scholarly journals Cerebral Venous Thrombosis in the Rhesus Monkey

1981 ◽  
Vol 18 (3) ◽  
pp. 326-334 ◽  
Author(s):  
W. D. Sheffield ◽  
R. A. Squire ◽  
J. D. Strandberg
Keyword(s):  
Ulcerative Colitis ◽  
Central Nervous System ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Rhesus Monkeys ◽  
Venous Occlusion ◽  
Thromboembolic Disease ◽  
Cerebral Veins ◽  
Centrum Semiovale ◽  
Internal Cerebral Veins

Cerebral venous thrombosis was identified in four rhesus monkeys. Two initially showed neurologic signs and three had diarrhea or dysentery. All four had severe intestinal disease, including three cases of ulcerative colitis complicated by extracerebral thromboembolic disease. Central nervous system lesions, confined to the centrum semiovale, were multiple thrombi of internal cerebral veins, perivenular demyelination, and gemistocytic astrocytosis. The lesions resembled those found in people with cerebral venous thrombosis, and support the hypothesis that perivenular demyelination may occur as a sequela to venous occlusion. The lesions were identical to those found in “leukoencephalosis and perivascular myelosis,” an entity of unknown cause previously described in monkeys.

Role of MRI in Cerebral Venous Thrombosis

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Eman Ahmad Shawki Geneidi ◽  
Nermeen Nasry Keriakos ◽  
Khaled Mostafa Mohammad Khaled
Keyword(s):  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Venous Occlusion ◽  
Acute Onset ◽  
Radiology Department ◽  
Cerebral Veins ◽  
Limb Weakness ◽  
Inflammatory Conditions ◽  
Imaging Department ◽  
The Brain

Abstract Background Cerebral venous thrombosis CVT is a type of stroke where the thrombosis occurs in the venous side of the brain circulation, leading to occlusion of one or more cerebral veins and Dural venous sinus. CVT is a potentially life-threatening disease, accounting for approximately 0.5 % of stroke cases. Aim of the Work The aim of this subject is to illustrate the various aspects of CVT on MRI. Patients and Methods This is a retrospective study included 30 patients (19 females &11 males), their ages range from 3 months to 74 years with the median age 22 years. Mean age 22.04 years. The study was performed in radiology department El Demerdash Hospital between March 2018 & September 2019. The study included patients presented to the Medical Imaging Department of Ain Shams university Al-Demerdash hospital with cerebral venous occlusion neurological symptoms or imaging diagnosis. Results In our study,. Most common presenting symptom was headache noted in 22 patients (73.3%) followed by eye manifestations (blurring of vision or clinically having papilledema) was the second most seen in 18 patients (60%). Then comes convulsions in8 patients (26.7 %), Limb weakness in 5 patients (16.7%), finally disturbed consciousness level in 4 patients (13.3%). Most common mode of onset was subacute which was seen in 16 patients (53.3%) acute onset was seen in 6 patients (20%) as predominantly isointense on T1 weighted images and hypo intense on T2 weighted images, chronic onset was seen in 8 patients (26.7%) as hypo intense signal in both T1 and T2 WIs. MRV successfully diagnosed occlusion in most cases by absence of signal intensity with consequent non-visualization of occluded sinuses or veins in almost all patients and except 3 patients; those were having just cortical veins thrombosis detected by T2* sequence electing blooming artifacts with intact sinuses, and dilated distal collaterals seen in 18 patients. Conclusion Dural venous occlusion can occur due to many factors as thrombosis, inflammatory conditions of the brain and tumors. Cerebral venous thrombosis (CVT) has long been a neglected entity because of complexities in diagnosis and non-specific clinical presentation. Conventional MRI and phase contrast MRV in conjugation with recent techniques such SWI & DWI were considered more accurate diagnostic tool, non invasive, non ionizing, with high resolution in evaluating patients with suspected cerebral venous occlusion or thrombosis. It is also considered very useful to demonstrate brain parenchymal affection, the age or stage of the thrombus and its extension

scholarly journals Cerebral Venous Thrombosis: What's New?

2021 ◽  
Vol 41 (01) ◽  
pp. 025-030
Author(s):  
Diana Aguiar de Sousa
Keyword(s):  
Young Adults ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Cerebral Veins ◽  
Cerebrovascular Disorder ◽  
Recent Advances ◽  
Children And Young Adults

AbstractThrombosis of the cerebral veins and sinuses (CVT) is a distinct cerebrovascular disorder that, unlike arterial stroke, most often affects children and young adults, especially women. In this review, we will summarize recent advances on the knowledge of patients with CVT.

scholarly journals Cerebral venous thrombosis in a patient with Down syndrome and coronavirus disease 2019: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Henry Robayo-Amortegui ◽  
Natalia Valenzuela-Faccini ◽  
Cesar Quecano-Rosas ◽  
Darlyng Zabala-Muñoz ◽  
Michel Perez-Garzon
Keyword(s):  
Risk Factors ◽  
Down Syndrome ◽  
Case Report ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Epidemiological Data ◽  
Thromboembolic Disease ◽  
Hispanic Woman ◽  
Case Presentation ◽  
The World

Abstract Background The new coronavirus disease 2019 pandemic has spread throughout most of the world. Cerebral venous thrombosis is a rare thromboembolic disease that can present as an extrapulmonary complication in coronavirus disease 2019 infection. Case presentation We report the case of a Hispanic woman with Down syndrome who has coronavirus disease 2019 and presents as a complication extensive cerebral venous thrombosis. Conclusions Cerebral venous thrombosis is a rare thromboembolic disease that can present as an extrapulmonary complication in coronavirus disease 2019 infection. In the absence of clinical and epidemiological data, it is important to carry out further investigation of the risk factors and pathophysiological causes related to the development of cerebrovascular thrombotic events in patients with Down syndrome with coronavirus disease 2019 infection.

