Telomerase reverse transcriptase rs2736098 polymorphism is associated with lung cancer: A meta-analysis

Background A meta-analysis was conducted to determine whether telomerase reverse transcriptase (TERT) rs2736098 polymorphism was related to the incidence of lung cancer. Methods We systematically searched the following three electronic databases: PubMed, Embase, and China National Knowledge Infrastructure (CNKI), for relevant articles. Statistical analysis was performed using the odds ratio (OR) and the corresponding 95% confidence interval (CI). Results Seven articles involving 3836 healthy controls and 3637 patients were included in this meta-analysis. TERT rs2736098 polymorphism was significantly related to lung cancer incidence (AA vs. GG: OR=1.83, 95% CI=1.58–2.12; AG vs. GG: OR=1.21, 95% CI=1.10–1.34; Dominant model: OR=1.33, 95% CI=1.22–1.46; Recessive model: OR=1.66, 95% CI=1.44–1.90). Moreover, this polymorphism was found to be correlated with the susceptibility to lung cancer when studies were stratified based on the sample size and the Hardy–Weinberg equilibrium. Conclusion The present findings indicate that the TERT rs2736098 polymorphism may be a risk factor for the development of lung cancer.

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Selenium Level in Patients with Vitiligo: A Meta-Analysis

BioMed Research International ◽

10.1155/2020/7580939 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7

Author(s):

Ting Dai ◽

Sun Xiaoying ◽

Xin Li ◽

Li Hongjin ◽

Zhou Yaqiong ◽

...

Keyword(s):

Subgroup Analysis ◽

Meta Analysis ◽

Selenium Level ◽

Serum Selenium ◽

Healthy Controls ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Significant Difference ◽

Comprehensive Search ◽

Caucasian Patients

Background. It has been reported that deficiency of selenium can cause autoimmune disease. This meta-analysis was aimed at evaluating whether there exits an association between selenium level and vitiligo. Methods. A comprehensive search was conducted on PubMed, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Med Online, and China VIP databases from the inception to February 12, 2019. The main outcome was the standardized mean difference (SMD) with 95% confidence interval (CI) in serum selenium level between vitiligo patients and healthy controls. Results. A total of 8 studies with 305 vitiligo patients and 6156 healthy controls were included in this meta-analysis. The results showed that there was no significant difference in selenium level between vitiligo patients and healthy controls (SMD=0.481, 95%CI=−0.642 to 1.604, Z=0.840, P>0.05). Further subgroup analysis stratified by area revealed that Asian vitiligo patients had decreased selenium level, while that finding was not observed in Caucasian patients (Asian: SMD=−0.303, 95%CI=−0.603 to −0.004, P<0.05; Caucasian: SMD=0.957, 95%CI=−0.752 to 2.665, P>0.05). Conclusions. Although overall selenium level was similar between vitiligo patients and health controls, subgroup analysis showed decreased levels of selenium in Asian vitiligo patients. It may suggest a clinical tailored administration of selenium supplementation in Asian vitiligo patients.

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Effects of TNF-α-308G/A Polymorphism on the Risk of Diabetic Nephropathy and Diabetic Retinopathy: An Updated Meta-Analysis

Hormone and Metabolic Research ◽

10.1055/a-1161-0088 ◽

2020 ◽

Vol 52 (10) ◽

pp. 724-731

Author(s):

Mengwei Liu ◽

Mengke Shang ◽

Yue Wang ◽

Qian Li ◽

Xiuping Liu ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Diabetic Nephropathy ◽

