Different HLA class II (DRB1 and DQB1) alleles determine either susceptibility or resistance to NMO and multiple sclerosis among the French Afro-Caribbean population

2010 ◽  
Vol 17 (1) ◽  
pp. 24-31 ◽  
Author(s):  
R Deschamps ◽  
L Paturel ◽  
S Jeannin ◽  
N Chausson ◽  
S Olindo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Odds Ratio ◽  
Hla Class I ◽  
Class Ii ◽  
Hla Class Ii ◽  
Healthy Controls ◽  
Pattern Distribution ◽  
Caribbean Population ◽  
Peripheral Blood Leucocytes ◽  
Control Study

Background:Despite similarities, neuromyelitis optica (NMO) can be distinguished from multiple sclerosis (MS) by clinical, radiological and serological findings. Objective:This case-control study aimed to determine whether patients with NMO or with MS in an Afro-Caribbean population originating from French West Indies shared the same or different HLA class I and II pattern distribution. Methods:The association with HLA class II (DRB1 and DQB1) alleles was tested in 42 NMO patients, 163 MS patients and 150 healthy controls. HLA-DRB1 and DQB1 typing was undertaken on genomic DNA extracted from peripheral blood leucocytes. Results:By comparison with healthy controls, significantly increased frequency of HLA-DRB1*03 (26.2% vs. 13%, odds ratio 2.4, 95% confidence interval 1.31–4.28, p after correction, cp 0.045) was observed in patients with NMO. By contrast, in MS patients, HLA-DRB1*15 (24.8% vs. 13%, odds ratio 2.21, 95% CI 1.45–3.36, cp < 0.0015), but not DRB1*03 allele, was positively associated with the disease. Moreover, a modest protective effect of HLA-DRB1*11 in the MS group, independently of DRB1*15 association, was found (13.7% vs. 7% in controls, odds ratio 0.48, p 0.006), but did not survive Bonferroni correction. Conclusion:In conclusion, comparison of the HLA-DRB1 and DQB1 distribution in NMO and MS in this Afro-Caribbean population shows important differences in the HLA associations among NMO and MS.

Association of susceptibility to multiple sclerosis in Southern Han Chinese with HLA-DRB1, -DPB1 alleles and DRB1-DPB1 haplotypes: distinct from other populations

2009 ◽  
Vol 15 (12) ◽  
pp. 1422-1430 ◽  
Author(s):  
Xiao-Mu Wu ◽  
Chaodong Wang ◽  
Kun-Nan Zhang ◽  
Ai-Yu Lin ◽  
Jun-ichi Kira ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Allele Frequency ◽  
Odds Ratio ◽  
Class Ii ◽  
Hla Class Ii ◽  
Allele Frequencies ◽  
Carriage Rate ◽  
Southern Chinese ◽  
Haplotype Frequencies ◽  
Effect Method

Association of HLA class II with multiple sclerosis (MS) has been widely studied in both Western and Oriental populations. However, such an association is not well documented in Chinese. The objective of this study was to examine the association between the susceptibility to conventional MS in Southern Chinese with HLA-DRB1,-DPB1 alleles and putative DRB1-DPB1 haplotypes. Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 60 patients with conventional MS and 95 controls. Allele frequencies were compared between patients and controls to identify MSassociated alleles. Relative predisposing effect method was used to compare haplotype frequencies in patients and controls and to identify possible predisposing DRB1-DPB1 haplotypes, which were further examined for differences in haplotype carriage rates between the two groups. We found that the allele frequency of DRB1*1501 was not different between patients (18.3%) and controls (21.1%) ( p = 0.837). In contrast, frequency of the DPB1*0501 allele was significantly higher in patients (90%) than in controls (67.4%) (odds ratio = 4.36, p = 0.0013, pcorr = 0.025). DRB1-DPB1 linkage haplotype in patients (8.33%) was significantly higher than in controls (0%) ( p < 0.0001) and the carriage rate of this haplotype was significantly increased in patients (15%) as compared with controls (0%) ( p = 0.00013, pcorr = 0.003). Combined, these results suggest that HLA-DRB1*1501 is not associated with susceptibility to conventional MS in Southern Chinese. Instead, both the DPB1*0501 allele and the DRB1*1602- DPB1*0501 haplotype are strong predisposing factors for conventional MS in this population. Our results establish that the HLA profiles of MS in Southern Chinese are distinct from other populations.

