One-Year Stability of the Devereux Early Childhood Assessment for Preschoolers, Second Edition

2017 ◽  
Vol 36 (8) ◽  
pp. 829-834
Author(s):  
John S. Carlson ◽  
Dylan S. T. Voris
Keyword(s):  
Early Childhood ◽  
Rating Scales ◽  
Progress Monitoring ◽  
Stability Study ◽  
Early Childhood Assessment ◽  
Parent Rating ◽  
Devereux Early Childhood Assessment ◽  
One Year ◽  
The Stability

The Devereux Early Childhood Assessment (DECA) and recently updated Devereux Early Childhood Assessment for Preschoolers, Second Edition (DECA-P2) are strength-based measures that can inform early intervention. Whereas the short-term psychometric properties of these parent rating scales are strong, little is known about their long-term stability. Study findings from a diverse Head Start sample ( N = 282, DECA; N = 346, DECA-P2) revealed 12-month, test–retest reliability of protective factors ( r = .65) to be equivalent on the DECA-P2 and the DECA. The stability of parent ratings of behavior concerns appears improved in the newer edition ( r = .53 vs. r = .46). Additional consideration should be given to the stability of the DECA-P2 and its use as short- and long-term social, emotional, and behavioral intervention progress monitoring tool.

scholarly journals Limitations and Challenges in the Stability of Cysteamine Eye Drop Compounded Formulations

2021 ◽  
Vol 15 (1) ◽  
pp. 2
Author(s):  
Cristina Martín-Sabroso ◽  
Mario Alonso-González ◽  
Ana Fernández-Carballido ◽  
Juan Aparicio-Blanco ◽  
Damián Córdoba-Díaz ◽  
...  
Keyword(s):  
Shelf Life ◽  
Stability Study ◽  
Eye Drops ◽  
Microbiological Analysis ◽  
Nitrogen Gas ◽  
Long Term Stability ◽  
Main Degradation Product ◽  
The Stability ◽  
Unstable Molecule

Accumulation of cystine crystals in the cornea of patients suffering from cystinosis is considered pathognomonic and can lead to severe ocular complications. Cysteamine eye drop compounded formulations, commonly prepared by hospital pharmacy services, are meant to diminish the build-up of corneal cystine crystals. The objective of this work was to analyze whether the shelf life proposed for six formulations prepared following different protocols used in hospital pharmacies is adequate to guarantee the quality and efficacy of cysteamine eye drops. The long-term and in-use stabilities of these preparations were studied using different parameters: content of cysteamine and its main degradation product cystamine; appearance, color and odor; pH and viscosity; and microbiological analysis. The results obtained show that degradation of cysteamine was between 20% and 50% after one month of storage in the long-term stability study and between 35% and 60% in the in-use study. These data confirm that cysteamine is a very unstable molecule in aqueous solution, the presence of oxygen being the main degradation factor. Saturation with nitrogen gas of the solutions offers a means of reducing cysteamine degradation. Overall, all the formulae studied presented high instability at the end of their shelf life, suggesting that their clinical efficacy might be dramatically compromised.

scholarly journals Carbidopa Capsules for Insulinoma Diagnostic: Compounding and Stability Study

2020 ◽  
Vol 4 (3-4) ◽  
pp. 99-104
Author(s):  
Christophe Curti ◽  
Fanny Mathias ◽  
Morane Savelli ◽  
Philippe Garrigue ◽  
Edouard Lamy ◽  
...  
Keyword(s):  
Single Dose ◽  
Hospital Pharmacy ◽  
Room Temperature ◽  
Active Pharmaceutical Ingredient ◽  
Oral Formulation ◽  
Stability Study ◽  
Dose Administration ◽  
Disease Associations ◽  
One Year ◽  
The Stability

AbstractBackgroundCarbidopa is a drug mainly used to treat Parkinson’s disease. Associations with levodopa or with levodopa/entacapone are commercialized, but there is no oral formulation of carbidopa alone available in Europe. As carbidopa can also be used as premedication of adult patients for insulinoma diagnosis, it must be compounded as single dose mg capsules. The single dose administration of a magistral preparation implies the compounding of only one capsule, or the loss of consequent quantities of active pharmaceutical ingredient. As an alternative solution, carbidopa capsules could be compounded as batches of hospital preparation.MethodWith this objective, a stability-indicating dosing method for 200 mg carbidopa capsules was developed. Then, the compounding process was assessed according to the European Pharmacopeia requirements. Finally, the stability of carbidopa capsules stored protected from light at room temperature was studied for one year.Results200 mg carbidopa capsules compounding process was validated on three independent batches. The beyond use date was fixed at one year.ConclusionOur work confirms that carbidopa 200 mg capsules can be realized in hospital pharmacy and its stability allows the compounding of large batches.

