 SNP and serum lipid levels between the two ethnic groups might partly result from different gene-environmental interactions.

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Serum Lipid Levels and Treatment Outcomes in Women Undergoing Assisted Reproduction: A Retrospective Cohort Study

Frontiers in Endocrinology ◽

10.3389/fendo.2021.633766 ◽

2021 ◽

Vol 12 ◽

Author(s):

Wang-Yu Cai ◽

Xi Luo ◽

Erxidi Chen ◽

Houyi Lv ◽

Kaiyou Fu ◽

...

Keyword(s):

Treatment Outcomes ◽

Assisted Reproduction ◽

Live Birth ◽

Serum Lipid ◽

Endometrial Thickness ◽

Density Lipoprotein ◽

Clinical Pregnancy ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Serum Lipid Levels

ObjectiveTo evaluate associations between serum lipid levels and treatment outcomes in women undergoing assisted reproduction.Materials and MethodsThe study included 2011 women who underwent in vitro fertilization/intracytoplasmic sperm injection with fresh embryo transfer. Serum lipid evaluation included total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). Ovarian stimulation outcomes included endometrial thickness and the number of oocytes retrieved, and reproductive outcomes included live birth, clinical pregnancy, and miscarriage.ResultsHigher HDL-C quartiles were associated with more oocytes retrieved. Lower TC (quartile 1 odds ratio [OR] 1.59 [1.21–2.08], quartile 3 OR 1.36 [1.04–1.77]), LDL-C (quartile 1 OR 1.41 [1.07–1.86]), and TG (quartile 2 OR 1.39 [1.06–1.84]) were independently associated with clinical pregnancy after adjusting for potential confounders. Lower LDL-C (quartile 1 OR 2.22 [1.58–3.13], quartile 2 OR 1.78 [1.27–2.50], quartile 3 OR 1.51 [1.07–2.13]), TC (quartile 1 OR 1.39 [1.00–1.93]), TG (quartile 1 OR 1.44 [1.03–2.03], quartile 2 OR 1.46 [1.04–2.04], quartile 3 OR 1.44 [1.04–1.99]), and higher HDL-C (quartile 2 OR 0.71 [0.51–0.99]) were independently associated with live birth. Higher LDL-C (quartile 1 OR 0.44 [0.30–0.66], quartile 2 OR 0.49 [0.33–0.73], quartile 3 OR 0.63 [0.43–0.94]) and lower HDL-C (quartile 1 OR 1.60 [1.07–2.39]) were independently associated with miscarriage.ConclusionsSerum lipid levels were associated with treatment outcomes in women undergoing assisted reproduction.

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Serum Apolipoprotein B/apolipoprotein A1 Ratio in Relation to Intervertebral Disc Herniation : A Cross-sectional Frequency-Matched Case-Control Study

10.21203/rs.3.rs-113468/v1 ◽

2020 ◽

Author(s):

Fei Chen ◽

Tongde Wu ◽

Song Guo ◽

Junwen Huang ◽

Qiang Fu ◽

...

Keyword(s):

Apolipoprotein B ◽

Serum Lipid ◽

Density Lipoprotein ◽

Apolipoprotein A1 ◽

Lipoprotein Cholesterol ◽

Control Group ◽

Lipid Levels ◽

Apo B ◽

Serum Lipid Levels ◽

Apo Ai

Abstract BackgroundIn recent decades, the serum lipid profile of apolipoprotein(a) (Lp(a)) level and apolipoprotein B/apolipoprotein A1 ratio (Apo B/ApoA1) ratio were found more representative for serum lipid level and were recognized as the independent risk factors for various diseases. Although the serum lipid levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) were found associated with symptomatic IDH, no studies have been conducted to date for the evaluation of the association of Apo AI, Apo B, Lp(a) and Apo B/Apo AI levels with symptomatic IDH.MaterialsA total of 1,839 Chinese patients were recruited in the present study. 918 patients were diagnosed as IDH cases and were enrolled in the experimental group. A control group of 921 patients underwent a physical examination during the same period. The serum lipid levels of TC, TG, LDL-C, HDL-C, Lp(a), Apo B and Apo B/Apo AI were examined and analyzed.ResultsThe patients in the control group were collected randomly from patients who were matched with the baseline levels of the aforementioned lipid molecular. The patients with IDH exhibited significantly higher TC, TG, LDL, Apo B and Lp(a) levels compared with the control subjects. The percentage of high-TC, high-TG, high-LDL, high-Apo B and high-Lp(a) were significantly higher in the IDH group. However, hyperlipidaemia was not associated with the degenerated segment of the IDH (P=0.201). The odds ratios (OR) for the incidence of IDH with an elevated LDL-C, TC, TG, Lp(a), Apo B and Apo B/Apo AI were 1.583, 1.74, 1.62, 1.58, 1.49 and 1.39, respectively. The correlation analysis revealed the correlation between elevated LDL-C, TC, TG, Apo B, Lp(a) and incidence of IDH was significant (R2LDL=0.017; R2TC=0.004; R2TG=0.015; R2Apo B=0.004; R2LP(a)=0.021) (P<0.05). ConclusionsThe present study suggests that elevated levels of serum TC, TG, LDL, Apo B, Lp(a) and Apo B/Apo AI are associated with a higher risk for IDH.

