scholarly journals Associations between Coronary Heart Disease and Individual Components of the Metabolic Syndrome according to Glucose Tolerance Status

2012 ◽  
Vol 40 (3) ◽  
pp. 934-942 ◽  
Author(s):  
X Gong ◽  
X Pan ◽  
X Chen ◽  
C Hong ◽  
J Hong ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Glucose Tolerance ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Postprandial Blood Glucose ◽  
The Metabolic Syndrome ◽  
Chd Risk

OBJECTIVE: To assess whether the contributions of individual metabolic syndrome components to coronary heart disease (CHD) risk vary in patients with different glucose tolerance. METHODS: A total of 1619 patients were included in this cross-sectional study. CHD, metabolic syndrome and glucose tolerance were assessed using coronary angiography, anthropometric and biochemical parameters, and an oral glucose tolerance test, respectively. Associations between CHD and components of metabolic syndrome were determined using logistic regression analysis. RESULTS: Low high-density lipoprotein-cholesterol (HDL-C) was the only CHD risk factor in patients with both CHD and metabolic syndrome who had normal glucose tolerance, after adjustments for age, smoking and low-density lipoprotein-cholesterol (LDL-C) concentration. In patients with CHD plus metabolic syndrome and prediabetes, the most important risk factor was hypertension; additional risk factors were high postprandial blood glucose (PBG) and low HDL-C. In patients with CHD plus metabolic syndrome and diabetes, high PBG was the strongest risk factor, followed by hypertension, high FBG and high waist circumference. CONCLUSIONS: Individual components of metabolic syndrome contributed variously to CHD across different glucose tolerance statuses.

Relationships between hostility and physiological coronary heart disease risk factors in young adults: the moderating influence of depressive tendencies

2000 ◽  
Vol 30 (2) ◽  
pp. 381-393 ◽  
Author(s):  
N. RAVAJA ◽  
T. KAUPPINEN ◽  
L. KELTIKANGAS-JÄRVINEN
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Young Adults ◽  
Heart Disease ◽  
Disease Risk ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Chd Risk ◽  
Chd Risk Factors

Background. We examined whether the relationships between hostility and physiological coronary heart disease (CHD) risk factors differ as a function of depressive tendencies (DT).Methods. The participants were 672 randomly selected healthy young adults who self-reported their hostility (anger, cynicism, and paranoia) and DT. The physiological CHD risk factors studied were systolic blood pressure, diastolic blood pressure, body-mass index, serum high-density lipoprotein cholesterol, serum low-density lipoprotein cholesterol and serum triglycerides.Results. We found that hostility was negatively associated with the physiological CHD risk factors among individuals exhibiting high DT while hostility was positively associated with, or unrelated to, the physiological risk factors among individuals showing low DT. The Hostility × DT interaction explained 2 to 5% of the variance in the physiological parameters.Conclusion. The findings suggest that DT have a moderating influence on the relationships between hostility and CHD risk. Despite the established risk factor status of hostility, lack of anger and hostility, when combined with high DT, may represent the most severe exhaustion where the individual has given up. Disregard of this fact may explain some null findings in the research on hostility and CHD risk.

Pseudocholinesterase/high-density lipoprotein cholesterol ratio in serum of normal persons and of hyperlipoproteinemics.

1983 ◽  
Vol 29 (6) ◽  
pp. 1031-1033 ◽  
Author(s):  
R Jain ◽  
K M Kutty ◽  
S N Huang ◽  
K Kean
Keyword(s):  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Cholesterol Ratio ◽  
Established Risk Factor

Abstract The proposed complementary risk factor, pseudocholinesterase/high-density lipoprotein cholesterol ratio, was significantly higher in patients with type IIb and IV hyperlipoproteinemias then in controls. In contrast, the established risk factor, total cholesterol/high-density lipoprotein cholesterol ratio, was significantly higher in patients with type IIa and IV hyperlipoproteinemias. Discriminant analysis indicated that prediction of risk for coronary heart disease on the basis of lipoprotein phenotypes can be improved by about 20% when both the above factors are assessed concurrently. On the basis of earlier studies in humans and animals, we also suggest that the proposed risk factor may provide a better understanding of events leading to enhanced risk for coronary heart disease as a consequence of nutrition and of abnormal metabolism of lipids and lipoproteins.

Apolipoprotein C-III: understanding an emerging cardiovascular risk factor

2008 ◽  
Vol 114 (10) ◽  
pp. 611-624 ◽  
Author(s):  
Esther M. M. Ooi ◽  
P. Hugh R. Barrett ◽  
Dick C. Chan ◽  
Gerald F. Watts
Keyword(s):  
Metabolic Syndrome ◽  
Risk Factor ◽  
Visceral Obesity ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Peroxisome Proliferator ◽  
Cvd Risk ◽  
Direct Role ◽  
The Metabolic Syndrome ◽  
Apolipoprotein C

