scholarly journals Meta-analysis of matrix metalloproteinase (MMP)-9 C1562T polymorphism and susceptibility to ischemic stroke in the Chinese population

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092642 ◽  
Author(s):  
Yan Jiang ◽  
HongYu Liu ◽  
Yukai Wang ◽  
Xinxiu Shi ◽  
Yankun Shao ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Matrix Metalloproteinase ◽  
Odds Ratio ◽  
Chinese Population ◽  
Meta Analysis ◽  
Gene Promoter ◽  
Recessive Model ◽  
China National Knowledge Infrastructure ◽  
Significant Difference ◽  
The Matrix

Objective Many studies have shown that the C1562T polymorphism in the matrix metalloproteinase (MMP)-9 gene promoter is associated with susceptibility to ischemic stroke (IS), but the association between them remains controversial. Our objective was to explore the relationship between MMP9 C1562T polymorphism and susceptibility to IS in the Chinese population. Methods We conducted a database search of Wanfang, China Science and Technology Journal database, China National Knowledge Infrastructure, Medline, Embase, PubMed and Springerlink through September 2019. Meta-analysis was performed using Stata15.0 software (StataCorp LP, College Station, TX, USA). Results Thirteen articles were included, including 3,996 patients and 3,815 controls. Among the Chinese population, the results showed no significant difference for the allele model (T vs. C; odds ratio = 1.05, 95%CI: 0.80–1.37). Significant differences were found in the dominant model (TT+TC vs. CC; odds ratio = 2.94, 95%CI: 1.58–5.45) and in the recessive model (TT vs. TC+CC; pooled OR = 0.81, 95%CI: 0.66–0.99). Neither the homozygous model or heterozygous model was significant. Conclusion We identified a correlation between MMP-9 C1562T polymorphism and IS in the Chinese population; the TT+TC genotype may increase the risk of IS.

scholarly journals Methylation in the matrix metalloproteinase-2 gene is associated with cerebral ischemic stroke

2017 ◽  
Vol 65 (4) ◽  
pp. 794-799 ◽  
Author(s):  
Hsiu-Fen Lin ◽  
Edward Hsi ◽  
Ling-Chun Huang ◽  
Yi-Chu Liao ◽  
Suh-Hang H Juo ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Matrix Metalloproteinase ◽  
Epigenetic Modification ◽  
Multivariate Regression Analysis ◽  
Matrix Metalloproteinase 2 ◽  
Large Artery ◽  
Stroke Subtype ◽  
Cpg Sites ◽  
Significant Difference ◽  
The Matrix

Matrix metalloproteinase-2 (MMP-2) is involved in the pathophysiology of stroke. Previous studies have shown that MMP-2 activity is increased in stroke; however, evidence of epigenetic regulation of the MMP-2 in stroke is still limited. We examined methylation of the MMP-2 promoter in patients with ischemic stroke. This study included 298 patients with ischemic stroke and 258 age-matched and sex-matched controls. MMP-2 promoter methylation levels were measured by pyrosequencing at eight potential cytosine-guanine (CpG) sites. Multivariate regression analysis was used to adjust for general stroke risk factors, and the specific effects of sex and stroke subtype were analysed. The methylation levels of MMP-2 in the peripheral blood of the patients with stroke were lower than controls in all eight CpG sites, especially at site 1, site 5, site 7, and site 8 (adjusted p=0.036, 0.002, 0.021, and 0.041, respectively). In subgroup analysis by sex, a significant association was found only in men but not in women. When the stroke subtype was considered, men with small-vessel stroke had significantly lower methylation levels at all MMP-2 CpG sites than the controls (3.01% vs 3.65%, adjusted p=0.018). Although men with large-artery atherosclerosis stroke also had lower MMP-2 methylation levels, no significant difference was found (3.25% vs 3.65%, adjusted p=0.253). Demethylation of the MMP-2 promoter in patients with ischemic stroke was in a sex and stroke subtype-specific manners. These findings may add to the understanding of epigenetic modification of MMP-2 on ischemic stroke.

scholarly journals Association between miR-499 rs3746444 polymorphism and ischemic stroke : A systematic review and meta-analysis

2019 ◽  
Author(s):  
Xiang Hong Liu ◽  
Mei Ling Liu ◽  
Rong Lin ◽  
Yaping Xing ◽  
Tingli Zhao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sensitivity Analysis ◽  
Ischemic Stroke ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Recessive Model ◽  
Dominant Model ◽  
Statistical Association ◽  
Large Heterogeneity ◽  
Allelic Model

