scholarly journals Markers of oxidative stress in dogs with heart failure

2017 ◽  
Vol 29 (5) ◽  
pp. 636-644 ◽  
Author(s):  
Barbara Verk ◽  
Alenka Nemec Svete ◽  
Janez Salobir ◽  
Vida Rezar ◽  
Aleksandra Domanjko Petrič
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Vitamin E ◽  
Small Animal ◽  
Cardiac Patients ◽  
Plasma Vitamin ◽  
Oxidative Stress Parameters ◽  
Health Council ◽  
The Individual ◽  
Stress Parameters

We tested the hypothesis that indirect measures of oxidative stress (vitamin E, glutathione peroxidase, and malondialdehyde) differ in dogs in heart failure resulting from either myxomatous mitral valve disease or dilated cardiomyopathy. Dogs were classified according to the International Small Animal Cardiac Health Council (ISACHC) classification. Additionally, the effect of cardiac therapy on oxidative stress parameters and N-terminal pro–B-type natriuretic peptide (NT-proBNP) in advanced stages of congestive heart failure was investigated. There were no significant differences in oxidative stress parameters between healthy dogs and the individual groups of cardiac patients. Significantly lower malondialdehyde (MDA) was observed in the ISACHC II group in comparison to ISACHC groups III and I. A significant positive correlation in treated patients was observed between NT-proBNP and MDA, NT-proBNP and vitamin E, as well as between MDA and vitamin E (and lipid-standardized vitamin E). No significant differences in any of the measured parameters were found between treated and non-treated cardiac patients. Our results suggest an association between MDA (the extent of lipid peroxidation) and NT-proBNP, vitamin E and NT-proBNP, as well as between MDA and vitamin E in treated canine patients. Plasma vitamin E concentration was maintained in all stages of cardiovascular disease in these canine patients.

scholarly journals Changes in Oxidative Stress Parameters as Response to Supplementation With Vitamin E and Omega-3 Fatty Acids in Male Workers Exposed to High Level Noise

2021 ◽  
Author(s):  
Hamzeh Mohammadi ◽  
Farideh Golbabaei ◽  
Somayeh Farhang Dehghan ◽  
Nariman Moradi ◽  
Maryam Chamari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Fatty Acids ◽  
Vitamin E ◽  
Assay Method ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Decremental Effect ◽  
Oxidative Stress Parameters ◽  
Incremental Effect ◽  
Stress Parameters

Abstract Background: The present study aimed to assess the effects of the supplementation consumption of vitamin E and Omega 3 fatty acid on the oxidative stress parameters among workers exposed to high levels of noise in an automobile parts manufacturing plant. Moreover, the effects of the exposure to noise on SOD, total oxidative stress (TAC) and MDA will be investigated. Methods: The participants were deployed into 4 groups (vitamin E (100 mg), Omega 3 fatty acids (180 mg EPA and 120 mg DHA), vitamin E+ Omega 3 and Placebo), as per the double-blind block randomization method. The oxidative stress parameters of the participants were analyzed before and after three month consumption of supplements via enzyme-linked immunosorbent assay method. The level of workers' exposure to noise, was measured according to ISO 9612. Results: Before intervention, mean MDA, SOD and TAC were 27.52 (7.46) nmol/ml, 58.84 (10.44) U/ml and 2.57 (0.67) mM respectively. After intervention, mean MDA, SOD and TAC were 24.57 (7.58) nmol/ml, 63.46 (11.02) U/ml and 2.70 (0.84) mM respectively. The use of supplement Omega 3 fatty acids had a significant decremental effect on MDA levels. The use of vitamin E alongside Omega 3 fatty acids had a significant incremental effect on SOD activity.Conclusion: Noise exposure had a decremental effect on TAC and SOD as well as an incremental effect on MDA, but this was only statistically significant for TAC. It appears that the simultaneous use of vitamin E and Omega 3 fatty acids for three months had a positive effect on the anti-oxidant performance of workers exposed to noise.

scholarly journals Is the Clinical Course of Non-Arteritic Ischemic Optic Neuropathy Associated with Oxidative Damage and the Dynamics of the Antioxidant Response?

