Development of PLA-HAp-CS-based biocompatible functional prototype: A case study

2018 ◽  
Vol 33 (3) ◽  
pp. 305-323 ◽  
Author(s):  
Nishant Ranjan ◽  
Rupinder Singh ◽  
IPS Ahuja
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Microscopic Analysis ◽  
Fused Deposition Modelling ◽  
Electron Microscopic ◽  
Dead Weight ◽  
Fused Deposition ◽  
Twin Screw ◽  
Functional Prototype

In this article, detailed procedure for the development of polylactic acid (PLA), hydroxyapatite (HAp) and chitosan (CS)-based biocompatible functional prototype has been outlined by using three-dimensional (3D) printing as a case study. The biocompatible composite-based feedstock filament (comprising of PLA-HAp-CS) has been prepared through twin-screw extruder (TSE) for open-source fused deposition modelling (FDM)-based 3D printer. This case study provides two-stage multifactor optimization: (a) for preparation of feedstock filament on TSE and (b) 3D printing on FDM based upon tensile and flexural samples. The results of study suggest that the best settings of input parameters for TSE are barrel temperature of 190°C, screw speed of 140 r/min and dead weight of 12 kg. Further, the optimized settings for FDM are layer thickness of 0.2 mm, deposition angle of 30/45° and infill density of 100%. The results have been supported by scanning electron microscopic analysis.

scholarly journals 3D Printing of Thermo-Sensitive Drugs

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1524
Author(s):  
Sadikalmahdi Abdella ◽  
Souha H. Youssef ◽  
Franklin Afinjuomo ◽  
Yunmei Song ◽  
Paris Fouladian ◽  
...  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Fused Deposition Modelling ◽  
Future Directions ◽  
Digital Light Processing ◽  
Fused Deposition ◽  
Printing Technique ◽  
3D Printed ◽  
Semi Solid ◽  
Selection Of

Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.

scholarly journals Three-dimensional Printing Versus Conventional Machining in the Creation of a Meatal Urethral Dilator: a Cost and Mechanical Strength Analysis

2020 ◽  
Author(s):  
Michael Yue-Cheng Chen ◽  
Jacob Skewes ◽  
Ryan Daley ◽  
Maria Ann Woodruff ◽  
Nicholas John Rukin
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Patient Specific ◽  
Strength Analysis ◽  
Fused Deposition Modelling ◽  
3D Printer ◽  
Current Time ◽  
Fused Deposition ◽  
3D Printed ◽  
Conventional Machining

Abstract BackgroundThree-dimensional (3D) printing is a promising technology but the limitations are often poorly understood. We compare different 3D printingmethods with conventional machining techniques in manufacturing meatal urethral dilators which were recently removed from the Australian market. MethodsA prototype dilator was 3D printed vertically orientated on a low cost fused deposition modelling (FDM) 3D printer in polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS). It was also 3D printed horizontally orientated in ABS on a high-end FDM 3D printer with soluble support material, as well as on a SLS 3D printer in medical nylon. The dilator was also machined in stainless steel using a lathe. All dilators were tested mechanically in a custom rig by hanging calibrated weights from the handle until the dilator snapped. ResultsThe horizontally printed ABS dilator experienced failure at a greater load than the vertically printed PLA and ABS dilators respectively (503g vs 283g vs 163g, p < 0.001). The SLS nylon dilator and machined steel dilator did not fail. The steel dilator is most expensive with a quantity of five at 98 USD each, but this decreases to 30 USD each for a quantity of 1000. In contrast, the cost for the SLS dilator is 33 USD each for five and 27 USD each for 1000. ConclusionsAt the current time 3D printing is not a replacement for conventional manufacturing. 3D printing is best used for patient-specific parts, prototyping or manufacturing complex parts that have additional functionality that cannot otherwise beachieved.

scholarly journals Modelling and Investigation of Crack Growth for 3D-Printed Acrylonitrile Butadiene Styrene (ABS) with Various Printing Parameters and Ambient Temperatures