Abstract Background: To explore the generic association between miR-499 rs3746444 polymorphism and ischemic stroke (IS). Methods: We performed a systematic review and meta-analysis, odds ratio (OR) and 95% confidence intervals (CIs) were used to estimate the association quantitively. Results: A total of 6 studies (involving 2569 IS cases and 2645 controls) were included. miR-499 (rs3746444) polymorphism showed a statistically significant association with IS risk in the allelic model (G allele vs A allele), the dominant model (GG+AG vs AA), the recessive model (GG vs AG+AA) and the homozygote model (GG vs AA). ORs of the above 4 models were 1.20 (95%CI: 1.02, 1.40), 1.21 (95%CI: 1.01, 1.46), 1.40 (95%CI: 1.04, 1.88), 1.48 (95%CI: 1.10, 2.00) respectively. The I square of the allelic model and the dominant model was 58% and 59%, indicating large heterogeneity among included studies. By sensitivity analysis, I square of the two models dropped to 34.5% and 38.4%, the ORs were 1.26 (95%CI: 1.13, 1.42) and 1.28 (95%CI: 1.12, 1.46), there was still a statistical association between miR-499 (rs3746444) polymorphism and IS. The heterozygote model (AG vs AA) was not statistically significant, the OR was 1.18 (95%CI: 0.99, 1.42), the I square was 54%. Notably, by sensitivity analysis, I square of the heterozygote model dropped to 34.6%, the OR was 1.25 (95%CI: 1.08, 1.43), indicating a statistically significant association between miR-499 (rs3746444) polymorphism and IS. There was no publication bias for all the models by Egger's test. Conclusion: miR-499 (rs3746444) polymorphisms is associated with the increase of IS risk.

Influence of the Matrix Metalloproteinase 9 Geners3918242 Polymorphism on Development of Ischemic Stroke: A Meta-analysis

2020 ◽  
Vol 133 ◽  
pp. e31-e61 ◽  
Author(s):  
Guangliang Wu ◽  
Haiyan Cai ◽  
Guoming Li ◽  
Shuhui Meng ◽  
Jingyan Huang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Matrix Metalloproteinase ◽  
Meta Analysis ◽  
Matrix Metalloproteinase 9 ◽  
The Matrix ◽  
Metalloproteinase 9

scholarly journals The R219K polymorphism of the ATP binding cassette subfamily A member 1 gene and susceptibility to ischemic stroke in Chinese population

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 274-282
Author(s):  
Jianmin Li ◽  
Ming Wen ◽  
Zhiping Zhang ◽  
Zhihua Qiu ◽  
Yiming Sun
Keyword(s):  
Ischemic Stroke ◽  
Odds Ratio ◽  
Chinese Population ◽  
Literature Search ◽  
Protective Factor ◽  
Meta Analysis ◽  
Strong Association ◽  
Southern Population ◽  
Northern Population ◽  
Strength Of Association

AbstractStroke is the major cause of death and disability worldwide. ABCA1 R219K has been suggested as a risk factor for ischemic stroke, but the results remain inconclusive in the Chinese population. This study aimed to assess the association between ABCA1 R219K and ischemic stroke using meta-analysis. A systematic literature search was conducted to select eligible studies and the pooled odds ratio (OR) with 95% confidence interval (CI) was used to evaluate the strength of association. Fourteen studies containing 2865 cases and 3227 controls were included in the meta-analysis and the results suggested that there is a strong association between ABCA1 R219K and the ischemic stroke risks (K vs. R: OR = 0.837, 95% CI: 0.735- 0.954, p=0.008; KK vs. RR: OR = 0.689, 95% CI: 0.520-0.912, p=0.009; KK+RK vs. RR: OR = 0.782, 95% CI: 0.691-0.885, p<0.001). Subgroup analysis revealed that significant association was found for the 4 genetic models (p<0.05) in the Southern population, while in the northern population significant association was only found under the dominant model (KK+RK vs. RR: OR = 0.744, 95% CI: 0.583- 0.949, p<0.017). This meta-analysis suggested that ABCA1 R219K polymorphism might be a protective factor against developing IS, indicating this SNP may contribute to the pathogenesis of ischemic stroke and might be potentially used as a biomarker to predict the susceptibility to ischemic stroke.

Abstract WP394: The Proteasome Subunit α Type 6 Rs1048990 Contributes To The Risk Of Ischemic Stroke And Its Subtypes: New Data And Meta-analysis

Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Lihua Yu ◽  
Jingjing Zhang ◽  
Jian Guo ◽  
Jinghuan Fang ◽  
Ning Chen ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Chinese Population ◽  
Meta Analysis ◽  
Significant Risk ◽  
Large Artery ◽  
Stroke Subtype ◽  
Vessel Occlusion ◽  
Proteasome Subunit ◽  
Expression Of Genes ◽  
Significant Difference

