Three-Dimensional Assessment of Craniofacial Features in Patients With Down Syndrome During the Mixed Dentition Period: A Case-Control Study

2021 ◽  
pp. 105566562199818
Author(s):  
Hideomi Takizawa ◽  
Masahiro Takahashi ◽  
Koutaro Maki
Keyword(s):  
Down Syndrome ◽  
Three Dimensional ◽  
Cranial Base ◽  
Craniofacial Morphology ◽  
Mixed Dentition ◽  
Linear Measurements ◽  
3 Dimensional ◽  
Anterior Nasal Spine ◽  
Craniofacial Features ◽  
And Control

Objectives: Down syndrome (DS) is a common congenital chromosomal disorder related to trisomy 21. Lateral cephalometric radiography studies have shown that patients with DS have characteristic craniofacial morphology; however, no 3-dimensional analysis studies have been performed to investigate the craniofacial features, including volumetric aspects, of patients with DS. The present study was performed to evaluate the craniofacial features, including volumetric aspects, of patients with DS and to compare these findings with control participants using cone beam computed tomography (CBCT). Materials and Methods: The study sample consisted of 12 patients with DS and 12 control participants. All participants were examined by means of CBCT; the resulting images were used for evaluation of maxillary and mandibular volume, cranial base, and craniofacial measurements. Differences between patients with DS and control participants were statistically analyzed using Student t test. Results: Compared to control participants, patients with DS exhibited statistically significant reductions in maxillary and mandibular volumes. Both sagittal and axial cranial base linear measurements were shorter in patients with DS than in control participants. In contrast, the cranial base angle was enhanced in patients with DS, compared with control participants. Moreover, condylion (Co)–gnathion, anterior nasal spine–menton, and Co-subspinale (point A) measurements were shorter in patients with DS than in control participants; the sella–nasion–mandibular plane angle was significantly reduced in patients with DS, compared with control participants. Conclusion: Our results suggest that patients with DS have distinct skeletal volume and craniofacial morphology features, relative to individuals without DS.

scholarly journals Geometric morphometric investigation of craniofacial morphological change in domesticated silver foxes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Timothy M. Kistner ◽  
Katherine D. Zink ◽  
Steven Worthington ◽  
Daniel E. Lieberman
Keyword(s):  
Three Dimensional ◽  
Cranial Base ◽  
Craniofacial Morphology ◽  
Wild Populations ◽  
Linear Measurements ◽  
Skeletal Morphology ◽  
Geometric Morphometric ◽  
Domestication Syndrome ◽  
Morphometric Investigation ◽  
Unselected Population

AbstractTo test the effects of domestication on craniofacial skeletal morphology, we used three-dimensional geometric morphometrics (GM) along with linear and endocranial measurements to compare selected (domesticated) and unselected foxes from the Russian Farm-Fox Experiment to wild foxes from the progenitor population from which the farmed foxes are derived. Contrary to previous findings, we find that domesticated and unselected foxes show minimal differences in craniofacial shape and size compared to the more substantial differences between the wild foxes and both populations of farmed foxes. GM analyses and linear measurements demonstrate that wild foxes differ from farmed foxes largely in terms of less cranial base flexion, relatively expanded cranial vaults, and increased endocranial volumes. These results challenge the assumption that the unselected population of foxes kept as part of the Russian Farm-Fox experiment are an appropriate proxy for ‘wild’ foxes in terms of craniofacial morphology and highlight the need to include wild populations in further studies of domestication syndrome to disentangle the phenotypic effects of multiple selection pressures. These findings also suggest that marked increases in docility cannot be reliably diagnosed from shape differences in craniofacial skeletal morphology.

scholarly journals Three-dimensional Evaluation of Mandibular Volume in Patients with Cleft Lip and Palate During the Deciduous Dentition Period

2019 ◽  
Vol 90 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Abhishekhi Shrestha ◽  
Masahiro Takahashi ◽  
Tetsutaro Yamaguchi ◽  
Mohamed Adel ◽  
Mayu Furuhata ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Three Dimensional ◽  
Pairwise Comparison ◽  
Craniofacial Morphology ◽  
Analysis Of Covariance ◽  
Control Group ◽  
Deciduous Dentition ◽  
Post Hoc ◽  
And Control

