Comparison of Oxidative Stress Parameters in Heart Failure Patients Depending on Ischaemic or Nonischaemic Aetiology

Background. Abnormalities in the oxidative and antioxidant states causing oxidative stress were both found in heart failure (HF) of various aetiologies and atherosclerosis. Aim of Study. The goals of the study were as follows: comparison of oxidative stress parameters (OSP) in ischaemic cardiomyopathy (ICM) (n=479) and nonischaemic cardiomyopathy (nICM) (n=295) patients; assessment of the relationships of OSP with functional capacity (NYHA class), maximal oxygen consumption (max.O2), left ventricle ejection fraction (LVEF), and NT-proBNP concentration; and determination of the mutual relations of OSP in subgroups of patients with ICM and n-ICM. Methods. Serum concentrations of total antioxidant capacity (TAC), total oxidant status (TOS), uric acid (UA), bilirubin, albumin, protein sulfhydryl groups (PSH), and malondialdehyde (MDA) were measured. The oxidative stress index (OSI) and MDA/PSH ratio were calculated. Results. Higher concentrations of TAC (1.14 vs 1.11 mmol/l; p<0.001) and MDA (1.80 vs 1.70 μmol/l; p<0.05) and higher MDA/PSH ratios (0.435 vs 0.358; p<0,001) were observed in ICM than in nICM patients. Simultaneously, lower values of the OSI index (4.27 vs 4.6; p<0,05), PSH (4.10 vs 4.75 μmol/g of protein; p<0,001), and bilirubin (12.70 vs 15.40 μmol/l; p<0,001) concentrations were indicated in ICM patients. There were no differences in TOS, UA, and albumin between the examined groups. The NYHA class and VO2max correlate with MDA, bilirubin, and albumin in both groups, while with UA only in the ICM group. Correlations between the NYHA class, VO2max, and PSH were indicated in nICM. The association of LVEF with UA, bilirubin, and albumin has been demonstrated in the ICM group. The study showed negative correlations between TAC, MDA, and PSH and positive between TAC and MDA in both groups. In ICM patients, MDA positively correlated with UA. A negative correlation between PSH and concentrations of UA and bilirubin was expressed only in the nICM group. Conclusion. The obtained results confirm the relationship between the severity of HF and oxidative stress. The mechanisms of oxidative stress and antioxidant defence are partially different in the ICM and the nICM patients.

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Clinical Significance of ROMs, OXY, SHp and HMGB-1 in Canine Leishmaniosis

Animals ◽

10.3390/ani11030754 ◽

2021 ◽

Vol 11 (3) ◽

pp. 754

Author(s):

Michela Pugliese ◽

Alessandra Sfacteria ◽

Gaetano Oliva ◽

Annastella Falcone ◽

Manuela Gizzarelli ◽

...

Keyword(s):

Oxidative Stress ◽

Lymph Nodes ◽

Clinical Signs ◽

Biological Tissues ◽

Stress Index ◽

Control Group ◽

Canine Leishmaniosis ◽

Oxidative Stress Parameters ◽

Stress Parameters

This study aimed to investigate the role of oxidative stress parameters (ROMs, OXY, SHp), the Oxidative Stress index (OSi), and High Mobility Group Box-1 protein (HMGB-1) in canine leishmaniosis (CanL). For this study, thirty dogs, naturally infected with Leishmania spp. (Leishmania Group, LEISH) and ten healthy adult dogs (control group, CTR) were included. The diagnosis of CanL was performed by a cytological examination of lymph nodes, real time polymerase chain reaction on biological tissues (lymph nodes and whole blood), and an immunofluorescence antibody test (IFAT) for the detection of anti-Leishmania antibodies associated with clinical signs such as dermatitis, lymphadenopathy, onychogryphosis, weight loss, cachexia, lameness, conjunctivitis, epistaxis, and hepatosplenomegaly. The HMGB-1 and oxidative stress parameters of the LEISH Group were compared with the values recorded in the CTR group (Mann Whitney Test, p < 0.05). Spearman rank correlation was applied to evaluate the correlation between the HMGB-1, oxidative stress biomarkers, hematological and biochemical parameters in the LEISH Group. Results showed statistically significant higher values of SHp in the LEISH Group. Specific correlation between the ROMs and the number of red blood cells, and between HGMB-1 and SHp were recorded. These preliminary data may suggest the potential role of oxidative stress in the pathogenesis of CanL. Further studies are undoubtedly required to evaluate the direct correlation between inflammation parameters with the different stages of CanL. Similarly, further research should investigate the role of ROMs in the onset of anemia.

