Eosinophilic Gastroenteritis with Splendore-Hoeppli Material in the Ferret (Mustela putorius furo)

1992 ◽  
Vol 29 (1) ◽  
pp. 21-26 ◽  
Author(s):  
J. G. Fox ◽  
L. S. Palley ◽  
R. Rose
Keyword(s):  
Clinical Signs ◽  
Infectious Agent ◽  
Multiple Organ ◽  
Eosinophilic Gastroenteritis ◽  
Human Beings ◽  
Mesenteric Lymph Nodes ◽  
Mustela Putorius ◽  
Mesenteric Lymph ◽  
Small Intestinal ◽  
Mustela Putorius Furo

Eosinophilic gastroenteritis, focal or diffuse with eosinophilic infiltrations of the stomach or intestine, has been described in human beings, cats, dogs, and horses. In this paper, we describe infiltration of the gastrointestinal tract with eosinophils accompanied by a circulating eosinophilia in six ferrets ( Mustela putorius furo). Clinical signs included chronic weight loss, anorexia, and diarrhea. The small intestines from five ferrets had diffuse infiltrates of eosinophils. This resulted in focal or multifocal loss of the muscular tunic in three ferrets. Two of these ferrets also had eosinophilic gastritis. Eosinophilic granulomas with Splendore-Hoeppli material were present in mesenteric lymph nodes in four ferrets. Two ferrets had multiple organ involvement; one had eosinophilic granulomas in the liver, mesentery, and choroid plexus as well as moderate parapancreatic segmental arteritis with infiltration of eosinophils and mural thrombosis. The second ferret had, in addition to moderate diffuse gastric and small intestinal eosinophilic mucosal infiltrations, interstitial eosinophilic pulmonary infiltrates. Examination of all tissues failed to reveal an infectious agent.

scholarly journals Detection of Swine Dysentery (SD) caused by Brachyspira hyodysenteriae via PCR in Northern Vietnam

2021 ◽  
Vol 4 (3) ◽  
pp. 1109-1116
Author(s):  
Nguyen Thi Thu Hang ◽  
Truong Quang Lam ◽  
Dao Le Anh ◽  
Nguyen Thi Hoa ◽  
Nguyen Thi Lan ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Mesenteric Lymph Nodes ◽  
Swine Dysentery ◽  
Brachyspira Hyodysenteriae ◽  
Northern Vietnam ◽  
Hygiene Practices ◽  
Mesenteric Lymph ◽  
Gross Lesions ◽  
Pcr Method ◽  
Weaning Pigs

This study aimed to diagnose swine dysentery (SD) caused by Brachyspira hyodysenteriae in pigs by the PCR method in Vietnam. Of the 250 samples, 29 isolates of B. hyodysenteriae (11.60%) were identified by PCR in seven provinces of Northern Vietnam, and the infection rate differed from region to region. From the positive cases of B. hyodysenteriae, we analyzed B. hyodysenteriae infected cases according to the ages of the pigs, farm sizes, and veterinary hygiene practices to get more information about the disease in Vietnam. The results showed that the positive B. hyodysenteriae samples were commonly seen in post-weaning pigs (32.14%) in households (20.73%) with poor hygiene (24.69%). Clinical signs of SD included high fever (100%); anorexia (100%); watery, bloody diarrhea, usually gray to brown in color (100%); and weight loss (86.42%). Gross lesions of SD were limited to the large intestine were described as having a fibrinous, blood-flecked membrane covering the mucosa (93.75%), swollen with hemorrhaged colon and cecum (75.00%), and mesenteric lymph nodes (81.25%).

Development of renal adenocarcinoma in a ferret with renal cortical cysts (Mustela putorius furo)

2021 ◽  
pp. 1-8
Author(s):  
Amanda D. Wong ◽  
Delphine Laniesse ◽  
Alex zur Linden ◽  
Ameet Singh ◽  
Leonardo Susta ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Renal Cysts ◽  
Clinical Findings ◽  
Surgical Removal ◽  
Mustela Putorius ◽  
Initial Examination ◽  
Contralateral Kidney ◽  
Renal Adenocarcinoma ◽  
Contrast Enhanced Ct ◽  
Mustela Putorius Furo