ABSTRACT Objectives To examine the relationship between mandibular volume and craniofacial morphology in patients with cleft lip and palate using cone beam computed tomography (CBCT) and to compare these findings with control (noncleft) patients undergoing CBCT for other purposes during the deciduous dentition period. Materials and Methods Eighty-four patients were categorized into the unilateral cleft lip and alveolus (UCLA) group (n = 25; mean age, 4.60 ± 0.40 years), unilateral cleft lip and palate (UCLP) group (n = 23; mean age, 4.52 ± 0.39 years), bilateral cleft lip and palate (BCLP) group (n = 22; mean age, 4.54 ± 0.37 years), and control group without cleft (n = 14; mean age, 5.19 ± 0.52 years). Mandibular volume and craniofacial cephalometric measurements were obtained using CBCT. All measurements were assessed by analysis of covariance (ANCOVA) using Bonferroni post hoc pairwise comparison tests. Results ANCOVA revealed no statistically significant differences in mandibular volume among the groups. SNA° and ANB° were significantly larger in the UCLA and BCLP groups than in the control group. SN-MP° was smallest in the UCLA group. Co-A in the UCLP group was shorter than in the UCLA and BCLP groups. Go-Gn was shortest in the UCLP and BCLP groups compared with the control group. Conclusions Three-dimensional evaluation of craniofacial morphology using CBCT can provide valuable information on malocclusion and other dentoskeletal problems among patients with CLP.

THREE-DIMENSIONAL AND 2-DIMENSIONAL ENDOSCOPIC EXPOSURE OF MIDLINE CRANIAL BASE TARGETS USING EXPANDED ENDONASAL AND TRANSCRANIAL APPROACHES

Neurosurgery ◽  
2009 ◽  
Vol 65 (6) ◽  
pp. 1116-1130 ◽  
Author(s):  
Jonathan Roth ◽  
Ameet Singh ◽  
Gurston Nyquist ◽  
Justin F. Fraser ◽  
Antonio Bernardo ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Improve Patient Safety ◽  
Cranial Nerves ◽  
Three Dimensional ◽  
Abducens Nerve ◽  
Cranial Base ◽  
Endoscopic Endonasal ◽  
3 Dimensional ◽  
Fresh Cadaver ◽  
Wide Exposure

Abstract OBJECTIVE Endoscopic endonasal approaches provide an access method to the midline cranial base. To integrate these approaches into neurosurgical practice, the extent of their anatomic exposure must be compared with that provided by more traditional transcranial approaches. METHODS Ten fresh cadaver heads were studied. Both endonasal and transcranial approaches to the midline cranial base were performed. The midline cranial base was divided into several areas, and the relative exposure provided by each approach was described and presented in both 2-dimensional and 3-dimensional images. Limitations and advantages of each approach are discussed. RESULTS The endonasal approaches achieved a direct and wide exposure of the midline extracranial and intracranial cranial base anatomy. The main lateral limitations of the endonasal approaches were the optic nerves, lateral cavernous sinus, vidian nerve, internal carotid artery, abducens nerve in Dorello's canal, jugular tubercle, and hypoglossal canals. Limitations of the transcranial approaches were the neurovascular structures which lie in the operative corridor and create narrow working spaces. CONCLUSION The endonasal approaches achieve a direct and wide exposure of the midline cranial base bilaterally. Lateral exposure, beyond the cranial nerves and carotid artery, are challenging. Transcranial approaches are limited by the narrow corridors provided by the cranial nerves, and they do not visualize the contralateral paramedian cranial base very well. Three-dimensional endoscopes augment the spatial orientation and may improve patient safety and the learning curve for endoscopic approaches to the midline cranial base.

scholarly journals Craniofacial morphology in down syndrome: a systematic review and meta-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ascensión Vicente ◽  
Luis-Alberto Bravo-González ◽  
Ana López-Romero ◽  
Clara Serna Muñoz ◽  
Julio Sánchez-Meca
Keyword(s):  
Down Syndrome ◽  
Meta Analysis ◽  
Cranial Base ◽  
Craniofacial Morphology ◽  
Effective Length ◽  
Publication Date ◽  
Base Length ◽  
Facial Height ◽  
Anterior Cranial Base ◽  
Cephalometric Measurements

AbstractThe aim of this study was to evaluate the craniofacial cephalometric characteristics of individuals with Down syndrome (DS), comparing them with healthy subjects. An electronic search was made in Pubmed, Embase, Lilacs, Scopus, Medline and Web of Science without imposing limitations on publication date or language. Studies were selecting following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. The PECO acronym was applied as follows: P (population), individuals with DS; E, (exposition) diagnosis of DS; C (comparison), individuals without DS; O (outcomes) craniofacial characteristics based on cephalometric measurements. Independent reviewers performed data extraction and assessed the methodological quality of the articles using the Newcastle–Ottawa Quality-Assessment-scale. Seven case–control studies were included in meta-analysis. Given the variability of the cephalometric measurements used, only those that had been reported in at least three or more works could be included. Anterior cranial base length (SN), posterior cranial base length (SBa), total cranial base length (BaN), effective length of the maxilla (CoA), sagittal relationship between subspinale and supramentale (ANB), anterior facial height (NMe), and posterior facial height (SGo) values were significantly lower in the DS population than among control subjects. No significant differences were found in sagittal position of subspinale relative to cranial base (SNA) and sagittal position of supramentale relative to cranial base (SNB). Summarizing, individuals with DS present a shorter and flatter cranial base than the general population, an upper jaw of reduced sagittal dimension, as well as a tendency toward prognatic profile, with the medium third of the face flattened and a reduced anterior and posterior facial heights.

