Effect of Different Dialyzer Membranes on Serum Angiotensin-Converting Enzyme during Hemodialysis

The effects of different dialyzer membranes on serum concentration of angiotensin-converting enzyme (ACE) and white blood cells during hemodialysis were examined on a cross-over basis in 20 chronically uremic patients. Hemodialysis with cuprophane membranes was associated with a significant (p < 0.001) fall in the mean leukocyte count during the 1st hour of treatment. The use of polymethylmetacrylate membranes resulted in a more attenuated form of leukopenia and with polyacrylonitrile membranes no change was observed during hemodialysis. Hemodialysis with each membrane caused a comparable, significant (p < 0.005) increase in serum ACE, independent of the degree of leukopenia but significantly (p < 0.001) correlated with the increases in serum proteins. We conclude that this increase in serum ACE concentration after hemodialysis does not reflect acute damage of the pulmonary vascular endothelium during treatment and most probably is a result of hemoconcentration. Therefore, serum ACE analysis is not an indicator of dialyzer membrane biocompatibility.

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Study of serum angiotensin converting enzyme levels in pemphigus vulgaris

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20182004 ◽

2018 ◽

Vol 4 (3) ◽

pp. 328

Author(s):

V. Anand Kumar ◽

J. Vijaya Shree

Keyword(s):

Angiotensin Converting Enzyme ◽

Pemphigus Vulgaris ◽

Control Group ◽

Study Group ◽

Converting Enzyme ◽

Serum Angiotensin Converting Enzyme ◽

Healthy Group ◽

Significant Difference ◽

The Mean ◽

And Control

Background: This study aimed to evaluate the serum angiotensin converting enzyme (ACE) levels in patients with pemphigus vulgaris compared with healthy volunteers.Methods: In this study, 40 patients were selected in the study group with pemphigus vulgaris and 40 patients were selected in the control group i.e. healthy group. Serum ACE levels were determined by spectrophotometric method.Results: The mean ACE levels in study group and control group were 26.98±15.87 and 32.57±20.98 respectively. There was no statistically significant difference between both the groups (p=0.11). The mean ACE levels were 26.25±12.36 and 26.14±13.89 in females and males respectively in the study group which showed no significant difference (p=0.95). In the control group, the mean ACE levels were 26.22±19.77 and 38.54±11.11 in females and males respectively which showed a statistically significant difference (p=0.04). The mean ACE levels were higher in healthy males when compared to the males in the study group. The mean serum levels in females of both the groups were almost same.Conclusions: The serum ACE level was considerably lower in male study group i.e. pemphigus vulgaris patients compared with male control group i.e. healthy group, despite lack of any significant difference of serum ACE level between pemphigus and control group. Hence, ACE might have some relation with pemphigus vulgaris especially in male patients.

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