scholarly journals HLA Class II Genotype Does Not Affect the Myelin Responsiveness of Multiple Sclerosis Patients

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2703
Author(s):  
Judith Derdelinckx ◽  
Irene Nkansah ◽  
Naomi Ooms ◽  
Laura Van Bruggen ◽  
Marie-Paule Emonds ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Specific Treatment ◽  
Human Leukocyte ◽  
Class Ii ◽  
Hla Class Ii ◽  
Specific Response ◽  
Healthy Controls ◽  
Treatment Approaches ◽  
Risk Alleles ◽  
Multiple Sclerosis Patients

Background: When aiming to restore myelin tolerance using antigen-specific treatment approaches in MS, the wide variety of myelin-derived antigens towards which immune responses are targeted in multiple sclerosis (MS) patients needs to be taken into account. Uncertainty remains as to whether the myelin reactivity pattern of a specific MS patient can be predicted based upon the human leukocyte antigen (HLA) class II haplotype of the patient. Methods: In this study, we analyzed the reactivity towards myelin oligodendrocyte glycoprotein (MOG), myelin basic protein (MBP) and proteolipid protein (PLP) peptides using direct interferon (IFN)-γ enzyme-linked immune absorbent spot (ELISPOT). Next, the HLA class II haplotype profile was determined by next-generation sequencing. In doing so, we aimed to evaluate the possible association between the precursor frequency of myelin-reactive T cells and the HLA haplotype. Results: Reactivity towards any of the analyzed peptides could be demonstrated in 65.0% (13/20) of MS patients and in 60.0% (6/10) of healthy controls. At least one of the MS risk alleles HLA-DRB1*15:01, HLA-DQA1*01:02 and HLA-DQB1*06:02 was found in 70.0% (14/20) of patients and in 20.0% (2/10) of healthy controls. No difference in the presence of a myelin-specific response, nor in the frequency of myelin peptide-reactive precursor cells could be detected among carriers and non-carriers of these risk alleles. Conclusion: No association between HLA haplotype and myelin reactivity profile was present in our study population. This complicates the development of antigen-specific treatment approaches and implies the need for multi-epitope targeting in an HLA-unrestricted manner to fully address the wide variation in myelin responses and HLA profiles in a heterogeneous group of MS patients.

Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis

2004 ◽  
Vol 63 (3) ◽  
pp. 237-247 ◽  
Author(s):  
H.F. Harbo ◽  
B.A. Lie ◽  
S. Sawcer ◽  
E.G. Celius ◽  
K.-Z. Dai ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Genetic Susceptibility ◽  
Hla Class I ◽  
Class Ii ◽  
Hla Class Ii ◽  
Class I ◽  
Class I Region

Multiple sclerosis: A modifying influence of HLA class I in an HLA class II associated autoimmune disease

1998 ◽  
Vol 90 (1) ◽  
pp. 103 ◽  
Author(s):  
A. Fogdell-Hahn ◽  
A. Ligers ◽  
M. Gronning ◽  
J. Hillert ◽  
O. Olerup
Keyword(s):  
Multiple Sclerosis ◽  
Autoimmune Disease ◽  
Hla Class I ◽  
Class Ii ◽  
Hla Class Ii ◽  
Class I

Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease

2000 ◽  
Vol 55 (2) ◽  
pp. 140-148 ◽  
Author(s):  
A. Fogdell-Hahn ◽  
A. Ligers ◽  
M. Grønning ◽  
J. Hillert ◽  
O. Olerup
Keyword(s):  
Multiple Sclerosis ◽  
Autoimmune Disease ◽  
Hla Class I ◽  
Class Ii ◽  
Hla Class Ii ◽  
Class I

HLA determinants of susceptibility to multiple sclerosis in an Arabian Gulf population

2004 ◽  
Vol 10 (4) ◽  
pp. 381-386 ◽  
Author(s):  
S Al-Shammri ◽  
R F Nelson ◽  
I Al-Muzairi ◽  
A O Akanji
Keyword(s):  
Multiple Sclerosis ◽  
Age At Onset ◽  
Disease Onset ◽  
Arabian Gulf ◽  
Hla Antigens ◽  
Hla Class I ◽  
Class Ii ◽  
Hla Class Ii ◽  
Class I ◽  
Class Ii Antigens

