Association of susceptibility to multiple sclerosis in Southern Han Chinese with HLA-DRB1, -DPB1 alleles and DRB1-DPB1 haplotypes: distinct from other populations

2009 ◽  
Vol 15 (12) ◽  
pp. 1422-1430 ◽  
Author(s):  
Xiao-Mu Wu ◽  
Chaodong Wang ◽  
Kun-Nan Zhang ◽  
Ai-Yu Lin ◽  
Jun-ichi Kira ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Allele Frequency ◽  
Odds Ratio ◽  
Class Ii ◽  
Hla Class Ii ◽  
Allele Frequencies ◽  
Carriage Rate ◽  
Southern Chinese ◽  
Haplotype Frequencies ◽  
Effect Method

Association of HLA class II with multiple sclerosis (MS) has been widely studied in both Western and Oriental populations. However, such an association is not well documented in Chinese. The objective of this study was to examine the association between the susceptibility to conventional MS in Southern Chinese with HLA-DRB1,-DPB1 alleles and putative DRB1-DPB1 haplotypes. Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 60 patients with conventional MS and 95 controls. Allele frequencies were compared between patients and controls to identify MSassociated alleles. Relative predisposing effect method was used to compare haplotype frequencies in patients and controls and to identify possible predisposing DRB1-DPB1 haplotypes, which were further examined for differences in haplotype carriage rates between the two groups. We found that the allele frequency of DRB1*1501 was not different between patients (18.3%) and controls (21.1%) ( p = 0.837). In contrast, frequency of the DPB1*0501 allele was significantly higher in patients (90%) than in controls (67.4%) (odds ratio = 4.36, p = 0.0013, pcorr = 0.025). DRB1-DPB1 linkage haplotype in patients (8.33%) was significantly higher than in controls (0%) ( p < 0.0001) and the carriage rate of this haplotype was significantly increased in patients (15%) as compared with controls (0%) ( p = 0.00013, pcorr = 0.003). Combined, these results suggest that HLA-DRB1*1501 is not associated with susceptibility to conventional MS in Southern Chinese. Instead, both the DPB1*0501 allele and the DRB1*1602- DPB1*0501 haplotype are strong predisposing factors for conventional MS in this population. Our results establish that the HLA profiles of MS in Southern Chinese are distinct from other populations.

Different HLA class II (DRB1 and DQB1) alleles determine either susceptibility or resistance to NMO and multiple sclerosis among the French Afro-Caribbean population

2010 ◽  
Vol 17 (1) ◽  
pp. 24-31 ◽  
Author(s):  
R Deschamps ◽  
L Paturel ◽  
S Jeannin ◽  
N Chausson ◽  
S Olindo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Odds Ratio ◽  
Hla Class I ◽  
Class Ii ◽  
Hla Class Ii ◽  
Healthy Controls ◽  
Pattern Distribution ◽  
Caribbean Population ◽  
Peripheral Blood Leucocytes ◽  
Control Study

Background:Despite similarities, neuromyelitis optica (NMO) can be distinguished from multiple sclerosis (MS) by clinical, radiological and serological findings. Objective:This case-control study aimed to determine whether patients with NMO or with MS in an Afro-Caribbean population originating from French West Indies shared the same or different HLA class I and II pattern distribution. Methods:The association with HLA class II (DRB1 and DQB1) alleles was tested in 42 NMO patients, 163 MS patients and 150 healthy controls. HLA-DRB1 and DQB1 typing was undertaken on genomic DNA extracted from peripheral blood leucocytes. Results:By comparison with healthy controls, significantly increased frequency of HLA-DRB1*03 (26.2% vs. 13%, odds ratio 2.4, 95% confidence interval 1.31–4.28, p after correction, cp 0.045) was observed in patients with NMO. By contrast, in MS patients, HLA-DRB1*15 (24.8% vs. 13%, odds ratio 2.21, 95% CI 1.45–3.36, cp < 0.0015), but not DRB1*03 allele, was positively associated with the disease. Moreover, a modest protective effect of HLA-DRB1*11 in the MS group, independently of DRB1*15 association, was found (13.7% vs. 7% in controls, odds ratio 0.48, p 0.006), but did not survive Bonferroni correction. Conclusion:In conclusion, comparison of the HLA-DRB1 and DQB1 distribution in NMO and MS in this Afro-Caribbean population shows important differences in the HLA associations among NMO and MS.

