Adenocarcinoma of the Olfactory Gland in the Dog

1974 ◽  
Vol 11 (2) ◽  
pp. 138-143 ◽  
Author(s):  
F. A. Zaki ◽  
S.-K. Liu
Keyword(s):  
White Matter ◽  
Epithelial Cells ◽  
Connective Tissue ◽  
Cerebral Hemispheres ◽  
Neoplastic Cells ◽  
The Masses ◽  
Connective Tissue Stroma ◽  
Neoplastic Epithelial Cells

Adenocarcinomas of the olfactory glands were diagnosed in five dogs. The tumors had invaded the adjacent olfactory and prefrontal areas of the cerebral hemispheres. The masses consisted of large sheets of neoplastic epithelial cells separated by connective tissue stroma. In some areas there were hemorrhage and necrosis. The anterior parts of the cerebral hemispheres had been destroyed by the invasive neoplastic cells, and the white matter in the areas was very edematous. Review of the medical and veterinary literature yielded no description of tumors originating in the olfactory glands.

scholarly journals Two Renal Tumors in Cottontail Rabbits (Sylvilagus floridanus)

1977 ◽  
Vol 14 (1) ◽  
pp. 29-35 ◽  
Author(s):  
W. W. Carlton ◽  
J. M. Dietz
Keyword(s):  
Epithelial Cells ◽  
Connective Tissue ◽  
Renal Tumors ◽  
Sylvilagus Floridanus ◽  
Tubular Structures ◽  
Renal Adenocarcinoma ◽  
Connective Tissue Stroma ◽  
Neoplastic Epithelial Cells

Renal tumors were found in two cottontail rabbits (Sylvilagus floridanus) about 1 year old. One tumor was intimately associated with the kidney and consisted of isolated ductular and tubular structures within an abundant connective tissue stroma and was diagnosed as a hamartoma of urogenital origin. The second was composed of epithelial cells arranged as alveolar structures with papillary projections, epithelium that was less differentiated into tubules and ducts, and neoplastic epithelial cells in solid sheets. The diagnosis of renal adenocarcinoma was based on the histologic features as metastasis had not occurred.

Ultrastructural Evaluation and Pathophysiology of Testicular Sertoli Cell Neoplasms from Dogs With a Syndrome of Hyperestrogenism

1973 ◽  
Vol 31 ◽  
pp. 384-385
Author(s):  
C. C. Capen ◽  
S. L. Martin
Keyword(s):  
Connective Tissue ◽  
Sertoli Cell ◽  
Testicular Neoplasms ◽  
Neoplastic Cells ◽  
Specific Objective ◽  
Pathologic Findings ◽  
Estrogenic Hormones ◽  
Excessive Secretion ◽  
Circulating Levels ◽  
Connective Tissue Stroma

A syndrome of feminization associated with testicular neoplasms has been reported frequently in male dogs but occurs rarely in man and other species. Although an excessive secretion of estrogenic hormones has been suspected on the basis of clinical and pathologic findings, elevated circulating levels have not been demonstrated conclusively. The specific objective of this investigation was to evaluate ultrastructural1y functional Sertoli cell neoplasms from 5 male dogs with feminization and to correlate these findings with the results of estrogen assays.The affected testes were enlarged, irregularly lobulated, firm and were retained in the abdomen of all dogs (Fig. 1A). The neoplastic cells were spindle-shaped or polyhedral and formed distinct tubules separated by a delicate connective tissue stroma (Fig. 1B).

Pituitary Chromophobe Adenoma in a Cat

1973 ◽  
Vol 10 (3) ◽  
pp. 232-237 ◽  
Author(s):  
F. A. Zaki ◽  
S.-K. Liu
Keyword(s):  
Connective Tissue ◽  
Pituitary Gland ◽  
Blood Vessels ◽  
Neoplastic Cells ◽  
Chromophobe Adenoma ◽  
Connective Tissue Stroma

Chromophobe adenoma was diagnosed in the pituitary gland of an 11-year-old domestic shorthaired cat. Histologically, the tumor consisted of a mass of cells with scant sinusoidal arrangement and connective tissue stroma and few blood vessels. In areas the neoplastic cells contained large vacuoles that occupied the entire cytoplasm and pushed the nuclei aside.

