Acute effects of methiocarb on oxidative damage and the protective effects of vitamin E and taurine in the liver and kidney of Wistar rats

2012 ◽  
Vol 29 (1) ◽  
pp. 60-71 ◽  
Author(s):  
Sibel Ozden ◽  
Betul Catalgol ◽  
Selda Gezginci-Oktayoglu ◽  
Ayse Karatug ◽  
Sehnaz Bolkent ◽  
...  
Keyword(s):  
Vitamin E ◽  
Oxidative Damage ◽  
Wistar Rats ◽  
Protective Effects ◽  
Acute Effects ◽  
Liver And Kidney

scholarly journals Amelioration of Cadmium-induced Oxidative Damage in Wistar Rats by Vitamin C, Zinc and N-Acetylcysteine

2021 ◽  
Author(s):  
Venkataramanaiah Poli ◽  
Renuka Madduru ◽  
Srinivasulu Reddy Motireddy
Keyword(s):  
Antioxidant Enzymes ◽  
Vitamin C ◽  
Oxidative Damage ◽  
Wistar Rats ◽  
Tissue Respiration ◽  
Protective Effects ◽  
Cd Toxicity ◽  
Lipid Oxidation Products ◽  
Liver And Kidney ◽  
The Impact

Abstract The present study was performed to determine the protective effects of Vitamin C, Zinc and N-Acetylcysteine individually or in combinations with Cd, to monitor amelioration capability against Cd-induced oxidative damage in Wistar rats. Nine groups of rats were studied as experimental group. The present experiment was conducted for 45 days. Liver and kidneys were excised for biochemical determinations through assaying of antioxidant enzymes and lipid oxidation products to assess the impact of Cd-toxicity and its amelioration by co-administration of Vitamin C, Zinc and NAC along with Cd. Basal Metabolic rates, Tissue Respiration rates of liver and kidney were found to be significantly decreased (p < 0.05) during Cd toxicity. Serum biochemical parameters were also found to be significantly altered to cope up with Cd toxicity. All the antioxidant enzymes and products were significantly inhibited (p < 0.05) or elevated in rat liver and kidney tissues during Cd-induced toxicity. Whereas with co-administration of Vitamin C, Zinc and NAC, into rats clearly demonstrates the amelioration of oxidative damage induced by Cd-toxicity. From the results obtained in the present study all the agents tested had protective effects against Cd-induced oxidative damage.

scholarly journals Prophylactic effect of vitamin E against hepatotoxicity, nephrotoxicity, haematological indices and histopathology induced by diazinon insecticide in mice

2009 ◽  
Vol 55 (3) ◽  
pp. 219-226 ◽  
Author(s):  
Nahla S. El-Shenawy ◽  
Rasha A. Al-Eisa ◽  
Fawzia El-Salmy ◽  
Omema Salah
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Kidney Function ◽  
Kidney Tissue ◽  
The Body ◽  
High Dose ◽  
Protective Effects ◽  
Histopathological Changes ◽  
Liver And Kidney ◽  
Haematological Indices

Abstract Considering that the involvement of reactive oxygen species (ROS) has been implicated in the toxicity of various pesticides, this study was designed to study the ameliorative effect of Vitamin E (100 mg/kg body weight) on mice (25 - 30 mg) treated with diazinon (32.5 or 16.25 mg/kg body weight) organophosphate insecticide for 14 days. Subchronic DZN exposure and the protective effects of vitamins E (vitE) were evaluated for their effects on haematological indices, the enzymes concerning liver damage [plasma alanine aminotransferase (ALT), aspartate aminotaransferase (AST), alkaline phosphatise (AIP), and some parameters of kidney function (urea and creatinine) in mice. Additionally, the histopathological changes in liver and kidney tissue were examined. The high dose of diazinon (DZNH) decreased the body weight significantly at the end of experiment. Additionally, the liver and kidney were examines for histopathological changes. The high dose of diazinon decreased body weight significantly. Moreover, there was a statistically significant decrease in haemoglobin (Hb), red blood cell (RBC) and hematocrit (Hct) in diazinon-treated mice compared to controls. This decrease was partially remedied in the diazinon-treated group that also received vitE. Damage in the liver and kidney tissues was also evident as elevated plasma ALT, AST, ALP, urea and creatinine. VitE partially counteracts the toxic effect of DZN and repairs tissue damage in the liver and kidney, especially when supplemented to 1/4 LD50 intoxicated animals. Histopathological changes in liver and kidney were observed only in 32.5 mg/kg DZN given group. These results suggest that the effects of DZN are dose dependent. No pathological findings were observed in vitE + DZN treated groups. According to the present study, we conclude that vitE can reduce the detrimental impacts of diazinon on haematological indicies, as well as liver and kidney function.