Polymers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 3737
Author(s):  
Yousef Lafi A. Alshammari ◽  
Feiyang He ◽  
Muhammad A. Khan
Keyword(s):  
3D Printing ◽  
Crack Growth ◽  
Three Dimensional ◽  
Acrylonitrile Butadiene Styrene ◽  
Fused Deposition Modelling ◽  
Structural Dynamic ◽  
Fused Deposition ◽  
Nozzle Size ◽  
Printing Parameters ◽  
Butadiene Styrene

Three-dimensional (3D) printing is one of the significant industrial manufacturing methods in the modern era. Many materials are used for 3D printing; however, as the most used material in fused deposition modelling (FDM) technology, acrylonitrile butadiene styrene (ABS) offers good mechanical properties. It is perfect for making structures for industrial applications in complex environments. Three-dimensional printing parameters, including building orientation, layers thickness, and nozzle size, critically affect the crack growth in FDM structures under complex loads. Therefore, this paper used the dynamic bending vibration test to investigate their influence on fatigue crack growth (FCG) rate under dynamic loads and the Paris power law constant C and m. The paper proposed an analytical solution to determine the stress intensity factor (SIF) at the crack tip based on the measurement of structural dynamic response. The experimental results show that the lower ambient temperature, as well as increased nozzle size and layer thickness, provide a lower FCG rate. The printing orientation, which is the same as loading, also slows the crack growth. The linear regression between these parameters and Paris Law’s coefficient also proves the same conclusion.

scholarly journals Parameters Affecting the Mechanical Properties of Three-Dimensional (3D) Printed Carbon Fiber-Reinforced Polylactide Composites

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2456
Author(s):  
Demei Lee ◽  
Guan-Yu Wu
Keyword(s):  
Mechanical Properties ◽  
Carbon Fiber ◽  
3D Printing ◽  
Three Dimensional ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Fused Deposition ◽  
Bed Temperature ◽  
3D Printed ◽  
The Impact

Three-dimensional (3D) printing is a manufacturing technology which creates three-dimensional objects layer-by-layer or drop-by-drop with minimal material waste. Despite the fact that 3D printing is a versatile and adaptable process and has advantages in establishing complex and net-shaped structures over conventional manufacturing methods, the challenge remains in identifying the optimal parameters for the 3D printing process. This study investigated the influence of processing parameters on the mechanical properties of Fused Deposition Modelling (FDM)-printed carbon fiber-filled polylactide (CFR-PLA) composites by employing an orthogonal array model. After printing, the tensile and impact strengths of the printed composites were measured, and the effects of different parameters on these strengths were examined. The experimental results indicate that 3D-printed CFR-PLA showed a rougher surface morphology than virgin PLA. For the variables selected in this analysis, bed temperature was identified as the most influential parameter on the tensile strength of CFR-PLA-printed parts, while bed temperature and print orientation were the key parameters affecting the impact strengths of printed composites. The 45° orientation printed parts also showed superior mechanical strengths than the 90° printed parts.

scholarly journals 3D Printing for Hip Implant Applications: A Review

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2682
Author(s):  
Obinna Okolie ◽  
Iwona Stachurek ◽  
Balasubramanian Kandasubramanian ◽  
James Njuguna
Keyword(s):  
3D Printing ◽  
Hip Replacement ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Ceramic Materials ◽  
Fused Deposition Modelling ◽  
Fused Deposition ◽  
Replacement Treatment ◽  
Determining Factors ◽  
3D Printed

There is a rising demand for replacement, regeneration of tissues and organ repairs for patients who suffer from diseased/damaged bones or tissues such as hip pains. The hip replacement treatment relies on the implant, which may not always meet the requirements due to mechanical and biocompatibility issues which in turn may aggravate the pain. To surpass these limitations, researchers are investigating the use of scaffolds as another approach for implants. Three-dimensional (3D) printing offers significant potential as an efficient fabrication technique on personalized organs as it is capable of biomimicking the intricate designs found in nature. In this review, the determining factors for hip replacement and the different fabrication techniques such as direct 3D printing, Fused Deposition Modelling (FDM), Selective Laser Sintering (SLS) and stereolithography (SLA) for hip replacement. The study also covers surface modifications of 3D printed implants and provides an overview on 3D tissue regeneration. To appreciate the current conventional hip replacement practices, the conventional metallic and ceramic materials are covered, highlighting their rationale as the material of choice. Next, the challenges, ethics and trends in the implants’ 3D printing are covered and conclusions drawn. The outlook and challenges are also presented here. The knowledge from this review indicates that 3D printing has enormous potential for providing a pathway for a sustainable hip replacement.

