Fibrosarcoma with Metastasis in a Rhesus Monkey

1973 ◽  
Vol 10 (4) ◽  
pp. 342-346 ◽  
Author(s):  
G. C. Todd ◽  
W. J. Griffing ◽  
G. R. Koenig
Keyword(s):  
Electron Microscopy ◽  
Rhesus Monkey ◽  
Nonhuman Primates ◽  
Light And Electron Microscopy ◽  
Axillary Lymph Nodes ◽  
Malignant Neoplasms ◽  
Axillary Lymph ◽  
Naturally Occurring ◽  
Primary Neoplasm ◽  
Male Rhesus

Malignant neoplasms that metastasize are uncommon in nonhuman primates. A naturally occurring fibrosarcoma of the forearm with metastasis to the axillary lymph nodes was found in an adult male Rhesus monkey. The primary neoplasm grew rapidly to a size of 8 x 10 x 18 cm. Diagnosis was based on characteristic morphologic findings by light and electron microscopy.

scholarly journals Electron Microscopy of the Bovine Cutaneous Papilloma

1966 ◽  
Vol 3 (3) ◽  
pp. 196-207 ◽  
Author(s):  
D. Brobst ◽  
E.J. Hinsman
Keyword(s):  
Electron Microscopy ◽  
Plasma Membranes ◽  
Light And Electron Microscopy ◽  
Degenerative Changes ◽  
Virus Like Particles ◽  
Cytoplasmic Vacuolation ◽  
Naturally Occurring ◽  
Prickle Cell ◽  
In Cells

Experimentally produced bovine cutaneous papillomas of 30, 76 and 112 days' duration as well as 3 naturally occurring bovine cutaneous papillomas were examined by light and electron microscopy. Degenerative changes were not observed in the fibromatous base of the 30-day-old papilloma. An alteration in all papillomas older than 30 days was cytoplasmic vacuolation in cells of the prickle cell and keratohyaline layers. As cells progressed upward their degeneration became more prominent. In the keratinized layers of 2 papillomas virus-like particles were observed within plasma membranes of keratinized cells.

scholarly journals Pancreatitis Associated with an Adenovirus in a Rhesus Monkey

1974 ◽  
Vol 11 (2) ◽  
pp. 165-171 ◽  
Author(s):  
F. W. Chandler ◽  
C. S. Callaway ◽  
S. R. Adams
Keyword(s):  
Electron Microscopy ◽  
Tissue Culture ◽  
Rhesus Monkey ◽  
Nonhuman Primate ◽  
Nonhuman Primates ◽  
Necrotizing Pancreatitis ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Culture Studies ◽  
Viral Particles

A juvenile Rhesus monkey died suddenly while being conditioned for tissue culture studies. A diagnosis of necrotizing pancreatitis associated with adenovirus was made on the basis of the demonstration by electron microscopy of paracrystalline arrays of viral particles and granular and fibrillar inclusions in necrotic pancreatic acinar cells. This is the first description of necrotizing pancreatitis in a nonhuman primate. Adenovirus should be considered in the etiology of pancreatitis in nonhuman primates.

scholarly journals Naturally occurring melioidosis in a colonized rhesus monkey (Macaca mulatta)

1986 ◽  
Vol 20 (4) ◽  
pp. 281-285 ◽  
Author(s):  
P. E. Fritz ◽  
J. G. Miller ◽  
M. Slayter ◽  
T. J. Smith
Keyword(s):  
Rhesus Monkey ◽  
Macaca Mulatta ◽  
Clinical Signs ◽  
Thoracic Vertebrae ◽  
Research Facility ◽  
Naturally Occurring ◽  
Pelvic Limb ◽  
Pseudomonas Pseudomallei ◽  
Thoracic Lesion ◽  
Male Rhesus

An aged wild-caught male rhesus monkey ( Macaca mulatta), maintained in a research facility for 10 years, developed bilateral pelvic limb paralysis without other signs of disease. Unresponsive to therapy, the monkey was killed and necropsied. Chronic inflammation with osteolysis of thoracic vertebrae 10-13 was observed. Pseudomonas pseudomallei was cultured and identified from cerebrospinal fluid obtained at the site of the thoracic lesion. This Gram-negative bacterium can cause infection in animals and man and may remain latent for years before the appearance of clinical signs.