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Relationship Between Oxidative Stress Parameters and Cystatin C Levels in Patients With Severe Preeclampsia

Medicina ◽

10.3390/medicina49030019 ◽

2013 ◽

Vol 49 (3) ◽

pp. 19 ◽

Cited By ~ 3

Author(s):

Saban Yalcin ◽

Turgay Ulas ◽

Mehmet Eren ◽

Harun Aydogan ◽

Aysun Camuzcuoglu ◽

...

Keyword(s):

Oxidative Stress ◽

Cystatin C ◽

Total Antioxidant Status ◽

Stress Index ◽

Oxidative Stress Index ◽

Oxidative Stress Parameters ◽

Total Antioxidant ◽

Group 2 ◽

Oxidant Status ◽

Group 1

Background and Objective. Oxidative stress is believed to play a role in the development of preeclampsia (PE). It is known that an increased cystatin C level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and cystatin C levels in patients with severe PE. Material and Methods. Forty-four patients with severe PE and 40 healthy pregnant women were recruited for the study. All study subjects were divided into 2 groups: group 1 (n=44) consisted of patients with severe PE, and group 2 (n=40) included healthy pregnant subjects. Blood samples were obtained from all subjects in order to measure the cystatin C level, total antioxidant status, and total oxidant status. The oxidative stress index was calculated. Results. The group 1 had significantly higher cystatin C, total oxidant status, oxidative stress index levels and lower total antioxidant status level as compared with the group 2 (P=0.001, P<0.001, P<0.001, P=0.036, respectively). The serum cystatin C level was significantly correlated with the oxidative stress index (r=0.609, P<0.001). Conclusions. The present study demonstrated that both oxidative stress and cystatin C levels were increased in patients with PE, and the increased cystatin C levels seem to be a consequence of oxidative stress. Correspondence to

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Intermittent Fasting Decreases Oxidative Stress Parameters and Increases Total Antioxidant Capacity

Biointerface Research in Applied Chemistry ◽

10.33263/briac125.67636775 ◽

2021 ◽

Vol 12 (5) ◽

pp. 6763-6775

Keyword(s):

Oxidative Stress ◽

Antioxidant Capacity ◽

Total Antioxidant Capacity ◽

Intermittent Fasting ◽

Sprague Dawley ◽

Oxidative Stress Parameters ◽

Sprague Dawley Rats ◽

Significant Difference ◽

Total Antioxidant ◽

Stress Parameters

Modern lifestyle with an unhealthy routine, including consumption of excessive food and less physical activity, is full of many complications like chronic and degenerative diseases. For driving a healthy life, following a prophylactic style is necessary. The simplest and available way is intermittent fasting (IF). IF can help weight management. IF may lower oxidative stress. Oxidative stress can be determined from the malondialdehyde (MDA) levels and tri acyl glycerol (TAG) in the blood. Also, it increases Total antioxidant capacity (TAC). This study aimed to determine the effect of both protocols, Alternate day fasting (ADF) and time-restricted feeding (TRF), on plasma MDA level, TAG concentration, and TAC level of Sprague Dawley rats. They were randomly assigned to 3 groups, i.e., control group (C), fasting group (ADF), fasting group (TRF). Fasting given in this research was ADF, comprising one day of fasting for 24 hours, alternating with one day of normal feed ad libitum in the span of 12 weeks, including fasting 12 hours for two days a week plus three days in the middle of the month. After 3-months, blood was taken for examination of MDA levels, TAG, and TAC levels. A significant difference among the three groups in MDA levels, TAG and TAC. (p<0.05 for all parameters). Groups conducted on intermittent fasting had lower levels of MDA, TAG concentration, and a high level of TAC. ADF was lower in MDA level and TAG concentration than TRF. ADF was higher in TAC level than TRF. Intermittent fasting (ADF and TRF) decreases the oxidative stress parameters and increases Total antioxidant capacity in Sprague Dawley rats. ADF is more effective than TRF.