Meta Analysis ◽

Asian Population ◽

Recessive Model ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Tnf Α ◽

Patients With Diabetes ◽

Major Factors

AbstractDiabetic nephropathy (DN) and diabetic retinopathy (DR) are the major factors of morbidity and mortality in the patients with diabetes mellitus (DM). Growing studies have investigated the relationship between the TNF-α-308G/A polymorphism and the susceptibility to DN and DR, without achieving consensus. Thus, we conducted this meta-analysis to reach more comprehensive conclusions for these issues. Eligible studies were retrieved through electronic databases such as PubMed, Embase, Web of Science and China National Knowledge Infrastructure. Summary of odds ratios (OR) and 95% confidence intervals (CIs) were generated to evaluate the intensity of the associations. Statistical analyses were performed by STATA 11.0 and RevMan 5.2. There are fourteen eligible publications involving nineteen studies in this meta-analysis. TNF-α-308G/A polymorphism was significantly related to increasing risk of DN under recessive model (OR=1.37, 95% CI=1.03–1.83) and homozygous model (OR=1.54, 95% CI=1.15–2.06). Moreover, the similar results were also obtained in Asian groups for DN (recessive: OR=1.69, 95% CI=1.18–2.42; homozygous: OR=1.99, 95% CI=1.38–2.86; respectively), and significant association was also detected between TNF-α-308G/A and DN susceptibility in type 2 DM in recessive model (OR=1.39, 95% CI=1.02–1.89). No significant association was observed between TNF-α-308G/A and DR susceptibility in total analyses and subgroup analyses by ethnicity and type of DM. TNF-α-308G/A polymorphism may enhance the susceptibility to diabetic nephropathy, especially in Asian population and in T2DM patients, but not diabetic retinopathy.

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Association between FSAP 1601G>A polymorphism and venous thromboembolism risk: A meta-analysis

Phlebology The Journal of Venous Disease ◽

10.1177/0268355519881604 ◽

2019 ◽

Vol 35 (5) ◽

pp. 345-353

Author(s):

Li Da ◽

Zhao Jiahui ◽

Li Xiaoqiang

Keyword(s):

Venous Thromboembolism ◽

Confidence Interval ◽

Odds Ratio ◽

Web Of Science ◽

Meta Analysis ◽

Factor Vii ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Bias Assessment ◽

Knowledge Infrastructure

Objective Previous several studies have shown that factor VII-activating protease (FSAP) gene 1601G>A polymorphism is related to the occurrence of venous thromboembolism, but the results are inconsistent and controversial. Therefore, we conducted a meta-analysis to explore the association between FSAP 1601G>A polymorphism and venous thromboembolism susceptibility. Methods We managed a systematic literature search through Pubmed, Embase, Web of Science, China National Knowledge Infrastructure, and WanFang databases to collect research data related to FSAP gene 1601G>A polymorphism and susceptibility to venous thromboembolism published before May 2019. Data analysis was performed through Revman 5.3 and Stata 12.0 software, the pooled odd ratios and 95% confidence intervals were calculated. Additionally, the sensitivity analysis and publication bias assessment were also performed. Results A total of seven case–control studies were included and evaluated, including 2411 venous thromboembolism cases and 2850 controls. The meta-analysis results revealed that the FSAP 1601G>A mutation is associated with venous thromboembolism risk, and statistically significance was observed under three genetic comparison models (A: G, odds ratio: 1.33, 95% confidence interval: 1.07–1.66; GA: GG, odds ratio: 1.34, 95% confidence interval: 1.06–1.68; and GA + AA: GG, odds ratio: 1.33, 95% confidence interval: 1.06–1.66). Conclusion This study demonstrated that the FSAP 1601G>A polymorphism may be associated with venous thromboembolism susceptibility.

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Associations Between Adipokines Gene Polymorphisms and Osteoarthritis: a Meta-analysis

10.21203/rs.3.rs-771310/v1 ◽

2021 ◽

Author(s):

Yuqing Wang ◽

Fanqiang Meng ◽

Jing Wu ◽

Huizhong Long ◽

Jiatian Li ◽

...

