Autistic Children Grow Up: An Eight to Twenty-Four Year Follow-Up Study

1986 ◽  
Vol 31 (6) ◽  
pp. 550-556 ◽  
Author(s):  
L. Wolf ◽  
B. Goldberg

Eighty questionnaires were sent to parents and/or caregivers of autistic persons diagnosed between 1960–73 at CPRI, a regional assessment and treatment centre. The objective was to determine their present place of residence, functioning ability, language development, program involvement, and seizure activity. The results of this study support evidence that more than 50 percent require long-term institutional care; almost one-third suffer epileptic seizures; there is a persistence of symptoms and difficulty in gaining useful speech; few live independently or are capable of employment.

2007 ◽  
Vol 31 (12) ◽  
pp. 450-453 ◽  
Author(s):  
Marie Whitty ◽  
John O'Connor

AIMS AND METHODThis study examined the 20-year outcome of 55 women who were pregnant and using opiates in 1985 and were attending the Drug Treatment Centre and Advisory Board, Dublin. We established outcome across a number of variables, including mortality, psychiatric and physical morbidity, psychosocial functioning, ongoing drug misuse and outcome of offspring.RESULTSAt 20-year follow-up 29 women (53%) were deceased. HIV was the commonest cause of death, accounting for 17 deaths (59%). Those who were alive at follow-up displayed high rates of unemployment (84%), illicit substance misuse (74%) and most were dependent on state-subsidised accommodation (78%).CLINICAL IMPLICATIONSMortality was higher in our group compared with other long-term follow-up samples. These findings suggest that such participants and their offspring require intensive long-term support and treatment.


1978 ◽  
Vol 23 (1_suppl) ◽  
pp. 1-21 ◽  
Author(s):  
Philip Barker

It is impossible to make any sort of comparative evaluation of the various treatment methods which have been recommended and tried for severe, chronic emotional and behavioural disorders in children and young people. Although many programs exist, and many more have existed and been reported, the case material has seldom been clearly defined, outcome studies have been limited and longer-term follow-up almost nil. To take simply the few programs which have been discussed in this paper, it is not known whether the young people treated in the California Youth Project, Aycliffe School, the Cotswold Community and the Alberta Parent Counsellors program are at all similar. All programs claim to be treating seriously disturbed children, but more detailed descriptions are needed. Achievement Place claims it deals with “pre-delinquent” youths, while clearly St. Charles Youth Treatment Centre, Aycliffe School and the California Youth Project treat serious established delinquents. So it may indeed be true, as Hoghughi (21) has suggested, that methods that work in certain situations are not readily transferred to others. Balbernie (8) seems to be on the right lines when he calls for precise diagnosis with an accurate definition of what the problem is and of who is supposed to be doing what about it, and with what aims. Similarly precise requirements seemed to be the policy of Hoghughi at Aycliffe School, when this was visited. Despite the problems of evaluating the different therapeutic approaches, certain points do seem clear from this review and from visits to centres. 1. In many cases treatment of the seriously disturbed, previously intractable, child is a very long-term proposition. A commitment to work with the boy, girl or family for several years, is often necessary. 2. Improvement achieved in residential settings, and while active treatment is in progress, is not always maintained subsequently. There is need for much more investigation of what determines whether improvement is maintained, but many programs provided little data about the aftercare given and the longer-term follow-up of the children treated. 3. Intensive treatment, whether residential or not, only makes sense in the context of a long-continuing program of management. Yet many programs, even the best ones, seem to work in relative isolation. 4. Sequential treatment seems to have much to recommend it, and is used, though in a somewhat different way, by all the four British programs that were visited. 5. Some severely disturbed children can be treated in alternative family settings, but which ones, and with what long-term results, is quite vague. These programs do however have several advantages: they keep children in the community, if not in their own homes; they avoid the dangers of institutionalization and the contaminant effects of living with a delinquent peer group; and they approximate more closely the sort of situation (that is, normal family life) which treatment should be helping children to adapt. They are also much less expensive than residential treatment. 6. There is a role for secure units. All who are familiar with the clinical group we are discussing are aware of the existence of a sub-group of very aggressive and violent children who must first be contained. Some of these children can only be constructively treated in a highly secure and very well-staffed unit, but in such a setting it seems that there is a prospect of providing them with some real help. The British “Youth Treatment Centre” concept does seem a useful one. Many points are unclear. These include the following: 1. Does family therapy have a significant part to play in these cases? There is suggestive evidence that it may in some, but many of these children have no families, or at least none with whom they are in contact, and often have been in institutions for much of their lives. 2. What future is there in “intermediate treatment” and community work? Is it in any way realistic to expect to help severely disturbed children by work in the community of which they are part? 3. Can a community approach like that of the California Youth Project make a real contribution to the problem? It seems that in many cases it is better than traditional institutional treatment, but that itself has great limitations. 4. Which of the many residential programs that have been tried is best for which type of problem? 5. How can residential programs be integrated with services in the child's own community to best advantage? 6. What should be the longer term aims of treatment? The various reports of different programs rarely consider this. In conclusion, two points stand out. The first is the need for properly planned and executed research into the treatment of these disorders. It is amazing that so much has been spent on treatment and so little on its evaluation. Perhaps residential treatment is often seen more as a way of getting difficult children out of their communities. The second conclusion is that surely more effort should be made to prevent these disorders. Relatively few of the children under consideration have been brought up in stable, loving homes by their two natural parents. The apparently progressive deterioration of family life, the abandonment of children to day care, the abrogation by many parents of real responsibility for their children and the loss of moral values and religious beliefs are alarming features of contemporary life. Bronfenbrenner (12) has recently commented on how “the American family is falling apart”, and expressed alarm about the current tendency of people to do their “own thing”, to the exclusion of the interests of others. While most children seem to be able to grow up healthily even in contemporary society, the number who become severely disturbed seems likely to increase as these changes in society occur. At the very least we should give a high priority to giving the very best alternative care to children deprived of normal family life.


