The Ultrastructure of Malignant Fibrous Histiocytoma (Case Report)

1977 ◽  
Vol 63 (4) ◽  
pp. 387-396 ◽  
Author(s):  
Luciano Lombardi ◽  
Silvana Pilotti ◽  
Antonino Carbone ◽  
Franco Rilke
Keyword(s):  
Electron Microscopy ◽  
Stem Cells ◽  
Case Report ◽  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Light And Electron Microscopy ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Cellular Types

A soft tissue malignant fibrous histiocytoma was studied by light and electron microscopy. The presence of fibroblast-like cells, histiocyte-like cells, undifferentiated stem cells, and xanthomatous cells was confirmed. Fibroblast- and histiocyte-like multinucleated giant cells were also observed. The observation of lysosomes in some fibroblast-like cells, the features of undifferentiated stem cells, and the presence of cells with intermediate characteristics common to xanthomatous, histiocytic, and stem cells suggest a strict relationship among these cellular types.

Benign Fibrous Histiocytoma: Report of Case

2003 ◽  
Vol 4 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Ümit Ertaş ◽  
M. Cemil Büyükkurt ◽  
Yasin Çiçek
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Panoramic Radiograph ◽  
Giant Cells ◽  
Benign Fibrous Histiocytoma ◽  
Multinucleated Giant Cells ◽  
Caucasian Male ◽  
Storiform Pattern ◽  
Radiolucent Lesion

Abstract Benign fibrous histiocytoma is a rare and usually painless oral neoplasm found in adults that may affect either soft tissue or bone typically noted in their fifth decade. This case was found in a 32 year-old Caucasian male who presented with a fairly well circumscribed unilocular radiolucent lesion extending from the mandibular right first incisor to the left first premolar and reaching the inferior mandible on a panoramic radiograph. A bony window was created and the intrabony lesion was curetted. Multiple sections revealed a cellular tumor composed of uniform spindle-shaped cells arranged in a prominent whorled or storiform pattern. Scattered xanthoma cells, multinucleated giant cells, lymphocytes, and deposits of hemosiderin were noted throughout the lesional stroma. Although malignant fibrous histiocytoma of the bone is relatively well known, benign fibrous histiocytoma of the bone is very rare. Citation Ertas U, Büyükkurt MC. Benign Fibrous Histiocytoma: Report of Case. J Contemp Dent Pract 2003 May;(4)2:074-079.

scholarly journals Primary Malignant Fibrous Histiocytoma of the Lung: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
I. Tsangaridou ◽  
G. Papamihalis ◽  
K. Stathopoulos ◽  
O. Konstantinopoulos ◽  
L. Thanos
Keyword(s):  
Radiation Therapy ◽  
Case Report ◽  
Soft Tissue ◽  
Surgical Resection ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Distant Recurrence ◽  
Local Relapse ◽  
Metastatic Lesions

Primary malignant fibrous histiocytoma (MFH) of the lung is extremely rare although it is among the most common soft tissue sarcomas in adults. Surgery is the primary mode of therapy, with high rates of local and distant recurrence, while radiation therapy appears to be a very useful adjunct, decreasing local relapse. We report a case of primary malignant fibrous histiocytoma of the lung. Fourteen years after surgical resection, the patient is still alive although with multiple metastatic lesions throughout his body.

Malignant fibrous histiocytoma of the floor of the mouth: case report

1995 ◽  
Vol 109 (7) ◽  
pp. 680-682 ◽  
Author(s):  
P. Poli ◽  
G. Floretti ◽  
G. Tessitori
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Clinical Symptoms ◽  
Fibrous Histiocytoma ◽  
Surgical Excision ◽  
Unusual Site ◽  
Wide Surgical Excision ◽  
Floor Of The Mouth

AbstractMalignant fibrous histiocytoma (MFH) is a common neoplasm of soft tissue. The floor of the mouth is an unusual site of origin and has not been described in the literature previously. Its rarity, aspecific clinical symptoms and complex histopathology combine to make the diagnosis difficult. The treatment of choice is wide surgical excision with adjunctive irradiation.