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Association between the TIMD4-HAVCR1 variants and serum lipid levels, coronary heart disease and ischemic stroke risk and atorvastatin lipid-lowering efficacy

Bioscience Reports ◽

10.1042/bsr20171058 ◽

2018 ◽

Vol 38 (1) ◽

Cited By ~ 8

Author(s):

Qing-Hui Zhang ◽

Rui-Xing Yin ◽

Wu-Xian Chen ◽

Xiao-Li Cao ◽

Yu-Ming Chen

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Ischemic Stroke ◽

Serum Lipid ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Lipid Lowering ◽

Lipid Levels ◽

Serum Lipid Levels ◽

Increased Risk

Little is known about the association of the TIMD4 (T-cell immunoglobulin and mucin domain 4 gene)-HAVCR1 (hepatitis A virus cellular receptor 1) variants and lipid metabolism, the risk of coronary heart disease (CHD) and ischemic stroke (IS). The present study aimed to determine the TIMD4-HAVCR1 variants, their haplotypes and gene–environment interactions on serum lipid levels, the risk of CHD and IS, and the lipid-lowering efficacy of atorvastatin in a southern Chinese Han population. Genotypes of three variants in 622 controls, 579 CHD, and 546 IS patients were determined by the Snapshot technology. Atorvastatin calcium tablet (20 mg/day) was given in 724 hyperlipidemic patients for 8 weeks after genotyping. The rs12522248 genotypic and allelic frequencies were different between controls and patients, and were associated with the risk of CHD and IS. The rs1501908G-rs12522248T-rs2036402T haplotype was associated with an increased risk of CHD; the G-C-T haplotype was associated with lower risk of CHD; and the C-C-C haplotype was associated with an increased risk of IS. Variants and their haplotypes in controls were associated with triglyceride (rs1501908), low-density lipoprotein cholesterol (LDL-C, rs1501908, G-T-T), high-density lipoprotein cholesterol (HDL-C, rs12522248, C-C-C) and the ratio of total cholesterol (TC) to HDL-C (C-C-C). Interactions of rs1501908- and rs2036402-alcohol (HDL-C); rs1501908- and rs12522248-high body mass index (hBMI, ≥24 kg/m2; TC); and TIMD4-HAVCR1 variants-atorvastatin on several lipid parameters were detected. Interactions of rs12522248TC/CC-hBMI, G-T-T-, and C-C-C-smoking on the risk of CHD; and C-C-C-smoking, C-C-C-, and G-C-T-hBMI on the risk of IS were also observed. These findings suggest that the TIMD4-HAVCR1 variants may be the genetic risk factors for CHD and IS.

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Association between CYP2C19 gene polymorphisms and lipid metabolism in Chinese patients with ischemic stroke

Journal of International Medical Research ◽

10.1177/0300060520934657 ◽

2020 ◽

Vol 48 (7) ◽

pp. 030006052093465

Author(s):

Yunxue Bai ◽

Ruicheng Huang ◽

Lagen Wan ◽

Rui Zhao

Keyword(s):

