Reconsidering outdoor temperature and cognition in multiple sclerosis

2015 ◽  
Vol 22 (5) ◽  
pp. 694-697 ◽  
Author(s):  
Brandon L Roberg ◽  
Jared M Bruce
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance ◽  
Significant Relationship ◽  
Current Work ◽  
Outdoor Temperature ◽  
Disease Manifestation

Background: Research in multiple sclerosis (MS) suggests warmer weather plays a role in disease manifestation. Objective: This work sought to replicate the finding that warmer outdoor temperatures are significantly associated with poorer cognition in MS. Methods: Associations between outdoor temperature and cognition were examined in three studies with a total of 263 patients with MS. Results: Contrary to previous research, no significant relationship was found between cognitive performance and outdoor temperature in MS. Conclusions: The results of the current work underscore the need to better understand if, when, and how cognitive performance may be influenced by seasonal variables in MS.

High-intensity interval exercise improves cognitive performance and reduces matrix metalloproteinases-2 serum levels in persons with multiple sclerosis: A randomized controlled trial

2017 ◽  
Vol 24 (12) ◽  
pp. 1635-1644 ◽  
Author(s):  
Philipp Zimmer ◽  
Wilhelm Bloch ◽  
Alexander Schenk ◽  
Max Oberste ◽  
Stefan Riedel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Matrix Metalloproteinases ◽  
Aerobic Exercise ◽  
Cognitive Performance ◽  
Verbal Memory ◽  
High Intensity ◽  
Controlled Trial ◽  
Exercise Programme ◽  
Healthy Elderly ◽  
The Impact

Background: Aerobic exercise can improve cognitive performance in healthy elderly people. Objective: The aim of this study was to investigate the influence of a 3-week high-intensity aerobic exercise programme (high-intensity training group (HIT)) on cognitive performance in persons with multiple sclerosis (MS) compared with a standard exercise programme (control training (CT)). Methods: A total of 60 persons with MS (Expanded Disability Status Scale (EDSS): 1.0–6.5) were randomized to a HIT group (3×/week for 20 minutes, including five 3-minute exercise intervals at 80% of peak oxygen uptake (VO2-peak)) or a CT group (continuously 5×/week for 30 minutes/session at 65% of VO2-peak). Cognitive performance was assessed using the Brief International Cognitive Assessment for MS at entry ( t0) and discharge ( t1). Furthermore, VO2-peak, brain-derived neurotrophic factor, serotonin and matrix metalloproteinases (MMP)-2 and -9 were measured. Results: Compared to CT, HIT significantly improved verbal memory. Significant improvements over time in executive functions were found in both groups. Secondary outcomes indicated significant improvements in VO2-peak and a significant reduction in MMP-2 in the HIT group only. Conclusion: HIT represents a promising strategy to improve verbal memory and physical fitness in persons with MS. Further research is needed to determine the impact of exercise on biomarkers in MS.

scholarly journals Identification of Cortical and Subcortical Correlates of Cognitive Performance in Multiple Sclerosis Using Voxel-Based Morphometry

2018 ◽  
Vol 9 ◽  
Author(s):  
Jordi A. Matías-Guiu ◽  
Ana Cortés-Martínez ◽  
Paloma Montero ◽  
Vanesa Pytel ◽  
Teresa Moreno-Ramos ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance ◽  
Voxel Based Morphometry

scholarly journals Assessment of Fatigue in Multiple Sclerosis

2017 ◽  
Vol 1 (02) ◽  
pp. E79-E85 ◽  
Author(s):  
Carina Sander ◽  
Hans-Ulrich Voelter ◽  
Hans-Peter Schlake ◽  
Paul Eling ◽  
Helmut Hildebrandt
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance ◽  
Causal Relation ◽  
Subjective Assessment ◽  
Clinically Isolated Syndrome ◽  
Professional Activity ◽  
Quality Of Sleep ◽  
Clinical Criteria ◽  
Clinical Interviews