Background: An association between HLA antigens and susceptibility to multiple sclerosis (MS) has been established, especially in Caucasian populations. Such associations have not been as clearly defined in many Arab populations, where even the frequencies of specific HLA antigens remain unclear. Objective: The study was designed to (i) investigate the frequencies of HLA Class I and II antigens in Kuwaiti Arabs with MS, and; (ii) assess possible inter-relationships between HLA Class II antigens and such clinical phenotypic variables in MS as age at onset, gender, disease subtype and scale of disability. Subjects and methods: HLA Class I (A, B, C) and Class II (DR, DQ) antigens’ tissue-typing was performed by the standard complement-dependent microlymphocytotoxicity technique in two groups of ageand sex-matched Kuwaiti subjects: (i) 67 patients with definite MS (48 relapsing-remitting, 19 relapsing-progressive) and (ii) 145 unrelated healthy controls. The frequencies of specific HLA types were then compared between patients with controls, and in the former, related to specified clinical parameters. Results: The frequencies for the Class I antigens: A9, A10, A19, A33, B5 and CW4 appeared higher with the presence of MS, although the numbers of positive subjects were rather low. For the Class II antigens, frequencies of DR4, DQ5, DQ6, DQ7 and DQ8 were increased while those for DR6 and DR1 were decreased in the patients with MS. HLA types DR15 and DR4 were present at higher frequencies in patients with a younger age at disease onset; DR15 also appeared more frequent in the female patients. Conclusion: There is a trend towards an association between HLA Class II antigens (DR4, DQ6, DQ7 and DQ8) and MS in Kuwaiti subjects. Additionally, it appeared that DR4 and DR15 were more frequent in females and those with an early onset of the disease. These patterns of HLA Class II determinants of susceptibility to MS differ from reports in some other populations, and may reflect the recognized variability in genetic influence on HLA and disease expression.

scholarly journals Multiple Sclerosis in French Canadians: Evidence for HLA Class II Susceptibility and Resistance Genes

1990 ◽  
Vol 17 (4) ◽  
pp. 382-386 ◽  
Author(s):  
D.G. Haegert ◽  
M. Michaud ◽  
G.S. Francis
Keyword(s):  
Multiple Sclerosis ◽  
Resistance Genes ◽  
Rflp Analysis ◽  
Class Ii ◽  
Hla Class Ii ◽  
Extended Haplotype ◽  
Allele Specific ◽  
Relationship Of ◽  
The Relationship ◽  
Susceptibility And Resistance

ABSTRACT:HLA class II DRBI, DQB1 and DQA1 gene probes were used to study DNA from unrelated French Canadian multiple sclerosis (MS) patients and controls by restriction fragment length polymorphism (RFLP) analysis. An MS-associated and linked series of allele-specific RFLPs or allogenotypes was identified among this relatively homogeneous ethnic group; the allogenotypes include DRwl5, DQw6 and a DQA1 allogenotype termed DQαlb. An additional allogenotype which cross-hybridizes with DQA1 and is termed DQA2 upper (DQA2U), was shown not only to be part of the MS-associated extended haplotype, but also to be independently associated with MS in DRwl5-negative patients. Conversely a second DQA2 allogenotype, termed DQA2 lower (DQA2L) and a DQB1 allogenotype (DQw7) linked to DQA2L showed negative correlations with MS. It seems likely that the relationship of the HLA class II gene region to MS is complex and that MS susceptibility may reflect interaction between disease susceptibility and resistance genes.

Vitamin D receptor polymorphisms and HLA-class II genotypes among Lebanese with multiple sclerosis – A pilot study

2014 ◽  
Vol 3 (6) ◽  
pp. 759 ◽  
Author(s):  
B. Yamout ◽  
N. Estaitieh ◽  
R. Mahfouz ◽  
N. Karaky ◽  
F. Jaber ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Pilot Study ◽  
Vitamin D Receptor ◽  
Class Ii ◽  
Hla Class Ii
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