Ischemic Stroke ◽

Lipid Metabolism ◽

Gene Polymorphisms ◽

Serum Lipid ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Control Group ◽

Lipid Levels ◽

Serum Lipid Levels ◽

Cyp2c19 Gene

Objective The CYP2C19 genetic variation may be involved in the development of atherosclerotic cardiovascular disease (ASCVD). Serum lipid levels are important risk factors for ASCVD, but the effect of the CYP2C19 gene on serum lipid metabolism remains unclear. This retrospective cohort study investigated the relationship between the CYP2C19 gene polymorphism and serum lipid levels in patients with ischemic stroke (IS). Methods IS patients (n = 230) and control subjects (n = 100) were enrolled. All patients were diagnosed with IS via clinical manifestations and brain magnetic resonance imaging. All patients were genotyped. Results Triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and apolipoprotein B (ApoB) levels were significantly higher and high-density lipoprotein-cholesterol (HDL-c) and apolipoprotein A1 (ApoA1) levels were significantly lower in the IS group compared with the control group. Lower ApoA1 levels and higher ApoB levels were significant predictive factors for IS. Patients with higher ApoB levels had a higher risk of IS recurrence. Compared with extensive metabolizers, intermediate and poor CYP2C19 metabolizers had a higher risk of IS recurrence. Conclusions Our study indicates CYP2C19 gene polymorphisms are related to lipid metabolism in patients with IS. IS patients who are poor CYP2C19 metabolizers may have a higher risk of disease recurrence.

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Homocysteine and Serum-Lipid Levels in Pulmonary Embolism

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029610395570 ◽

2011 ◽

Vol 17 (6) ◽

pp. E186-E189 ◽

Cited By ~ 4

Author(s):

Aysegul Karalezli ◽

Ebru Sengül Parlak ◽

Asiye Kanbay ◽

Aysegul Senturk ◽

H. Canan Hasanoglu

Keyword(s):

Pulmonary Embolism ◽

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Serum Lipid ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Control Group ◽

Lipid Levels ◽

Serum Lipid Levels

Pulmonary embolism (PE) is a fatal disease that arises from genetic and environmental factors. There is little evidence for low high-density lipoprotein cholesterol (HDL-C) with hyperhomocysteinemia to lead to PE. Therefore, we evaluated homocysteine levels and lipid profile in PE patients and to display risk for PE. Forty six patients with proven PE and 46 healthy controls were included in the study. Homocysteine and serum lipid levels were calculated and compared in both groups. There were no significant differences between two groups in terms of total cholesterol, triglyceride, and low-density lipoprotein cholesterol. In PE group, HDL-C levels were found significantly lower in comparison to the control group ( P = .004). Mean homocysteine levels were significantly higher in PE group than in the control group ( P = .001). High-density lipoprotein cholesterol levels were significantly low in which homocysteine levels were high in the PE group. We thought that low HDL-C level with hyperhomocysteinemia is susceptible to PE.

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Serum Lipids are Novel Predictors for Thyroid Autoimmunity in the General Population with Normal TSH Levels From A Cross-Sectional Study

10.21203/rs.3.rs-185316/v1 ◽

2021 ◽

Author(s):

Jiarong Li ◽

Zixiao Wang ◽

He Liu ◽

Jinrong Fu ◽

Fengye Qin ◽

...

Keyword(s):

General Population ◽

Serum Lipid ◽

Serum Lipids ◽

Thyroid Autoimmunity ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Lipid Levels ◽

Thyroid Autoantibody ◽

Serum Lipid Levels ◽

Tsh Levels

Abstract Objective Serum lipids have been shown to regulate inflammatory and immune processes, but little is known about their association with thyroid autoimmunity. This study aimed to investigate the association of serum lipids with thyroid autoantibody positivity in the general population with normal thyroid-stimulating hormone (TSH) levels. Methods Data regarding the 7,688 subjects’ baseline characteristics were retrospectively collected. All subjects were categorized into four groups according to thyroid autoantibodies against thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) positivity and serum lipid levels were compared. Binary logistic regression models were used to evaluate the risk of TgAb or TPOAb positivity with increasing serum lipid levels. Results In 6,456 included subjects, after adjusting for confounders, the risk of TgAb positivity was positively associated with increasing low-density lipoprotein cholesterol (LDL-C) levels (OR 1.10, 95%CI 1.02–1.19, P = 0.014) and negatively correlated with the increasing high-density lipoprotein cholesterol (HDL-C) levels (OR 0.80, 95%CI 0.67–0.96, P = 0.014). In female subjects, the association between increasing LDL-C (OR 1.15, 95%CI 1.05–1.26, P = 0.004) or HDL-C levels (OR 0.74, 95%CI 0.60–0.91, P = 0.005) and TgAb positivity become more pronounced. Moreover, there was a positive correlation between LDL-C levels and TPOAb positivity (OR 1.14, 95%CI 1.02–1.26, P = 0.016). Conclusion We have shown the associations of HDL-C and LDL-C with thyroid autoantibody positivity in the general population with normal TSH levels in a gender-dependent manner. This study highlights that serum lipids may be new predictors of thyroid autoimmunity even when TSH is within the reference range.

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