scholarly journals Nicardipine Hydrochloride Injectable Phase IV Open-Label Clinical Trial: Study on the Anti-Hypertensive Effect and Safety of Nicardipine for Acute Aortic Dissection

2002 ◽  
Vol 30 (3) ◽  
pp. 337-345 ◽  
Author(s):  
KH Kim ◽  
IS Moon ◽  
JS Park ◽  
YB Koh ◽  
H Ahn
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Aortic Dissection ◽  
Acute Aortic Dissection ◽  
Open Label ◽  
Multicentre Phase ◽  
The Third ◽  
Arterial Blood ◽  
Blood Pressures ◽  
Phase Iv

We performed a multicentre, phase IV, open-label clinical trial to examine the clinical usefulness of a continuous infusion of nicardipine hydrochloride to control hypertension in 31 patients with acute aortic dissection. Target blood pressure levels were reached within 15 min in 16 patients; in 15–30 min in 10 patients; in 30–45 min in three patients; and in 45–60 min in two patients. Baseline average systolic, diastolic and mean arterial blood pressures were 147 ± 23 mmHg, 82 ± 18 mmHg and 104 ± 18 mmHg, respectively, with third-day pressures significantly reduced at 119 ± 12 mmHg, 69 ± 9 mmHg and 86 ± 8 mmHg. Blood pressures after discontinuation of the infusion were not significantly different from those measured on the third day of infusion and no definite adverse effects attributable to the treatment were observed. Nicardipine hydrochloride was both effective and safe at controlling blood pressure in patients with acute aortic dissection.

scholarly journals Efficiency of atorvastatin on in-hospital mortality of patients with acute aortic dissection (AAD): study protocol for a randomized, open-label, superiority clinical trial

2021 ◽  
Author(s):  
Yequn Chen ◽  
Nianling Xiong ◽  
Xin Wang ◽  
Shiwan Wu ◽  
Liangli Hong ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Aortic Dissection ◽  
Hospital Mortality ◽  
Acute Aortic Dissection ◽  
Lipid Lowering ◽  
Control Group ◽  
Open Label ◽  
Medical College ◽  
Conventional Drug ◽  
Registration Number

Abstract Background: Dyslipidemia and local inflammation at sites of lipid deposition on blood vessel walls have been demonstrated to be risk factors for patients with acute aortic dissection (AAD). Statins have anti-inflammatory and lipid-lowering effects, which suggest that statins may play an important role in prevention and treatment of AAD. Some retrospective studies show that statins can protect patients with aortic dissection. However, the effect of statins on survival of AAD patients has been scarcely investigated, especially in randomized trials. In this study, we will perform a randomized clinical trial to understand whether statins can reduce in-hospital mortality of AAD patients. Methods: A total of 384 subjects diagnosed with AAD in the First Affiliated Hospital of Shantou University Medical College will be recruited. Participants will be randomly divided into an atorvastatin-treated or control group. The primary outcome will be the in-hospital mortality. Discussion: This study is designed to verify the efficacy of atorvastatin on reducing in-hospital mortality of patients with AAD. The aim is to provide a new means of improving survival as a complement to conventional drug therapy.Trial registration: Registered by the Chinese Clinical Trials Registry (Registration number: ChiCTR1900023515, http://www.chictr.org.cn/edit.aspx?pid=38275&htm=4). Registered 1 June 2019.

scholarly journals Efficiency of atorvastatin on in-hospital mortality of patients with acute aortic dissection (AAD): study protocol for a randomized, open-label, superiority clinical trial

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yequn Chen ◽  
Nianling Xiong ◽  
Xin Wang ◽  
Shiwan Wu ◽  
Liangli Hong ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Aortic Dissection ◽  
Hospital Mortality ◽  
Acute Aortic Dissection ◽  
Lipid Lowering ◽  
Control Group ◽  
Open Label ◽  
Medical College ◽  
Conventional Drug ◽  
Clinical Trials Registry

