scholarly journals Safety and Functional Integrity of Continuous Glucose Monitoring Components After Simulated Radiologic Procedures

2020 ◽  
pp. 193229682092094 ◽  
Author(s):  
Christopher Thomas ◽  
John B. Welsh ◽  
Spencer Lu ◽  
J. Michael Gray

Background: We investigated wearable components of the Dexcom G6 continuous glucose monitoring (CGM) System in simulated therapeutic and diagnostic radiologic procedures. Methods: G6 transmitters were loaded with simulated glucose data and attached to sensors. Sets of sensor/transmitter pairs were exposed to x-rays to simulate a radiotherapeutic procedure and to radiofrequency (RF) and magnetic fields to simulate diagnostic magnetic resonance imaging (MRI). The x-ray simulation provided a cumulative dose of 80 Gy. The MRI simulation used RF fields oscillating at 64 or 128 MHz and magnetic fields of 1.5 or 3 T. During the MRI simulation, displacement force, induced heating, and induced currents were measured. After the simulations, bench tests were used to assess data integrity on the transmitters and responsiveness of sensors to various concentrations of aqueous glucose. Results: Glucose concentrations reported by sensor/transmitter pairs after undergoing x-irradiation or a simulated MRI exam were similar to those from control (unexposed) devices. During the 3 T MRI simulation, the devices experienced a displacement force of 306 g, which was insufficient to dislodge the sensor/transmitter from the substrate, RF-induced heating of <2°C, and an induced current of <16 pA. Data stored on the transmitters prior to the MRI simulation remained intact. Conclusion: Wearable components of the G6 CGM System retain basic functionality and data integrity after exposure to simulated therapeutic and diagnostic radiologic procedures. The devices are unlikely to be affected by x-irradiation used in typical imaging studies. Simulated MRI procedures create displacement force, minimal heating, and current in sensor/transmitter pairs.

Author(s):  
Gregory L. Finch ◽  
Richard G. Cuddihy

The elemental composition of individual particles is commonly measured by using energydispersive spectroscopic microanalysis (EDS) of samples excited with electron beam irradiation. Similarly, several investigators have characterized particles by using external monochromatic X-irradiation rather than electrons. However, there is little available information describing measurements of particulate characteristic X rays produced not from external sources of radiation, but rather from internal radiation contained within the particle itself. Here, we describe the low-energy (< 20 KeV) characteristic X-ray spectra produced by internal radiation self-excitation of two general types of particulate samples; individual radioactive particles produced during the Chernobyl nuclear reactor accident and radioactive fused aluminosilicate particles (FAP). In addition, we compare these spectra with those generated by conventional EDS.Approximately thirty radioactive particle samples from the Chernobyl accident were on a sample of wood that was near the reactor when the accident occurred. Individual particles still on the wood were microdissected from the bulk matrix after bulk autoradiography.


2016 ◽  
Vol 12 (S329) ◽  
pp. 369-372
Author(s):  
C. L. Fletcher ◽  
V. Petit ◽  
Y. Nazé ◽  
G. A. Wade ◽  
R. H. Townsend ◽  
...  

AbstractRecent spectropolarimetric surveys of bright, hot stars have found that ~10% of OB-type stars contain strong (mostly dipolar) surface magnetic fields (~kG). The prominent paradigm describing the interaction between the stellar winds and the surface magnetic field is the magnetically confined wind shock (MCWS) model. In this model, the stellar wind plasma is forced to move along the closed field loops of the magnetic field, colliding at the magnetic equator, and creating a shock. As the shocked material cools radiatively it will emit X-rays. Therefore, X-ray spectroscopy is a key tool in detecting and characterizing the hot wind material confined by the magnetic fields of these stars. Some B-type stars are found to have very short rotational periods. The effects of the rapid rotation on the X-ray production within the magnetosphere have yet to be explored in detail. The added centrifugal force due to rapid rotation is predicted to cause faster wind outflows along the field lines, leading to higher shock temperatures and harder X-rays. However, this is not observed in all rapidly rotating magnetic B-type stars. In order to address this from a theoretical point of view, we use the X-ray Analytical Dynamical Magnetosphere (XADM) model, originally developed for slow rotators, with an implementation of new rapid rotational physics. Using X-ray spectroscopy from ESA’s XMM-Newton space telescope, we observed 5 rapidly rotating B-types stars to add to the previous list of observations. Comparing the observed X-ray luminosity and hardness ratio to that predicted by the XADM allows us to determine the role the added centrifugal force plays in the magnetospheric X-ray emission of these stars.


Development ◽  
1977 ◽  
Vol 39 (1) ◽  
pp. 253-259
Author(s):  
M. Bownes ◽  
L. A. Sunnell

Drosophila embryos were treated at specific stages during early embryogenesis with various doses of X-irradiation. The lethality at various times during development was established and pattern defects in the adults noted. It was observed that the most sensitive stages of embryogenesis to X-ray-induced lethality were also the stages where most morphological defects were found in the adults which emerged. This suggests that presumptive larval and adult cells are sensitive to X-rays at the same stages of embryogenesis.


2010 ◽  
Vol 6 (S272) ◽  
pp. 208-209 ◽  
Author(s):  
Véronique Petit ◽  
Gregg A. Wade ◽  
Evelyne Alecian ◽  
Laurent Drissen ◽  
Thierry Montmerle ◽  
...  

AbstractIn some massive stars, magnetic fields are thought to confine the outflowing radiatively-driven wind. Although theoretical models and MHD simulations are able to illustrate the dynamics of such a magnetized wind, the impact of this wind-field interaction on the observable properties of a magnetic star - X-ray emission, photometric and spectral variability - is still unclear. The aim of this study is to examine the relationship between magnetism, stellar winds and X-ray emission of OB stars, by providing empirical observations and confronting theory. In conjunction with the COUP survey of the Orion Nebula Cluster, we carried out spectropolarimatric ESPaDOnS observations to determine the magnetic properties of massive OB stars of this cluster.