2022 ◽  
Author(s):  
kaya N engin ◽  
Duygu Harmancı Karagülle ◽  
Ceren Durmaz Engin ◽  
Melis Kant ◽  
Aylin Yaman ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Oxidative Damage ◽  
Patient Group ◽  
Optic Neuropathy ◽  
Clinical Course ◽  
Antioxidant Response ◽  
Ischemic Optic Neuropathy ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Abstract Purpose: Oxidative stress is known to be a decisive factor in the wide etiopathogenesis of optic neuropathy. This study aimed to comprehensively evaluate the interaction of optic neuropathy’s clinical course with systemic oxidative damage and antioxidant response dynamics in a large series.Methods: This case-controlled clinical study included 33 non-arteritic anterior ischemic optic neuropathy patients and 32 healthy individuals. Extensive systemic oxidation profiles were statistically compared between the two groups, and correlations between the clinical and biochemical data in the patient group were analyzed.Results: Vitamin E and MDA levels were significantly higher in the patient group. Significant correlations were observed in the analyses between clinical findings and oxidative stress parameters. Correlations between vitamin E and intraocular pressure, between B12 and cup-to-disc ratio, between antioxidant glutathione and SOD enzyme systems, and between uric acid and age were found to be very significant. As significant correlations were found in either clinical and biochemical data or in oxidative stress parameters, correlations between vitamin E and cholesterol, MDA was found to be very significant. Conclusions: This study not only supplies significant information regarding oxidative damage and antioxidant response in NAION, but also points out the specific interactions of neuromodulators, like vitamin E, in intracellular signaling pathways and regulation mechanisms. A better reading of these connections may help improve diagnosis, follow-ups and treatment criteria and strategies.

scholarly journals Comparison of Oxidative Stress Parameters in Heart Failure Patients Depending on Ischaemic or Nonischaemic Aetiology

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Ewa Romuk ◽  
Celina Wojciechowska ◽  
Wojciech Jacheć ◽  
Jolanta Nowak ◽  
Jacek Niedziela ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Nyha Class ◽  
Maximal Oxygen Consumption ◽  
Stress Index ◽  
Oxidative Stress Parameters ◽  
Total Antioxidant ◽  
Mutual Relations ◽  
Protein Sulfhydryl Groups ◽  
Stress Parameters

Background. Abnormalities in the oxidative and antioxidant states causing oxidative stress were both found in heart failure (HF) of various aetiologies and atherosclerosis. Aim of Study. The goals of the study were as follows: comparison of oxidative stress parameters (OSP) in ischaemic cardiomyopathy (ICM) (n=479) and nonischaemic cardiomyopathy (nICM) (n=295) patients; assessment of the relationships of OSP with functional capacity (NYHA class), maximal oxygen consumption (max.O2), left ventricle ejection fraction (LVEF), and NT-proBNP concentration; and determination of the mutual relations of OSP in subgroups of patients with ICM and n-ICM. Methods. Serum concentrations of total antioxidant capacity (TAC), total oxidant status (TOS), uric acid (UA), bilirubin, albumin, protein sulfhydryl groups (PSH), and malondialdehyde (MDA) were measured. The oxidative stress index (OSI) and MDA/PSH ratio were calculated. Results. Higher concentrations of TAC (1.14 vs 1.11 mmol/l; p<0.001) and MDA (1.80 vs 1.70 μmol/l; p<0.05) and higher MDA/PSH ratios (0.435 vs 0.358; p<0,001) were observed in ICM than in nICM patients. Simultaneously, lower values of the OSI index (4.27 vs 4.6; p<0,05), PSH (4.10 vs 4.75 μmol/g of protein; p<0,001), and bilirubin (12.70 vs 15.40 μmol/l; p<0,001) concentrations were indicated in ICM patients. There were no differences in TOS, UA, and albumin between the examined groups. The NYHA class and VO2max correlate with MDA, bilirubin, and albumin in both groups, while with UA only in the ICM group. Correlations between the NYHA class, VO2max, and PSH were indicated in nICM. The association of LVEF with UA, bilirubin, and albumin has been demonstrated in the ICM group. The study showed negative correlations between TAC, MDA, and PSH and positive between TAC and MDA in both groups. In ICM patients, MDA positively correlated with UA. A negative correlation between PSH and concentrations of UA and bilirubin was expressed only in the nICM group. Conclusion. The obtained results confirm the relationship between the severity of HF and oxidative stress. The mechanisms of oxidative stress and antioxidant defence are partially different in the ICM and the nICM patients.