Abstract CASE DESCRIPTION A 5.5-year-old 0.929-kg spayed female domestic ferret (Mustela putorius furo) underwent serial abdominal ultrasonographic and clinicopathologic examinations after multiple renal cysts were detected bilaterally during a routine examination. CLINICAL FINDINGS The ferret was apparently healthy at the start of the monitoring period and had no clinical signs for > 20 months. Four months after the initial examination, the largest cyst became increasingly mineralized; 17 months after detection, it had increased in size and become amorphous, and the ferret’s plasma BUN concentration was mildly high. Within 21 months after the first visit, a nodule was detectable, and hydronephrosis developed in the kidney with the largest cyst. Findings for fine-needle aspirates from the nodule were consistent with renal carcinoma. TREATMENT AND OUTCOME Contrast-enhanced CT revealed severe unilateral nephromegaly with no contrast uptake in the affected ureter. Following surgical removal of the affected kidney, histologic examination identified renal adenocarcinoma replacing the entire renal cortex and medulla. The ferret was euthanized postoperatively because of declining condition. On necropsy, metastasis to a mesenteric lymph node was identified; comorbidities included 2 other neoplasms and acute, severe injury of the contralateral kidney. CLINICAL RELEVANCE Neoplastic transformation of a renal cyst was suspected in the ferret of this report on the basis of observed ultrasonographic changes over time and extensive infiltration of the neoplasm throughout the affected kidney. Renal cysts are linked to renal neoplasia in other species, and the findings for this patient supported the need for periodic monitoring of renal cysts in ferrets.

scholarly journals Selenization of S. cerevisiae increases its protective potential in experimental autoimmune encephalomyelitis by triggering an intestinal immunomodulatory loop

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Thais Fernanda de Campos Fraga-Silva ◽  
Luiza Ayumi Nishiyama Mimura ◽  
Larissa Ragozo Cardoso de Oliveira ◽  
Juliana Helena dos Santos Toledo ◽  
Patrícia Aparecida Borim ◽  
...  
Keyword(s):  
Immune Response ◽  
Experimental Autoimmune Encephalomyelitis ◽  
Lymph Nodes ◽  
Therapeutic Potential ◽  
Clinical Signs ◽  
Mesenteric Lymph Nodes ◽  
Autoimmune Encephalomyelitis ◽  
Complementary Medicines ◽  
Mesenteric Lymph ◽  
Experimental Autoimmune

AbstractMultiple sclerosis is an autoimmune disease that affects the myelinated central nervous system (CNS) neurons and triggers physical and cognitive disabilities. Conventional therapy is based on disease-modifying drugs that control disease severity but can also be deleterious. Complementary medicines have been adopted and evidence indicates that yeast supplements can improve symptoms mainly by modulating the immune response. In this investigation, we evaluated the therapeutic potential of Saccharomyces cerevisiae and its selenized derivative (Selemax) in experimental autoimmune encephalomyelitis (EAE). Female C57BL/6 mice submitted to EAE induction were orally supplemented with these yeasts by gavage from day 0 to day 14 after EAE induction. Both supplements determined significant reduction in clinical signs concomitantly with diminished Th1 immune response in CNS, increased proportion of Foxp3+ lymphocytes in inguinal and mesenteric lymph nodes and increased microbiota diversity. However, Selemax was more effective clinically and immunologically; it reduced disease prevalence more sharply, increased the proportion of CD103+ dendritic cells expressing high levels of PD-L1 in mesenteric lymph nodes and reduced the intestinal inflammatory process more strongly than S. cerevisiae. These results suggest a clear gut-brain axis modulation by selenized S. cerevisiae and suggest their inclusion in clinical trials.

scholarly journals Epizootic Disseminated Toxoplasmosis in Captive Slender-tailed Meerkats (Suricata suricatta)

1997 ◽  
Vol 34 (1) ◽  
pp. 1-7 ◽  
Author(s):  
C. Juan-Sallés ◽  
N. Prats ◽  
S. López ◽  
M. Domingo ◽  
A. J. Marco ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Neospora Caninum ◽  
Clinical Signs ◽  
Giant Cells ◽  
Mesenteric Lymph Nodes ◽  
Suricata Suricatta ◽  
Mesenteric Lymph ◽  
Clinicopathologic Findings ◽  
Foamy Macrophages

Fatal disseminated toxoplasmosis was diagnosed in seven captive slender-tailed meerkats ( Suricata suricatta) according to clinicopathologic findings and immunohistochemistry. Five of nine meerkats died during an outbreak in late 1994. These included four kits (2.5 to 4.5 months old) and a 4-year-old meerkat. Two other meerkats, both adults, died in 1992 and 1995. Respiratory insufficiency (4/7) and incoordination (3/7) were the most consistent clinical signs, although two of seven meerkats died unexpectedly. At necropsy, the lungs were reddened and noncollapsed (6/7), and had multiple pale round foci (4/7). Yellow foci of necrosis in mesenteric lymph nodes (4/7), splenomegaly (3/7), and hydropericardium (3/7) were other common gross findings. Microscopically, interstitial pneumonia was present in all seven meerkats, being acute to subacute in six of them. Type 2 pneumocyte hyperplasia, aggregates of foamy macrophages, and giant cells were consistently seen. Multifocal to locally extensive necrosis of mesenteric lymph nodes (4/7), mild to severe multifocal necrotizing hepatitis (5/6), and mild nonsuppurative encephalitis (4/6) were also seen. Toxoplasma-like organisms were consistently associated with these lesions and were stained by the avidin biotin peroxidase procedure with an antiserum that does not cross-react with Neospora caninum. Meerkats were most likely infected after an oral, primary exposure to Toxoplasma. Several observations indicate that meerkats may be highly susceptible to toxoplasmosis.