The Parental Craniofacial Morphological Features in Chinese Patients with Sporadic Nonsyndromic Cleft Lip with or without Palate

2009 ◽  
Vol 46 (5) ◽  
pp. 468-476 ◽  
Author(s):  
Da-wei Lu ◽  
Bing Shi ◽  
Huai-qing Chen ◽  
Yu Li ◽  
Tian Meng ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Cranial Base ◽  
Craniofacial Morphology ◽  
Chinese Patients ◽  
Gonial Angle ◽  
Base Angle ◽  
Craniofacial Features ◽  
Axis Length ◽  
Student’S T

Objective: To evaluate the parental craniofacial morphology in Chinese patients with sporadic nonsyndromic cleft lip with or without palate. Methods: A total of 98 parental pairs of nonsyndromic unilateral incomplete cleft lip children, 207 parental pairs of nonsyndromic complete cleft lip and palate children, and 206 normal persons from Sichuan University were involved in this study. A conventional cephalometric analysis was used to measure angles, linear distances, and their ratios. Two-sample Student's t tests and a multivariate discriminant analysis were applied to the data. Results: Data indicate that the unaffected parents of nonsyndromic cleft lip children had on average significantly more acute cranial base angle (Angle N-S-Ba) and larger nasal width (NC-NC′) (p < .01). The healthy parents of nonsyndromic cleft lip and palate children consistently displayed a more acute cranial base angle (Angle N-S-Ba), shorter palatal length (A- PNS) and maxillary length (PNS-ANS), a more obtuse gonial angle (Angle Me-Go-Ar), and a larger y-axis length (S-Gn) and nasal width (NC-NC′) (p < .01). Conclusions: All these results indicate that the healthy parents of patients with nonsyndromic cleft lip with or without palate show distinct characteristics in craniofacial morphology. These parental craniofacial features are more obvious in patients with cleft lip with palate than those with cleft lip only. In general, the characteristics seem to be more distinct in the fathers than in the mothers of cleft patients.

scholarly journals Evaluation of Growth and Development of Late Mixed Dentition Upper Dental Arch with Normal Occlusion Using 3-Dimensional Digital Models

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Dapeng Yang ◽  
Shuran Liang ◽  
Ke Zhang ◽  
Weimin Gao ◽  
Yuxing Bai
Keyword(s):  
Growth And Development ◽  
Three Dimensional ◽  
Mixed Dentition ◽  
Dental Arch ◽  
3 Dimensional ◽  
Normal Occlusion ◽  
Dimensional Measurements ◽  
Dimensional Growth ◽  
Dental Arch Length ◽  
Beijing China

Objective. The purpose of this study was to observe the three-dimensional growth and development of the maxillary arch in 10-year-olds with normal occlusion during the late mixed dentition stage. Methods. Forty-four 10-year-old students (22 males and 22 females) who had normal occlusion during late mixed dentition were selected from an elementary school in Beijing, China. Once per year for three consecutive years, a dental cast was obtained from each subject, and the cast was scanned with a 3D digital scanner (R700 3D). The three-dimensional measurements of the maxillary dental arch and the inclination of the bilateral maxillary first molars were obtained from the digital model. Results. The upper anterior arch length (UAAL), upper total arch length (UTAL), upper inter primary or permanent canine width (UICW), upper intermolar width (UIMW), and upper dental arch length (UDAL) increased by 0.959 mm, 0.583 mm, 0.955 mm, 1.462 mm, and 2.46 mm, respectively, over the two years (P<0.001). UR6BL and UL6BL decreased by 4.416° and 7.133°, respectively, over the two years (P<0.001). The values of the UICW and UIMW were 1.67 mm and 1.86 mm, respectively, larger in males than in females at 12 years old (P<0.01). The change in the UTAL was 0.431 mm greater in males than in females over the 2 years (P<0.05). Conclusion. The UAAL, UTAL, UICW, UIMW, and UDAL in 10- to 12-year-olds with normal occlusion increased with age. The buccolingual inclination of the bilateral maxillary first molars inclined to the palatal side with age. The UICW and UIMW were larger in males than in females at 12 years old. The male UTAL increased more than the female UTAL over the 2 years.