Background and purpose: The proteasome subunit α type 6 (PSMA6) is an important proteolytic protein regulating the expression of genes involved in inflammation. Recently, a functional polymorphism rs1048990, located in PSMA6 , has been reported with the susceptibility to ischemic stroke (IS) in several ethnic cohorts, but the results were inconsistent. Moreover, it still lacks the data in Asian. The purpose of the present study was to determine whether this polymorphism confers significant risk to IS in a Chinese population. Methods: A total of 1102 IS cases and 975 healthy controls were analyzed in our study. We genotyped rs1048990 with ligation detection reaction (LDR) method and then performed a meta-analysis. Results: Significant association between rs1048990 in PSMA6 and ischemic stroke was observed in all comparison models (genotype, p =0.016; allele, p =0.004; CG+GG vs. CC, adjusted p =0.006; GG vs. CG+CC, adjusted p =0.038). Further stratification for stroke subtype, similar differences also can be found in large artery atherosclerosis and cardioembolism, but not small vessel occlusion. In addition, in the analysis of genotype-phenotype correlation, the onset ages of allele-G carriers have a trend to be older than non-carriers’ ( p <0.001). In the meta-analysis, there is no significant difference between rs1048990 and ischemic stroke, for the great discrepancy of the genotype composition between Caucasian and Chinese. Conclusion: Our study suggests that rs1048990 contributes to the risk of IS and its subtypes in Chinese population, but these associations may vary in different ethnic populations.

scholarly journals A Matrix Metalloproteinase-1 Polymorphism,MMP1–1607(1G>2G), Is Associated with Increased Cancer Risk: A Meta-Analysis Including 21,327 Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Zhonghan Zhou ◽  
Xiaocheng Ma ◽  
Fangming Wang ◽  
Lijiang Sun ◽  
Guiming Zhang
Keyword(s):  
Cancer Risk ◽  
Matrix Metalloproteinase ◽  
Meta Analysis ◽  
Recessive Model ◽  
Elevated Risk ◽  
Cancer Risks ◽  
Matrix Metalloproteinase 1 ◽  
The Matrix ◽  
Cancer Types ◽  
Allele Model

Although the matrix metalloproteinase-1 (MMP1) polymorphismMMP1–1607 (1G>2G) has been associated with susceptibility to various cancers, these findings are controversial. Therefore, we conducted this meta-analysis to explore the association betweenMMP1–1607 (1G>2G) and cancer risk. A systematic search of literature through PubMed, Embase, ISI Web of Knowledge, and Google Scholar yielded 77 articles with 21,327 cancer patients and 23,245 controls. The association between theMMP1–1607 (1G>2G) polymorphism and cancer risks was detected in an allele model (2G vs. 1G, overall risk [OR]: 1.174, 95% confidence interval [CI]: 1.107–1.244), a dominant model (2G2G/1G2G vs. 1G1G OR, OR: 1.192, 95% CI: 1.090–1.303), and a recessive model (2G2G vs. 1G2G/1G1G, OR: 1.231, 95% CI: 1.141–1.329). In subgroup analysis, these associations were detected in both Asians and Caucasians. After stratification by cancer types, associations were found in lung, colorectal, nervous system, renal, bladder, and nasopharyngeal cancers. This meta-analysis revealed thatMMP1–1607 (1G>2G) polymorphism was significantly associated with elevated risk of cancers.

scholarly journals Telomerase reverse transcriptase rs2736098 polymorphism is associated with lung cancer: A meta-analysis

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052093617
Author(s):  
Meihua Wang ◽  
Yaping Sun
Keyword(s):  
Lung Cancer ◽  
Reverse Transcriptase ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Recessive Model ◽  
Telomerase Reverse Transcriptase ◽  
Healthy Controls ◽  
China National Knowledge Infrastructure ◽  
Knowledge Infrastructure ◽  
Hardy Weinberg Equilibrium

Background A meta-analysis was conducted to determine whether telomerase reverse transcriptase (TERT) rs2736098 polymorphism was related to the incidence of lung cancer. Methods We systematically searched the following three electronic databases: PubMed, Embase, and China National Knowledge Infrastructure (CNKI), for relevant articles. Statistical analysis was performed using the odds ratio (OR) and the corresponding 95% confidence interval (CI). Results Seven articles involving 3836 healthy controls and 3637 patients were included in this meta-analysis. TERT rs2736098 polymorphism was significantly related to lung cancer incidence (AA vs. GG: OR=1.83, 95% CI=1.58–2.12; AG vs. GG: OR=1.21, 95% CI=1.10–1.34; Dominant model: OR=1.33, 95% CI=1.22–1.46; Recessive model: OR=1.66, 95% CI=1.44–1.90). Moreover, this polymorphism was found to be correlated with the susceptibility to lung cancer when studies were stratified based on the sample size and the Hardy–Weinberg equilibrium. Conclusion The present findings indicate that the TERT rs2736098 polymorphism may be a risk factor for the development of lung cancer.

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