1993 ◽  
Vol 141 ◽  
pp. 258-262
Author(s):  
Taro Sakao

AbstractWe present hard X-ray imaging observations by Yohkoh of the 15 November, 1991 flare. The pre-impulsive and the impulsive phase observations are summarized as follows: (1) Hard X-ray sources in the precursor (or pre–impulsive) phase appear in a much wider area compared with the impulsive phase sources and they show clear evolution just before the onset of the impulsive phase. This suggests that some global re-structuring of coronal magnetic fields led to the impulsive energy release. (2) In the impulsive phase, at the peaks of the individual spikes of the time profile, the bulk of the hard X-ray emission (above 20 keV) originates from the footpoints of the flaring loop. At the valleys between the spikes, X-rays below 30 keV are emitted from near the loop top, while higher energy ones (above 30 keV) are still emitted from the footpoints. Such behavior of hard X-ray sources can be explained by the partial precipitation model.


1996 ◽  
Vol 21 (3) ◽  
pp. 384-387 ◽  
Author(s):  
M. ARNER ◽  
K. JONSSON ◽  
P. ASPENBERG

We report a case of complete palmar dislocation of the lunate in a rheumatoid patient. X-rays showed a normal bone structure of the lunate without sclerosis or collapse and on MRI an almost normal signal intensity was found. The lunate was removed. Histological examination showed complete necrosis of both marrow and bone cells, and tetracycline labelling showed no fluorescence. This case illustrates that neither X-ray nor magnetic resonance imaging (MRI) can detect complete bone necrosis. When X-ray or MRI changes do occur, these are indications of cellular events following some degree of spontaneous revascularization.


2008 ◽  
Vol 4 (S259) ◽  
pp. 449-452 ◽  
Author(s):  
Véronique Petit ◽  
G. A. Wade ◽  
L. Drissen ◽  
T. Montmerle ◽  
E. Alecian

AbstractIn massive stars, magnetic fields are thought to confine the outflowing radiatively-driven wind, resulting in X-ray emission that is harder, more variable and more efficient than that produced by instability-generated shocks in non-magnetic winds. Although magnetic confinement of stellar winds has been shown to strongly modify the mass-loss and X-ray characteristics of massive OB stars, we lack a detailed understanding of the complex processes responsible. The aim of this study is to examine the relationship between magnetism, stellar winds and X-ray emission of OB stars. In conjunction with a Chandra survey of the Orion Nebula Cluster, we carried out spectropolarimatric ESPaDOnS observations to determine the magnetic properties of massive OB stars of this cluster.


2013 ◽  
Vol 9 (S302) ◽  
pp. 330-333
Author(s):  
V. Petit ◽  
D. H. Cohen ◽  
Y. Nazé ◽  
M. Gagné ◽  
R. H. D. Townsend ◽  
...  

AbstractThe magnetic activity of solar-type and low-mass stars is a well known source of coronal X-ray emission. At the other end of the main sequence, X-rays emission is instead associated with the powerful, radiatively driven winds of massive stars. Indeed, the intrinsically unstable line-driving mechanism of OB star winds gives rise to shock-heated, soft emission (~0.5 keV) distributed throughout the wind. Recently, the latest generation of spectropolarimetric instrumentation has uncovered a population of massive OB-stars hosting strong, organized magnetic fields. The magnetic characteristics of these stars are similar to the apparently fossil magnetic fields of the chemically peculiar ApBp stars. Magnetic channeling of these OB stars' strong winds leads to the formation of large-scale shock-heated magnetospheres, which can modify UV resonance lines, create complex distributions of cooled Halpha emitting material, and radiate hard (~2-5 keV) X-rays. This presentation summarizes our coordinated observational and modelling efforts to characterize the manifestation of these magnetospheres in the X-ray domain, providing an important contrast between the emission originating in shocks associated with the large-scale fossil fields of massive stars, and the X-rays associated with the activity of complex, dynamo-generated fields in lower-mass stars.


1952 ◽  
Vol 35 (6) ◽  
pp. 865-871 ◽  
Author(s):  
E. S. Guzman Barron ◽  
S. Louise Seki

On x-irradiation of the eggs and sperm of Arbacia punctulata there was inhibition of respiration with relatively large doses, whereas there was an increase with small doses. The dose required to produce an increase of respiration depended on the degree of sensitivity of the cell to the effect of ionizing radiation. Sperm cells were more sensitive; then came fertilized eggs; unfertilized eggs were the least sensitive. The inhibiting effect of x-rays on cell division was observed even on irradiation with x-ray doses which produced an increase of respiration. These results are compared to similar effects produced by thiol reagents and are attributed to oxidation of the thiol compounds in the cell.


Keyword(s):  
X Rays ◽  
X Ray ◽  
The Past ◽  

1. It is well known that the accurate measurement of the energies of the secondary cathode rays excited by homogeneous X-rays can yield results capable of supplementing our knowledge of the most probable values of the fundamental atomic constants. this application of the "magnetic spectrograph" has already been discussed by one of us in some detail, and kretschmar has published an account of accurate measurements on X-ray electrons, from which he has deduced very consistent values of e / m 0 . In this work Kretschmar used molybdenum K radiations, and produced his magnetic fields by a large solenoid. 2. We have during the past fifteen months photographed a large number of secondary cathode-ray spectra, using cooper K as primary X radiation. For a few elements, for which the results will be detailed later in this paper, we have made very careful measurements of the energies, cross-checking the observations by working in a wide range magnetic fields.


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