Keyword(s):

Gene Polymorphisms ◽

Web Of Science ◽

Meta Analysis ◽

Recessive Model ◽

Systematic Search ◽

Dominant Model ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Registration Number ◽

Allele Model

Abstract Background: Adipokines gene polymorphisms are speculated to have associations with the risk of osteoarthritis (OA), but evidences remain conflicting. This study therefore aimed to examine the potential associations between adipokines gene polymorphisms and OA.Methods: A systematic search was performed on PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang up to March 31, 2020. Meta-analysis was carried out by focusing on associations between adipokines gene polymorphisms and OA with allele model, dominant model, recessive model, homozygote model, and heterozygote model.Results: The present meta-analysis included 13 studies containing 3,661 OA patients and 4,864 controls for analysis. Significant associations were observed between ADIPOQ rs2241766 and OA in Asians (dominant: OR = 1.35, 95% CI 1.03-1.78; heterozygote: OR = 1.43, 95% CI 1.07-1.19), between LEPR rs1137101 and OA in the overall population (recessive: OR = 0.40, 95% CI 0.21-0.79; homozygote: OR = 0.38, 95% CI 0.18-0.79), between VISFATIN rs4730153 and OA in Asians (allele: OR = 0.58, 95% CI 0.41-0.83; dominant: OR = 0.57, 95% CI 0.39-0.83; heterozygote: OR = 0.59, 95% CI 0.40-0.86), and between VISFATIN rs16872158 and OA in Asians (allele: OR = 1.84, 95% CI 1.26-2.68; dominant: OR = 1.94, 95% CI 1.31-2.89; heterozygote: OR = 1.97, 95% CI 1.31-2.95).Conclusions: Adipokines gene polymorphisms may be associated with OA. In particular, associations were observed in ADIPOQ rs2241766, LEPR rs1137101, VISFATIN rs4730153, and VISFATIN rs16872158 in the present study. PROSPERO registration number: CRD42020187664.

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Meta-analysis of matrix metalloproteinase (MMP)-9 C1562T polymorphism and susceptibility to ischemic stroke in the Chinese population

Journal of International Medical Research ◽

10.1177/0300060520926427 ◽

2020 ◽

Vol 48 (6) ◽

pp. 030006052092642 ◽

Cited By ~ 1

Author(s):

Yan Jiang ◽

HongYu Liu ◽

Yukai Wang ◽

Xinxiu Shi ◽

Yankun Shao ◽

...

Keyword(s):

Ischemic Stroke ◽

Matrix Metalloproteinase ◽

Odds Ratio ◽

Chinese Population ◽

Meta Analysis ◽

Gene Promoter ◽

Recessive Model ◽

China National Knowledge Infrastructure ◽

Significant Difference ◽

The Matrix

Objective Many studies have shown that the C1562T polymorphism in the matrix metalloproteinase (MMP)-9 gene promoter is associated with susceptibility to ischemic stroke (IS), but the association between them remains controversial. Our objective was to explore the relationship between MMP9 C1562T polymorphism and susceptibility to IS in the Chinese population. Methods We conducted a database search of Wanfang, China Science and Technology Journal database, China National Knowledge Infrastructure, Medline, Embase, PubMed and Springerlink through September 2019. Meta-analysis was performed using Stata15.0 software (StataCorp LP, College Station, TX, USA). Results Thirteen articles were included, including 3,996 patients and 3,815 controls. Among the Chinese population, the results showed no significant difference for the allele model (T vs. C; odds ratio = 1.05, 95%CI: 0.80–1.37). Significant differences were found in the dominant model (TT+TC vs. CC; odds ratio = 2.94, 95%CI: 1.58–5.45) and in the recessive model (TT vs. TC+CC; pooled OR = 0.81, 95%CI: 0.66–0.99). Neither the homozygous model or heterozygous model was significant. Conclusion We identified a correlation between MMP-9 C1562T polymorphism and IS in the Chinese population; the TT+TC genotype may increase the risk of IS.