Glomerulonephropathies in Plasmodium inui-infected rhesus monkey: a primate model and possible applications for human quartan malaria

Parasitology ◽  
2014 ◽  
Vol 141 (12) ◽  
pp. 1638-1645 ◽  
Author(s):  
L. F. NIMRI ◽  
H. N. LANNERS
Keyword(s):  
Electron Microscopy ◽  
Rhesus Monkey ◽  
Mesangial Cells ◽  
Morphological Changes ◽  
Clinical Chemistry ◽  
Light And Electron Microscopy ◽  
Histopathological Changes ◽  
Primate Model ◽  
Nephritic Syndrome ◽  
Plasmodium Inui

SUMMARYNone of the few animal models proposed for the study of human quartan malaria nephritic syndrome have shown complete pathological findings that are similar to those seen in humans. This study investigated the histopathological changes in kidneys in 10 Plasmodium inui infected Macaca mulatta monkeys by light and electron microscopy in order to develop a suitable animal model for human quartan malaria. Ten healthy adult rhesus monkeys were infected with P. inui and clinical chemistry and haematologic tests were done before and after infection. A renal biopsy sample was collected before infection as a baseline control and another biopsy was collected after infection. Histopathological changes examined by light and transmission electron microscopy (TEM) revealed abnormalities in all infected monkeys to variable degrees. Several electron-dense discrete or diffused mesangial deposits, and increase in mesangial cells and matrix were associated with the morphological changes observed by light microscope. This pattern is consistent with membranoproliferative glomerulonephritis type reported in humans infected with Plasmodium malariae. Results strongly support that the P. inui-infected rhesus monkey develop an immune-complex-mediated glomerulonephritis in the course of the infection. Therefore, this experimental model represents a useful tool to better understand the different parameters and the consequences of quartan malaria infections comparable to situations in humans.

scholarly journals The adult oligodendrocyte can participate in remyelination

2018 ◽  
Vol 115 (50) ◽  
pp. E11807-E11816 ◽  
Author(s):  
Ian D. Duncan ◽  
Abigail B. Radcliff ◽  
Moones Heidari ◽  
Grahame Kidd ◽  
Benjamin K. August ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Multiple Sclerosis ◽  
Nonhuman Primates ◽  
Light And Electron Microscopy ◽  
Vitamin B ◽  
Oligodendrocyte Progenitor Cells ◽  
Large Animal ◽  
Myelin Sheaths ◽  
Large Animal Models ◽  
2D And 3D

Endogenous remyelination of the CNS can be robust and restore function, yet in multiple sclerosis it becomes less complete with time. Promoting remyelination is a major therapeutic goal, both to restore function and to protect axons from degeneration. Remyelination is thought to depend on oligodendrocyte progenitor cells, giving rise to nascent remyelinating oligodendrocytes. Surviving, mature oligodendrocytes are largely regarded as being uninvolved. We have examined this question using two large animal models. In the first model, there is extensive demyelination and remyelination of the CNS, yet oligodendrocytes survive, and in recovered animals there is a mix of remyelinated axons interspersed between mature, thick myelin sheaths. Using 2D and 3D light and electron microscopy, we show that many oligodendrocytes are connected to mature and remyelinated myelin sheaths, which we conclude are cells that have reextended processes to contact demyelinated axons while maintaining mature myelin internodes. In the second model in vitamin B12-deficient nonhuman primates, we demonstrate that surviving mature oligodendrocytes extend processes and ensheath demyelinated axons. These data indicate that mature oligodendrocytes can participate in remyelination.

scholarly journals Age changes in rhesus monkey ciliary muscle: Light and electron microscopy

1988 ◽  
Vol 47 (6) ◽  
pp. 885-899 ◽  
Author(s):  
Elke Lütjen-Drecoll ◽  
Ernst Tamm ◽  
Paul L. Kaufman
Keyword(s):  
Electron Microscopy ◽  
Rhesus Monkey ◽  
Light And Electron Microscopy ◽  
Ciliary Muscle ◽  
Age Changes

Oval Lipid Corneal Opacities in Beagles: V. Ultrastructure

1982 ◽  
Vol 19 (2) ◽  
pp. 150-159 ◽  
Author(s):  
W.L. Spangler ◽  
G.O. Waring ◽  
L. A. Morrin
Keyword(s):  
Electron Microscopy ◽  
Light And Electron Microscopy ◽  
Beagle Dog ◽  
Naturally Occurring ◽  
Corneal Opacities

