scholarly journals The influence of design variations in footwear medial-lateral support on the running biomechanics of older female runners

Author(s):  
Kim Lilley ◽  
Victoria Stiles ◽  
Sharon Dixon

Reports of greater incidence of knee pain and injury in older female runners compared with their younger counterparts may be associated with differences in lower limb biomechanics that influence knee joint loading. The aim of this study was to investigate footwear interventions aimed at influencing lower limb biomechanics in older female runners (>45 years). Strategies for reducing peak rearfoot eversion and the external knee adductor moment were investigated, since both measures have been associated with knee joint injury. Twenty female runners (mean age 50.7 ± 5.6 years) performed 10 running trials in four footwear conditions: neutral running shoe (Control); neutral shoe with 4° medial heel wedge insole (Medial Wedge); neutral shoe with 4° lateral heel wedge insole (Lateral Wedge); and neutral shoe with combined insole with 5° lateral wedge and medial arch support (Combined Insole). Peak rearfoot eversion and knee external adductor moment were compared for the four conditions using RMANOVA and post-hoc Tukey tests ( p < 0.05). Compared with the Control, peak rearfoot eversion was lower for the Combined Insole condition, with this value being lower than for all other insole conditions ( p < 0.05). Compared with the Control, the peak knee external adductor moment was lower for the Lateral Wedge and the Combined Insole conditions ( p < 0.05). These results support the use of a combined insole with lateral wedge and medial arch support for the reduction of peak rearfoot eversion and peak knee external adductor moment, variables that have been associated with increased risk of knee injury. If aiming to reduce knee external adductor moment alone, then the lateral wedge technology employed in this study provides an effective method for older female runners.

2019 ◽  
Vol 3 (18) ◽  
pp. 2700-2711 ◽  
Author(s):  
Chunyan Gao ◽  
Jocelyn A. Schroeder ◽  
Feng Xue ◽  
Weiqing Jing ◽  
Yuanhua Cai ◽  
...  

Key Points Hematopoietic cell–targeted antibody-drug conjugate preconditioning is highly effective for platelet gene therapy in hemophilia A mice. Platelet-specific FVIII gene therapy can effectively prevent a needle-induced knee joint injury in hemophilia A mice.


Cartilage ◽  
2020 ◽  
pp. 194760352094293
Author(s):  
Nikhil Potpally ◽  
Scott Rodeo ◽  
Paul So ◽  
Ken Mautner ◽  
Michael Baria ◽  
...  

The knee joint is one of the most frequently injured joints in the body, and the resulting injury may often lead to the presence of a bloody effusion, or hemarthrosis. The acute management of this condition can have long-lasting implications, and may ultimately result in the early onset of osteoarthritis in this population. Heme, a breakdown product of erythrocytes, and associated pro-inflammatory mediators, are known to have deleterious interactions with cartilage and synovium. The presence of blood in a joint following injury can precipitate these effects and accelerate the degenerative changes in the joint. Currently, there is no consensus on the optimal management of a traumatic knee joint injury with a hemarthrosis. Nontraumatic hemarthosis, seen most commonly in hemophilia patients, has a set of established guidelines that does not routinely recommend drainage of the joint. This article presents a rationale for joint aspiration to minimize the harmful effects of blood following traumatic hemarthrosis.


2006 ◽  
Vol 2006.55 (0) ◽  
pp. 143-144
Author(s):  
Kazutoshi NAKANO ◽  
Sota YAMAMOTO ◽  
Takayuki KUSHIDA ◽  
Eiichi TANAKA ◽  
Koji MIZUNO

2014 ◽  
Vol 22 ◽  
pp. S31-S32 ◽  
Author(s):  
J.L. Whittaker ◽  
L.J. Woodhouse ◽  
J.L. Jaremko ◽  
R. Krawetz ◽  
C.A. Emery

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