Correlation of soluble adhesion molecules in blood and cerebrospinal fluid with magnetic resonance imaging activity in patients with multiple sclerosis

1998 ◽  
Vol 4 (3) ◽  
pp. 178-182 ◽  
Author(s):  
Peter Rieckmann ◽  
Bernd Altenhofen ◽  
Antje Riegel ◽  
Boris Kallmann ◽  
K Felgenhauer
Keyword(s):  
Cerebrospinal Fluid ◽  
Magnetic Resonance ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Serum Levels ◽  
Magnetic Resonance Images ◽  
Intercellular Adhesion Molecule ◽  
Soluble Adhesion Molecules ◽  
Cross Sectional ◽  
Positive Correlation

Several studies have reported a positive correlation between levels of soluble adhesion molecules in serum or cerebrospinal fluid and cranial MRI activity. We performed a cross-sectional study in 46 patients with newly diagnosed MS and determined levels of soluble intercellular adhesion molecule-1 (sICAM-1) as well as vascular cell adhesion molecule-1 (sVCAM-1) in correlation to the number and area of gadolinium enhancing lesions on cranial magnetic resonance images (MRI). The data revealed a significant positive correlation between sVCAM-1 serum levels and gadolinium enhancing lesions. In addition, CSF to serum ratios for sICAM-1 and sVCAM-1 correlated to MRI activity. In patients with a single enhancing lesion (SEL) there was a negative correlation between the QsCAM and the distance of the SEL to the ventricles. As these adhesion molecules are stable and markers of disease activity in MS, we further investigated sVCAM-1 serum levels during treatment with interferon beta-1b (Betaferon®). Significant increases in serum levels for sVCAM-1 in patients receiving Betaferon were associated with a favourable treatment response after 1 year in 17 out of 19 patients and correlated to decreased MRI activity, whereas stable or reduced sVCAM-1 levels occured more often in non-responders (five out of six patients). Therefore it can be hypothezised that soluble adhesion molecules are released from cerebral endothelial cells as an early immunoregulatory activity of the immune system to reduce cellular traffic across the blood brain barrier and this is further enhanced by IFN-beta treatment.

scholarly journals Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications

2019 ◽  
Vol 48 (4) ◽  
pp. 030006051989385
Author(s):  
Gehan A Hegazy ◽  
Zuhier Awan ◽  
Enayat Hashem ◽  
Nabil Al-Ama ◽  
Asmaa Basha Abunaji
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Serum Levels ◽  
Macrovascular Complications ◽  
Soluble Adhesion Molecules

Objective Type 2 diabetes mellitus (T2DM) is a main risk factor for development of cardiovascular diseases (CVDs) and endothelial dysfunction. This study aimed to investigate serum levels of soluble vascular cell adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), and endothelium selectin (sE-selectin) in T2DM patients with macrovascular complications. Methods A cross-sectional study of 21 controls, 30 T2DM patients without CVDs, and 30 T2DM patients with CVDs was conducted. Serum levels of soluble adhesion molecules including sVCAM-1, sICAM-1, and sE-selectin were determined using ELISA. Results Serum levels of sVCAM-1, sICAM-1, and sE-selectin were higher in T2DM patients than in controls. Levels of serum sVCAM-1 were higher in T2DM patients with CVDs compared with T2DM patients without CVDs. In T2DM patients with CVDs, significant positive associations were observed between sVCAM-1, sICAM-1, and sE-selectin levels (r = 0.575, p = 0.001 and r = 0.378, p = 0.040). Conclusions Circulating levels of soluble adhesion molecules were elevated in T2DM patients, regardless of whether the patients had cardiovascular complications. Only sVCAM-1 was considered a useful marker for the prediction of CVDs in T2DM patients.