2008 ◽  
Vol 62 (suppl_1) ◽  
pp. ONS51-ONS56 ◽  
Author(s):  
Jeremy D.W. Greenlee ◽  
Charles Teo ◽  
Ali Ghahreman ◽  
Bernard Kwok

Abstract Objective: To further assess the safety and long-term efficacy of endoscopic resection of colloid cysts of the third ventricle. Methods: A retrospective review of a series of 35 consecutive patients (18 male, 17 female) with colloid cysts treated by endoscopic surgery was undertaken. Results: The mean patient age was 32.4 years (range, 11–54 yr). Headache was the most common presenting symptom (22 patients). The average tumor size was 18 mm (range, 3–50 mm). The endoscopic technique could not be completed in six patients, necessitating conversion to an open craniotomy and a transcortical approach to the colloid cyst. All patients had histologically confirmed colloid cysts of the third ventricle, and complete resection of the lesion was confirmed macroscopically and radiologically in all patients. There were no deaths. Two patients developed aseptic meningitis without any permanent sequelae. One patient developed unilateral hydrocephalus attributable to obstruction of the foramen of Monro, which was treated with endoscopic septum pellucidotomy. The median follow-up period was 88 months (range, 10–132 mo). There was one asymptomatic radiological recurrence. No seizures occurred after surgery. Conclusion: The results of this study support the role of endoscopic resection in the treatment of patients with colloid cysts as a safe and effective modality. In some cases, conversion to an open procedure may be required. Additional follow-up will be required to continue to address the duration of lesion-free survival.


2013 ◽  
Vol 44 (6) ◽  
pp. 1245-1256 ◽  
Author(s):  
M.-C. Geoffroy ◽  
D. Gunnell ◽  
C. Power

BackgroundWe aimed to elucidate early antecedents of suicide including possible mediation by early child development.MethodUsing the 1958 birth cohort, based on British births in March 1958, individuals were followed up to adulthood. We used data collected at birth and at age 7 years from various informants. Suicides occurring up to 31 May 2009 were identified from linked national death certificates. Multivariable Cox proportional hazard models were used to investigate risk factors.ResultsAltogether 12399 participants (n = 44 suicides) had complete data. The strongest prenatal risk factors for suicide were: birth order, with risk increasing in later-born children [ptrend = 0.063, adjusted hazard ratio (HR)], e.g. for fourth- or later-born children [HR = 2.27, 95% confidence interval (CI) 0.90–5.75]; young maternal age (HR = 1.18, 95% CI 0.34–4.13 for ⩽19 years and HR = 0.41, 95% CI 0.19–0.91 for >29 years, ptrend = 0.034); and low (<2.5 kg) birth weight (HR = 2.48, 95% CI 1.03–5.95). The strongest risk factors at 7 years were externalizing problems in males (HR = 2.96, 95% CI 1.03–8.47, ptrend = 0.050) and number of emotional adversities (i.e. parental death, neglected appearance, domestic tension, institutional care, contact with social services, parental divorce/separation and bullying) for which there was a graded association with risk of suicide (ptrend = 0.033); the highest (HR = 3.12, 95% CI 1.01–9.62) was for persons with three or more adversities.ConclusionsRisk factors recorded at birth and at 7 years may influence an individual's long-term risk of suicide, suggesting that trajectories leading to suicide have roots in early life. Some factors are amenable to intervention, but for others a better understanding of causal mechanisms may provide new insights for intervention to reduce suicide risk.