Abstract Background Dyslipidemia and local inflammation at sites of lipid deposition on blood vessel walls have been demonstrated to be risk factors for patients with acute aortic dissection (AAD). Statins have anti-inflammatory and lipid-lowering effects, which suggest that statins may play an important role in the prevention and treatment of AAD. Some retrospective studies show that statins can protect patients with aortic dissection. However, the effect of statins on the survival of AAD patients has been scarcely investigated, especially in randomized trials. In this study, we will perform a randomized clinical trial to understand whether statins can reduce in-hospital mortality of AAD patients. Methods A total of 384 subjects diagnosed with AAD in the First Affiliated Hospital of Shantou University Medical College will be recruited. Participants will be randomly divided into an atorvastatin-treated or control group. The primary outcome will be the in-hospital mortality at 30 days. Discussion This study is designed to verify the efficacy of atorvastatin on reducing in-hospital mortality of patients with AAD. The aim is to provide a new means of improving survival as a complement to conventional drug therapy. Trial registration Chinese Clinical Trials Registry ChiCTR1900023515. Registered on 1 June 2019.

Validity of Neonatal Blood Pressure Obtained By The Manometric Method

PEDIATRICS ◽  
1973 ◽  
Vol 52 (2) ◽  
pp. 293-296
Author(s):  
Rosemary D. Leake ◽  
Paul R. Williams ◽  
William Oh
Keyword(s):  
Blood Pressure ◽  
Neonatal Intensive Care ◽  
Umbilical Artery ◽  
Neonatal Intensive Care Units ◽  
Arterial Blood ◽  
Direct Recording ◽  
Blood Pressures ◽  
Manometric Method ◽  
Neonatal Blood ◽  
Precise Relationship

In neonatal intensive care units where direct arterial blood pressures obtained via a transducer are unavailable, a fluid-filled spinal manometer has been used. The latter method is practical and convenient although its validity has not been confirmed. This study is designed to establish the precise relationship between the blood pressure obtained by the manometric method and by direct recording via the arterial transducer. Materials and Methods Eleven infants with umbilical artery catheters in place 1 to 2 cm above the diaphragm were selected for the study. In all instances, the arterial catheters were placed for clinical management of various illnesses.

Validity of phonoarteriographic blood pressures during rest and exercise

1964 ◽  
Vol 19 (6) ◽  
pp. 1219-1233 ◽  
Author(s):  
Joseph A. Mastropaolo ◽  
Jeremiah Stamler ◽  
David M. Berkson ◽  
Hans U. Wessel ◽  
Walter E. Jackson
Keyword(s):  
Blood Pressure ◽  
Fitness Testing ◽  
Physical Effort ◽  
Indirect Measurements ◽  
Arterial Blood ◽  
Hearing Acuity ◽  
Pulse Sound ◽  
Blood Pressures ◽  
Pressure Record ◽  
Rest And Exercise

A modification of the auscultatory blood pressure method, the phonoarteriogram, was developed. The innovated method essentially is a modified amplifying stethoscope. The pressure in the cuff is recorded from a pressure transducer, and the systolic and diastolic criteria are recorded from a microphone. The phonoarteriogram gives the advantages of a permanent record, includes pulse rate and pulse sound data, is not affected by hearing acuity, permits determinations often denied using auscultation in high ambient noise and exercise conditions, and eliminates observer bias. Three hundred and forty resting determinations and 218 exercise determinations on 60 subjects indicated good agreement between the phonoarteriogram and auscultation. In 50 systolic and diastolic intra-arterial determinations before compression of the cuff, during rest and exercise from one subject, the phonoarteriogram was as valid as auscultation. In 56 intra-arterial determinations during deflation of the cuff, i.e., simultaneous with the indirect measurements, during rest and exercise from a second subject, the phonoarteriogram was less fallible than auscultation, particularly during exercise. Phonoarteriograms are valid, reliable, and objective blood pressure record blood pressure determination; auscultatory blood pressure; intra-arterial blood pressure; physical fitness testing; ausculation; effort or physical effort; exercise; exertion; fatigue; methods, physiological; instrumentation; pulse; work Submitted on January 16, 1964

scholarly journals Wavelet Autoregulation Monitoring Identifies Blood Pressures Associated With Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiuyun Liu ◽  
Aylin Tekes ◽  
Jamie Perin ◽  
May W. Chen ◽  
Bruno P. Soares ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Brain Injury ◽  
Therapeutic Hypothermia ◽  
Near Infrared ◽  
Brain Regions ◽  
Hypoxic Ischemic Encephalopathy ◽  
Volume Index ◽  
Arterial Blood ◽  
Blood Pressures ◽  
Ischemic Encephalopathy

