Very High Weight Gain During Exclusive Breastfeeding Followed by Slowdown During Complementary Feeding: Two Case Reports

2018 ◽  
Vol 35 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Melanie Wange Larsson ◽  
Anni Larnkjær ◽  
Sophie Hilario Christensen ◽  
Christian Mølgaard ◽  
Kim F. Michaelsen
2014 ◽  
Vol 65 (4) ◽  
pp. 317-323 ◽  
Author(s):  
Igor Ya Kon ◽  
Natalia M. Shilina ◽  
Maria V. Gmoshinskaya ◽  
Tatiana A. Ivanushkina

2013 ◽  
Vol 95 (1) ◽  
pp. 4-13 ◽  
Author(s):  
PHILIP W. HEDRICK

SummaryWith many molecular markers in many species, research efforts in quantitative genetics have focused on dissecting these traits and understanding the importance of factors such as correlated response due to hitchhiking or pleiotropy. Here, in an examination of long-term selection experiments in mice, the evidence strongly supports the primary importance of hitchhiking on the coat colour loci brown and dilute in mice selected for high weight gain. First, the amount of observed change in coat colour allele frequency could not be explained by genetic drift alone, implying that selection was of high importance. Second, the allele frequency changes included reversals in the direction change, but there were still positive correlations in the early generations with differences in weight gain between the phenotypes. Third, the correlation between the change in allele frequencies and phenotypic difference in weight gain declined over time, consistent with the decay expected from linkage associations. Fourth, the changes at both loci in a short-term selection experiment for low weight gain were in the opposite direction than the changes in the contemporaneous related population selected for high weight gain.


2017 ◽  
Vol 94 ◽  
pp. 62-69 ◽  
Author(s):  
O. Godin ◽  
M. Leboyer ◽  
F. Schürhoff ◽  
L. Boyer ◽  
M. Andrianarisoa ◽  
...  

1984 ◽  
Vol 102 (2) ◽  
pp. 353-359 ◽  
Author(s):  
D. M. B. Chestnutt

SummaryOver a period of 3 years 18 autumn-calving, single suckled, April-weaned cows were stocked at three rates at pasture to gain 132, 70 or 25 kg (H, M and L respectively) between April and August and fed to lose 100, 54 or – 13 kg (H, M and L respectively) while housed between November and April, the relative total energy intake over winter being 0·64, 0·83 and 1·00 respectively. Milk yield was reduced by 2·68 kg/day on the H and 1·25 kg/day on the M treatment and as a result calves gained 37 and 10 kg less respectively over winter than on the L treatment. However, despite poorer calf performance economic considerations would indicate a preference for high weight gain during the grazing season and a corresponding loss over winter.


2013 ◽  
Vol 89 (12) ◽  
pp. 967-972 ◽  
Author(s):  
Samuel Clark Berngard ◽  
Jennifer Bishop Berngard ◽  
Nancy F. Krebs ◽  
Ana Garcés ◽  
Leland V. Miller ◽  
...  

CNS Spectrums ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 160-160
Author(s):  
Michael J. Doane ◽  
Leona Bessonova ◽  
Kathleen Mortimer ◽  
Harry Cheng ◽  
Gregory Donadio ◽  
...  

AbstractAmong patients with schizophrenia (SZ) and bipolar I disorder (BD-I) treated with second-generation antipsychotics (SGAs), clinically-significant weight gain (CSWG) and treatment interruptions (TIs) are challenges that may result in morbidity/mortality.CSWG and TIs were assessed among patients who initiated oral SGAs of moderate-to-high weight gain risk (no exposure to index SGAs/first-generation antipsychotics for =12 months) using medical records/claims (OM1 Data Cloud; January 2013-February 2020). Outcomes included CSWG (=7% increase in baseline weight) and TIs (switches [to SGAs of low weight gain risk/long-acting injectables] or discontinuations [no SGAs for >30 days]). Descriptive analyses included proportions of patients with CSWG and TIs, and median time to these outcomes.Approximately three-quarters of patients were overweight/obese at baseline (SZ: N=8,174; BD-I: N=9,142). Within 3 months of SGA initiation, 12% of all patients experienced CSWG. For patients on treatment with index SGAs for >6 months (SZ: 29%; BD-I: 27%), 28% (SZ) and 30% (BD-I) experienced CSWG during follow-up. Median time to CSWG was 14 weeks. CSWG results were numerically similar among patients with SZ and BD-I.Over 96% of patients had TIs during follow-up (median time of 12 [SZ] and 13 [BD-I] weeks). Among patients with CSWG and subsequent TIs and weight measurements, 74% did not return to baseline weight after interrupting treatment; the remainder returned to baseline weight with median times of 38 (SZ) and 39 (BD-I) weeks. Results suggest that most patients with CSWG do not return to baseline weight after stopping treatment with oral SGAs of moderate-to-high weight gain risk.Funding. Alkermes, Inc.


2012 ◽  
Vol 24 (5) ◽  
pp. 633-639 ◽  
Author(s):  
Jianduan Zhang ◽  
Jingxiong Jiang ◽  
John H. Himes ◽  
Jing Zhang ◽  
Guoyan Liu ◽  
...  

Thorax ◽  
2020 ◽  
Vol 75 (4) ◽  
pp. 313-320 ◽  
Author(s):  
Gabriela P Peralta ◽  
Alessandro Marcon ◽  
Anne-Elie Carsin ◽  
Michael J Abramson ◽  
Simone Accordini ◽  
...  

BackgroundPrevious studies have reported an association between weight increase and excess lung function decline in young adults followed for short periods. We aimed to estimate lung function trajectories during adulthood from 20-year weight change profiles using data from the population-based European Community Respiratory Health Survey (ECRHS).MethodsWe included 3673 participants recruited at age 20–44 years with repeated measurements of weight and lung function (forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1)) in three study waves (1991–93, 1999–2003, 2010–14) until they were 39–67 years of age. We classified subjects into weight change profiles according to baseline body mass index (BMI) categories and weight change over 20 years. We estimated trajectories of lung function over time as a function of weight change profiles using population-averaged generalised estimating equations.ResultsIn individuals with normal BMI, overweight and obesity at baseline, moderate (0.25–1 kg/year) and high weight gain (>1 kg/year) during follow-up were associated with accelerated FVC and FEV1 declines. Compared with participants with baseline normal BMI and stable weight (±0.25 kg/year), obese individuals with high weight gain during follow-up had −1011 mL (95% CI −1.259 to −763) lower estimated FVC at 65 years despite similar estimated FVC levels at 25 years. Obese individuals at baseline who lost weight (<−0.25 kg/year) exhibited an attenuation of FVC and FEV1 declines. We found no association between weight change profiles and FEV1/FVC decline.ConclusionModerate and high weight gain over 20 years was associated with accelerated lung function decline, while weight loss was related to its attenuation. Control of weight gain is important for maintaining good lung function in adult life.


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