scholarly journals Multiple Sclerosis in French Canadians: Evidence for HLA Class II Susceptibility and Resistance Genes

1990 ◽  
Vol 17 (4) ◽  
pp. 382-386 ◽  
Author(s):  
D.G. Haegert ◽  
M. Michaud ◽  
G.S. Francis
Keyword(s):  
Multiple Sclerosis ◽  
Resistance Genes ◽  
Rflp Analysis ◽  
Class Ii ◽  
Hla Class Ii ◽  
Extended Haplotype ◽  
Allele Specific ◽  
Relationship Of ◽  
The Relationship ◽  
Susceptibility And Resistance

ABSTRACT:HLA class II DRBI, DQB1 and DQA1 gene probes were used to study DNA from unrelated French Canadian multiple sclerosis (MS) patients and controls by restriction fragment length polymorphism (RFLP) analysis. An MS-associated and linked series of allele-specific RFLPs or allogenotypes was identified among this relatively homogeneous ethnic group; the allogenotypes include DRwl5, DQw6 and a DQA1 allogenotype termed DQαlb. An additional allogenotype which cross-hybridizes with DQA1 and is termed DQA2 upper (DQA2U), was shown not only to be part of the MS-associated extended haplotype, but also to be independently associated with MS in DRwl5-negative patients. Conversely a second DQA2 allogenotype, termed DQA2 lower (DQA2L) and a DQB1 allogenotype (DQw7) linked to DQA2L showed negative correlations with MS. It seems likely that the relationship of the HLA class II gene region to MS is complex and that MS susceptibility may reflect interaction between disease susceptibility and resistance genes.

Vitamin D receptor polymorphisms and HLA-class II genotypes among Lebanese with multiple sclerosis – A pilot study

2014 ◽  
Vol 3 (6) ◽  
pp. 759 ◽  
Author(s):  
B. Yamout ◽  
N. Estaitieh ◽  
R. Mahfouz ◽  
N. Karaky ◽  
F. Jaber ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Pilot Study ◽  
Vitamin D Receptor ◽  
Class Ii ◽  
Hla Class Ii

Vitamin D receptor gene polymorphism in multiple sclerosis and the association with HLA class II alleles

2000 ◽  
Vol 177 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Masaaki Niino ◽  
Toshiyuki Fukazawa ◽  
Ichiro Yabe ◽  
Seiji Kikuchi ◽  
Hidenao Sasaki ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Gene Polymorphism ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Class Ii ◽  
Hla Class Ii ◽  
Vitamin D Receptor Gene ◽  
Receptor Gene Polymorphism ◽  
Hla Class Ii Alleles

HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain)

2009 ◽  
Vol 256 (12) ◽  
pp. 1977-1988 ◽  
Author(s):  
Oscar Fernández ◽  
Alfredo R-Antigüedad ◽  
María Jesús Pinto-Medel ◽  
Mari Mar Mendibe ◽  
Nestor Acosta ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Basque Country ◽  
Class Ii ◽  
Hla Class Ii ◽  
Hla Class Ii Alleles

Evolution of Pacific/Asian populations inferred from HLA class II allele frequency distributions

2000 ◽  
Vol 55 (5) ◽  
pp. 383-400 ◽  
Author(s):  
S.J. Mack ◽  
T.L. Bugawan ◽  
P.V. Moonsamy ◽  
J.A. Erlich ◽  
E.A. Trachtenberg ◽  
...  
Keyword(s):  
Allele Frequency ◽  
Class Ii ◽  
Hla Class Ii ◽  
Frequency Distributions ◽  
Asian Populations

HLA Specificities and Predisposition to the Development of Multiple Myeloma (MM).