Successful Treatment of Cerebral Venous Thrombosis Associated with Ulcerative Colitis

2013 ◽  
Vol 22 (8) ◽  
pp. e684-e686
Author(s):  
Satoshi Suda ◽  
Ken-ichiro Katsura ◽  
Seiji Okubo ◽  
Arata Abe ◽  
Kentaro Suzuki ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Venous Thrombosis ◽  
Successful Treatment ◽  
Cerebral Venous Thrombosis

scholarly journals Cerebral venous thrombosis secondary to hyperthyroidism: A case report

2018 ◽  
Vol 15 (1) ◽  
pp. 29-31
Author(s):  
Basant Pant ◽  
Malika Bajracharya ◽  
Avinash Chandra ◽  
Ramita Bati ◽  
Reema Rajbhadari ◽  
...  
Keyword(s):  
Case Report ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis ◽  
Thrombus Formation ◽  
Thyroid Function Test ◽  
Transverse Sinus ◽  
Severe Headache ◽  
Cerebral Veins ◽  
First Case ◽  
Red Flag

Cerebral Venous Thrombosis (CVT) is a rare form of Stroke characterized by thrombus formation in the cerebral veins. CVT is a result of various reasons among which the hyperthyroidism is not so frequently encountered. This is probably the first case report published from Nepal. The aim of this case report is to give the message that persistent severe headache in patient with hyperthyroidism can be the red flag and needs to be investigated further. We present a case of a 35 years old female who presented with complaints of severe headache and persistent in nature associated with vomiting since 5 days. She was a diagnosed subacute thryroiditis and under medicine from 1 month before presenting to us. Her Magnetic Resonance Venography (MRV) brain showed venous thrombosis within superior saggital sinus, left transverse sinus and sigmoid sinus. Her thyroid function test showed pretreatment T3 of 2.98 ng/ml T4 of 1.02 mg/ ml and TSH of 0.12 μIU/L. She was kept on anticoagulants and other supportive measures. The patient showed improving status with the conservative management.Nepal Journal of Neuroscience 15:29-31, 2018

Cerebral venous thrombosis in a patient with ulcerative colitis

2007 ◽  
Vol 13 (12) ◽  
pp. 1588-1589 ◽  
Author(s):  
Sandeep Chauhan ◽  
Atul Sachdev ◽  
Sanjay DʼCruz ◽  
Koyal Jain ◽  
Ram Singh
Keyword(s):  
Ulcerative Colitis ◽  
Venous Thrombosis ◽  
Cerebral Venous Thrombosis

Matrix Metalloproteinase-9 Levels are Associated with Brain Lesion and Persistent Venous Occlusion in Patients with Cerebral Venous Thrombosis

2021 ◽  
Author(s):  
Diana Aguiar de Sousa ◽  
Maria Conceição Pereira-Santos ◽  
Ana Serra-Caetano ◽  
Lia Lucas Neto ◽  
Ana Luísa Sousa ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Venous Thrombosis ◽  
Brain Damage ◽  
Cerebral Venous Thrombosis ◽  
Brain Lesion ◽  
Venous Occlusion ◽  
Matrix Metalloproteinase 9 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Venous Recanalization ◽  
Metalloproteinase 9

Abstract Background Elucidating mechanisms of brain damage in cerebral venous thrombosis (CVT) would be instrumental to develop targeted therapies and improve prognosis prediction. Matrix metalloproteinase-9 (MMP-9), a gelatinase that degrades major components of the basal lamina, has been associated to blood–brain barrier disruption. We aimed to assess, in patients with CVT, the temporal change in serum concentrations of MMP-9 and its association with key imaging and clinical outcomes. Methods Pathophysiology of Venous Infarction—PRediction of InfarctiOn and RecanalIzaTion in CVT (PRIORITy-CVT) was a multicenter prospective cohort study of patients with newly diagnosed CVT. Serial collection of peripheral blood samples performed on day 1, 3, and 8, and standardized magnetic resonance imaging on day 1, 8, and 90. MMP-9 was quantified using enzyme-linked immunosorbent assay in 59 patients and 22 healthy controls. Primary outcomes were parenchymal brain lesion, early evolution of brain lesion, early recanalization, and functional outcome on day 90. Results CVT patients with parenchymal brain lesion had higher baseline concentrations of MMP-9 compared with controls (adjusted p = 0.001). The area under receiver operating characteristic curve value for MMP-9 for predicting brain lesion was 0.71 (95% confidence interval [CI]: 0.57–0.85, p = 0.009). Patients with venous recanalization showed early decline of circulating MMP-9 and significantly lower levels on day 8 (p = 0.021). Higher MMP-9 on day 8 was associated with persistent venous occlusion (odds ratio: 1.20 [per 20 ng/mL], 95% CI: 1.02–1.43, p = 0.030). Conclusion We report a novel relationship among MMP-9, parenchymal brain damage, and early venous recanalization, suggesting that circulating MMP-9 is a dynamic marker of brain tissue damage in patients with CVT.

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