Evaluation of aspect of some oxidative stress parameters using vitamin E, proanthocyanidin and N-acetylcysteine against exposure to cyfluthrin in mice

2007 ◽  
Vol 88 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Gokhan Eraslan ◽  
Sahan Saygi ◽  
Dinc Essiz ◽  
Abdurrahman Aksoy ◽  
Husamettin Gul ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals Effects of acute alcohol consumption and vitamin E co-treatment on oxidative stress parameters in rats tongue

2009 ◽  
Vol 47 (6) ◽  
pp. 1058-1063 ◽  
Author(s):  
V.C. Carrard ◽  
A.S. Pires ◽  
M. Mendez ◽  
F. Mattos ◽  
J.C.F. Moreira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Alcohol Consumption ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on oxidative stress parameters: A systematic review and meta-analysis

2020 ◽  
Vol 39 (4) ◽  
pp. 1019-1025 ◽  
Author(s):  
Mahdi Sepidarkish ◽  
Maryam Akbari-Fakhrabadi ◽  
Elnaz Daneshzad ◽  
Mahsa Yavari ◽  
Mahroo Rezaeinejad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Fatty Acid ◽  
Vitamin E ◽  
Meta Analysis ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals Sublethal Toxicity of Thiamethoxam Insecticide in Albino Mice: Biochemical, Oxidative Damage and Histopathological Evaluations

2020 ◽  
Vol 4 (1) ◽  
pp. 017-028
Author(s):  
Gamal Elsayed Abouelghar ◽  
Rania Ibrahim Yassien ◽  
Zeinab Abd-Elghany El-Bermawy ◽  
Hager Ali Ammar ◽  
Yassmin Abd-Elaziz Shalaby
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Oral Toxicity ◽  
Oxidative Stress Parameters ◽  
Ameliorative Effect ◽  
Sublethal Doses ◽  
Albino Mice ◽  
Stress Parameters

The Neonicotinoid insecticides are presently used in great amounts, but this can be a problem when the possible risks of occupational and environmental contamination are considered. The objective of this study was to investigate the potential adverse effects of sublethal doses of Thiamethoxam insecticide on serum biochemical, oxidative stress and histological alterations in male albino mice via 28-day repeated-dose oral toxicity study. The possible ameliorative effect of selenium plus vitamin E against the harmful effects of Thiamethoxam was also investigated. Mice in Thiamethoxam-treated groups received three sublethal doses (6, 12, and 30 mg/kg b.w./day). Animals in another group were orally co-administered selenium + vitamin E with the higher dose of insecticide. The results showed that Thiamethoxam significantly (p < 0.05) increased cholesterol levels and liver enzyme activities, in dose-dependent manner, compared to those of the control group. Levels of creatinine were not significantly changed, whereas uric acid increased at high doses. The oxidative stress parameters were significantly increased in association with decrease in total antioxidants level. The histological analysis revealed that the higher dose induced various alterations in tissues of vital organs, i.e. liver, kidney, lung and testes. Interestingly, the ameliorative effect of selenium + vitamin E in restoring the oxidative stress parameters was reflected by reducing severity of histopathological lesions. In conclusion, it appears that the sublethal dose < 6.0 mg/kg b.w./day, in repeated dose 28-day oral toxicity study, in male albino mice may be considered as No-Observed-Adverse-Effect-Level (NOAEL) of Thiamethoxam. Additionally, the antioxidant selenium, in mixture with vitamin E, showed an ameliorative effect against Thiamethoxam-induced toxicity.

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