2021 ◽  
Vol 12 ◽  
pp. 216
Author(s):  
Laura Beatriz López López ◽  
Jesús Adrián Moles Herbera ◽  
Silvia Vázquez Sufuentes ◽  
David Fustero de Miguel ◽  
Amanda Avedillo Ruidíaz ◽  
...  

Background: Lesions in the temporomesial region can be reached by various approaches: subtemporal, transsylvian, transcortical, interhemispheric parieto-occipital, or supracerebellar transtentorial (SCTT). The choice varies according to the characteristics of the lesion and neighboring structures. Case Description: In this clinical case, it is presented a 56-year-old man with long-term evolution of drug-resistant epilepsy secondary to a cavernoma in the left parahippocampal gyrus. After assessing the lesion, it was decided a SCTT approach for its resection in a semi-sitting position, to avoid language disorders or visual damage. The surgery was uneventful and the patient did not present epileptic seizures during 6-month follow-up. Conclusion: Performing a SCTT is safe and feasible option for resection of lesions located in the basal temporomesial region without causing damage to neighboring structures, especially those located in the middle and posterior two-thirds of temporal region.


2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S465-S466
Author(s):  
M Chaparro ◽  
A Garre ◽  
M Iborra ◽  
M Sierra ◽  
M Barreiro-de Acosta ◽  
...  

Abstract Background The development program (UNIFI) has shown promising results of ustekinumab in ulcerative colitis (UC) treatment that should be confirmed in clinical practice. Aims Primary: to evaluate the durability of ustekinumab treatment in UC patients in clinical practice. Secondary: to assess the short-term response (at week 16) and the long-term effectiveness (at maximum follow-up) and to assess the safety of ustekinumab in clinical practice. Methods Patients included in the prospectively maintained ENEIDA registry who received at least one intravenous dose of ustekinumab due to active UC [Partial Mayo Score (PMS) &gt;2] were included. Clinical activity and effectiveness were defined based on PMS. Results 95 patients were included (table 1). At week 16, 53% of patients had clinical response (including 35% of patients in remission) (figure 1). In the multivariate analysis, elevated serum C-reactive protein was the only variable significantly associated with clinical remission. Long-term remission is represented in figure 2. 36% of patients discontinued the treatment with ustekinumab during a median follow-up of 31 weeks. The probability of maintaining ustekinumab treatment was 87% at week 16, 63% at week 56, and 59% at week 72 (figure 3); primary failure was the main reason for ustekinumab discontinuation. No variable was associated with risk of discontinuation. Three patients reported adverse events; one of them had a fatal severe SARS-CoV-2 infection. Conclusion Ustekinumab is effective both in the short and the long-term in real-life, even in a highly refractory cohort. Higher inflammatory burden at baseline correlated with lower probability of achieving remission. Safety was consistent with the known profile of ustekinumab.


2020 ◽  
pp. 1-12
Author(s):  
Karsten Elmose-Østerlund ◽  
Graham Cuskelly ◽  
Jens Høyer-Kruse ◽  
Christian Røj Voldby

Despite a rich literature on organizational capacity (OC) in voluntary sports clubs (VSCs), few studies have examined OC building and its long-term sustainability. Against this background, the authors identified changes in OC among VSCs that participated in a club development program and examined the sustainability of these changes. The authors collected survey data 9 months after participation comparing the participating VSCs (n = 62) with similar nonparticipating VSCs (n = 64). A selection of the participating VSCs was then contacted 3–4 years later for a follow-up survey (n = 48) and focus group interviews (n = 5). The results show that (a) significant differences in human resource capacity, planning and development capacity, and infrastructure and process capacity were visible between the participating and nonparticipating VSCs, and that (b) certain changes in OC remain in the clubs 3–4 years after participation. A sustainable change was that core volunteers related differently to the work in their respective VSCs.


2013 ◽  
Vol 71 (7) ◽  
pp. 462-464 ◽  
Author(s):  
Paulo José Lorenzoni ◽  
Lucas Pires Augusto ◽  
Cláudia Suemi Kamoi Kay ◽  
Rosana Herminia Scola ◽  
Lineu Cesar Werneck

Thymoma screening is recommended at the onset of myasthenia gravis (MG) or when patients with MG present with clinical deterioration or a progressive increase of anti-acetylcholine receptor antibody. However, it is unknown if it is necessary to repeat the screening of thymoma at fixed intervals, even in the absence of MG deterioration, when the initial screening is negative. We analyzed the recurrence rate and incidence of new thymoma in a series of patients with well-controlled MG. The sample consisted of 53 patients, aged 17 to 72 years, and the follow-up varied between 75 and 472 months. The chest computerized tomography detected thymus abnormalities in eight patients at the initial screening and no abnormalities in all patients at a second screening after five years. The findings of this study support the classical opinion that screening for thymoma should be recommended only if there is clinical deterioration due to the disease.


Sign in / Sign up

Export Citation Format

Share Document