Central Nervous System Infections Due to Streptococcus anginosus Group: A Single-Center Case Series

2021 ◽  
pp. 088307382110521
Author(s):  
Sujana Madathil ◽  
Satsuki Matsumoto ◽  
Katherine D. Mathews ◽  
Joseph Glykys
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Infection ◽  
Delayed Diagnosis ◽  
Case Series ◽  
Central Nervous System Infections ◽  
Retrospective Case ◽  
University Of Iowa ◽  
Timely Initiation ◽  
Streptococcus Anginosus

Background The Streptococcus anginosus group is known for its pathogenicity and tendency for abscess formation. The S anginosus group also causes brain abscesses, yet few studies describe this presentation in the pediatric neurology literature. We describe 5 patients with central nervous system infection due to S anginosus group evaluated by child neurologists at the University of Iowa from 2014 to 2020. Methods We performed a retrospective case series review of electronic medical records detailing the clinical presentation and course of pediatric patients with S anginosus group–associated central nervous system infection. Results We identified 4 males and 1 female (8, 11, 14, 16, and 21 years). Brain imaging showed abscesses in 4 cases and empyema in 1. All underwent neurosurgical intervention and antibiotic treatment. Cultures obtained during the neurosurgical procedure grew S anginosus group (4 cases with Streptococcus intermedius and 1 with Streptococcus constellatus). An 8-year-old boy with a delayed diagnosis died from brain herniation. Conclusions Central nervous system infections due to the S anginosus group can be life-threatening. Neuroimaging plays a key role in the early identification of abscesses. Prompt surgical intervention and timely initiation of antibiotics are critical for optimal outcomes.

scholarly journals Candida central nervous system infection after neurosurgery: a single-institution case series and literature review

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Hongwei Chen ◽  
Wenkai Cong ◽  
Dongcheng Xie ◽  
Shengjie Wang ◽  
Jianxing Niu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Literature Review ◽  
Central Nervous System Infection ◽  
Case Series ◽  
Single Institution

scholarly journals Infection of the central nervous system caused by varicella zoster virus reactivation: a retrospective case series study

2013 ◽  
Vol 17 (7) ◽  
pp. e529-e534 ◽  
Author(s):  
Juan Carlos Lozano Becerra ◽  
Robert Sieber ◽  
Gladys Martinetti ◽  
Silvia Tschuor Costa ◽  
Pascal Meylan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Varicella Zoster Virus ◽  
Case Series ◽  
Virus Reactivation ◽  
Retrospective Case ◽  
Varicella Zoster ◽  
Case Series Study ◽  
The Central Nervous System ◽  
Series Study

scholarly journals Partial Status Epilepticus with Paradoxical Protein-Cytologic Dissociation in Cerebrospinal Fluid

2020 ◽  
Author(s):  
Neeraj Singh ◽  
John J. Lansing ◽  
Aparna Polavarapu
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Status Epilepticus ◽  
Central Nervous System Infection ◽  
Case Series ◽  
Refractory Status Epilepticus ◽  
Multiple Drug ◽  
High Morbidity ◽  
Drug Interventions

AbstractStatus epilepticus is associated with high morbidity and mortality, often requiring multiple drug interventions and intensive care monitoring. Etiology of status epilepticus plays a crucial role in the treatment, natural course and outcome of the patient, prompting extensive testing and imaging. For example, an important risk for status epilepticus in adults and children is the presence of an underlying viral or bacterial central nervous system infection, appropriate treatment of which can improve the outcome of the patient. We present three cases of new-onset refractory status epilepticus in women who did not have evidence of a central nervous system infection and had significantly elevated leukocytes compared to protein in the cerebrospinal fluid. This finding suggests an autoimmune etiology; however, standard autoimmune testing was unremarkable in all cases. This case series highlights the variability in presentation and clinical course in patients presenting with status epilepticus of unknown cause, and we discuss the importance of further research into appropriate and reliable diagnostic evaluations.

Orbital relapse in children treated for Pre-B ALL, a retrospective case series

2020 ◽  
pp. 1-7
Author(s):  
Komal Seher ◽  
Saadiya Javed Khan
Keyword(s):  
Central Nervous System ◽  
Bone Marrow ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Case Series ◽  
Signs And Symptoms ◽  
Ocular Tissue ◽  
Cell Leukaemia ◽  
Retrospective Case ◽  
Ocular Lesions

Abstract About 85-90% of children with B-cell leukaemia are cured. If relapse occurs it is usually in the bone marrow (BM), followed by extramedullary sites. Ocular lesions occur secondary to the accumulation of circulating blasts in the uvea, optic disc, intra-ocular tissue as well as fluid. Here we report four patients with ocular complaints that led to the diagnosis of relapse. Among 475 children with leukaemia treated from January 2013 to December 2018, 50 (10.5%) patients relapsed. Four (8%) out of these 50 presented with orbital symptoms. Central Nervous System (CNS) evaluation by cerebrospinal fluid (CSF) was negative at relapse. Relapse was treated with chemotherapy R3 protocol. Three (75%) patients are alive, while the fourth patient had a second BM relapse and died. Ophthalmic signs and symptoms in patients with treated leukaemia warrant a thorough evaluation. Continuous...  

Central Nervous System Infection With Eikenella corrodens: Report of Two Cases

PEDIATRICS ◽  
1976 ◽  
Vol 57 (2) ◽  
pp. 264-265
Author(s):  
James E. Rubenstein ◽  
Marc F. Lieberman ◽  
Natan Gadoth
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Course ◽  
Central Nervous System Infection ◽  
Central Nervous System Infections ◽  
Eikenella Corrodens

Two cases of central nervous system infections from which E. corrodens has been isolated are reported. The portals of entry, clinical course, and antimicrobial responses conform to other reports in the literature. The importance of obtaining careful anaerobic cultures is emphasized.

scholarly journals Comorbidities and factors associated with central nervous system infections and death in non-perinatal listeriosis: a clinical case series

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
C. Maertens De Noordhout ◽  
B. Devleesschauwer ◽  
A. Maertens De Noordhout ◽  
J. Blocher ◽  
J. A. Haagsma ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Case ◽  
Case Series ◽  
Central Nervous System Infections ◽  
Factors Associated

scholarly journals Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam

2020 ◽  
Vol 7 (9) ◽  
Author(s):  
Mohamad Yasmin ◽  
Jennifer Hanrahan ◽  
Steven Marshall ◽  
Thomas P Lodise ◽  
Liang Chen ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Therapeutic Drug Monitoring ◽  
Klebsiella Pneumoniae ◽  
Drug Monitoring ◽  
Central Nervous System Infection ◽  
Multidrug Resistant ◽  
Therapeutic Drug ◽  
Central Nervous System Infections ◽  
Klebsiella Pneumoniae Carbapenemase

Abstract This report describes the treatment of Klebsiella pneumoniae carbapenemase (KPC)–3–producing multidrug-resistant K. pneumoniae with ceftazidime/avibactam (CAZ-AVI) in a patient who developed postneurosurgical meningitis and bacteremia. Therapeutic drug monitoring of cerebrospinal fluid and blood samples demonstrated CAZ-AVI concentration levels 20-fold greater than the minimum inhibitory concentration in the first 60 minutes postinfusion, providing evidence for the utility of CAZ-AVI in treating KPC–Klebsiella pneumoniae central nervous system infections.

Sign in / Sign up

Export Citation Format

Share Document