Zingerone prevents lead‐induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats

2020 ◽  
Author(s):  
Insha Amin ◽  
Ishraq Hussain ◽  
Muneeb U. Rehman ◽  
Bilal Ahmad Mir ◽  
Showkat Ahmad Ganaie ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Wistar Rats ◽  
Liver And Kidney

Protective Effects of Increasing Vitamin E and A Doses on Cisplatin-Induced Oxidative Damage to Kidney Tissue in Rats

2005 ◽  
Vol 75 (4) ◽  
pp. 340-344 ◽  
Author(s):  
Meltem Ozlen Dillioglugil ◽  
Hale Maral Kir ◽  
Mehmet Dogan Gulkac ◽  
Aylin Özon Kanli ◽  
Hacı Kahya Ozdogan ◽  
...  
Keyword(s):  
Vitamin E ◽  
Oxidative Damage ◽  
Kidney Tissue ◽  
Protective Effects

scholarly journals Hepato-Renal-Curative Effect of the Herbal Supplement of Aloe vera Linn Gel versus Moringa oleifera on Acetaminophen-Induced Damage on the Liver and Kidney of Wistar Rats (Rattus novergicus)

2021 ◽  
pp. 12-23
Author(s):  
Chukwunyere Ogechi Abaekwume ◽  
Hope Delesi Kagbo
Keyword(s):  
Normal Control ◽  
Wistar Rats ◽  
Moringa Oleifera ◽  
Renal Toxicity ◽  
Aloe Vera ◽  
Control Treatment ◽  
Protective Effects ◽  
Herbal Supplement ◽  
Liver And Kidney ◽  
Animal House

Background: Acetaminophen (APAP, paracetamol) is the most frequently used over-the counter analgesic and antipyretic drug. Conversely, its overdose leads to both liver and kidney damage. Several scientific reports have focused majorly on protective effects of medicinal plants on APAP –induced hepato-renal-toxicity. actually, there is a dearth of work on the hepato-renal-curative effects of the herbal drugs supplements on APAP induced toxicity. Aims: In the present study, Aloe vera (ALOV) gel versus Moringa oleifera (MORN) leaf supplement effects was evaluated curatively against Acetaminophen (APAP) induced hepato- renal-toxicity.  Study Design:  This study was an experimental study in the Animal House of the Department of Pharmacology University of Port Harcourt. The work lasted for 7 days. Methodology: Twenty adult wistar rats weighing 185-220 g were divided into four (4) groups of five (5) animals each and treated orally as follows: group 1(normal control) received distilled water (7days), group 2 received 1 g/kg acetaminophen (APAP) (2 days), whereas group 3-4  received APAP (2 days) followed by 500 mg/kg of ALOV and MORN supplements respectively for 5 days. At the end of the experiment, animals from different groups were anaesthesized, the liver and kidney tissues were dissected and blood collected subjected to different biochemical, antioxidants, and histopathological test. Statistical Analysis: was done using One-Way Anova followed by Tukey’s Post-hoc Test. Results: APAP caused significant (P<0.05) decrease in creatinine with significant (P<0.01) increase and decrease in liver enzymes and renal catalase levels respectively in relation to normal control. Treatment of rats with the ALOV and MORN supplements attenuated the elevated liver and kidney biochemistry as well as improved histopathological alterations by APAP treatment. Conclusion: The supplements demonstrated restorative ability. MORN and ALOV supplements extract can be suggested as a convincing remedy against APAP-induced hepato-renal-toxicity.

Methiocarb-induced oxidative damage following subacute exposure and the protective effects of vitamin E and taurine in rats

2009 ◽  
Vol 47 (7) ◽  
pp. 1676-1684 ◽  
Author(s):  
Sibel Ozden ◽  
Betul Catalgol ◽  
Selda Gezginci-Oktayoglu ◽  
Pelin Arda-Pirincci ◽  
Sehnaz Bolkent ◽  
...  
Keyword(s):  
Vitamin E ◽  
Oxidative Damage ◽  
Protective Effects ◽  
Subacute Exposure
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