Rectosigmoid Endometriosis Vascular Patterns at Intraoperative Indocyanine Green Angiography and their Correlation with Clinicopathological Data

2020 ◽  
pp. 155335062093014 ◽  
Author(s):  
Diego Raimondo ◽  
Manuela Mastronardi ◽  
Mohamed Mabrouk ◽  
Gabriella Cafagna ◽  
Paolo Salucci ◽  
...  
Keyword(s):  
Minimally Invasive Surgery ◽  
Pilot Study ◽  
Adverse Effects ◽  
Indocyanine Green ◽  
Indocyanine Green Angiography ◽  
Maximum Diameter ◽  
Direct Visualization ◽  
Prospective Pilot Study ◽  
Icg Angiography ◽  
Safe Technique

Introduction. The objective of the study was to evaluate the presence of different rectosigmoid endometriosis (RSE) vascular patterns using intraoperative indocyanine green (ICG) angiography and their correlation with clinicopathological data. Material and Methods. A prospective pilot study on 30 consecutive symptomatic women affected by RSE and scheduled for minimally invasive surgery between May 2018 and January 2019. ICG was used for the intraoperative evaluation of RSE vascularization. Perfusion grade was classified as follows: 0-1 = no or low fluorescence (hypovascular pattern); 2 = regular fluorescence, similar to healthy surrounding rectosigmoid tract (isovascular pattern); and 3-4 = diffuse or abundant fluorescence (hypervascular pattern). Results. Thirty women were intravenously injected with ICG after nodule exposure. No adverse effects related to ICG use were noted. After a 5- to 50-s latency from ICG injection, the real-time direct visualization of RSE perfusion showed diffuse or abundant fluorescence in 12/30 (40%) women, while in the remaining 18/30 (60%), fluorescence was poor or absent. No statistical differences were observed between the 2 groups regarding preoperative, intraoperative, and histological variables analyzed, except for a maximum diameter of bowel lesions and microvessel density (MVD). Hypovascular nodules had a larger maximum diameter (39.5 ± 15.6 mm vs 30.3 ± 11.4 mm, P < .05) and lower MVD (154.6+/43.6 vs 281.1+/−77.4, P < .05) than hypervascular ones. Conclusions. ICG angiography is a feasible and safe technique to intraoperatively assess RSE vascularization. The majority (60%) of endometriotic nodule presented a hypovascular pattern. The hypovascular pattern seems to be associated with a larger nodule size and lower MVD.

scholarly journals Evaluation of Idiopathic Choroidal Neovascularization with Indocyanine Green Angiography in Patients Undergoing Bevacizumab Therapy

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Ryan B. Rush ◽  
Sloan W. Rush
Keyword(s):  
Visual Acuity ◽  
Indocyanine Green ◽  
Choroidal Neovascularization ◽  
Indocyanine Green Angiography ◽  
Clinical Course ◽  
Intravitreal Bevacizumab ◽  
Clinical Implications ◽  
Snellen Visual Acuity ◽  
Icg Angiography

Purpose. To examine the clinical implications of change in choroidal neovascularization (CNV) size on indocyanine green (ICG) angiography in subjects with idiopathic CNV undergoing bevacizumab therapy.Methods. The charts of subjects with an idiopathic CNV treated by a modified PRN regimen with intravitreal bevacizumab over a 12-month period were retrospectively reviewed.Results. There were 34 subjects included in the analysis. Baseline CNV sizes of less than 1.0 mm2on ICG angiography correlated with complete CNV resolution (P=0.0404), fewer injections delivered (P=0.0002), and better Snellen visual acuity (P=0.0098) at 12 months. Subjects that experienced a 33% or more reduction in CNV size on ICG angiography at 2 months had complete CNV resolution (P=0.0047) and fewer injections (P<0.0001) at 12 months compared to subjects that did not experience a 33% or more reduction in CNV size on ICG angiography at 2 months.Conclusions. Smaller baseline CNV size on ICG angiography resulted in better visual acuity and fewer injections at 12 months, and a reduction of 33% or more in CNV size after 2 months may predict a better clinical course in subjects with idiopathic CNV undergoing bevacizumab therapy.

scholarly journals Usefulness of Indocyanine Green Angiography for Evaluation of Blood Supply in a Reconstructed Gastric Tube During Esophagectomy

2013 ◽  
Vol 97 (4) ◽  
pp. 340-344 ◽  
Author(s):  
Toru Ishiguro ◽  
Youichi Kumagai ◽  
Tomojiro Ono ◽  
Hideko Imaizumi ◽  
Hiroaki Honjo ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Indocyanine Green ◽  
Proton Pump ◽  
Gastric Tube ◽  
Indocyanine Green Angiography ◽  
Blood Perfusion ◽  
Gastric Ulcers ◽  
Subtotal Esophagectomy ◽  
Icg Angiography ◽  
Time Of Admission