scholarly journals Cholangiocarcinoma in an American Rhea (Rhea Americana araneipes)

2015 ◽  
Vol 45 (2) ◽  
pp. 284-287 ◽  
Author(s):  
Paulo Ricardo Dell'Armelina Rocha ◽  
Letícya Lerner Lopes ◽  
Laura Peixoto de Arruda ◽  
Caroline Argenta Pescador ◽  
Raquel Aparecida Sales da Cruz ◽  
...  
Keyword(s):  
Bile Duct ◽  
Epithelial Cells ◽  
Connective Tissue ◽  
Adult Female ◽  
Neoplastic Cells ◽  
Rhea Americana ◽  
Duct Epithelium ◽  
Bile Duct Epithelium ◽  
Biliary Ducts ◽  
Cut Surface

Cholangiocarcinomas are neoplasms that originate from the bile duct epithelium. The present case described a cholangiocarcinoma in an adult female American Rhea (Rhea Americana araneipes) by means of gross, histopathology and immunohistochemistry. Irregular, firm, multifocal, yellow-white masses, measuring from 0.4 to 6cm in diameter were observed in both liver lobes. At the cut surface, multiple firm nodules filled with connective tissue were present. Microscopically, the neoplasia was composed of small, irregular, gland-like structures of neoplastic cells surrounded by connective tissue. The cells resembled epithelial cells of the hepatic biliary ducts. Neoplastic cells were positive for cytokeratin and negative for vimentin. This is the first report of a malignant fatal neoplasia in an American Rhea.

scholarly journals Amyloid-Producing Odontogenic Tumors of the Facial Skin in Three Cats

2016 ◽  
Vol 54 (2) ◽  
pp. 218-221 ◽  
Author(s):  
K. Hirayama ◽  
C. Endoh ◽  
Y. Kagawa ◽  
T. Ohmachi ◽  
T. Yamagami ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Congo Red ◽  
Polyclonal Antibodies ◽  
Odontogenic Tumors ◽  
Polarization Microscopy ◽  
Facial Skin ◽  
Domestic Cats ◽  
Neoplastic Cells ◽  
Varied Intensity ◽  
Neoplastic Epithelial Cells

Amyloid-producing odontogenic tumors (APOTs) of the facial skin were diagnosed in 3 domestic cats. The neoplasms had the histopathological characteristics of the odontogenic tumor. The neoplastic cells were present in irregular islands, strands, and sheets. The peripheral neoplastic cells of the islands and strands were arranged in a palisading fashion, while the central cells were polyhedral to stellate and randomly arranged. Multiple spherules of homogeneous eosinophilic material were closely apposed to the neoplastic epithelial cells. The spherules stained with Congo red and produced an apple green birefringence under polarization microscopy, indicative of amyloid. Immunohistochemically, amyloid materials of the neoplasms reacted with polyclonal antibodies for ameloblastin, amelogenin, and sheathlin antibodies. Neoplastic epithelial cells also reacted with antiameloblastin, amelogenin, and sheathlin antibodies, with varied intensity. The histopathological and immunohistochemical characteristics of dermal neoplasms of the 3 cats were analogous to those of APOTs reported in the dog and the cat.

Induction and Differentiation of Dental Epithelium in Vivo and in Vitro

1982 ◽  
Vol 40 ◽  
pp. 142-145
Author(s):  
E. J. Kollar
Keyword(s):  
Connective Tissue ◽  
Oral Mucosa ◽  
Basal Lamina ◽  
Functional Derivatives ◽  
Specific Source ◽  
Dental Epithelium ◽  
Connective Tissue Stroma

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.