Effect of Premature Sagittal Suture Closure on Craniofacial Morphology in a Prehistoric Male Hopi

1994 ◽  
Vol 31 (5) ◽  
pp. 385-396 ◽  
Author(s):  
Luci Ann P. Kohn ◽  
Michael W. Vannier ◽  
Jeffrey L. Marsh ◽  
James M. Cheverud
Keyword(s):  
Finite Element ◽  
Three Dimensional ◽  
Cranial Base ◽  
Craniofacial Morphology ◽  
Cranial Vault ◽  
Normal Male ◽  
Scaling Analysis ◽  
Sagittal Suture ◽  
Normal Individuals ◽  
Suture Closure

Scaphocephaly is caused by premature sagittal suture closure. It restricts medial-lateral growth of the cranial vault which appears longer and narrower than normal. We examined how this natural malformation affected morphology of the cranial base and face. A prehistoric adult male Hopi with scaphocephaly was compared to 19 normal male Hopi (Old Walpi Series, Field Museum of Natural History, Chicago, IL). Three-dimensional coordinates of 53 landmarks were recorded on the cranial vault, cranial base, and face. Finite element scaling analysis was used to test for significant differences between the scaphocephalic and normal Individuals in craniofacial morphology. Finite element scaling results indicated that scaphocephaly has a profound effect on cranial vault morphology. However, morphology of the cranial base and face were only slightly affected and, typically, are within the normal range of variation for the sample. An abnormality in the cranial base Is not associated with scaphocephaly in this individual.

Three-Dimensional Reconstruction Using Stereo Pairs from Serial Thick Sections

1977 ◽  
Vol 35 ◽  
pp. 562-563
Author(s):  
Robert Glaeser ◽  
Thomas Bauer ◽  
David Grano
Keyword(s):  
Three Dimensional ◽  
Dimensional Structure ◽  
Serial Sections ◽  
Thin Sections ◽  
3 Dimensional ◽  
Transmission Electron ◽  
Freeze Dried ◽  
Dimensional Reconstruction ◽  
Stereo Imagery ◽  
Whole Mounts

In transmission electron microscopy, the 3-dimensional structure of an object is usually obtained in one of two ways. For objects which can be included in one specimen, as for example with elements included in freeze- dried whole mounts and examined with a high voltage microscope, stereo pairs can be obtained which exhibit the 3-D structure of the element. For objects which can not be included in one specimen, the 3-D shape is obtained by reconstruction from serial sections. However, without stereo imagery, only detail which remains constant within the thickness of the section can be used in the reconstruction; consequently, the choice is between a low resolution reconstruction using a few thick sections and a better resolution reconstruction using many thin sections, generally a tedious chore. This paper describes an approach to 3-D reconstruction which uses stereo images of serial thick sections to reconstruct an object including detail which changes within the depth of an individual thick section.

Design and calibration of an IVEM for general 3-dimensional imaging of non-diffracting materials

1992 ◽  
Vol 50 (2) ◽  
pp. 1040-1041
Author(s):  
Neil Rowlands ◽  
Jeff Price ◽  
Michael Kersker ◽  
Seichi Suzuki ◽  
Steve Young ◽  
...  
Keyword(s):  
3D Imaging ◽  
Tomographic Reconstruction ◽  
Three Dimensional ◽  
3 Dimensional ◽  
3D Microstructure ◽  
Image Translation ◽  
Digital Correlation ◽  
On Line ◽  
Mechanical Stage ◽  
Projection Angle

Three-dimensional (3D) microstructure visualization on the electron microscope requires that the sample be tilted to different positions to collect a series of projections. This tilting should be performed rapidly for on-line stereo viewing and precisely for off-line tomographic reconstruction. Usually a projection series is collected using mechanical stage tilt alone. The stereo pairs must be viewed off-line and the 60 to 120 tomographic projections must be aligned with fiduciary markers or digital correlation methods. The delay in viewing stereo pairs and the alignment problems in tomographic reconstruction could be eliminated or improved by tilting the beam if such tilt could be accomplished without image translation.A microscope capable of beam tilt with simultaneous image shift to eliminate tilt-induced translation has been investigated for 3D imaging of thick (1 μm) biologic specimens. By tilting the beam above and through the specimen and bringing it back below the specimen, a brightfield image with a projection angle corresponding to the beam tilt angle can be recorded (Fig. 1a).

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