Abstract We report a case of necrosis of a reconstructed gastric tube in a 77-year-old male patient who had undergone esophagectomy. At the time of admission, the patient had active gastric ulcers, but these were resolved by treatment with a proton pump inhibitor. Subtotal esophagectomy with gastric tube reconstruction was performed. Visually, the reconstructed gastric tube appeared to be well perfused with blood. Using indocyanine green (ICG) fluorescence imaging the gastroepiploic vessels were well enhanced and no enhancement was visable 3 to 4 cm from the tip of the gastric tube. Four days after esophagectomy, gastric tube necrosis was confirmed, necessitating a second operation. The necrosis of the gastric tube matched the area that had been shown to lack blood perfusion by ICG angiography imaging. It seems that ICG angiography is useful for the evaluation of perfusion in a reconstructed gastric tube.

Near-Infrared Imaging Using Intravenous Indocyanine Green at a Conventional Dose to Locate Pulmonary Metastases: A Pilot Study

2018 ◽  
Vol 67 (08) ◽  
pp. 688-691 ◽  
Author(s):  
Masatsugu Hamaji ◽  
Toyofumi Fengshi Chen-Yoshikawa ◽  
Manabu Minami ◽  
Hiroshi Date
Keyword(s):  
Computed Tomography ◽  
Pilot Study ◽  
Indocyanine Green ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Pulmonary Metastases ◽  
Pulmonary Metastasectomy ◽  
Maximum Diameter ◽  
Conventional Dose ◽  
Metastatic Lesions

AbstractIntravenous indocyanine green (ICG) has been reported to localize intra-abdominal metastatic lesions in several clinical trials. Our pilot study aimed to investigate the feasibility and safety of ICG fluorescence localization in pulmonary metastasectomy using a near-infrared fluorescence thoracoscope. Each patient received intravenous 0.25 or 0.5 mg/kg of ICG. The maximum diameter of the tumor on computed tomography ranged from 0.5 to 3.5 (median: 1.15) cm. Intravenous ICG injection localized pulmonary metastases in a portion (3 patients) of the enrolled patients. Our preliminary results provided us with important information to modify the study protocol.

scholarly journals Anaphylaxis during intraoperative indocyanine green angiography: A complication to watch out

2016 ◽  
Vol 03 (02) ◽  
pp. 126-128 ◽  
Author(s):  
Harnarayan Singh ◽  
Ankur Bajaj ◽  
Kiran Jangra ◽  
Sviashanmugam Dhandapani
Keyword(s):  
Indocyanine Green ◽  
Indocyanine Green Angiography ◽  
Icg Angiography

AbstractIndocyanine green (ICG) angiography is widely used in cerebrovascular neurosurgery. We would like to report a case of intraoperative anaphylaxis to ICG during aneurysmal clipping and a view from the neurosurgeons’ perspective during such an event.

scholarly journals Fluorescence image-guided lymphadenectomy using indocyanine green and near infrared technology during robotic gastrectomy: a prospective pilot study: IG-MIG Study

2019 ◽  
Vol 1 (1) ◽  
pp. 5-8
Author(s):  
Jacopo Desiderio ◽  
Anna Mariniello ◽  
Stefano Trastulli ◽  
Amilcare Parisi ◽  
Vito D'Andrea
Keyword(s):  
Gastric Cancer ◽  
Pilot Study ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Control Group ◽  
Cancer Type ◽  
Prospective Pilot Study ◽  
Experimental Group

Background: Gastric cancer is a worldwide challenge due to its spread, even epidemic in some areas, and the high mortality rates. Lymphadenectomy is considered the fundamental step during radical gastrectomy. In recent years, some researchers have tried to find a way to improve the surgical identifi cation of the lymphatic drainage routes and lymph node stations. This new surgical frontier is the so called “navigation surgery”. Among the diff erent reported solutions, lately, the indocyanine green (ICG) has drawn attention. It is a fluorescence dye, that can be detected in the near infrared spectral band (NIR). The development of specific fluorescence imaging devices has allowed surgeons to visualize tumors, vascular and lymphatic structures. The Da Vinci Xi robotic system has an integrated imaging technology that has been used in colo-rectal and hepatobiliary surgery. However, up to date, the combined use of fluorescence imaging and robotic technology has not been evaluated during lymphadenectomy in gastric cancer. Methods: General design: to evaluate the role of fluorescence imaging during robotic lymphadenectomy for gastric cancer. Type of study: interventional prospective pilot study. Duration: 18 months. Experimental group: patients undergoing dissection assisted by ICG. Control group: patients undergoing the same surgery without the injection of ICG. Primary outcomes: Fluorescent lymph nodes (FLNs) identification rate, accuracy of the procedure, comparison with the control group on the total number of lymph nodes retrieved. Sample size: 20 patients in the experimental group, 20 patients in the control group. Ethics: This study is conducted in compliance with ethical principles originating from the Helsinki Declaration, within the guidelines of Good Clinical Practice and relevant laws/regulations. Trial registration number: NCT03931044

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