Soluble Intercellular Adhesion Molecule-1 (sICAM-1) in serum and cerebrospinal fluid of demyelinating diseases of the central and peripheral nervous system

1998 ◽  
Vol 4 (1) ◽  
pp. 39-44 ◽  
Author(s):  
M Trojano ◽  
C Avolio ◽  
M Ruggieri ◽  
F De Robertis ◽  
F Giuliani ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Adhesion Molecule ◽  
Serum Levels ◽  
Intercellular Adhesion ◽  
Demyelinating Diseases ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Mean Values ◽  
Soluble Intercellular Adhesion Molecule

Serum and cerebrospinal fluid (CSF) soluble Intercellular adhesion molecule-1 (ICAM-1) levels were evaluated (ELISA) in 22 untreated and 13 corticosteroid-treated active relapsing remitting (RR) Multiple Sclerosis (MS), in 10 untreated and 10 corticosteroid-treated Guillain-Barré syndrome (GBS) and in 17 non-inflammatory neurological diseases (NIND). Twenty-eight clinically inactive RR MS were assayed for serum sICAM-1 before and after 3 months treatment of 8 MIU rIFNb-1b taken s.c. every other day. High sICAM-1 serum levels above the NIND values were found in untreated clinically active MS and in untreated GBS (P50.05) but not in the untreated clinically inactive MS group. The active MS group showed significantly (P=0.0001) higher sICAM-1 serum levels if compared to the inactive group. Corticosteroid-treated active MS and GBS patients showed lower (P50.05) serum sICAM-1 levels than the corresponding untreated groups. Serum sICAM-1 levels after 3 months of rIFNb-1b treatment (P50.0001, paired t-test) resulted increased compared to pretreatment values in MS. The mean values of CSF/serum sICAM-1: CSF/serum Albumin ratios (sICAM-1 Index) in active untreated MS patients were higher compared to NIND (P50.005) and to corticosteroid-treated MS group (P=0.01). sICAM Index values in GBS did not differ from those in NIND. The results seem to suggest potential roles for serum sICAM-1 in downregulating the ongoing inflammatory response at the blood-brain barrier level and for CSF sICAM-1 in the maintenance of a central nervous system local immune response.

Soluble Adhesion Molecules E-Cadherin, Intercellular Adhesion Molecule-1, and E-Selectin as Lung Cancer Biomarkers

CHEST Journal ◽  
2010 ◽  
Vol 138 (5) ◽  
pp. 1173-1179 ◽  
Author(s):  
Athena Gogali ◽  
Konstantinos Charalabopoulos ◽  
Iris Zampira ◽  
Athanasios K. Konstantinidis ◽  
Fanny Tachmazoglou ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Cancer Biomarkers ◽  
Intercellular Adhesion ◽  
Intercellular Adhesion Molecule ◽  
Intercellular Adhesion Molecule 1 ◽  
Soluble Adhesion Molecules ◽  
E Cadherin

scholarly journals Association of dietary inflammatory potential (DIP) and endothelial function biomarkers among female nurses of Isfahan hospitals

2021 ◽  
Author(s):  
Mohammad Gholizadeh ◽  
Ebrahim Falahi ◽  
Ammar Hassanzadeh Keshteli ◽  
Ahmadreza Yazdan Nik ◽  
Parvaneh Saneei ◽  
...  
Keyword(s):  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Plasma Levels ◽  
Intercellular Adhesion Molecule ◽  
Cluster Sampling ◽  
Dietary Inflammatory Index ◽  
Cross Sectional ◽  
Endothelial Markers ◽  
Inflammatory Index ◽  
Female Nurses

Abstract Dietary inflammatory index (DIP) is a new dietary index designed to evaluate individuals’ diets. In addition, adhesion molecules are important biomarkers for assessing endothelium inflammation that they related to atherosclerosis and cardiovascular disease. Also, there is no study for assessing the association between adhesion molecules and DIP until now as well as other studies that assessed the relationship between dietary inflammatory index or DIP have controversy. The purpose of this cross-sectional study was to determine the correlation between DII and endothelial markers such as E-selectin, intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) among female nurses from Isfahan. In this study, dietary inflammatory potential (DIP) was used instead of DII. This study was performed on 420 healthy nurses. The nurses were selected by random cluster sampling method from private and public Isfahan hospitals. A validated food frequency questionnaire (FFQ) was applied to assess the dietary inflammatory potential. A fasting blood sample was collected for measuring the plasma levels of the endothelial markers and other variables. After adjusting different potential confounders, no statistical association was found between DIP and sICAM-1, E–selectin and sVCAM-1 in model I (P=0.57, 0.98 and 0.45), model II (P=0.57, 0.98 and 0.45) and model III (P=0.67, 0.92 and 0.50) in comparison to the crude group (P=0.35, 0.83 and 0.49, respectively). The results revealed that the plasma levels of endothelial markers including E-selectin, sICAM-1, and sVCAM-1 were not significantly associated with DIP in female nurses.