Malignant Fibrous Histiocytoma of the Left Atrium

1996 ◽  
Vol 4 (4) ◽  
pp. 230-232
Author(s):  
Rajendar Krishan Suri ◽  
Ratna S Manjari ◽  
Neerod Kumar Jha ◽  
Vaiphei Kim ◽  
Rajnish Juneja ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Malignant Fibrous Histiocytoma ◽  
Left Atrial ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Atrial Myxoma ◽  
Postoperative Course ◽  
Left Atrial Myxoma ◽  
The Right

A 25-year-old female presented with symptoms resembling those of critical mitral stenosis. Echocardiography revealed a left atrial mass without a stalk, which was suspected to be a left atrial myxoma. An irregular soft friable mass was found at surgery. It measured 10 × 8 cm, with finger-like extensions and occupied almost the entire left atrial cavity, extending into the three tributaries of the right pulmonary vein. Histopathology of the excised tumor including electron microscopy showed a pleomorphic cytology interlaced with bundles, areas of necrosis, and occasional bizarre tumor giant cells. Characteristic histiocytes containing lysosomes identified the tumor as malignant fibrous histiocytoma. A postoperative course of radiotherapy with a dose of 4,000 cGy/20 fractions was applied to the mediastinum. At follow-up 4 months later the patient was asymptomatic. This case is reported because of the extreme rarity of left atrial malignant fibrous histiocytoma.

Tc-99m-methylene diphosphonate (Tc-99m MDP) and Ga-67 concentration in soft tissue malignant fibrous histiocytoma (MFH): Case report

1993 ◽  
Vol 7 (1) ◽  
pp. 57-60
Author(s):  
Toshiyuki Kida ◽  
Koji Hoshi ◽  
Ryouichi Hoshino ◽  
Yuji Fujita ◽  
Shiro Munakata ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Methylene Diphosphonate

scholarly journals Ultrastructure of a Feline Extraskeletal Giant Cell Tumor (Malignant Fibrous Histiocytoma)

1981 ◽  
Vol 18 (6) ◽  
pp. 738-744 ◽  
Author(s):  
A. W. Confer ◽  
F. M. Enright ◽  
G. B. Beard
Keyword(s):  
Endoplasmic Reticulum ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Rough Endoplasmic Reticulum ◽  
Malignant Fibrous Histiocytoma ◽  
Mononuclear Cells ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Cell Tumor ◽  
Multinucleated Giant Cells

A subcutaneous extraskeletal giant cell tumor (malignant fibrous histiocytoma) was excised repeatedly from a 9-year-old Domestic Shorthair cat. Ultrastructurally, the mass was composed of fibroblast-like, histiocyte-like, and multinucleated giant cells, and some undifferentiated cells and mononuclear cells intermediate between the fibroblast-like and histiocyte-like cells. Fibroblast-like cells were characterized by abundant well-developed rough endoplasmic reticulum, relatively smooth cytoplasmic membranes, few lysosomal structures, and finely granular chromatin. Histiocyte-like cells resembled immature macrophages. The cell membranes had many villous projections. Rough endoplasmic reticulum varied in quantity. Lysosomes were numerous. Multinucleated giant cells had characteristics of both the fibroblast-like and histiocyte-like cells. No viral particles were seen.

scholarly journals Primary giant cell malignant fibrous histiocytoma-associated with renal calculus

2014 ◽  
Vol 8 (3-4) ◽  
pp. 193 ◽  
Author(s):  
Adem Altunkol ◽  
Murat Savas ◽  
Halil Ciftci ◽  
Mehmet Gulum ◽  
Ismail Yagmur ◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Giant Cell ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Renal Calculus ◽  
Fibrous Histiocytomas ◽  
Malignant Fibrous Histiocytomas ◽  
Visceral Organs

Malignant fibrous histiocytomas (MFH) are the most commonly seen soft tissue sarcomas in adults. It is rarely seen in some visceral organs. Kidneys are the parenchymal organs in which MFHs are most frequently seen. More than 50 cases of primary renal MFH have been reported. Among these cases, only 1 was reported as primary giant cell subtype in association with urolithiasis. This case report is the second such case with the these characteristics.

Origin of histiocyte‐like cells and multinucleated giant cells in malignant fibrous histiocytoma: Neoplastic or reactive?

1999 ◽  
Vol 49 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Hiroshi Hatano ◽  
Kunihiko Tokunaga ◽  
Akira Ogose ◽  
Satoshi Imaizumi ◽  
Tadashi Hayami ◽  
...  
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Multinucleated Giant Cells
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