Lesions of Subclinical Doberman Hepatitis

1998 ◽  
Vol 35 (5) ◽  
pp. 361-369 ◽  
Author(s):  
M. Speeti ◽  
J. Eriksson ◽  
S. Saari ◽  
E. Westermarck
Keyword(s):  
Bile Duct ◽  
Biopsy Specimen ◽  
Clinical Signs ◽  
Inflammatory Cells ◽  
Bile Duct Proliferation ◽  
Two Samples ◽  
Doberman Pinschers ◽  
Initial Biopsy ◽  
Piecemeal Necrosis ◽  
Histologic Changes

This investigation describes histologic lesions in the livers of 18 Doberman Pinschers suffering from subclinical doberman hepatitis (DH). The dogs' ages ranged from 2.5 to 7 years; 15 were females and 3 were males. At the time of liver biopsy, the dogs had no clinical signs of liver disease, although serum alanine aminotransferase (ALT) values had been elevated in two samples in successive months. In the histologic examination, all biopsies revealed parenchymal and portal mononuclear inflammation. In the parenchyma, the inflammation was diffuse, with multifocal clusters of inflammatory cells. The periportal reaction was usually mild to moderate. Bridging necrosis (3/18) and bile duct proliferation (2/18) were rare. Excessive copper was detected by rubeinic acid stain in every specimen. Postmortem liver samples were obtained from nine dogs 3.5–65 months after the initial biopsy specimen; five of these dogs had been euthanatized for reasons other than DH, and liver specimens revealed piecemeal necrosis (5/5), bridging necrosis (3/5), and bile duct proliferation (2/5). Four of them had been euthanatized because of DH. Liver lesions of these dogs were typical for chronic active hepatitis, with bridging and piecemeal necrosis (4/4), portal expansion (4/4), bile duct proliferation (4/4), and fibrosis (4/4). A scoring system was used to evaluate changes numerically from biopsy to postmortem samples. Lesions in all dogs had progressed. The most important histologic changes were expansion of portal areas ( P = 0.008), increased periportal and bridging necrosis ( P = 0.008), increased fibrosis ( P = 0.016), and proliferation of the bile ducts ( P = 0.063).

Clinico-pathologic observations of spontaneous hepatic coccidiosis in broiler rabbits maintained in Bannerghatta biological park in Karnataka state of India

2019 ◽  
Author(s):  
V. Manjunatha ◽  
M. Rout ◽  
C.S Sujay ◽  
N. Jaisingh ◽  
Nikitha Salin ◽  
...  
Keyword(s):  
Bile Duct ◽  
Clinical Signs ◽  
Inflammatory Cells ◽  
Cell Aggregation ◽  
Stunted Growth ◽  
Hepatic Cells ◽  
Karnataka State ◽  
Biochemical Examination ◽  
Eimeria Stiedae ◽  
Hepatic Coccidiosis

The present study reports the clinico-pathologic changes observed in spontaneous hepatic coccidiosis caused by Eimeria stiedae in rabbits at Bannerghatta Biological Park (BBP) in Karnataka state of India. The clinical signs observed in the affected rabbits included sudden death, stunted growth, anorexia, weight loss, diarrhoea and abdominal pain. Increased liver enzymes and bilirubin was noticed upon biochemical examination. At necropsy, lesions included grossly enlarged liver (hepatomegaly) with presence of discrete yellowish-white nodules ranging from 1mm to 5mm size throughout the parenchyma containing a thick creamy white fluid. Faecal sample examination demonstrated the presence of Eimeria oocyts. The impression smears from the liver and intestinal mucosa also showed Eimeria oocysts, degenerative changes, necrotic cells and mononuclear cell aggregation to form oocyst granuloma. Histological observation revealed distension of bile duct, hyperplasia of epithelium along with numerous coccidian oocysts at the centre. Granulomatous tissues were observed to have encircled the bile duct with infiltration of inflammatory cells. Microscopic examination of exudates from liver also revealed numerous oocysts of E. stiedae. Multiple areas of coagulative necrosis of hepatic cells surrounded with inflammatory cells were also found.