A Low-Cost Method to Prepare Biocompatible Filaments with Enhanced Physico-mechanical Properties for FDM 3D Printing

2020 ◽  
Vol 18 ◽  
Author(s):  
Deck Khong Tan ◽  
Niko Münzenrieder ◽  
Mohammed Maniruzzaman ◽  
Ali Nokhodchi
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Fused Deposition Modelling ◽  
Processing Temperature ◽  
Melt Extrusion ◽  
Screw Extruder ◽  
Fused Deposition ◽  
Single Screw ◽  
Pharmaceutical Applications ◽  
Twin Screw

Background: Fused Deposition Modelling (FDM) 3D printing has received much interest as a fabrication method in the medical and pharmaceutical industry due to its accessibility and cost-effectiveness. A low-cost method to produce biocompatible and biodegradable filaments can improve the usability of FDM 3D printing for biomedical applications. Objectives: The feasibility of producing low-cost filaments suitable for FDM 3D printing via single screw and twin-screw hot melt extrusion was explored. Methods: A single-screw extruder and a twin-screw extruder were used to produce biocompatible filaments composed of varying concentrations of polyethylene glycol (PEG) at 10%, 20%, 30% w/w and polylactic acid (PLA) 90%, 80% and 70% w/w, respectively. DSC, TGA and FTIR were employed to investigate the effect of PEG on the PLA filaments. Results: The presence of PEG lowered the processing temperature of the formulation compositions via melt-extrusion, making it suitable for pharmaceutical applications. The use of PEG can lower the melting point of the PLA polymer to 170 °C, hence lowering the printing temperature. PEG can also improve the plasticity of the filaments, as the rupture strain of twinscrew extruded filaments increased up to 10-fold as compared to the commercial filaments. Advanced application of FTIR analysis confirmed the compatibility and miscibility of PEG with PLA. Conclusion: Twin-screw extrusion is more effective in producing a polymeric mixture of filaments as the mixing is more homogenous. The PEG/PLA filament is suitable to be used in 3D printing of medical or pharmaceutical applications such as medical implants, drug delivery systems, or personalised tablets.

Investigating the Mechanical Behavior of 3D Printed PLA-Coco Coir Composites

2021 ◽  
Vol 1046 ◽  
pp. 125-132
Author(s):  
Paul Eric C. Maglalang ◽  
Blessie A. Basilia ◽  
Araceli Magsino Monsada
Keyword(s):  
Mechanical Properties ◽  
Particle Size ◽  
3D Printing ◽  
Fused Deposition Modelling ◽  
Coir Fiber ◽  
Fiber Concentration ◽  
Fused Deposition ◽  
Twin Screw ◽  
Raster Angle ◽  
Composite Filament

It is quite amazing that the use of 3D printing techniques, especially the Fused Deposition Modelling (FDM) has delivered such significance in terms of cost reduction, time saver features where a different variety of thermoplastic and composite materials (Biodegradable and Non-biodegradable) are well developed. Different sectors have continually developed natural organic materials that are also both structurally composite in nature. Similarly, the use of different fibers that are abundantly accessible and considered as renewable resources which can be optionally combined with other biodegradable materials is a great challenge through the use of the FDM printing method. The study aims to determine the effect of different particle size and raster angle at a certain fiber concentration which could affect the mechanical properties of the composite by developing a printable composite filament made of Polylactic Acid (PLA) and Coco Coir materials using a filament maker and FDM printer. The composite filament was fabricated and optimized using a twin-screw extruder and 3D Devo Filament maker. 3D printing of samples for mechanical testing was conducted using three (3) raster angles (45o, 60o, and 75o) and various particle sizes of coco coir fiber reinforcement in the PLA matrix. Results showed that the < 74μm particle size of the coco-coir exhibited a 24% and 175% increase in tensile strength and izod impact strength compared to the pure PLA at 60o and 75o raster angles, respectively. Likewise, the reinforcement of <149μm particle size coco coir at 45o raster angle contributes to an increase of 4.8% flexural and 176% compressive strength compared to pure PLA. The study concludes that there is an improvement in the mechanical properties of the PLA-Coco Coir composite at a certain particle size and raster angle in 3D printing.