Factors Involved In the Plasminogen Activation System in Human Breast Tumours

1994 ◽  
Vol 71 (05) ◽  
pp. 684-691 ◽  
Author(s):  
László Damjanovich ◽  
Csaba Turzó ◽  
Róza Ádány
Keyword(s):  
Epithelial Cells ◽  
Connective Tissue ◽  
Plasminogen Activators ◽  
Breast Tumour ◽  
Plasminogen Activation ◽  
Malignant Tumours ◽  
Plasminogen Activation System ◽  
Activation System ◽  
Malignant Breast ◽  
Pai 1

SummaryThe plasminogen activation system is a delicately balanced assembly of enzymes which seems to have primary influence on tumour progression. The conversion of plasminogen into serine protease plasmin with fibrinolytic activity depends on the actual balance between plasminogen activators (urokinase type; u-PA and tissue type; t-PA) and their inhibitors (type 1 and 2 plasminogen activator inhibitors; PAI-1 and PAI-2). The purpose of this study was to determine the exact histological localization of all the major factors involved in plasminogen activation, and activation inhibition (plasmin system) in benign and malignant breast tumour samples. Our results show that factors of the plasmin system are present both in benign and malignant tumours. Cancer cells strongly labelled for both u-PA and t-PA, but epithelial cells of fibroadenoma samples were also stained for plasminogen activators at least as intensively as tumour cells in cancerous tissues. In fibroadenomas, all the epithelial cells were labelled for PAM. Staining became sporadic in malignant tumours, cells located at the periphery of tumour cell clusters regularly did not show reaction for PAI-1. In the benign tumour samples the perialveolar connective tissue stroma contained a lot of PAI-1 positive cells, showing characteristics of fibroblasts; but their number was strongly decreased in the stroma of malignant tumours. These findings indicate that the higher level of u-PA antigen, detected in malignant breast tumour samples by biochemical techniques, does not necessarily indicate increased u-PA production by tumour cells but it might be owing to the increased number of cells producing u-PA as well. In malignant tumours PAI-1 seems to be decreased in the frontage of malignant cell invasion; i.e. malignant cells at the host/tumour interface do not express PAI-1 in morphologically detectable quantity and in the peritumoural connective tissue the number of fibroblasts containing PAI-1 is also decreased.

scholarly journals GASTRIC CARCINOMA WITH OSSEOUS METAPLASIA IN A DOG

2012 ◽  
Vol 17 (3) ◽  
Author(s):  
Irina Ferraz Amorim ◽  
Celia Lopes ◽  
Rui M Gil da Costa ◽  
Augusto MR Faustino ◽  
Fatima Gartner ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Epithelial Cells ◽  
Gastric Carcinoma ◽  
Heterotopic Ossification ◽  
Bone Tissue ◽  
Exploratory Laparotomy ◽  
Osseous Metaplasia ◽  
Mucin Production ◽  
Positive Immunostaining ◽  
Neoplastic Epithelial Cells

This report describes an unprecedented case of a gastric carcinoma with osseous metaplasia in a 8-year-old male standard poodle. An exploratory laparotomy revealed a firm yellowish nodular mass in the pyloric region. The lesion was surgically removed and submitted for current histological examination. Immunohistochemistry was performed employing monoclonal antibodies for pan-cytokeratin, vimentin, smooth muscular a-actin and BMP-2/4. The mass consisted in neoplastic proliferation of epithelial cells, arranged in a tubular or acinar pattern and supported by scirrhous stroma, with mucin production and multiple foci of heterotopic ossification. Neoplastic epithelial cells showed strong positive immunostaining for AE1/AE3 and BMP-2/4, although they were negative for both vimentin and a-actin. Histopathological findings suggested that the bone tissue may be primarily originated from neoplastic epithelial cells which directly circumscribe the osseous metaplasia foci.

scholarly journals Cartilaginous Choristoma of the Gingiva: A Rare Clinical Entity

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Ramalingam Suganya ◽  
Narasimhan Malathi ◽  
Subramani Vijaya Nirmala ◽  
Chinnaswami Ravindran ◽  
Harikrishnan Thamizhchelvan
Keyword(s):  
Connective Tissue ◽  
Histopathological Examination ◽  
Clinical Entity ◽  
Fibrous Connective Tissue ◽  
Rare Clinical Entity ◽  
Normal Cells ◽  
Connective Tissue Stroma

Choristomas are rare entities which are aggregates of microscopically normal cells or tissues in aberrant locations. They are a “heterotopic” rest of cells, as they appear as a tumor-like mass. Herein we report a case of cartilaginous choristoma in a 54-year-old male who presented with a swelling on right lower gingiva. The histopathological examination revealed features of a well circumscribed mass of mature cartilage in a dense fibrous connective tissue stroma.

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