The concurrence of visceral obesity, insulin resistance and dyslipidaemia comprises the concept of the metabolic syndrome. The metabolic syndrome is an escalating problem in developed and developing societies that tracks with the obesity epidemic. Dyslipidaemia in the metabolic syndrome is potently atherogenic and, hence, is a major risk factor for CVD (cardiovascular disease) in these subjects. It is globally characterized by hypertriglyceridaemia, near normal LDL (low-density lipoprotein)-cholesterol and low plasma HDL (high-density lipoprotein)-cholesterol. ApoC-III (apolipoprotein C-III), an important regulator of lipoprotein metabolism, is strongly associated with hypertriglyceridaemia and the progression of CVD. ApoC-III impairs the lipolysis of TRLs [triacylglycerol (triglyceride)-rich lipoproteins] by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. In the circulation, apoC-III is associated with TRLs and HDL, and freely exchanges among these lipoprotein particle systems. However, to fully understand the complex physiology and pathophysiology requires the application of tracer methodology and mathematical modelling. In addition, experimental evidence shows that apoC-III may also have a direct role in atherosclerosis. In the metabolic syndrome, increased apoC-III concentration, resulting from hepatic overproduction of VLDL (very-LDL) apoC-III, is strongly associated with delayed catabolism of triacylglycerols and TRLs. Several therapies pertinent to the metabolic syndrome, such as PPAR (peroxisome-proliferator-activated receptor) agonists and statins, can regulate apoC-III transport in the metabolic syndrome. Regulating apoC-III metabolism may be an important new therapeutic approach to managing dyslipidaemia and CVD risk in the metabolic syndrome.

Abstract 10909: LDL and HDL Particle vs. Cholesterol Concentration in Metabolic Syndrome and Diabetes for the Prediction of Coronary Heart Disease: The Multiethnic Study of Atherosclerosis

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
David M Tehrani ◽  
Yanglu Zhao ◽  
Michael Blaha ◽  
Samia Mora ◽  
Rachel Mackey ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Density Lipoprotein ◽  
Cholesterol Concentration ◽  
Event Prediction ◽  
Chd Risk ◽  
A Prospective Study ◽  
Relationship Of

Background: A more important role of both low and density lipoprotein (LDL-P and HDL-P) than cholesterol (LDL-C and HDL-C) concentration in predicting coronary heart disease (CHD) has been noted. However, the role of these factors and extent of particle-cholesterol discordance in metabolic syndrome (MetS) and diabetes (DM) for event prediction is unknown. Methods: In adults aged 45-84 from the Multi-Ethnic Study of Atherosclerosis, a prospective study of subjects without baseline cardiovascular disease, we defined percent discordance of LDL and HDL based on a subject’s difference between baseline particle and cholesterol percentiles. Separate Cox regressions adjusted for standard risk factors were performed to assess the relationship of the continuous lipoprotein discordance variables, as well as LDL-C, LDL-P, HDL-C, and HDL-P, to incident CHD events in those with DM, MetS (without DM), or neither condition. Results: Among 6,417 subjects (52.5% male, mean age 62.1) with 10 year follow-up, those with DM and MetS had significantly greater LDL and HDL discordance compared to those without these conditions (Figure). In discordance models, only LDL discordance [per standard deviation (SD)] within the MetS group was positively associated with CHD events [Hazard Ratio (HR) =1.25, p<0.01]. In models with individual particle/cholesterol variables (per SD), within the DM group, HDL-P was negatively (HR=0.71, p<0.05) and LDL-C positively (HR=1.47, p<0.05) associated with CHD. In those with MetS, only LDL-P was positively associated with CHD (HR=1.34, p<0.05). In those with neither disease, only LDL-C was positively associated with CHD (HR=1.27, p<0.05). Conclusion: LDL discordance (mainly through higher LDL-P) in those with MetS and higher LDL-C with lower HDL-P in those with DM predicts CHD risk. These results support a potential role for examining lipoprotein particles and discordances in persons with MetS and DM to better assess CHD risk.

scholarly journals Risk factors for coronary heart disease and actual diagnostic criteria for diabetes mellitus

2009 ◽  
Vol 66 (12) ◽  
pp. 973-978 ◽  
Author(s):  
Natasa Mitrovic-Perisic ◽  
Slobodan Antic
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Glucose Tolerance ◽  
Diagnostic Criteria ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Chronic Hyperglycemia ◽  
Increased Risk

Background/Aim. Recent studies indicate that the prevalence of diabetes mellitus (DM) type 2 is increasing in the world. Chronic hyperglycemia in DM is associated with a long term damage, dysfunction and failure of various organs, especially retina, kidney, nerves and, in addition, with an increased risk of cardiovasclar disease. For a long time the illness has been unknown. Early diagnosis of diabetes could suspend the development of diabetic complications. The aim of the study was to establish risk for the development of coronary disease in the patients evaluated by the use of new diagnostic criteria for DM. Methods. The study included 930 participants without diagnosis of DM, hypertension, dyslipidemia, nor coronary heart disease two years before the study. The patients went through measuring of fasting plasma glycemia, erythrocytes, hematocrit, cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, aspartate aminotransferase and alanine aminotransferase. In the group with hyperglycemia the 2-hour oral glucose tolerance test was performed. We analyzed ECG and made blood pressure monitoring, and also measured body mass, height, waist and hip circumference. We analyzed life style, especially smoking, and exercise and family history. Results. Diabetes prevalence was 2.68%, and prevalences of impaired fasting glucose, impaired glucose tolerance and DM were 12.15%. Average age of males and females was 38 and 45 years, respectively. In the healthy population there was higher frequency of smokers (55% vs 42%), but in the population with hyperglycemia there were more obesity (23% vs 10.5%), hypertension (39% vs 9%), hypercholesterolemia (76% vs 44.1%), lower HDL-C (52.2% vs 25.7%). Cummulative risk factor in healthy subjects, and those with hyperglycemia were 5.6% and 14%, respectively. Conclusion. Subjects with hyperglicemia without diagnosis of DM have higher risk factors for coronary heart disease.

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