Low-grade inflammation and depressive symptoms as predictors of abdominal obesity

AbstractDespite increasing evidence for an association between circulating uric acid (UA) and depression, the directionality of this association remains unclear and is potentially moderated by low-grade inflammation. Thus, the present study aimed to investigate the cross-sectional association between serum UA concentration and depressive symptoms in Korean individuals with and without low-grade inflammation, as measured using serum high-specific C-reactive protein (hs-CRP) levels. The final study sample comprised 4188 participants, aged 19–79 years, from the Korea National Health and Nutrition Examination Study 2016. Data on serum uric acid (UA) concentrations, serum hs-CRP levels, Patient Health Questionnaire-9 (PHQ-9) scores, and relative covariates were retrieved. Negative binomial regression with adjustment for the complex sample design was used to analyze the associations. After adjusting for covariates, log-transformed serum UA concentrations and total PHQ-9 scores were positively associated (incidence rate ratio [IRR] = 1.34 [95% confidence interval [CI] = 1.09–1.66]) for participants without low-grade inflammation and inversely associated (IRR = 0.64 [95% CI = 0.45–0.92]) for participants with low-grade inflammation. In conclusion, the direction of the association between serum UA and depressive symptoms was the opposite in participants with and without low-grade inflammation. The study has the limitation of potential uncontrolled confounders.

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Persistent Depressive Symptoms are Independent Predictors of Low-Grade Inflammation Onset Among Healthy Individuals

Arquivos Brasileiros de Cardiologia ◽

10.5935/abc.20170080 ◽

2017 ◽

Cited By ~ 2

Author(s):

Fábio Gazelato de Mello Franco ◽

Antonio Gabriele Laurinavicius ◽

Paulo A. Lotufo ◽

Raquel D. Conceição ◽

Fernando Morita ◽

...

Keyword(s):

Depressive Symptoms ◽

Low Grade ◽

Healthy Individuals ◽

Low Grade Inflammation

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Exploring low grade inflammation by soluble urokinase plasminogen activator receptor levels in schizophrenia: a sex-dependent association with depressive symptoms

BMC Psychiatry ◽

10.1186/s12888-021-03522-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Therese Torgersen Bigseth ◽

John Abel Engh ◽

Jens Egeland ◽

Eivind Andersen ◽

Ole Andreas Andreassen ◽

...

Keyword(s):

Depressive Symptoms ◽

Plasminogen Activator ◽

Immune Activation ◽

Urokinase Plasminogen Activator ◽

Low Grade ◽

Urokinase Plasminogen Activator Receptor ◽

Identification Test ◽

Disorder Identification ◽

Plasminogen Activator Receptor ◽

Low Grade Inflammation

Abstract Background There is evidence of increased low grade inflammation (LGI) in schizophrenia patients. However, the inter-individual variation is large and the association with demographic, somatic and psychiatric factors remains unclear. Our aim was to explore whether levels of the novel LGI marker soluble urokinase plasminogen activator receptor (suPAR) were associated with clinical factors in schizophrenia and if such associations were sex-dependent. Method In this observational study a total of 187 participants with schizophrenia (108 males, 79 females) underwent physical examination and assessment with clinical interviews (Positive and Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), Alcohol Use Disorder Identification Test (AUDIT), and Drug Use Disorder Identification Test (DUDIT)). Blood levels of suPAR, glucose, lipids, and high sensitivity C-reactive protein (hsCRP) were determined and body mass index (BMI) calculated. Multivariable linear regression analyses were used adjusting for confounders, and sex interaction tested in significant variables. Results Adjusting for sex, age, current tobacco smoking and BMI, we found that levels of hsCRP and depressive symptoms (CDSS) were positively associated with levels of suPAR (p < 0.001). The association between suPAR and CDSS score was significant in females (p < 0.001) but not in males. Immune activation measured by hsCRP was not associated with depressive symptoms after adjusting for BMI. Conclusion Our findings indicate that increased suPAR levels are associated with depressive symptoms in females with schizophrenia, suggesting aberrant immune activation in this subgroup. Our results warrant further studies, including longitudinal follow-up of suPAR levels in schizophrenia and experimental studies of mechanisms.

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Low-grade inflammation differentiates between symptoms of apathy and depression in community-dwelling older individuals

International Psychogeriatrics ◽

10.1017/s1041610214002683 ◽

2014 ◽

Vol 27 (4) ◽

pp. 639-647 ◽

Cited By ~ 16

Author(s):

Lisa S. M. Eurelings ◽

Edo Richard ◽

Piet Eikelenboom ◽

Willem A. van Gool ◽

Eric P. Moll van Charante

Keyword(s):

Depressive Symptoms ◽

Geriatric Depression Scale ◽

Depression Scale ◽

Population Based ◽

Community Dwelling ◽

Low Grade ◽

Older Individuals ◽

Cross Sectional ◽

Low Grade Inflammation

ABSTRACTBackground:Systemic low-grade inflammation has repeatedly been associated with depression in old age, but the relationship with apathy is less clear. The present study assessed whether C-reactive protein (CRP) is differentially associated with symptoms of apathy and depression.Methods:A population-based cohort study was carried-out. At baseline and after two and four years of follow-up, CRP levels were assessed and symptoms of apathy and depression were measured using the 15-item Geriatric Depression Scale. Logistic regression analysis was used to investigate the cross-sectional and longitudinal associations of CRP with symptoms of apathy and depression.Results:Two thousand forty-seven community-dwelling participants (70–78 years) without a history of cardiovascular disease or stroke were studied. A cross-sectional association was found between CRP and apathy symptoms at three time points (odds ratio (OR) per natural log unit increase in CRP: baseline visit = 1.40, 95% CI = 1.12–1.75; two-year follow-up visit = 1.62, 95% CI = 1.17–2.25; four-year follow-up visit = 1.51, 95% CI = 1.03–2.21). This did not change after adjustment for demographics and depressive symptoms, and was slightly attenuated after adjustment for cardiovascular risk factors. No cross-sectional association was found with depressive symptoms. Baseline CRP did not predict incident apathy or depressive symptoms during four years of follow-up.Conclusions:Increased CRP levels are associated with apathy symptoms but not with depressive symptoms. This suggests a differential effect of inflammation on apathy and depression. In older persons, symptoms of apathy may be a behavioral manifestation of concurrent low-grade inflammation.

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