Dysfunctional cerebrovascular autoregulation may contribute to neurologic injury in neonatal hypoxic-ischemic encephalopathy (HIE). Identifying the optimal mean arterial blood pressure (MAPopt) that best supports autoregulation could help identify hemodynamic goals that support neurologic recovery. In neonates who received therapeutic hypothermia for HIE, we hypothesized that the wavelet hemoglobin volume index (wHVx) would identify MAPopt and that blood pressures closer to MAPopt would be associated with less brain injury on MRI. We also tested a correlation-derived hemoglobin volume index (HVx) and single- and multi-window data processing methodology. Autoregulation was monitored in consecutive 3-h periods using near infrared spectroscopy in an observational study. The neonates had a mean MAP of 54 mmHg (standard deviation: 9) during hypothermia. Greater blood pressure above the MAPopt from single-window wHVx was associated with less injury in the paracentral gyri (p = 0.044; n = 63), basal ganglia (p = 0.015), thalamus (p = 0.013), and brainstem (p = 0.041) after adjustments for sex, vasopressor use, seizures, arterial carbon dioxide level, and a perinatal insult score. Blood pressure exceeding MAPopt from the multi-window, correlation HVx was associated with less injury in the brainstem (p = 0.021) but not in other brain regions. We conclude that applying wavelet methodology to short autoregulation monitoring periods may improve the identification of MAPopt values that are associated with brain injury. Having blood pressure above MAPopt with an upper MAP of ~50–60 mmHg may reduce the risk of brain injury during therapeutic hypothermia. Though a cause-and-effect relationship cannot be inferred, the data support the need for randomized studies of autoregulation and brain injury in neonates with HIE.

scholarly journals Bloodletting has no effect on the blood pressure abnormalities of hyperandrogenic women taking oral contraceptives in a randomized clinical trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Manuel Luque-Ramírez ◽  
Andrés E. Ortiz-Flores ◽  
Lía Nattero-Chávez ◽  
M.Ángeles Martínez-García ◽  
María Insenser ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Iron Overload ◽  
Oral Contraceptives ◽  
Polycystic Ovary ◽  
Experimental Period ◽  
Adult Women ◽  
Open Label ◽  
Iron Depletion ◽  
Functional Hyperandrogenism

AbstractNormoferritinemic women with functional hyperandrogenism show a mild iron overload. Iron excess, hyperandrogenism, and cardioautonomic dysfunction contribute to blood pressure (BP) abnormalities in these patients. Furthermore, combined oral contraceptives (COC) prescribed for hyperandrogenic symptoms may worse BP recordings. Iron depletion by phlebotomy appears to lower BP in other acquired iron overload conditions. We aimed to determine the effect of iron depletion on the office BP, ambulatory BP monitoring, and frequency of hypertension in patients with functional hyperandrogenism submitted to standard therapy with COC. We conducted a phase 2 randomized, controlled, parallel, open-label clinical trial (NCT02460445) in adult women with functional hyperandrogenism including hyperandrogenic polycystic ovary syndrome and idiopathic hyperandrogenism. After a 3-month run-in period of treatment with 35 µg ethinylestradiol plus 2 mg cyproterone acetate, participants were randomized (1:1) to three scheduled bloodlettings or observation for another 9 months. Main outcome measures were the changes in office BP, 24-h-ambulatory BP, and frequency of hypertension in both study arms. From June 2015 to June 2019, 33 women were included in the intention-to-treat analyses. We observed an increase in mean office systolic BP [mean of the differences (MD): 2.5 (0.3–4.8) mmHg] and night-time ambulatory systolic BP [MD 4.1 (1.4–6.8) mmHg] after 3 months on COC. The percentage of nocturnal BP non-dippers also increased, from 28.1 to 92.3% (P < 0.001). Office and ambulatory BP did not change throughout the experimental period of the trial, both when considering all women as a whole or as a function of the study arm. The frequency of the non-dipping pattern in BP decreased during the experimental period [OR 0.694 (0.577–0.835), P < 0.001], regardless of the study arm. Decreasing iron stores by scheduled bloodletting does not override the BP abnormalities caused by COC in women with functional hyperandrogenism.

