scholarly journals Reference intervals for serum progastrin-releasing peptide in healthy Chinese adults with electrochemiluminescence immunoassay

2018 ◽  
Vol 33 (4) ◽  
pp. 482-486 ◽  
Author(s):  
Yuanqing Yang ◽  
Taiqing Zheng ◽  
Hongmin Jiang ◽  
Aiguo Tang ◽  
Zhongyuan Xiang
Keyword(s):  
Chinese Population ◽  
Clinical Work ◽  
Reference Intervals ◽  
Healthy Individuals ◽  
Chinese Adults ◽  
Geographical Regions ◽  
Electrochemiluminescence Immunoassay ◽  
Healthy Chinese ◽  
Age Range ◽  
Apparently Healthy

Background: Reliable reference intervals for serum progastrin-releasing peptide (ProGRP) in healthy Chinese adults with electrochemiluminescence immunoassay (ECLIA) are still lacking in the Chinese population. Objectives: The study aims to establish reference intervals for ProGRP with ECLIA in apparently healthy Chinese adults. Methods: A total of 384 apparently healthy individuals from six representative geographical regions in China were enrolled: 200 males and 184 females with a mean age of 43.4±12.2 years, and an age range from 21 to 85 years. Serum ProGRP levels were analyzed on Cobas e601 automatic immunoassay analyzer with ECLIA. Reference intervals for serum ProGRP with ECLIA were determined following CLSI C28-A3 guidelines using a nonparametric method. Results: In an apparently healthy Chinese population, the reference intervals for serum ProGRP with ECLIA were ⩽53.92 ng/L for adults aged 21–70 years and ⩽75.69 ng/L for adults aged >70 years, respectively. Conclusions: The reference values for serum ProGRP with ECLIA in an apparently healthy Chinese population were established according to the CLSI C28-A3 document, providing a reference for the clinical work.

Thyroid autoimmunity and thyroid hormone reference intervals in apparently healthy Chinese adults

2009 ◽  
Vol 405 (1-2) ◽  
pp. 156-159 ◽  
Author(s):  
Frank A. Quinn ◽  
May C.M. Tam ◽  
Philip T.L. Wong ◽  
Patrick K.W. Poon ◽  
Marianne S.T. Leung
Keyword(s):  
Thyroid Hormone ◽  
Thyroid Autoimmunity ◽  
Reference Intervals ◽  
Chinese Adults ◽  
Healthy Chinese ◽  
Apparently Healthy

Distribution of Measured GFR in Apparently Healthy Chinese Adults

2010 ◽  
Vol 56 (2) ◽  
pp. 420-421 ◽  
Author(s):  
Ying-Chun Ma ◽  
Li Zuo ◽  
Liang Chen ◽  
Zhi-Mei Su ◽  
Shen Meng ◽  
...  
Keyword(s):  
Chinese Adults ◽  
Healthy Chinese ◽  
Measured Gfr ◽  
Apparently Healthy

scholarly journals A Study on Medically Inclined Apparently Healthy Individuals Acquiring Urinary Tract Infections in North-Central, Nigeria

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Daniel David Otobo
Keyword(s):  
Urinary Tract ◽  
Nursing Students ◽  
Urinary Tract Infections ◽  
University Teaching ◽  
Healthy Individuals ◽  
Predisposing Factor ◽  
Medical College Campus ◽  
Tract Infections ◽  
Age Range ◽  
Apparently Healthy

Background: Urinary tract infections (UTI) simply the symptomatic or asymptomatic colonization of the kidneys, ureters, urinary bladder or/and the urethra by microorganisms, commonly bacteria. When these infections affect the kidneys, it is known as pyelonephritis. Objectives: To calculate the percentile risk of medically inclined apparently healthy individuals acquiring urinary tract infection. Methods: Written consent was sought on every questionnaire. It was carried out within the period of August to November, 2018. The study was done with over 160 persons; 154 questionnaires were accepted as properly filled. The questionnaires were gender specific. Persons cut across doctors, nurses, laboratory scientists, nursing students and medical students. The sampling study used was single blinded method. Areas studied were Plateau state (Jos University Teaching Hospital, Plateau Specialist Hospital and school of Midwifery; Vom), Abuja (University of Abuja Medical College Campus) and Nasarawa state (Bingham University). Data was collected, tabulated and classified into mild, moderate and high risks. (males, N = 71 with an age range of 19 - 45 years; females, N = 83 with an age range of 19 - 44 years). Results: Assessment criteria male/female low risk 42 (59.2%)/10 (12.0%), moderate risk 23 (32.4%)/29 (34.9%) and high risk 6 (08.5%)/44 (53.0%). Conclusions: Hygiene is a crucial factor in predisposition to UTI. Women are at higher risk of acquiring urinary tract infections. Sickle cell may be a predisposing factor to pyelonephritis.

Essential Data Derived from Biological Variation for Establishment and Use of Lipid Analyses

1989 ◽  
Vol 26 (3) ◽  
pp. 281-285 ◽  
Author(s):  
Robert P Ford
Keyword(s):  
General Population ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Population Based ◽  
Reference Intervals ◽  
High Density ◽  
Healthy Individuals ◽  
Apparently Healthy

The analytical and biological components of variation of total cholesterol, high density lipoprotein (HDL) cholesterol, HDL3 cholesterol, HDL2 cholesterol and apolipoproteins A-I and B in serum were assessed in 12 apparently healthy individuals. All analytes showed marked individuality and therefore conventional population based reference intervals are of little use. The differences required for serial results to have changed significantly for these assays were calculated. The data presented confirm that the assays studied have limited value in screening the general population.

