Clinical–pathological characteristics and short-term follow-up associated with proliferation, apoptosis and angiogenesis in a prospective cohort of patients with colorectal tumours

We investigate the clinical and pathological features related to variations in colorectal tumour apoptosis, proliferation and angiogenesis and the influence of the latter in short-term mortality (2 years); 551 tumour samples from a prospective cohort of patients with colorectal cancer were examined and tumour biology markers were determined as follows: percentage of apoptotic cells, by the terminal deoxynucleotidyl transferase (TdT) dUTP Nick-End Labeling technique; Ki-67 antigen, as a cell proliferation marker and density of microvessels (as a marker of angiogenesis). An increase in the percentage of cellular apoptosis is significantly related to the presence of poorly differentiated tumours, with vascular invasion (p < 0.001). The CD105 angiogenesis marker is not related to any clinical–pathological parameter except that of higher frequency in older patients (p = 0.03). Ki-67 is more frequently expressed in tumours with less nervous invasion (p = 0.05). Neither apoptosis nor angiogenesis present any significant association with short-term survival. The only marker clearly related to 2-year survival is Ki-67, which is shown to be a good prognostic factor in the multivariate analysis (hazard ratio = 0.49; 95% confidence interval = 0.27–0.90). Therefore, in a prospective cohort of colorectal cancer patients, only Ki-67 is a marker of good prognosis in short-term follow-up.

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Short term outcome for colorectal cancer patients undergoing surgery in Tertiary care center in Eastern India

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2020.11.277 ◽

2021 ◽

Vol 47 (2) ◽

pp. e50-e51

Author(s):

Abhitesh Singh ◽

Anshul Jain ◽

Dillip Muduly ◽

Mahesh Sultania ◽

Jyoti Ranjan Swain ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Care Center ◽

Tertiary Care ◽

Tertiary Care Center ◽

Eastern India ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome ◽

Colorectal Cancer Patients

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Identification of Lifestyle Behaviors Associated with Recurrence and Survival in Colorectal Cancer Patients Using Random Survival Forests

Cancers ◽

10.3390/cancers13102442 ◽

2021 ◽

Vol 13 (10) ◽

pp. 2442

Author(s):

Moniek van Zutphen ◽

Fränzel J. B. van Duijnhoven ◽

Evertine Wesselink ◽

Ruud W. M. Schrauwen ◽

Ewout A. Kouwenhoven ◽

...

Keyword(s):

Colorectal Cancer ◽

Recurrence Risk ◽

Lifestyle Behaviors ◽

Sugary Drinks ◽

All Cause Mortality ◽

Random Survival Forests ◽

Colorectal Cancer Patients ◽

Survival Forests ◽

Risk Of Cancer

Current lifestyle recommendations for cancer survivors are the same as those for the general public to decrease their risk of cancer. However, it is unclear which lifestyle behaviors are most important for prognosis. We aimed to identify which lifestyle behaviors were most important regarding colorectal cancer (CRC) recurrence and all-cause mortality with a data-driven method. The study consisted of 1180 newly diagnosed stage I–III CRC patients from a prospective cohort study. Lifestyle behaviors included in the current recommendations, as well as additional lifestyle behaviors related to diet, physical activity, adiposity, alcohol use, and smoking were assessed six months after diagnosis. These behaviors were simultaneously analyzed as potential predictors of recurrence or all-cause mortality with Random Survival Forests (RSFs). We observed 148 recurrences during 2.6-year median follow-up and 152 deaths during 4.8-year median follow-up. Higher intakes of sugary drinks were associated with increased recurrence risk. For all-cause mortality, fruit and vegetable, liquid fat and oil, and animal protein intake were identified as the most important lifestyle behaviors. These behaviors showed non-linear associations with all-cause mortality. Our exploratory RSF findings give new ideas on potential associations between certain lifestyle behaviors and CRC prognosis that still need to be confirmed in other cohorts of CRC survivors.

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Influence of Postoperative Changes in Sarcopenia on Long-Term Survival in Non-Metastatic Colorectal Cancer Patients

Cancers ◽

10.3390/cancers13102410 ◽

2021 ◽

Vol 13 (10) ◽

pp. 2410

Author(s):

Chungyeop Lee ◽

In-Ja Park ◽

Kyung-Won Kim ◽

Yongbin Shin ◽

Seok-Byung Lim ◽

...