scholarly journals Diabetes-prone BioBreeding rats do not have a normal immune response when weaned to a diet containing fermentable fibre

2005 ◽  
Vol 93 (5) ◽  
pp. 645-653 ◽  
Author(s):  
RoseMarie Stillie ◽  
Rhonda C. Bell ◽  
Catherine J. Field
Keyword(s):  
Lymph Nodes ◽  
Stimulation Index ◽  
Control Diet ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Intestinal Length ◽  
Small Intestinal ◽  
Normal Immune Response

Diet is known to modulate the development of diabetes in diabetes-prone BioBreeding (BBdp) rats. The objective of the present study was to determine the effect of fermentable fibre (FF) on immune function in BBdp and diabetes-resistant BioBreeding (BBdr) rats after weaning. Weanling BBdp (thirty-six to thirty-eight per diet) and BBdr rats (thirty to thirty-two per diet) were fed a nutritionally complete, semi-purified, casein-based diet containing either cellulose (control diet, 8 % w/w) or FF (3·2 % cellulose+4·8 % w/w inulin). At 35 d, the small intestine was excised and lymphocytes isolated from spleen, mesenteric lymph nodes and Peyer's patches. Feeding FF to both BBdr and BBdp rats affected the production of anti-inflammatory cytokines (P=0·02). In BBdr rats, feeding FF compared with cellulose resulted in an increased small intestinal length (P=0·0031), higher proliferative (stimulation) index from both splenocytes (P=0·001) and mesenteric lymph nodes (P=0·04), and an increased proportion of CD8+ T-cells in the Peyer's patches (P=0·003). We did not observe an effect of diet on the number of IgA-bearing cells in the jejunum from BBdr rats. Feeding FF to BBdp rats did not affect the same parameters. BBdp rats had both a higher proportion of B-cells in the Peyer's patches (P=0·01) and a higher number of IgA+ cells in the jejunum (P=0·0036) when fed a diet containing FF, a response not observed in BBdr rats. We demonstrate that several aspects of the BBdp immune system respond differently than that of BBdr rats when challenged at weaning with FF.

scholarly journals Intestinal lesions in pigs affected with postweaning multisystemic wasting syndrome

2008 ◽  
Vol 28 (6) ◽  
pp. 313-318 ◽  
Author(s):  
Priscila Zlotowski ◽  
André M.R. Corrêa ◽  
David E.S.N. Barcellos ◽  
Cláudio E.F. Cruz ◽  
William Asanome ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Villous Atrophy ◽  
Clinical Signs ◽  
Postweaning Multisystemic Wasting Syndrome ◽  
Porcine Circovirus ◽  
Mesenteric Lymph Nodes ◽  
Salmonella Spp ◽  
Wasting Syndrome ◽  
Mesenteric Lymph ◽  
Intestinal Lesions

Samples of mesenteric lymph nodes and intestines from 79 unthrifty 3- to 5-month-old postweaning pigs, confirmed as naturally affected with postweaning multisystemic wasting syndrome (PMWS), were studied. Pigs originated from 12 farms in southern Brazil and were selected on the basis of clinical signs and/or gross lesions suggestive of enteric disorder. Lymphohistiocytic infiltrates of varying intensity were associated with anti-porcine circovirus type 2 (anti-PCV2) immunostaining (IS) in samples of intestines and mesenteric lymph nodes from all pigs. Although most findings were similar to those described in PCV2-associated enteritis, anti-PCV2 IS in association with depletion of the goblet cell mucin stores (24 pigs), diffuse ileal villous atrophy and fusion (18 pigs), and dilatation of the lymphatic vessels (11 pigs) combined or not with lymphangitis were also observed. PCV2 antigen was immunohistochemically demonstrated in the cytoplasm and nuclei from intralesional epithelial cells, histiocytes, and endothelial-like cells in intestinal tissues. Together these findings imply an association with PCV2. The presence of co-infections by Lawsonia intracellularis, Brachyspira spp., Mycobacterium spp., Salmonella spp., rotavirus, parvovirus, coronavirus and enteric calicivirus with PCV2 in the intestinal lesions was investigated.