Circulating Endothelial Cell/Leukocyte Adhesion Molecules in Atherosclerosis

1994 ◽  
Vol 72 (01) ◽  
pp. 151-154 ◽  
Author(s):  
Andrew D Blann ◽  
Charles N McCollum
Keyword(s):  
Endothelial Cell ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Cell Activation ◽  
Leukocyte Adhesion ◽  
Clinical Manifestations ◽  
Intercellular Adhesion Molecule ◽  
Endothelial Cell Activation ◽  
Soluble Adhesion Molecules ◽  
Von Willebrand

SummarySoluble adhesion molecules E-selectin, intercellular adhesion molecule (sICAM) and vascular cell adhesion molecule (sVCAM) were measured alongside von Willebrand factor (vWf) in 40 patients with peripheral vascular disease (PVD), 43 with ischaemic heart disease (IHD) and in equal numbers of age and sex matched asymptomatic controls. Increased vWf was found in patients with IHD (p = 0.0008) and in patients with PVD (p = 0.0001) relative to their respective controls but levels did not differ between the two patient groups. Raised sICAM was found in both PVD (p = 0.0003) and IHD (p = 0.0059) compared to their respective controls and was higher in PVD than in IHD (p = 0.0088). In the subjects taken as a whole, there was no correlation between vWf and sICAM. Levels of soluble E-sel-ectin and sVCAM did not differ in patients or controls. These data suggest that soluble ICAM may be useful as an index of endothelial cell activation in clinical manifestations of atherosclerosis.

Detection of soluble intercellular adhesion molecule—1 and vascular cell adhesion molecule—1 in both cerebrospinal fluid and serum of patients after aneurysmal subarachnoid hemorrhage

2004 ◽  
Vol 101 (6) ◽  
pp. 1030-1036 ◽  
Author(s):  
Mehmet Yasar Kaynar ◽  
Taner Tanriverdi ◽  
Ali Metin Kafadar ◽  
Tibet Kacira ◽  
Hafize Uzun ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Intercellular Adhesion Molecule ◽  
Vascular Cell Adhesion ◽  
Intercellular Adhesion Molecule 1 ◽  
Content Type ◽  
Cell Adhesion Molecule 1 ◽  
Fine Print

Object. The aim of this study was to explore whether levels of intercellular adhesion molecule—1 (ICAM-1) and vascular cell adhesion molecule—1 (VCAM-1) are elevated in the cerebrospinal fluid (CSF) and serum of patients after aneurysmal subarachnoid hemorrhage (SAH). Methods. This prospective clinical study focused on 21 patients who had recently suffered an SAH due to aneurysmal rupture and 15 control patients with hydrocephalus who had no other central nervous system disease. Cerebrospinal fluid and serum samples obtained within the first 3 days and on the 5th and 7th days of SAH were assayed for ICAM-1 and VCAM-1 by using quantitative enzyme-linked immunosorbent assays. Levels of soluble forms of ICAM-1 (p = 0.00001) and VCAM-1 (p = 0.009) in the patients' CSF and those of ICAM-1 (p = 0.00001) and VCAM-1 (p = 0.00001) in their serum were found to be elevated after SAH compared with levels in the CSF and serum of control patients with hydrocephalus. In addition, when the authors compared the increased levels of adhesion molecules in the CSF and serum of patients after SAH, the only statistically insignificant difference that they found was between the levels of VCAM-1 in serum obtained on Days 5 and 7 after SAH (p = 0.27). Conclusions. Adhesion molecules are a group of macromolecules that may participate in the inflammatory process, a common pathway leading to vasospasm after SAH. Leukocyte adherence to the vascular endothelium, which is induced by adhesion molecules, has been believed to be the initial signal of the development of vasospasm. The authors have demonstrated the synchronized elevation of two adhesion molecules in both CSF and serum following aneurysmal SAH. Blocking of ICAM-1 as well as VCAM-1 by monoclonal antibodies post-SAH may provide a beneficial effect on vasospasm.

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