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The efficacy of alpha-lipoic acid and/or gabapentin on the oxidant-antioxidant system in patients with diabetic polyneuropathy

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20203424 ◽

2020 ◽

Vol 8 (8) ◽

pp. 2777

Author(s):

Hatice Ferhan Komurcu ◽

Pervin Baran ◽

Ozcan Erel ◽

Omer Anlar

Keyword(s):

Oxidative Stress ◽

Lipoic Acid ◽

Diabetic Polyneuropathy ◽

Serum Levels ◽

Paraoxonase 1 ◽

Stress Index ◽

Alpha Lipoic Acid ◽

Oxidative Stress Parameters ◽

Significant Difference ◽

Stress Parameters

Background: Diabetic peripheral sensorimotor polyneuropathy is the most common complication seen in patients with diabetes mellitus (DM). Oxidant system plays a crucial role in its physiopathology. We investigated the changes in the serum levels of total antioxidant status (TAS), total oxidant status (TOS), paraoxonase-1 (PON1) and oxidative stress index (OSI) to evaluate the antioxidant efficacy of alpha lipoic acid (ALA) and/or gabapentin in patients with diabetic polyneuropathy (DPN).Methods: Sixty-three type 2 DM patients with diabetic polyneuropathy (DPN) were enrolled in the study. Patients with DPN were divided into four groups in terms of their treatment: Group 1 consisted of treatment-naive patients; patients treated with ALA, gabapentin or combination of ALA and gabapentin comprised groups 2, 3, and 4, respectively. The patients received the medications for at least six weeks. Serum levels of TAS, TOS, PON1 and OSI were analyzed.Results: No significant difference was observed between the groups according to the oxidative stress parameters studied.Conclusions: The use of ALA and/or gabapentin in patients with DPN did not significantly affect the oxidative stress parameters, including TAS, TOS, PON1, and OSI.

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The Impact of Endometritis on Specific Oxidative Stress Parameters in Cows

Journal of the Hellenic Veterinary Medical Society ◽

10.12681/jhvms.15610 ◽

2018 ◽

Vol 68 (2) ◽

pp. 231

Author(s):

S. KAYA ◽

M. ÖĞÜN ◽

H. ÖZEN ◽

M. KURU ◽

L. ŞAHIN ◽

...

Keyword(s):

Oxidative Stress ◽

Control Group ◽

Group Iii ◽

Uterine Infection ◽

Oxidative Stress Parameters ◽

Group I ◽

Early Postpartum ◽

Total Antioxidant ◽

The Impact ◽

Stress Parameters

This study was aimed to investigate the presence of uterine infection and the relationship between the severity of uterine infection and some oxidative stress parameters in cows in early postpartum period. Sixty six cows that were in the period between the 30th and 32rd days of postpartum were included in the study. Endometrial inflammation was scored according to the condition of the uterus at rectal and ultrasonographic examinations and the character and amount of uterine discharge from endometritis I through III, the latest being the most severe. Endometrial samples were taken from the clinically healthy animals by cytobrush method, and then stained with Giemsa for presence of polymorphonuclear leukocytes (PMN). Cows with a PMN percentage less than 18% were considered to be healthy (control, n=20). All cows were sampled for blood. Nitric oxide (NO) levels in Group I (Endometritis I; n=20), Group II (Endometritis II; n=16), Group III (Endometritis III; n=10) and the control group were determined to be 23.0±0.63 nmol/mL, 32.23±0.97 nmol/mL, 36.56±0.48 nmol/mL, and 11.10±0.29 nmol/mL, respectively. The differences among the groups were found to be statistically significant. Malondialdehyde (MDA) level was highest in Group III (6.38±0.13 μmol/L), and its level significantly decreased with the reduced severity of endometritis. The comparison of the groups for total antioxidant capacity (TAC) and total oxidant capacity (TOC) demonstrated that endometritis caused a decrease in TAC levels (P<0.05), but did not affect TOC levels. Endometritis increased serum NO and MDA levels, and decreased TAC levels, but had no effect on TOC levels. In conclusion, NO and MDA, as well as TAC can be used as a biochemical marker for estimation of the severity of endometritis in cows.

