Origin of histiocyte‐like cells and multinucleated giant cells in malignant fibrous histiocytoma: Neoplastic or reactive?

1999 ◽  
Vol 49 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Hiroshi Hatano ◽  
Kunihiko Tokunaga ◽  
Akira Ogose ◽  
Satoshi Imaizumi ◽  
Tadashi Hayami ◽  
...  
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Multinucleated Giant Cells

Benign Fibrous Histiocytoma: Report of Case

2003 ◽  
Vol 4 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Ümit Ertaş ◽  
M. Cemil Büyükkurt ◽  
Yasin Çiçek
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Panoramic Radiograph ◽  
Giant Cells ◽  
Benign Fibrous Histiocytoma ◽  
Multinucleated Giant Cells ◽  
Caucasian Male ◽  
Storiform Pattern ◽  
Radiolucent Lesion

Abstract Benign fibrous histiocytoma is a rare and usually painless oral neoplasm found in adults that may affect either soft tissue or bone typically noted in their fifth decade. This case was found in a 32 year-old Caucasian male who presented with a fairly well circumscribed unilocular radiolucent lesion extending from the mandibular right first incisor to the left first premolar and reaching the inferior mandible on a panoramic radiograph. A bony window was created and the intrabony lesion was curetted. Multiple sections revealed a cellular tumor composed of uniform spindle-shaped cells arranged in a prominent whorled or storiform pattern. Scattered xanthoma cells, multinucleated giant cells, lymphocytes, and deposits of hemosiderin were noted throughout the lesional stroma. Although malignant fibrous histiocytoma of the bone is relatively well known, benign fibrous histiocytoma of the bone is very rare. Citation Ertas U, Büyükkurt MC. Benign Fibrous Histiocytoma: Report of Case. J Contemp Dent Pract 2003 May;(4)2:074-079.

The Ultrastructure of Malignant Fibrous Histiocytoma (Case Report)

1977 ◽  
Vol 63 (4) ◽  
pp. 387-396 ◽  
Author(s):  
Luciano Lombardi ◽  
Silvana Pilotti ◽  
Antonino Carbone ◽  
Franco Rilke
Keyword(s):  
Electron Microscopy ◽  
Stem Cells ◽  
Case Report ◽  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Light And Electron Microscopy ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Cellular Types

A soft tissue malignant fibrous histiocytoma was studied by light and electron microscopy. The presence of fibroblast-like cells, histiocyte-like cells, undifferentiated stem cells, and xanthomatous cells was confirmed. Fibroblast- and histiocyte-like multinucleated giant cells were also observed. The observation of lysosomes in some fibroblast-like cells, the features of undifferentiated stem cells, and the presence of cells with intermediate characteristics common to xanthomatous, histiocytic, and stem cells suggest a strict relationship among these cellular types.

scholarly journals Ultrastructure of a Feline Extraskeletal Giant Cell Tumor (Malignant Fibrous Histiocytoma)

1981 ◽  
Vol 18 (6) ◽  
pp. 738-744 ◽  
Author(s):  
A. W. Confer ◽  
F. M. Enright ◽  
G. B. Beard
Keyword(s):  
Endoplasmic Reticulum ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Rough Endoplasmic Reticulum ◽  
Malignant Fibrous Histiocytoma ◽  
Mononuclear Cells ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Cell Tumor ◽  
Multinucleated Giant Cells

A subcutaneous extraskeletal giant cell tumor (malignant fibrous histiocytoma) was excised repeatedly from a 9-year-old Domestic Shorthair cat. Ultrastructurally, the mass was composed of fibroblast-like, histiocyte-like, and multinucleated giant cells, and some undifferentiated cells and mononuclear cells intermediate between the fibroblast-like and histiocyte-like cells. Fibroblast-like cells were characterized by abundant well-developed rough endoplasmic reticulum, relatively smooth cytoplasmic membranes, few lysosomal structures, and finely granular chromatin. Histiocyte-like cells resembled immature macrophages. The cell membranes had many villous projections. Rough endoplasmic reticulum varied in quantity. Lysosomes were numerous. Multinucleated giant cells had characteristics of both the fibroblast-like and histiocyte-like cells. No viral particles were seen.

Malignant fibrous histiocytoma of the meninges

1981 ◽  
Vol 55 (6) ◽  
pp. 957-962 ◽  
Author(s):  
Uma P. Kalyanaraman ◽  
John J. Taraska ◽  
Joshua A. Fierer ◽  
Patrick W. Elwood
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Cell Of Origin ◽  
Left Frontal Lobe ◽  
Content Type ◽  
Undifferentiated Cells ◽  
The Central Nervous System ◽  
Meningeal Tumors ◽  
Fibroblastic Cells

✓ A case of malignant fibrous histiocytoma arising from the meninges in a 12-year-old boy is reported. This tumor presented as an extracerebral hemorrhagic mass in the left frontal lobe without obvious invasion of the underlying brain. Histologically, a malignant tumor with the characteristic storiform pattern of malignant fibrous histiocytoma with focal areas of hemorrhage was observed. Ultrastructurally, fibroblastic cells, undifferentiated cells, histiocytic-type cells, multinucleated tumor giant cells, and xanthomatous cells were distinctly seen. The possible cell of origin of these meningeal tumors and their prognosis are discussed. The significance of considering this entity in the differential diagnosis of those tumors of the central nervous system with a spindle-cell or xanthomatous component is discussed, and the value of ultrastructural and immunocytochemical study with glial fibrillary acidic protein in the diagnosis is stressed.