Keyword(s):

Colorectal Cancer ◽

Metastatic Colorectal Cancer ◽

Cancer Patients ◽

Medical Center ◽

The Body ◽

Term Survival ◽

Postoperative Changes ◽

Asan Medical ◽

Colorectal Cancer Patients

The effect of perioperative sarcopenic changes on prognosis remains unclear. We conducted a retrospective cohort study with 2333 non-metastatic colorectal cancer patients treated between January 2009 and December 2012 at the Asan Medical Center. The body composition at diagnosis was measured via abdominopelvic computed tomography (CT) using Asan-J software. Patients underwent CT scans preoperatively, as well as at 6 months–1 year and 2–3 years postoperatively. The primary outcome was the association between perioperative sarcopenic changes and survival. According to sarcopenic criteria, 1155 (49.5%), 890 (38.2%), and 893 (38.3%) patients had sarcopenia preoperatively, 6 months–1 year, and 2–3 years postoperatively, respectively. The 5-year overall survival (OS) (95.8% vs. 92.1%, hazard ratio (HR) = 2.234, p < 0.001) and 5-year recurrence-free survival (RFS) (93.2% vs. 86.2%, HR = 2.251, p < 0.001) rates were significantly lower in patients with preoperative sarcopenia. Both OS and RFS were lower in patients with persistent sarcopenia 2–3 years postoperatively than in those who recovered (OS: 96.2% vs. 90.2%, p = 0.001; RFS: 91.1% vs. 83.9%, p = 0.002). In multivariate analysis, postoperative sarcopenia was confirmed as an independent factor associated with decreased OS and RFS. Pre- and postoperative sarcopenia and changes in the condition during surveillance were associated with oncological outcomes.

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Bacterial Translocation May Influence the Long-Term Survival in Colorectal Cancer Patients

Diseases of the Colon & Rectum ◽

10.1007/s10350-006-0827-4 ◽

2007 ◽

Vol 50 (3) ◽

pp. 323-330 ◽

Cited By ~ 15

Author(s):

Kin F. Chin ◽

R. Kallam ◽

Colm OʼBoyle ◽

John MacFie

Keyword(s):

Colorectal Cancer ◽

Cancer Patients ◽

Bacterial Translocation ◽

Term Survival ◽

Long Term Survival ◽

Colorectal Cancer Patients

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Preoperative evaluation of skeletal muscle mass in the risk assessment for the short‑term outcome of elderly colorectal cancer patients undergoing colectomy

Molecular and Clinical Oncology ◽

10.3892/mco.2018.1607 ◽

2018 ◽

Author(s):

Hiroshi Tamagawa ◽

Toru Aoyama ◽

Kenta Iguchi ◽

Hirohito Fujikawa ◽

Sho Sawazaki ◽

...

Keyword(s):

Colorectal Cancer ◽

Risk Assessment ◽

Skeletal Muscle ◽

Cancer Patients ◽

Skeletal Muscle Mass ◽

Preoperative Evaluation ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome ◽

Colorectal Cancer Patients

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Targeted Plasma Metabolic Profiles and Risk of Recurrence in Stage II and III Colorectal Cancer Patients: Results from an International Cohort Consortium

Metabolites ◽

10.3390/metabo11030129 ◽

2021 ◽

Vol 11 (3) ◽

pp. 129

Author(s):

Jennifer Ose ◽

Biljana Gigic ◽

Stefanie Brezina ◽

Tengda Lin ◽

Andreas Baierl ◽

...

Keyword(s):

Colorectal Cancer ◽

Multiple Testing ◽

Tumor Stage ◽

Stage Ii ◽

Sphingolipid Metabolism ◽

Risk Of Recurrence ◽

Cox Proportional Hazard Models ◽

Edta Plasma ◽

Colorectal Cancer Patients

The identification of patients at high-risk for colorectal cancer (CRC) recurrence remains an unmet clinical need. The aim of this study was to investigate associations of metabolites with risk of recurrence in stage II/III CRC patients. A targeted metabolomics assay (128 metabolites measured) was performed on pre-surgery collected EDTA plasma samples from n = 440 newly diagnosed stage II/III CRC patients. Patients have been recruited from four prospective cohort studies as part of an international consortium: Metabolomic profiles throughout the continuum of CRC (MetaboCCC). Cox proportional hazard models were computed to investigate associations of metabolites with recurrence, adjusted for age, sex, tumor stage, tumor site, body mass index, and cohort; false discovery rate (FDR) was used to account for multiple testing. Sixty-nine patients (15%) had a recurrence after a median follow-up time of 20 months. We identified 13 metabolites that were nominally associated with a reduced risk of recurrence. None of the associations were statistically significant after controlling for multiple testing. Pathway topology analyses did not reveal statistically significant associations between recurrence and alterations in metabolic pathways (e.g., sphingolipid metabolism p = 0.04; pFDR = 1.00). To conclude, we did not observe statistically significant associations between metabolites and CRC recurrence using a well-established metabolomics assay. The observed results require follow-up in larger studies.

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