Naturally occurring, oval opacities at the junction of the middle and inferior thirds of the cornea were found in an experimental beagle dog colony and were examined by light and electron microscopy. Abnormalities were limited to the anterior stroma and consisted of extracellular rhomboid crystalline spaces. Spherical or elliptical vacuolar spaces, sometimes containing electron-dense amorphous debris, distorted stromal lamellae. Stromal keratocytes in affected areas revealed a range of changes from hyperplasia of organelles to degeneration and necrosis.

scholarly journals Prognostic factors and overall survival of breast cancer in the city of Goiania, Brazil: a population-based study

2017 ◽  
Vol 44 (5) ◽  
pp. 435-443 ◽  
Author(s):  
Ruffo de Freitas Júnior ◽  
Rodrigo Disconzi Nunes ◽  
Edesio Martins ◽  
Maria Paula Curado ◽  
Nilceana Maya Aires Freitas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Prognostic Factors ◽  
Tumor Size ◽  
Hormone Receptors ◽  
Population Based ◽  
Axillary Lymph Nodes ◽  
Malignant Neoplasms ◽  
Axillary Lymph ◽  
The City

ABSTRACT Objective: to analyze the overall survival and prognostic factors of women with breast cancer in the city of Goiânia. Methods: this is a retrospective, cross-sectional, observational study that included women with malignant neoplasms of the breast identified by the Goiânia Population-based Cancer Registry. The variables studied were age at diagnosis, tumor size, staging, axillary lymph node involvement, tumor grade, disease extent, hormone receptors, and c-erb-B2 oncoprotein. We performed overall survival analyzes of five and ten years. Results: we included 2,273 patients in the study, with an overall survival of 72.1% in five years and 57.8% in ten years. In the multivariate analysis adjusted for tumor size, the factors that influenced the prognosis were axillary lymph nodes, histological grade, progesterone receptor, c erb B2, T staging and disease extension. Conclusion: overall survival in ten years is below that observed in other countries, and possibly reflects what happens with the majority of the Brazilian population. The prognostic factors found in this population follow the same international patterns.

scholarly journals Insular Amyloidosis in Spontaneously Diabetic Nonhuman Primates

1982 ◽  
Vol 19 (7_suppl) ◽  
pp. 181-192 ◽  
Author(s):  
J. L. Palotay ◽  
C. F. Howard
Keyword(s):  
Diabetes Mellitus ◽  
Electron Microscopy ◽  
Alcian Blue ◽  
Nonhuman Primates ◽  
Effective Means ◽  
Light And Electron Microscopy ◽  
Fibrillar Structure ◽  
Islet Amyloid ◽  
Transmission Electron ◽  
Amyloid Accumulation

Sections of pancreas from 21 nonhuman primates with diabetes mellitus were examined by light and electron microscopy. All monkeys showed amyloid accumulation in the islets of Langerhans. Amyloid was identified by its dichroism with three different stains: Congo red, changing from red to yellowish-green; standardized toluidine blue, changing from blue to red; and sulfated alcian blue, changing from blue-green to pink. Sulfated alcian blue was a rapid and effective means of detecting amyloid. The characteristic fibrillar structure of amyloid was seen with transmission electron microscopy. Deposition of islet amyloid was independent of the presence or absence of amyloid in other organs. Results indicate that nonhuman primates offer a model for studying the sequential development of insular amyloidotic diabetes mellitus.

The Morphology of Vacuolated Cells in the Liver Following Administration of Vitamin A.

1973 ◽  
Vol 31 ◽  
pp. 408-409
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti
Keyword(s):  
Electron Microscopy ◽  
Body Weight ◽  
Vitamin A ◽  
Light And Electron Microscopy ◽  
Liver Cells ◽  
Prominent Feature ◽  
Vascular Space ◽  
Vacuolated Cell ◽  
Vacuolated Cells ◽  
Vacuolated Cytoplasm

Vacuolated cells in the liver of young rats were studied by light and electron microscopy following the administration of vitamin A (200 units per gram of body weight). Their characteristics were compared with similar cells found in untreated animals.In rats given vitamin A, cells with vacuolated cytoplasm were a prominent feature. These cells were found mostly in a perisinusoidal location, although some appeared to be in between liver cells (Fig. 1). Electron microscopy confirmed their location in Disse's space adjacent to the sinusoid and in recesses between liver cells. Some appeared to be bordering the lumen of the sinusoid, but careful observation usually revealed a tenuous endothelial process separating the vacuolated cell from the vascular space. In appropriate sections, fenestrations in the thin endothelial processes were noted (Fig. 2, arrow).

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