Malignant Fibrous Histiocytoma of the Left Atrium

1996 ◽  
Vol 4 (4) ◽  
pp. 230-232
Author(s):  
Rajendar Krishan Suri ◽  
Ratna S Manjari ◽  
Neerod Kumar Jha ◽  
Vaiphei Kim ◽  
Rajnish Juneja ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Malignant Fibrous Histiocytoma ◽  
Left Atrial ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Atrial Myxoma ◽  
Postoperative Course ◽  
Left Atrial Myxoma ◽  
The Right

A 25-year-old female presented with symptoms resembling those of critical mitral stenosis. Echocardiography revealed a left atrial mass without a stalk, which was suspected to be a left atrial myxoma. An irregular soft friable mass was found at surgery. It measured 10 × 8 cm, with finger-like extensions and occupied almost the entire left atrial cavity, extending into the three tributaries of the right pulmonary vein. Histopathology of the excised tumor including electron microscopy showed a pleomorphic cytology interlaced with bundles, areas of necrosis, and occasional bizarre tumor giant cells. Characteristic histiocytes containing lysosomes identified the tumor as malignant fibrous histiocytoma. A postoperative course of radiotherapy with a dose of 4,000 cGy/20 fractions was applied to the mediastinum. At follow-up 4 months later the patient was asymptomatic. This case is reported because of the extreme rarity of left atrial malignant fibrous histiocytoma.

scholarly journals Malignant fibrous histiocytoma in a budgerigar (Melopsittacus undulatus)

2020 ◽  
Vol 71 (3) ◽  
pp. 2407
Author(s):  
Η. ÖZEN ◽  
S. DAĞ ◽  
E. KARAKURT ◽  
E. BÜYÜK
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Melopsittacus Undulatus ◽  
Right Wing ◽  
Subcutaneous Mass ◽  
Mitotic Figures ◽  
The Right ◽  
Microscopic Findings ◽  
Pleomorphic Cells

In this report, a case of malignant fibrous histiocytoma in a budgerigar (Melopsittacus undulatus) is described. At necropsy, a tumorous subcutaneous mass was noted to be located under the right wing at the level of humerus in a budgerigar. On microscopic examination, the tumor was composed of pleomorphic cells having mostly round to oval large nucleus. Presence of occasional bands composed of fibroblastoid cells were noted. Occasional giant cells and mitotic figures were also observed. Based on the microscopic findings, a diagnosis of malignant fibrous histiocytoma was made. The present case in an exotic bird was found to be interesting, since malignant fibrous histiocytomas are rare tumors of domestic animals and mostly seen in dogs.

scholarly journals Cholesterotic Fibrous Histiocytoma in a Patient with Metabolic Syndrome

2017 ◽  
Vol 9 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Masatoshi Deguchi ◽  
Setsuya Aiba
Keyword(s):  
Metabolic Syndrome ◽  
Skin Biopsy ◽  
Male Patient ◽  
Rare Case ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Lower Leg ◽  
Multinucleated Giant Cells ◽  
First Report ◽  
The Many

Among the many variants of dermatofibroma, dermatofibroma with cholesterol cleft (cholesterotic fibrous histiocytoma) is extremely rare. Here, we describe the case of a 50-year-old male patient with a cholesterotic fibrous histiocytoma on his left lower leg. He presented with a hyperkeratotic nodule 6 mm in diameter with a brown surface on the extensor surface of his left lower leg. The lesion had developed over the course of a few years without any tendency to heal. A skin biopsy performed on the tumor showed histopathological findings compatible with those of dermatofibroma. Interestingly, the lesion included many cholesterol clefts, as well as foamy histiocytes and multinucleated giant cells around them. He had had metabolic syndrome for years. To the best of our knowledge, this is the first report of a cholesterotic fibrous histiocytoma in a patient with metabolic syndrome. We conclude that the altered microenvironment caused by metabolic syndrome, as well as hyperlipoproteinemia itself, may play a role in the pathogenesis of this rare case.

scholarly journals Primary Malignant Fibrous Histiocytoma of Proximal Humerus with Pathological Fracture- Case Report

2021 ◽  
pp. 148-153
Author(s):  
Malkesh D. Shah ◽  
Ajinkya Arun Naik ◽  
Sai Sabharish Reddy ◽  
Sarvang M. Desai
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Pathological Fracture ◽  
Mononuclear Cells ◽  
Proximal Humerus ◽  
Fibrous Histiocytoma ◽  
Histopathological Examination ◽  
Giant Cells ◽  
Left Shoulder ◽  
Intralesional Curettage ◽  
Operative Specimen

Malignant fibrous histiocytoma (MFH) is a tumor of late adulthood that occurs in men more commonly than women. Proximal humerus involvement in PMFH is comparatively rare. A 45 year old female presented with complain of pain and mild swelling over the left shoulder with restricted range of movement since 15 days. Radiography of the affected part was suggestive of an osteolytic eccentric lesion with a pathological fracture. A trucut needle biopsy showed minimal tumour tissue with abundant necrosis and showed giant cells with pleomorphic mononuclear cells. So intralesional curettage followed by osteosynthesis with PHILLOS plating and bone cementing was done. Intra operative specimen sent for histopathological examination showed presence of fibroblast cells arranged in storiform pattern s/o MFH along with occasional multinucleated giant cells. Postoperatively patient was started with adjuvant chemotherapy. Patient had good results functionally and clinically with no signs of recurrence till follow up of 1.5 years.

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