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Evaluation of the effects of esmolol and remifentanil for controlled hypotension application on hemodynamics and oxidative stress parameters

Anaesthesia, Pain & Intensive Care ◽

10.35975/apic.v24i1.1217 ◽

2020 ◽

Vol 24 (1) ◽

pp. 20-27

Author(s):

Hülya Kaşıkara ◽

Rüveyda İrem Demircioğlu ◽

Muhammet Gözdemir ◽

Safinaz Karabayırlı ◽

Hüsamettin Erdamar ◽

...

Keyword(s):

Oxidative Stress ◽

Surgical Intervention ◽

Stress Index ◽

Control Group ◽

Loading Dose ◽

Controlled Hypotension ◽

Oxidative Stress Parameters ◽

Total Antioxidant ◽

And Oxidative Stress ◽

Remifentanil Group

Introduction: Anesthesia induced during a surgical intervention, the duration of the surgical intervention, and the surgical intervention itself tend to affect immune functions, resulting in the formation of free radicals in the metabolism. Free radicals can cause postoperative disorders by targeting biomolecules in the cell, such as lipids, carbohydrates, proteins, and DNA. In the present study, we used remifentanil or esmolol to induce a controlled hypotension in patients who were undergoing septorhinoplasty under general anesthesia, and we planned to compare the effect of these agents on hemodynamics and oxidative stress relative to the control group. Methodology: A total of 75 patients aged between 18 and 65 y, ASA I-II, planned to undergo elective septorhinoplasty, were included in this study. Patients were randomly divided into the following three groups: Group R (remifentanil group, n = 25); Group E (esmolol group, n = 25); and Group C (control, n = 25). Anesthesia was induced with 2 mg/kg propofol 2 mg/kg, fentanyl 1 µg/kg, and rocuronium 0.6 mg/kg. Immediately after induction, Group R was started loading dose of remifentanil 1 µg/kg/min, followed by infusion at 0.25–0.50 µg/kg/min. In Group E, a loading dose of esmolol 500 µg/kg was given for 1 min, then infusion was continued @ 150–300 µg/kg. A targeted mean arterial pressure (MAP) of 55–65 mmHg was aimed. In Group C, remifentanil was infused at 0.1–0.2 µg/kg/min until a MAP of 70–100 mmHg was reached. During operation; systolic (SAP), diastolic (DAP) and mean arterial pressure (MAP), heart rate (HR), peripheral oxygen saturation (SpO2), EtCO2 (end tidal CO2) were recorded before induction, after induction, after intubation, at 5-min intervals during the first 30 min, and then at 10-min intervals during the intervention. The amounts of remifentanil and esmolol consumed by the patients during the operation were calculated and recorded. Blood samples that were taken twice, preoperatively and postoperatively, for malondialdehyde (MDA), superoxide dismutase (SOD), total oxidant level (TOL), total antioxidant level (TAL), and oxidative stress index (OSI). Results: MAP showed a greater decrease starting from the 25th min and 40th min after intubation in remifentanil group and esmolol group respectively, compared to the control group. In the remifentanil and control groups, there was a statistically significant decrease in the postoperative OSI levels compared to the preoperative levels. One the other hand, in the esmolol group, there was no statistically significant difference between the preoperative and postoperative median OSI levels. There was a significant increase in the postoperative TAL of the remifentanil group compared to the preoperative level. Conclusion: It was observed that during a hypotensive anesthesia induced by remifentanil or esmolol, remifentanil ensured more stable operating conditions in terms of hemodynamics compared with esmolol, and that remifentanil was also superior to esmolol in reducing oxidative stress. Abbreviations: TOL: Total oxidant level; TAL: Total antioxidant level; SOD: Superoxide dismutase; MDA: Malondialdehyde; OSI: Oxidative stress index Citation: Kaşıkara H, Demircioğlu RI, Gözdemir M, Karabayırlı S, Erdamar H, Namuslu M, Yazıcı U, Yüksel A. Evaluation of the effects of esmolol and remifentanil for controlled hypotension application on hemodynamics and oxidative stress parameters. Anaesth pain & intensiv care 2019;23(2):__ DOI: https://doi.org/10.35975/apic.v24i1. Received : 18 January 2019 Reviewed : 3 February 2019 Revised : 1 May 2019 Accepted : 9 May 2019

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An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease

Medicina ◽

10.3390/medicina55060275 ◽

2019 ◽

Vol 55 (6) ◽

pp. 275 ◽

Cited By ~ 1

Author(s):

Veysel Agan ◽

Hakim Celik ◽

Mehmet Ali Eren ◽

Fatma Zehra Agan ◽

Ozcan Erel ◽

...