JUVENILE OSTEOPOROSIS: REPORT OF A CASE INCLUDING A DESCRIPTION OF SOME METABOLIC AND MICRORADIOGRAPHIC STUDIES

PEDIATRICS ◽  
1967 ◽  
Vol 40 (4) ◽  
pp. 649-655
Author(s):  
Mark D. Cloutier ◽  
Alvin B. Hayles ◽  
B. Lawrence Riggs ◽  
Jenifer Jowsey ◽  
William H. Bickel
Keyword(s):  
Bone Resorption ◽  
Biopsy Specimen ◽  
Iliac Crest ◽  
Calcium Balance ◽  
Metabolic Balance ◽  
Iliac Crest Biopsy ◽  
Normal Bone ◽  
Threefold Increase ◽  
Spontaneous Improvement ◽  
Initial Biopsy

A case of idiopathic osteoporosis in a 12-year-old girl has been reported. Quantitative microradiographic studies of a biopsy specimen of iliac crest showed normal bone formation and an almost threefold increase in the level of bone resorption. The patient was observed without treatment, and a spontaneous clinical remission with roentgenographic improvement occurred. A second iliac crest biopsy specimen, obtained 15 months after the initial biopsy at a time when roentgenographic improvement was apparent, showed a return toward normal of the level of bone resorption. Metabolic balance studies conducted at this time showed that the patient was approximately in calcium balance. Because the majority of the previously reported cases have also exhibited spontaneous improvement, it is suggested that initially observation alone is indicated.

Amoebiasis of the Penis: A Review and Update

2020 ◽  
Vol 1 (1) ◽  
pp. 01-12
Author(s):  
Anthony Venyo
Keyword(s):  
Squamous Cell Carcinoma ◽  
Biopsy Specimen ◽  
Inflammatory Cells ◽  
Glans Penis ◽  
Granuloma Inguinale ◽  
History Of ◽  
High Index Of Suspicion ◽  
Microscopic Pathology ◽  
Rare Situation ◽  
Male Homosexuals

Ulceration of the penis/foreskin which would tend to be painful, Swelling of the penis, Oedema of the penis, Discharge from ulcer or inflamed area of penis that could be purulent or may contain blood, Balanoposthitis, Exudation from a penile ulcer which could be mild, profuse, purulent or bloody, Sloughing off of part of the foreskin and other tissues with resulting hypospadias, indurated swelling of the penis which may initially involve one part of the penis but could quickly spread, A history of homosexual coital activity may be obtained, The spouse of a man who has Amoebiasis of the penis could also have Amoebiasis of vulva, cervix or endometrium, The prepuce may not be retractable, There may be ulceration or swelling of the glans penis that may be irregular. Clinical examination findings in cases of Amoebiasis of the penis could reveal some of the ensuing: The general and systematic examinations may be normal. Examination of the penis may show: Tight non-retractile foreskin, Ulceration of foreskin, Swelling of the foreskin, Swelling of the glans penis, Ulceration and swelling of glans penis., Swelling and inflammation of the shaft of the penis, Ulceration on the shaft of the penis, Development of an iatrogenic hypospadias which was not there before, The inguinal lymph nodes may not be palpable but sometimes they may be enlarged on one side or on both sides, The penile swelling may involve part of the penis but at times on rare occasions the entire penis may be swollen, the penile swelling could on rare occasions extend to the supra-pubic area, On rare occasions the swelling of the penis could extend to include the scrotum but this is extremely rare. Amoebiasis of the penis does mimic various common conditions that affect the penis including: squamous cell carcinoma of the penis, chancroid, primary syphilitic ulcer of the penis, granuloma inguinale, balanoposthitis, and many other lesions affecting the penis. A high-index of suspicion is required to diagnose Amoebiasis of the penis. Clinicians need to be aware that male homosexuals who practice penetrative penis-anal coital activity have a higher risk of developing amoebiasis of the penis especially in Amoebiasis endemic countries. If an individual is suspected to have balanoposthitis or non-specific infection of the penis and is treated with antibiotics but the lesion does not respond to treatment, amoebiasis of the penis should be suspected. Secretions and discharges from the penile ulcer as well as biopsies of the penile lesion should be submitted for pathology examination which would demonstrate trophozoites, entamoebae as well as inflammatory cells. Even if carcinoma of the penis is initially suspected biopsy of the penile lesion would show features of Amoebiasis in the absence of any features of malignancy but in the very rare situation of a combination of Amoebiasis of the penis and carcinoma of the penis microscopic pathology examination of a biopsy specimen of the penile lesion would show features of Amoebiasis and carcinoma of the penis. .Amoebiasis of the penis does quickly and effectively respond to anti-amoebic medicaments.

scholarly journals Acute fasciolosis in cattle in southern Brazil

2013 ◽  
Vol 33 (6) ◽  
pp. 705-709 ◽  
Author(s):  
Maria de Lourdes Adrien ◽  
Ana Lucia Schild ◽  
Clairton Marcolongo-Pereira ◽  
Letícia Fiss ◽  
Jerônimo L. Ruas ◽  
...  
Keyword(s):  
Fasciola Hepatica ◽  
Abdominal Cavity ◽  
Clinical Signs ◽  
Early Spring ◽  
Eosinophil Infiltration ◽  
Coagulation Necrosis ◽  
Economic Losses ◽  
Southern Brazil ◽  
Bile Duct Proliferation ◽  
Mild Anemia