3D Printing: Basic Concepts Mathematics and Technologies

2013 ◽  
Vol 2 (2) ◽  
pp. 58-71
Author(s):  
Alexander Rompas ◽  
Charalampos Tsirmpas ◽  
Ianos Papatheodorou ◽  
Georgia Koutsouri ◽  
Dimitris Koutsouris
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Real Life ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Three Dimensional Objects ◽  
Stl File ◽  
Fused Deposition ◽  
3D Printers ◽  
Object Layer

3D printing is about being able to print any object layer by layer. But if one questions this proposition, can one find any three-dimensional objects that can't be printed layer by layer? To banish any disbeliefs the authors walked together through the mathematics that prove 3d printing is feasible for any real life object. 3d printers create three-dimensional objects by building them up layer by layer. The current generation of 3d printers typically requires input from a CAD program in the form of an STL file, which defines a shape by a list of triangle vertices. The vast majority of 3d printers use two techniques, FDM (Fused Deposition Modelling) and PBP (Powder Binder Printing). One advanced form of 3d printing that has been an area of increasing scientific interest the recent years is bioprinting. Cell printers utilizing techniques similar to FDM were developed for bioprinting. These printers give us the ability to place cells in positions that mimic their respective positions in organs. Finally, through a series of case studies the authors show that 3d printers have made a massive breakthrough in medicine lately.

scholarly journals Modern Applications of 3D Printing: The Case of an Artificial Ear Splint Model

2021 ◽  
Vol 4 (3) ◽  
pp. 54
Author(s):  
Athanasios Argyropoulos ◽  
Pantelis N. Botsaris
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Shape Preservation ◽  
Patient Specific ◽  
Fused Deposition Modelling ◽  
Comprehensive Overview ◽  
Protruding Ears ◽  
Fused Deposition ◽  
Custom Made ◽  
Wide Range

Three-dimensional (3D) printing is a leading manufacturing technique in the medical field. The constantly improving quality of 3D printers has revolutionized the approach to new challenges in medicine for a wide range of applications including otoplasty, medical devices, and tissue engineering. The aim of this study is to provide a comprehensive overview of an artificial ear splint model applied to the human auricle for the treatment of stick-out protruding ears. The deformity of stick-out protruding ears remains a significant challenge, where the complex and distinctive shape preservation are key factors. To address this challenge, we have developed a protocol that involves photogrammetry techniques, reverse engineering technologies, a smart prototype design, and 3D printing processes. Specifically, we fabricated a 3D printed ear splint model via fused deposition modelling (FDM) technology by testing two materials, a thermoplastic polyester elastomer material (Z-Flex) and polycaprolactone (PCL 100). Our strategy affords a custom-made and patient-specific artificial ear aligner with mechanical properties that ensures sufficient preservation of the auricular shape by applying a force on the helix and antihelix and enables the ears to pin back to the head.

scholarly journals Surface Roughness Effect on the 3d Printed Butt Joints Strength

2015 ◽  
Author(s):  
V. Kovan ◽  
G. Altan ◽  
E.S. Topal ◽  
H.E. Camurlu
Keyword(s):  
Surface Roughness ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Three Dimensional ◽  
Thickness Effect ◽  
Fused Deposition Modelling ◽  
Three Dimensional Printing ◽  
Fused Deposition ◽  
3D Printed ◽  
Dimensional Object

Three-dimensional printing or 3D printing (also called additive manufacturing) is any of various processes used to make a three-dimensional object. Fused deposition modelling (FDM) is an additive manufacturing technology commonly used for modelling, prototyping, and production applications. It is one of the techniques used for 3D printing. FDM is somewhat restricted in the size and the variation of shapes that may be fabricated. For parts too large to fit on a single build, for faster job builds with less support material, or for parts with finer features, sectioning and bonding FDM parts is a great solution. The strength of adhesive bonded FDM parts is affected by the surface roughness. In this study, the layer thickness effect on bonding strength is experimentally studied and the results are discussed.

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