scholarly journals Cavitation of mesenteric lymph nodes, splenic atrophy, and a flat small intestinal mucosa

1984 ◽  
Vol 87 (3) ◽  
pp. 606-614 ◽  
Author(s):  
C. Matuchansky ◽  
R. Colin ◽  
J. Hemet ◽  
G. Touchard ◽  
P. Babin ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Intestinal Mucosa ◽  
Small Intestinal Mucosa ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Small Intestinal ◽  
Splenic Atrophy

scholarly journals Experimental poisoning by Brachiaria decumbens in rabbits

2018 ◽  
Vol 38 (10) ◽  
pp. 1885-1889
Author(s):  
Kiyoko U. Utiumi ◽  
Adriana S. Albuquerque ◽  
Alexandre S. Burque ◽  
Fernanda R. Souza ◽  
Luciana Sonne ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Clinical Signs ◽  
Lectin Histochemistry ◽  
Economic Losses ◽  
Maintenance Cost ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph ◽  
Fresh Plant ◽  
Foamy Macrophages ◽  
Cattle And Sheep

ABSTRACT: Brachiaria spp. are important sources of forage for ruminants in Brazil, due to the easy cultivation, good resistance to drought, good adaptation to different soils and low maintenance cost. However, the ingestion of this grass has been related to photosensitization outbreaks in cattle and sheep with significant economic losses. The hepatotoxic effects related to the ingestion of grass are the formation of crystals and foamy macrophages due to the accumulation of toxic metabolites. The use of cattle and sheep in experiments involving the plant presents several obstacles in the ethical, economic and animal management. The objective of this study was to evaluate the sensitivity of rabbits as an experimental model for B. decumbens poisoning. Two experiments were carried out. In Experiment 1 four rabbits received the fresh plant in daily doses of 10, 20, 40 and 80g/kg body weight for 120 days. In Experiment 2 three rabbits received the fresh plant in amounts of 500g daily with duration of 210 days. The animals of Experiment 1 showed no clinical signs and no macroscopic and microscopic changes characteristic of B. decumbens poisoning. In Experiment 2 the animals also showed no clinical signs or significant macroscopic alterations. Histological analysis showed isolated foamy macrophages or present in random groups of cells in the liver and mesenteric lymph nodes. Samples of liver and mesenteric lymph nodes of the rabbits of Experiment 2 were submitted to the lectin-histochemistry technique. The WGA, sWGA and RCA lectins showed reactivity in foamy macrophages in both organs. This is the first study of our knowledge that demonstrates histopathological lesions caused expetimentally by Brachiaria spp. in rabbits, demonstrating its potential as an animal model.

scholarly journals Oral Infection with Signature-Tagged Listeria monocytogenes Reveals Organ-Specific Growth and Dissemination Routes in Guinea Pigs

2011 ◽  
Vol 80 (2) ◽  
pp. 720-732 ◽  
Author(s):  
Jody A. Melton-Witt ◽  
Susanne M. Rafelski ◽  
Daniel A. Portnoy ◽  
Anna I. Bakardjiev
Keyword(s):  
Listeria Monocytogenes ◽  
Lymph Nodes ◽  
Guinea Pigs ◽  
Mesenteric Lymph Nodes ◽  
Intestinal Villi ◽  
Content Type ◽  
Direct Pathway ◽  
Mesenteric Lymph ◽  
Organ Specific ◽  
Small Intestinal

ABSTRACTListeria monocytogenescauses a serious food-borne disease due to its ability to spread from the intestine to other organs, a process that is poorly understood. In this study we used 20 signature-tagged wild-type clones ofL. monocytogenesin guinea pigs in combination with extensive quantitative data analysis to gain insight into extraintestinal dissemination. We show thatL. monocytogenescolonized the liver in all asymptomatic animals. Spread to the liver occurred as early as 4 h after ingestion via a direct pathway from the intestine to the liver. This direct pathway contributed significantly to the bacterial load in the liver and was followed by a second wave of dissemination via the mesenteric lymph nodes (indirect pathway). Furthermore, bacteria were eliminated in the liver, whereas small intestinal villi provided a niche for bacterial replication, indicating organ-specific differences in net bacterial growth. Bacteria were shed back from intestinal villi into the small intestinal lumen and reinfected the Peyer's patches. Together, these results support a novel dissemination model whereL. monocytogenesreplicates in intestinal villi, is shed into the lumen, and reinfects intestinal immune cells that traffic to liver and mesenteric lymph nodes, a process that occurs even during asymptomatic colonization.

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