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Serum Fetuin-A Levels in Patients with Cardiovascular Disease: A Meta-Analysis

BioMed Research International ◽

10.1155/2014/691540 ◽

2014 ◽

Vol 2014 ◽

pp. 1-9 ◽

Cited By ~ 14

Author(s):

Ze-Lin Sun ◽

Qi-Ying Xie ◽

Gong-Liang Guo ◽

Ke Ma ◽

Yuan-Yuan Huang

Keyword(s):

Web Of Science ◽

Meta Analysis ◽

Serum Levels ◽

Arterial Calcification ◽

Cochrane Library ◽

Healthy Controls ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Fetuin A ◽

Knowledge Infrastructure

Background. Fetuin-A (FA) suppresses arterial calcification, promotes insulin resistance, and appears to be elevated in patients with cardiovascular diseases (CVD), but the data is still inconsistent. To clarify the correlation between serum FA levels and the presence and severity of CVDs, we performed this meta-analysis.Method. Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases. Data from eligible studies were extracted and included in the meta-analysis using a random-effects model.Results. Ten case-control studies, including 1,281 patients with CVDs and 2,663 healthy controls, were included. The results showed significant differences in serum levels of FA between the CVDs patients and the healthy controls (SMD = 1.36, 95%CI: 0.37–2.36,P=0.007). Ethnicity-subgroup analysis implied that low serum FA levels are related to CVDs in Caucasians (SMD = 1.73, 95%CI: 0.20–3.26,P=0.026), but not in Asians (SMD = 1.04, 95%CI: −0.33–2.40,P=0.138).Conclusion. The data indicated that decreased serum FA level is correlated with the development of CVDs. FA might be clinically valuable for reflecting the progression of CVDs.

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Association of angiotensin ІІ type 1 receptor gene A1166C polymorphism with cancer risk: An updated meta-analysis

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320319827207 ◽

2019 ◽

Vol 20 (1) ◽

pp. 147032031982720

Author(s):

Xue Hu ◽

Jing Chen

Keyword(s):

Cancer Risk ◽

Meta Analysis ◽

Receptor Gene ◽

Recessive Model ◽

Cancer Type ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

A1166c Polymorphism ◽

Risk Of Cancer

Objective: The association between angiotensin II type 1 receptor ( AGTR1) gene A1166C polymorphism and cancer risk has been investigated in many studies. However, the results have been inconclusive. A meta-analysis was performed to obtain a more precise estimation of the relationship. Methods: The PubMed and China National Knowledge Infrastructure databases were searched for published literature. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strengths of association. Results: Ten studies, including 1553 patients and 1904 controls, were included in the meta-analysis. Overall, there were no significant associations between the AGTR1 gene A1166C polymorphism and cancer risk in the general population (CC vs AA: OR = 1.09, 95% CI = 0.50–2.37; AC vs AA: OR = 1.54, 95% CI = 0.81–2.91; dominant model: OR = 1.46, 95% CI = 0.77–2.79; recessive model: OR = 1.12, 95% CI = 0.84–1.49). In a subgroup analysis by nationality and cancer type, the results also showed no association between this polymorphism and cancer risk. Conclusions: This meta-analysis demonstrated that the AGTR1 gene A1166C polymorphism does not appear to be related to the risk of cancer.

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Association between eNOS 4b/a Polymorphism and the Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus: A Meta-Analysis

Journal of Diabetes Research ◽

10.1155/2014/549747 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Ze-jun Ma ◽

Rui Chen ◽

Hui-Zhu Ren ◽

Xin Guo ◽

Jun Guo ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Meta Analysis ◽

Additive Model ◽

Recessive Model ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Precise Estimation ◽

Type 2 Diabetic ◽

Allelic Model

Many studies have assessed the association between eNOS-4b/a polymorphism and the risk of diabetic retinopathy (DR) among type 2 diabetic subjects. However, the results are inconsistent. In order to derive a more precise estimation of the association, a meta-analysis was conducted. Fifteen studies with 3, 183 cases and 3, 410 controls were enrolled by searching the databases of Pubmed, Embase, China National Knowledge Infrastructure (CNKI), and Chinese Wanfang Database. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. The main analysis indicated no significant association between eNOS-4b/a polymorphism and the risk of DR in overall population [allelic model:OR=0.94(0.79–1.11); additive model:OR=0.91(0.73–1.14); recessive model:OR=1.01(0.81–1.25); dominant model:OR=0.91(0.75–1.09)]. Subgroup analysis by ethnicity also indicated no significant association. In conclusion, the current meta-analysis did not observe any association between the polymorphism of eNOS 4b/a and the risk of DR among type 2 diabetic subjects. However, larger well-designed studies are required to confirm this finding.