This study describes the epidemiological and pathological aspects of an outbreak of acute fasciolosis in cattle in southern Brazil. Fifteen out of 70 three-year-old pregnant cows lost weight in the 30-40 days prior to calving. Clinical signs included diarrhea, weakness, mild anemia and jaundice. Dark yellow fluid in the abdominal cavity was observed at necropsy. Fibrin and clotted blood were adhered to the pericardium and lung, primarily in the diaphragmatic lobes. The liver was enlarged, and the capsular surface was irregular with clear areas and petechiae. At the cut surface, the liver was irregular, firm and edematous, and several hemorrhagic channels could be observed. Areas of fibrosis through the parenchyma and whitish thrombi occluding the great vessels were also observed. The livers of 10 cows that not died were condemned at slaughter for lesions of fasciolosis similar to those observed at necropsy. Microscopically, the liver showed areas of coagulation necrosis, extensive hemorrhages in the streaks or foci and disruption of the parenchyma with neutrophil and eosinophil infiltration. Fibrosis and bile duct proliferation were also observed. Immature Fasciola hepatica flukes were observed in the parenchyma surrounded by degenerated hepatocytes, neutrophils, eosinophils, and hemorrhages. The outbreak occurred on a farm located in an area endemic for fasciolosis, although the acute form of the disease is not common in cattle in this region. It is likely that the cows were infected by F. hepatica metacercariae released in the late fall or early spring in the rice stubble where the herd was grazing prior to calving. Although mortality due to fasciolosis in cattle is infrequent, outbreaks can occur and treatments that are effective in both the immature and adult forms of the parasite should be administered to prevent economic losses.

scholarly journals the Study of some histopathological changes occurring in white laboratory mice infected with Cutaneous Leishmaniasis in Al – diwaniyah province, Iraq.

2021 ◽  
Vol 26 (4) ◽  
Author(s):  
Lubna.A.Al-ibrahimi Edu ◽  
Hind Al-shabani ◽  
Marwa sami alwan
Keyword(s):  
Bile Duct ◽  
Mediterranean Region ◽  
Histological Study ◽  
Inflammatory Cells ◽  
Skin Lesions ◽  
Intracellular Parasite ◽  
Laboratory Mice ◽  
Histopathological Changes ◽  
Radial Arrangement ◽  
Dermis Layer

          Leishmaniasis is caused by an intracellular parasite . It is endemic in Asia, Africa, the Americas, and the Mediterranean region. Worldwide, 1.5 to 2 million new cases occur each year .The histological study of the liver tissue of white laboratory mice (Mus musculus) infected with L. major a parasite showed The presence of severe steatosis of hepatocytes Hepatocyte degeneration, And loss of the radial arrangement of hepatocytes, With heavy infiltration in inflammatory cells, especially phagocytes( Macrophage) with  Hyperplasia and congestion of the bile duct  .  As for histological sections of skin lesions taken from ear , Foot , tail ، were showed epidermal ulcerative , Accompanied by severe leaching of the dermis layer neutrophil ,polymorph lymphocytes ، with hemorrhage of ​​the dermis, with necrosis of the epidermal cells of all skin lesions in the ear, foot and tail.

Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats

2003 ◽  
Vol 285 (5) ◽  
pp. G1004-G1013 ◽  
Author(s):  
Zhi Zhong ◽  
Matthias Froh ◽  
Mark Lehnert ◽  
Robert Schoonhoven ◽  
Liu Yang ◽  
...  
Keyword(s):  
Bile Duct ◽  
Liver Fibrosis ◽  
Transforming Growth Factor ◽  
Bile Duct Ligation ◽  
Smooth Muscle Actin ◽  
Control Diet ◽  
Free Radical Scavengers ◽  
Bile Duct Proliferation ◽  
Duct Ligation ◽  
Experimental Cholestasis