Keyword(s):

Oxidative Stress ◽

Protein Carbonyl ◽

Stress Index ◽

Control Group ◽

Graves Disease ◽

Disease Group ◽

Free Triiodothyronine ◽

Oxidative Stress Parameters ◽

Total Thiol ◽

Stress Parameters

Background and objectives: The aim of this study was to research oxidative stress and thiol/disulphide homeostasis in Graves’ patients. Materials and Methods: The study included 33 Graves’ patients (research group) and 35 healthy subjects (control group). Serum oxidative stress and thiol/disulphide homeostasis (a new and automated spectrophotometric method developed by Erel and Neselioglu) parameters were studied and compared between the groups. Results: The native and total thiol levels and the native thiol/total thiol ratio were lower in patients with Graves’ disease compared to the control group (p < 0.001, p < 0.001, and p = 0.006, respectively). TOS (total antioxidant status), PC (protein carbonyl), OSI (Oxidative stress index), and disulphide/native thiol and disulphide/total thiol ratios were determined to be higher in the Graves’ disease group than in the control group (p < 0.001, p = 0.001, p = 0.001, p = 0.004, and p = 0.006, respectively). In the Graves’ disease group, the free triiodothyronine (FT3) and free thyroxine (FT4) levels were significantly positively correlated with impaired thiol/disulphide homeostasis and oxidative stress parameters (p < 0.05). Conclusion: The results of the current study demonstrated that oxidative stress and thiol/disulphide homeostasis increased towards disulphide formation due to thiol oxidation in Graves’ disease. In addition, a positive correlation of FT3 and FT4 was observed with oxidative stress parameters and impaired thiol/disulphide homeostasis.

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Effect of Topical Prostaglandin F2α Analogs on Selected Oxidative Stress Parameters in the Tear Film

Medicina ◽

10.3390/medicina55070366 ◽

2019 ◽

Vol 55 (7) ◽

pp. 366

Author(s):

Lech Sedlak ◽

Maria Zych ◽

Weronika Wojnar ◽

Dorota Wyględowska-Promieńska

Keyword(s):

Oxidative Stress ◽

Open Angle Glaucoma ◽

Tear Film ◽

Prostaglandin F2α ◽

Study Groups ◽

Stress Index ◽

Control Group ◽

Oxidative Stress Parameters ◽

Preservative Free ◽

Stress Parameters

Background and Objectives: Topically administered antiglaucoma medications, especially those containing benzalkonium chloride (BAC), may cause local adverse effects and compromise ocular surface. The aim of the study was to assess the effect of topical prostaglandin F2α analogs (PGAs): preservative-free latanoprost, BAC-preserved latanoprost, preservative-free tafluprost, and BAC-preserved bimatoprost, on selected oxidative stress parameters in the tear film. Materials and Methods: The patients were divided into five groups: group C (n = 25) control group—subjects who did not use topical antiglaucoma medications, group L (n = 22)—patients using topical preservative-free latanoprost, group L+BAC (n = 25)—patients using topical BAC-preserved latanoprost, group T (n = 19)—patients using topical preservative-free tafluprost, and group B+BAC (n = 17)—patients using topical BAC-preserved bimatoprost. The oxidative stress markers in the tear film samples were evaluated: total protein (TP) concentration, advanced oxidation protein products (AOPP) content, total sulfhydryl (-SH) groups content, the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as Total Oxidant Status (TOS), Total Antioxidant Response (TAR), and Oxidative Stress Index (OSI). Results: The TP concentrations in the groups L, L+BAC, and B+BAC were statistically significantly higher in comparison with group C. The SOD and CAT activities in the groups L+BAC and B+BAC were statistically significantly higher when compared to group C. As compared to group C, AOPP and TOS were statistically significantly higher in all the study groups. OSI was found to be statistically significantly higher in the groups L+BAC, T, and B+BAC in comparison with group C. Conclusion: Use of topical PGAs by the patients with ocular hypertension or primary open-angle glaucoma is associated with increased oxidative stress in the tear film which is additionally exacerbated by the presence of BAC in the formulation.