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The CD14 gene –159C/T polymorphism and the risk of ischemic stroke: a meta-analysis

Journal of International Medical Research ◽

10.1177/0300060519886241 ◽

2019 ◽

Vol 48 (3) ◽

pp. 030006051988624

Author(s):

Meihua Xu ◽

Linghua Wang ◽

Lihua Sun ◽

Zhaodong Li ◽

Hua Zhang

Keyword(s):

Ischemic Stroke ◽

Total Population ◽

Web Of Science ◽

Meta Analysis ◽

Relevant Literature ◽

Recessive Model ◽

Knowledge Infrastructure ◽

Hardy Weinberg Equilibrium ◽

Chinese National Knowledge Infrastructure ◽

Cd14 Gene

Background To investigate the association between the CD14 –159C/T polymorphism and ischemic stroke (IS). Methods Relevant literature was searched by retrieving EMBASE, Web of Science, Chinese National Knowledge Infrastructure, and PubMed databases. R version 3.33 software was applied to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results Seven qualified studies with a total of 2058 IS patients and 2123 controls were included. There was no significant association between the CD14 –159C/T polymorphism and IS risk in the total population (TT vs CC: OR = 0.84, 95% CI = 0.58–1.20; CT vs CC: OR = 0.96, 95% CI = 0.82–1.12; dominant model: OR = 1.02, 95% CI = 0.80–1.30; recessive model: OR = 0.82, 95% CI = 0.57–1.19). Similarly, subgroup analysis according to ethnicity and Hardy–Weinberg equilibrium also found no significant interrelation. Conclusion Our findings suggest that the CD14 –159C/T polymorphism does not contribute to the risk of IS. Well-designed studies with more subjects are required to further validate these results.

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The rs9340799 polymorphism of the estrogen receptor alpha (ESR1) gene and its association with breast cancer susceptibility

Scientific Reports ◽

10.1038/s41598-021-97935-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Shing Cheng Tan ◽

Teck Yew Low ◽

Ezanee Azlina Mohamad Hanif ◽

Mohamad Ayub Khan Sharzehan ◽

Hamed Kord-Varkaneh ◽

...

Keyword(s):

Breast Cancer ◽

Estrogen Receptor Alpha ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Menopausal Status ◽

Breast Cancer Susceptibility ◽

Recessive Model ◽

China National Knowledge Infrastructure ◽

Knowledge Infrastructure ◽

Allele Model

AbstractThe ESR1 rs9340799 polymorphism has been frequently investigated with regard to its association with breast cancer (BC) susceptibility, but the findings have been inconclusive. In this work, we aimed to address the inconsistencies in study findings by performing a systematic review and meta-analysis. Eligible studies were identified from the Web of Science, PubMed, Scopus, China National Knowledge Infrastructure, VIP and Wanfang databases based on the predefined inclusion and exclusion criteria. The pooled odds ratio (OR) was then calculated under five genetic models: homozygous (GG vs. AA), heterozygous (AG vs. AA), dominant (AG + GG vs. AA), recessive (GG vs. AA + AG) and allele (G vs. A). Combined results from 23 studies involving 34,721 subjects indicated a lack of significant association between the polymorphism and BC susceptibility (homozygous model, OR = 1.045, 95% CI 0.887–1.231, P = 0.601; heterozygous model, OR = 0.941, 95% CI 0.861–1.030, P = 0.186; dominant model, OR = 0.957, 95% CI 0.875–1.045, P = 0.327; recessive model, OR = 1.053, 95% CI 0.908–1.222, P = 0.495; allele model, OR = 0.987, 95% CI 0.919–1.059, P = 0.709). Subgroup analyses by ethnicity, menopausal status and study quality also revealed no statistically significant association (P > 0.05). In conclusion, our results showed that the ESR1 rs9340799 polymorphism was not associated with BC susceptibility, suggesting its limited potential as a genetic marker for BC.

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