Accumulation of hydrophobic bile acids during cholestasis leads to generation of oxygen free radicals in the liver. Accordingly, this study investigated whether polyphenols from green tea Camellia sinenesis, which are potent free radical scavengers, decrease hepatic injury caused by experimental cholestasis. Rats were fed a standard chow or a diet containing 0.1% polyphenolic extracts from C. sinenesis starting 3 days before bile duct ligation. After bile duct ligation, serum alanine transaminase increased to 760 U/l after 1 day in rats fed a control diet. Focal necrosis and bile duct proliferation were also observed after 1–2 days, and fibrosis developed 2–3 wk after bile duct ligation. Additionally, procollagen-α1(I) mRNA increased 30-fold 3 wk after bile duct ligation, accompanied by increased expression of α-smooth muscle actin and transforming growth factor-β and the accumulation of 4-hydroxynenonal, an end product of lipid peroxidation. Polyphenol feeding blocked or blunted all of these bile duct ligation-dependent changes by 45–73%. Together, the results indicate that cholestasis due to bile duct ligation causes liver injury by mechanisms involving oxidative stress. Polyphenols from C. sinenesis scavenge oxygen radicals and prevent activation of stellate cells, thereby minimizing liver fibrosis.

Lens and Anterior Uvea

2022 ◽  
pp. 359-392
Keyword(s):  
Macular Edema ◽  
Anterior Uveitis ◽  
Clinical Signs ◽  
Inflammatory Cells ◽  
Clinical Findings ◽  
Eye Drops ◽  
Systemic Diseases ◽  
Intravitreal Triamcinolone ◽  
Keratic Precipitates ◽  
Intravitreal Triamcinolone Injection

This chapter illustrates photos of clinical signs seen in uveitis and interesting cases of lens pathologies. Anterior uveitis is the inflammation of the iris and the ciliary body. Anterior uveitis can be idiopathic, isolated, or associated with systemic diseases. The clinical findings observed in anterior uveitis include keratic precipitates, inflammatory cells and flare in anterior chamber, hypopyon, rarely hyphema, miosis, iris nodules and atrophy, synechiae, and band keratopathy in chronic cases (shown in corneal degenerations chapter). The inflammation in anterior uveitis is almost always immune. Treatment includes steroid eye drops, cycloplegic drops, sub-Tenon steroid injections when cystoid macular edema is present. Chronic macular edema can be treated with intravitreal Triamcinolone injection and Dexamethasone implants. In cases of refractory anterior uveitis or associated immune systemic diseases, immunomodulatory treatment or biologic agents are prescribed.

scholarly journals Intraductal Papillary Neoplasm of the Bile Duct With Invasive Adenocarcinoma Complicating IgG4-related Sclerosing Cholangitis: Report of a Case

2017 ◽  
Vol 102 (1-2) ◽  
pp. 70-76
Author(s):  
Ryo Ashida ◽  
Teiichi Sugiura ◽  
Yukiyasu Okamura ◽  
Takaaki Ito ◽  
Keiko Sasaki ◽  
...  
Keyword(s):  
Bile Duct ◽  
Sclerosing Cholangitis ◽  
Invasive Carcinoma ◽  
Extrahepatic Bile Duct ◽  
Inflammatory Cells ◽  
Wall Thickening ◽  
Multidetector Row Computed Tomography ◽  
Intraductal Papillary Neoplasm ◽  
Serum Igg4 ◽  
Papillary Neoplasm

Although there have been many previous studies of IgG4-related SC focusing on the differential diagnosis from cholangiocarcinoma, only a few patients with cholangiocarcinoma against a background of IgG4-related SC have been reported. We herein present a case of intraductal papillary neoplasm of the bile duct (IPNB) associated with invasive carcinoma complicating IgG4-related sclerosing cholangitis. A 71-year-old female with icterus was admitted to a local hospital, where stricture of the extrahepatic bile duct were detected, and subsequently referred to our hospital for possible surgery. Abdominal multidetector-row computed tomography demonstrated marked wall thickening along the entire extrahepatic bile duct. The left lateral superior bile duct (B2) and left lateral inferior duct (B3) were individually obstructed, and percutaneous transhepatic biliary drainage catheters were placed in B2 and B3 separately. The patient was diagnosed to have diffusely spread cholangiocarcinoma and underwent right hepatic trisectionectomy with caudate lobectomy and pancreatoduodenectomy. A histological examination revealed intraductal papillary tumors composed of fibrovascular stalks covered by neoplastic epithelium. Carcinomatous invasion of the papillary tumors was observed in the fibromuscular layer, and there was abundant infiltration of inflammatory cells with fibrosis outside of the cancerous tissue. The inflammatory cells were primarily composed of plasma cells, a majority of which were positive for IgG4 (>30 cells/high-power field); the postoperative serum IgG4 level was 890 mg/dL. Therefore, a diagnosis of coexisting IPNB associated with invasive carcinoma and IgG4-related sclerosing cholangitis was made. To the best of our knowledge, this is the first report of IPNB complicating IgG4-related sclerosing cholangitis.

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