AbstractOne of the most frequent symptoms in multiple sclerosis (MS) is fatigue. It has a major impact on quality of life as well as on professional activity. Even nowadays it is still unclear what constitutes an adequate assessment of the perceived fatigue.The following overview will discuss different possibilities to assess fatigue with the help of questionnaires, clinical interviews or the objective measurement of cognitive performance. Furthermore, a structured guideline for the assessment of fatigue will be proposed. Clinical criteria for MS related fatigue include the main symptoms, their everyday relevance, the possible causal relation with the cause of disease (the underlying MS), as well as an exclusion of other possible somatic or psychological reasons. It is recommended to use the “Würzburger Erschöpfungs-Inventar bei Multipler Sklerose (WEIMUS)” (English: Würzburg Fatigue Inventory for Multiple Sclerosis) and especially the “Fatigue Scale for Motor and Cognitive Functions” (FSMC), as these questionnaires distinguish between motor and cognitive fatigue and due to the larger number of research studies using the FSMC. Moreover, the presence of depression, quality of sleep and daytime sleepiness should be assessed. In addition, general cognitive performance as well as performance during monotonous stimulation (vigilance) should be assessed. This may be relevant for the evaluation of a patient’s capacity to work, and for determining prognosis, as there are indications for a relation to relapse frequency, a change from a clinically isolated syndrome (CIS) to an MS diagnosis with an increase of brain atrophy.All in all, it can be said, that despite the growing convergence of diagnostic criteria, the available studies of the objective as well as the subjective assessment of fatigue are still not sufficient and further research is needed.

scholarly journals A-12 Differential Effects of Symptom Clusters at Baseline on Cognitive Performance

2020 ◽  
Vol 35 (5) ◽  
pp. 608-608
Author(s):  
A Datoc ◽  
L Issac ◽  
R Bennett ◽  
L Lashley
Keyword(s):  
Cognitive Performance ◽  
Significant Relationship ◽  
Symptom Clusters ◽  
Return To Play ◽  
High School Athletes ◽  
Motor Tasks ◽  
Individualized Approach ◽  
Visual Motor ◽  
Archival Database ◽  
Composite Scores

Abstract Objective The purpose of this study was to observe the effects of self-reported affective, sleep, and vestibular-somatic symptomatology on cognitive performance at baseline as measured by ImPACT. Method Participants were selected from a de-identified archival database of high school athletes aged 13–18. Symptom clusters included affective (N = 435, 61.7% female, Mage = 15.46), sleep (N = 435, 53.8% female, Mage = 15.49), and vestibular-somatic (N = 435, 52.2% male, Mage = 15.31). Three One-Way ANOVAs compared baseline composite scores between athletes who reported varying levels of symptomatology within each symptom cluster. Athletes were divided into groups based on their reported symptoms: None (n = 145), Mild (n = 145), and Moderate/Severe (n = 145). Significance was found at p = 0.01. Results No significant relationship between self-reported affective or sleep symptomatology and cognitive performance was observed. A significant relationship was shown between self-reported vestibular-somatic symptomatology regarding the Visual-Motor composite [F (2,432) = 5.925, p = .003]. Bonferroni pairwise comparisons revealed athletes with no reported vestibular-somatic symptoms performed significantly better on Visual-Motor tasks than those with Mild and Moderate/Severe symptoms. Conclusions These results may assist in the understanding of the influence of symptoms reported by athletes’ post-concussion. While those with varying levels of vestibular-somatic symptomatology were found to have significantly different performance on Visual-Motor tasks, this cluster of symptoms was not found to impact other domains of cognitive functioning. The influence of symptoms on cognitive performance likely varies between individual athletes, which can have implications on return-to-play decisions. This highlights the critical need for an individualized approach to be utilized when evaluating athletes post-concussion considering the current literature to date.

Walking and cognitive performance in adults with multiple sclerosis: Do age and fatigability matter?

2020 ◽  
Vol 42 ◽  
pp. 102136
Author(s):  
C. Danielle Jones ◽  
Katie L. Cederberg ◽  
E. Morghen Sikes ◽  
Glenn R. Wylie ◽  
Robert W. Motl ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Performance
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