Characteristic of the Prevalence of J Wave in Apparently Healthy Chinese Adults

2008 ◽  
Vol 39 (2) ◽  
pp. 232-235 ◽  
Author(s):  
Chen Kui ◽  
Huang Congxin ◽  
Wang Xi ◽  
Tang Yan-hong ◽  
Emmy Okello ◽  
...  
Keyword(s):  
Chinese Adults ◽  
Healthy Chinese ◽  
J Wave ◽  
Apparently Healthy

Biological variation of serum neurofilament light chain

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Claus Vinter Bødker Hviid ◽  
Anne Tranberg Madsen ◽  
Anne Winther-Larsen
Keyword(s):  
Light Chain ◽  
Reference Intervals ◽  
Biological Variation ◽  
Healthy Individuals ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Linear Mixed Effects ◽  
Serial Measurements ◽  
Analytical Variation ◽  
Apparently Healthy

Abstract Objectives The neurofilament light chain (NfL) has emerged as a versatile biomarker for CNS-diseases and is approaching clinical use. The observed changes in NfL levels are frequently of limited magnitude and in order to make clinical decisions based on NfL measurements, it is essential that biological variation is not confused with clinically relevant changes. The present study was designed to evaluate the biological variation of serum NfL. Methods Apparently healthy individuals (n=33) were submitted to blood draws for three days in a row. On the second day, blood draws were performed every third hour for 12 h. NfL was quantified in serum using the Simoa™ HD-1 platform. The within-subject variation (CVI) and between-subject variation (CVG) were calculated using linear mixed-effects models. Results The overall median value of NfL was 6.3 pg/mL (range 2.1–19.1). The CVI was 3.1% and the CVG was 35.6%. An increase in two serial measurements had to exceed 24.3% to be classified as significant at the 95% confidence level. Serum NfL levels remained stable during the day (p=0.40), whereas a minute variation (6.0–6.6 pg/mL) was observed from day-to-day (p=0.02). Conclusions Serum NfL is subject to tight homeostatic regulation with none or neglectable semidiurnal and day-to-day variation, but considerable between-subject variation exists. This emphasizes serum NfL as a well-suited biomarker for disease monitoring, but warrants caution when interpreting NfL levels in relation to reference intervals in a diagnosis setting. Furthermore, NfL’s tight regulation requires that the analytical variation is kept at a minimum.

scholarly journals Serum thyroid hormone reference intervals in the apparently healthy individuals of Zhengzhou area of China

2014 ◽  
Vol 13 (3) ◽  
pp. 7275-7281 ◽  
Author(s):  
P. Wang ◽  
Y.J. Gao ◽  
J. Cheng ◽  
G.L. Kong ◽  
Y. Wang ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Reference Intervals ◽  
Healthy Individuals ◽  
Serum Thyroid Hormone ◽  
Apparently Healthy

Establishing reference intervals for sex hormones and SHBG in apparently healthy Chinese adult men based on a multicenter study

2018 ◽  
Vol 56 (7) ◽  
pp. 1152-1160 ◽  
Author(s):  
Songlin Yu ◽  
Ling Qiu ◽  
Min Liu ◽  
Shijun Li ◽  
Zhihua Tao ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Multicenter Study ◽  
Reference Intervals ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Chinese Men ◽  
Adult Men ◽  
Age Related ◽  
Healthy Chinese ◽  
Apparently Healthy

AbstractBackground:Measuring sex hormones is essential in diagnosing health issues such as testicular dysfunction, male infertility and feminization syndrome. However, there are no reports on reference intervals (RIs) in Chinese men. We conducted a nationwide multicenter study to establish RIs for seven sex hormones (luteinizing hormone [LH], follicle-stimulating hormone [FSH], prolactin [PRL], total testosterone [TT], free testosterone [FT], bioavailable testosterone [BAT] and estrogen [E2]), as well as sex hormone-binding globulin (SHBG).Methods:In 2013, 1043 apparently healthy adult men from five representative cities in China (Beijing, Hangzhou, Guangzhou, Dalian and Urumqi) were recruited; hormones were measured using an automated immunoassay analyzer. Multiple regression analysis (MRA) was performed to identify sources of variation (SVs) that might influence the hormone serum levels. RIs were computed using the parametric method.Results:Dalian and Hangzhou had significantly higher E2 values than other cities; age was a major source of variation for FSH, LH, PRL, SHBG, FT and BAT. FSH, LH and SHBG increased significantly with age, while PRL, FT and BAT decreased with age. TT showed no significant age-related changes. Median (RIs) derived without partition by age were as follows: FSH, 5.6 (1.9–16.3) IU/L; LH, 4.2 (1.6–10.0) IU/L; PRL, 189 (88–450) mIU/L; E2, 85 (4.7–195) pmol/L; SHBG, 29.4 (11.5–66.3) nmol/L; TT, 15.6 (7.4–24.5) nmol/L; FT, 0.31 (0.16–0.52) nmol/L; and BAT, 8.0 (3.7–13.2) nmol/L. RIs were also derived in accordance with between-city and between-age differences.Conclusions: RIs were established for sex hormones and SHBG in apparently healthy Chinese men in consideration of age.

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