Long-term changes in rumen fermentation in defaunated sheep

1991 ◽  
Vol 1991 ◽  
pp. 77-77
Author(s):  
P.P. Frumholtz ◽  
R.J. Wallace ◽  
C.J. Newbold ◽  
E.R. Ørskov
Keyword(s):  
Animal Species ◽  
Fish Meal ◽  
Jugular Vein ◽  
Rumen Fermentation ◽  
Bacteria And Fungi ◽  
One Year ◽  
The Stability ◽  
Ciliate Protozoa

The removal of ciliate protozoa, or defaunation, results in the establishment of a new ecosystem in the rumen, consisting only of bacteria and fungi. Although extensive research has been done on ciliate-free ruminants, the role of protozoa in the rumen still provokes considerable debate. The diversity of experimental design, such as animal species, defaunation method, and diet could account for many of the differences observed between defaunation studies. Also it is important to examine the stability of the ciliate-free ecosystem. The aim of this study was to investigate changes in rumen fermentation of ciliate-free sheep over a period of one year.Eight male castrated sheep, weighing 60-70 kg, received twice daily 700 g of a diet of hay, barley, molasses, fish meal and vitamins/minerals (500, 299.5, 100, 91 and 9.5 g/kg DM respectively). Four sheep were defaunated by the rumen washing technique (Jouany and Senaud, 1979) and kept in isolated pens while the other four were left faunated with a mixed type A ciliate protozoa population. Rumen samples were withdrawn via the rumen cannula and blood samples were taken from the jugular vein -1, 0, 1, 2, 4 and 6 h after feeding. There were three sampling periods: one month, six months and one year after defaunation.

Long-Term Release from High Level Waste Glass - Part IV: The Effect of Leaching Mechanism

1984 ◽  
Vol 44 ◽  
Author(s):  
Eberhard Freude ◽  
Bernd Grambow ◽  
Werner Lutze ◽  
Harald Rabe ◽  
Rodney C. Ewing
Keyword(s):  
Linear Time ◽  
High Surface ◽  
High Level Waste ◽  
Corrosion Mechanism ◽  
Surface Areas ◽  
One Year ◽  
The Stability ◽  
High Level ◽  
Long Term Behavior

During the past ten years extensive data have been determined for the corrosion of nuclear waste forms in short-term laboratory experiments (usually less than one year). The long-term behavior of glass has been inferred by: (1) the acceleration of corrosion rates at high temperatures [1]; (2) the use of high surface areas of the glass to small volumes of solution [1]; and the analysis of natural glasses altered over long periods of geologic time [2, 3]. The most recent efforts have concentrated on understanding the mechanisms of corrosion [1, 4, 5]. The corrosion mechanism may be used to make long-term extrapolations of the “stability” of the waste form. In this paper, we consider a linear time dependence for the corrosion under near saturation conditions and use a rate equation in the QTERM code [6, 7, 8] to model the long-term behavior of the German glass, C-31−3EC [9], JSS A [10, 11] and SRL TDS 131 [1]. The data base for C-31−3EC has been published elsewhere [9, 12, 13, 14], and we include experimental work completed by Rabe for boron and silica, at 200°C.

scholarly journals Odporni rodzice – odporne dzieci. Jak zasoby psychiczne rodziny wpływają na odporność psychiczną dziecka

2021 ◽  
Vol 16 (2(60)) ◽  
pp. 101-117
Author(s):  
Iwona Sikorska ◽  
Magdalena Adamczyk-Banach ◽  
Mateusz Polak
Keyword(s):  
Early Childhood ◽  
Early Childhood Assessment ◽  
Devereux Early Childhood Assessment

Odporność psychiczna dziecka jest zasobem opartym na czynnikach biologicznych (temperament, stan zdrowia) i społecznych (wpływ wychowawczy i atmosfera w rodzinie). Badania nad radzeniem sobie ze stresem pokazują, że odporna rodzina kształtuje odporne dziecko. Celem badania było poszukiwanie związków pomiędzy odpornością psychiczną rodziców i ich dzieci. Osobami badanymi byli rodzice dzieci w wieku przedszkolnym (N = 129) w wieku 5-6 lat (M = 5,77, SE = 0,44), w tym 121 matek oraz 115 ojców, z ośmiu przedszkoli na terenie Krakowa. Zastosowano dwie metody psychometryczne wypełniane przez rodziców: skalę obserwacyjną DECA (The Devereux Early Childhood Assessment), mierzącą odporność psychiczną dziecka i jej składowe (inicjatywę, samokontrolę i przywiązanie) oraz natężenie dziecięcych zachowań problemowych, a także Skalę Prężności Psychicznej SPP-25 do oceny poziomu odporności psychicznej rodziców. Badanie wykazało silne, pozytywne związki odporności psychicznej rodziców z odpornością psychiczną ich dzieci, tak w ujęciu całościowym, jak i w zakresie jej czynników składowych. Nie zaobserwowano istotnych różnic w profilach odporności pomiędzy dziećmi z wyższym i niższym poziomem zachowań problemowych. Doświadczenie trudnych wydarzeń życiowych wiązało się z niższym poziomem wszystkich aspektów odporności psychicznej zarówno u dzieci, jak i u ich rodziców. Upowszechnianie wiedzy o znaczeniu posiadania i rozwijania zasobów odporności psychicznej rodziców dla zdrowia psychicznego ich dzieci jest ważnym zadaniem społecznym na drodze popularyzacji wiedzy, jak i pedagogizacji rodziców w przedszkolu.

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