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Correlation between oxidative stress parameters and left ventricular geometry in patients with chronic heart failure

Acta Facultatis Medicae Naissensis ◽

10.5937/afmnai2003241s ◽

2020 ◽

Vol 37 (3) ◽

pp. 241-251

Author(s):

Sandra Šarić ◽

Tatjana Cvetković ◽

Dejan Petrović ◽

Valentina Mitić ◽

Sanja Stojanović ◽

...

Keyword(s):

Oxidative Stress ◽

Heart Failure ◽

Chronic Heart Failure ◽

Catalase Activity ◽

Left Ventricular ◽

Left Ventricular Geometry ◽

Sh Groups ◽

Oxidative Stress Parameters ◽

Ventricular Geometry ◽

Stress Parameters

Oxidative stress, as one of the pathophysiological mechanisms involved in the reduction of myocardial contractility, stimulates the proliferation of cardiac fibroblasts and the activation of matrix metalloproteinases, which leads to extracellular matrix remodeling. Left ventricular hypertrophy (LVH) is a well-known independent risk factor for cardiovascular events. The aim of this research was to determine the connection between the parameters of oxidative stress and left ventricular geometry indicators in patients with chronic heart failure. The study included 81 subjects diagnosed with heart failure and 68 subjects in the control group. Parameters of myocardial morphology and left ventricular function were measured by echocardiography. Thiobarbituric acid reactive substances (TBARS) content, advanced oxidation protein products (AOPP), total serum SH groups and catalase activity were performed in both groups. The results showed that there were significantly higher concentrations of TBARS, AOPP, and SH groups in patients compared to controls (p < 0.01) and higher concentration of TBARS in patients with concentric hypertrophy compared to patients with normal geometry (p < 0.05). Correlation analysis showed a strong positive correlation between geometry parameters and myocardial function and TBARS and negative correlation between the right ventricule diameter and catalase activity. The results of this study show that oxidative stress parameters are significantly elevated in patients with heart failure, and that concentrations of TBARS and AOPP - the markers of lipid and protein oxidation, strongly correlate with left ventricular geometry parameters.

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Markers of oxidative stress in dogs with heart failure

Journal of Veterinary Diagnostic Investigation ◽

10.1177/1040638717711995 ◽

2017 ◽

Vol 29 (5) ◽

pp. 636-644 ◽

Cited By ~ 7

Author(s):

Barbara Verk ◽

Alenka Nemec Svete ◽

Janez Salobir ◽

Vida Rezar ◽

Aleksandra Domanjko Petrič

Keyword(s):

Oxidative Stress ◽

Heart Failure ◽

Vitamin E ◽

Small Animal ◽

Cardiac Patients ◽

Plasma Vitamin ◽

Oxidative Stress Parameters ◽

Health Council ◽

The Individual ◽

Stress Parameters

We tested the hypothesis that indirect measures of oxidative stress (vitamin E, glutathione peroxidase, and malondialdehyde) differ in dogs in heart failure resulting from either myxomatous mitral valve disease or dilated cardiomyopathy. Dogs were classified according to the International Small Animal Cardiac Health Council (ISACHC) classification. Additionally, the effect of cardiac therapy on oxidative stress parameters and N-terminal pro–B-type natriuretic peptide (NT-proBNP) in advanced stages of congestive heart failure was investigated. There were no significant differences in oxidative stress parameters between healthy dogs and the individual groups of cardiac patients. Significantly lower malondialdehyde (MDA) was observed in the ISACHC II group in comparison to ISACHC groups III and I. A significant positive correlation in treated patients was observed between NT-proBNP and MDA, NT-proBNP and vitamin E, as well as between MDA and vitamin E (and lipid-standardized vitamin E). No significant differences in any of the measured parameters were found between treated and non-treated cardiac patients. Our results suggest an association between MDA (the extent of lipid peroxidation) and NT-proBNP, vitamin E and NT-proBNP, as well as between MDA and vitamin E in treated canine patients. Plasma vitamin E concentration was maintained in all stages of cardiovascular disease in these canine patients.

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