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 1688-1688
Author(s):  
Meral Beksac ◽  
Martin Maiers ◽  
Loren Gragert ◽  
Stephen Spellman ◽  
Smriti Shrestha ◽  
...  
Keyword(s):  
Protective Effect ◽  
Odds Ratio ◽  
Allele Frequencies ◽  
Single Locus ◽  
Hla Typing ◽  
Control Group ◽  
Comparison Results ◽  
Haplotype Frequencies ◽  
Locus Allele ◽  
Chi Square Analysis

Abstract Background: HLA associations for the risk of developing MM have been described in various non-Caucasian ethnic groups but have not revealed consistent results. Racial and genetic differences in cytokine polymorphisms linked to extended haplotypes; association of autoimmune disorders with HLA types; the proximity of the HLA Class I and II genes to TNF and other Class III genes responsible for complement and cytokines suggest that HLA polymorphisms may be associated with the risk of developing MM. Aim: We compared HLA-A,-B and -DRB1 2-digit allele and haplotype frequencies in patients with MM to the normal population in order to define HLA specificities associated with the risk of developing MM. Methods: A cohort of 1803 US Caucasian patients with MM were identified based on availability of HLA-A, B, DRB1 DNA-based typing or serologic typing converted to 2-digit alleles. These patients had either received a matched sibling allogeneic transplant for MM reported to the CIBMTR (N=174) or had HLA typing performed for an unrelated donor search conducted through the US National Marrow Donor Program (NMDP) (N=1629). HLA-A, B and DRB1 allele frequencies among patients were compared to A-B-DRB1 frequencies in HLA typed healthy US Caucasian controls (N= 433838) from the NMDP database. The most frequent alleles among patients and controls as well as HLA haplotype frequencies generated using the EM (expectation-maximization) algorithm were compared using Chi-Square analysis with Bonferroni correction for the number of comparisons. Results: Patients with MM had a median age of 49 (range 3–78) years and M/F ratio of 1.86 (1172/631). The controls had a median age of 44 (range 18–60) years and M/F ratio of 0.735 (183785/250053). Comparison of HLA-A, -B and –DRB1 single-locus allele frequencies between the myeloma patients and controls (those in the top 10 in either group) revealed similarity except for HLA-B*07 and B*44. B*44 was observed less frequently among the patients (a protective effect) frequency (f): 0.126 vs 0.145 (p= 0.005, Odds Ratio (OR): 0.848). On the contrary, HLA-B*07 was more common (a predisposing effect) among patients (OR: 1.135, p=0.047). Among the top 20 two locus (HLA-A-B and HLA-B-DRB1) haplotype frequencies in either group, B*44-DRB1*13 and B*07-DRB1*13 were significant: OR: 0.506 and 1.714 (p=0.003 and 0.007) respectively. A-B-DRB1 haplotype comparisons showed significance for: A*02-B*44-DRB1*04 (OR: 0.686, p=0.021), A*02-B*44-DRB1*13 (OR: 0.445, p=0.065) and A*02-B*07-DRB1*04 (OR: 1.968, p=0.029) confirming the single and B-DRB1 combination comparison results. Significantly different HLA-A, -B and -DRB1 single-locus allele or haplotype frequencies between patients and controls are shown in table 1. Conclusion: This is the largest epidemiologic study of HLA allele frequencies and the first study on HLA haplotype frequencies in MM. We observed a protective effect on the risk of developing MM with B*44 and a predisposing effect with B*07. Similar predisposing and protective haplotype associations were observed with A*02-B*07-DRB1*04 and A*02-B*44-DRB1*04 respectively. A revised analysis using a gender-matched control group is in progress. Further study including major histocompatibility region SNP mapping and candidate gene testing will help elucidate the genetic basis underlying this observation. Table 1. Allele/Haplotype Frequency Controls Frequency MM Odds Ratio (OR) P value (corrected) OR = odds of observing the allele/haplotype in patients compared to controls A*02-B*44-DRB1*13 0.00620 0.00277 0.445 0.065 B*44-DRB1*13 0.01359 0.00686 0.507 0.003 A*02-B*44-DRB1*04 0.02605 0.01813 0.686 0.021 B*44 0.14552 0.12618 0.848 0.005 B*07 0.13313 0.14836 1.134 0.047 B*07-DRB1*13 0.00814 0.01397 1.714 0.007 A*02-B*07-DRB1*04 0.00367 0.00721 1.968 0.029

HLA class II allele frequencies in the Lebanese population

Gene ◽  
2012 ◽  
Vol 506 (2) ◽  
pp. 396-399 ◽  
Author(s):  
Sara Khansa ◽  
Rouba Hoteit ◽  
Dina Shammaa ◽  
Rabab Abdel Khalek ◽  
Hussein El Halas ◽  
...  
Keyword(s):  
Class Ii ◽  
Hla Class Ii ◽  
Allele Frequencies ◽  
Lebanese Population
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