scholarly journals Study of Inter-arm Variation of Blood Pressure in Normal and Diabetic In-dividual in Out Patient Department of Nepal Medical College

2021 ◽  
Vol 1 (1) ◽  
pp. 12-16
Author(s):  
Pragati Poudyel ◽  
Seerina Adhikari
Keyword(s):  
Blood Pressure ◽  
Cuff Pressure ◽  
Developed Countries ◽  
Sitting Posture ◽  
Medical College ◽  
Arterial Blood ◽  
Measure Blood Pressure ◽  
Normal Individuals ◽  
Blood Pressures ◽  
The Comparative Study

 Introduction: Growing incidence of hypertension and its significant association with diabetes mellitus are being observed in both developing and developed countries around globe. Scanty literature is available about the comparative study of inter-arm variation of blood pressure in normal individuals and diabetic among Nepalese population. This research was performed to determine extent of inter-arm variation in normal individuals and diabetics. Methods: A descriptive observational study was carried out from 2013 January to 2014 January in a tertiary level teaching hospital of Nepal. After taking the consent and giving necessary instructions, blood pressures were measured in both the arms one after another in sitting posture using mercurial sphygmomanometer and Littman cardiosonic stethoscope. Arterial blood pressure was measured by palpatory method followed by auscultatory method The cuff pressure at which the tap sound were first perceived was noted as systolic blood pressure (SBP). Similarly, diastolic blood pressure (DBP) was noted at the point where the sound disappeared. Results: A total of 120 volunteers between ages of 40-80 years were studied. Highly significant inter-arm variation of both SBP and DBP was found in diabetics as compared to normal (p<0.01). Highly significant inter-arm variation was found in diabetic male and female as compared to their normal counter parts (p<0.01). Conclusion: This study showed that there was significant inter-arm variation of SBP and DBP in diabetic and normal individual. So, this study encourages to measure blood pressure (BP) in both arms for proper treatment planning of an individuals.

scholarly journals Acute Hemodynamic Changes Associated with Zumba and ZOCA Dance Exercises among Females of Selected Gyms in Lusaka, Zambia

2020 ◽  
Vol 2 (1) ◽  
pp. 84-91
Author(s):  
Chanda Grace Chisunka ◽  
◽  
Gibson Sijumbila ◽  
Fastone Goma ◽  
◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Systolic Blood Pressure ◽  
Hemodynamic Changes ◽  
Aerobic Dance ◽  
Arterial Blood ◽  
Effective Dynamic ◽  
Blood Pressure Monitors ◽  
Blood Pressures

Background: Dynamic exercises are known to elicit hemodynamic changes such as an increase in arterial blood pressure and heart rate. Zumba and ZOCA are part of a fast growing group of dance fitness programmes designed to provide a cardiovascular dynamic workout. Despite their growing popularity, very few studies have been done to provide knowledge regarding the hemodynamic changes associated with these exercises. Methods: Case study in which 27 females took part in either a Zumba or ZOCA class. Using digital blood pressure monitors, recordings of blood pressure and heart rate were taken, firstly, before commencement of the exercise, secondly, after 30 minutes after exercise and thirdly, at the end of the class.Results: Mean baseline blood pressures were 118 (SD = 14) mmHg and 77 (SD = 7) mmHg, systolic and diastolic blood pressures, respectively. After 30 minutes of dancing, mean systolic blood pressure increased to 130 (SD = 19) mmHg (p˂ 0.05) while diastolic blood pressureonly rose to an average of 80 (SD = 8) mmHg (p˃ 0.05). At the end of the class (after the cool down phase) mean systolic blood pressure reduced to 109 (SD = 13) mmHg (p˂0.05) while diastolic blood pressure reduced to 74(SD = 12) mmHg (p˂ 0.05). Conclusions: Zumba and ZOCA elicited significant hemodynamic changes that can be attributed to these exercises stimulating the cardiovascular regulatory mechanisms (e.g central command and exercise-pressor) sufficiently and hence resulting in autonomic adjustmentsthat were concurrent with effective dynamic exercise. Keywords: Blood Pressure, Heart Rate, Aerobic, Dance Exercise

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