How It Started, How It Is Going: The Future of Artificial Pancreas Systems (Automated Insulin Delivery Systems)

2021 ◽  
pp. 193229682110275
Author(s):  
Dana Lewis
Keyword(s):  
First Generation ◽  
Artificial Pancreas ◽  
Insulin Delivery ◽  
Delivery Systems ◽  
Diabetes Therapy ◽  
Unmet Expectations ◽  
The Future ◽  
Time In Range ◽  
Improved Technology

Originally, the future of automated insulin delivery (AID) systems, or artificial pancreas systems (APS), was having them at all, in any form. We’ve learned in the last half dozen years that the future of all artificial pancreas systems holds higher time in range, less work required to manage automated insulin delivery systems to improve quality of life, and the ability to input critical information back into the system itself. The data and user experience stories make it clear: APS works. APS are an improvement over other diabetes therapy methods when they are made available, accessible, and affordable. Understanding the unmet expectations of current users of first generation APS technology may also aid in the development of improved technology and user experiences for the future of APS.

scholarly journals The future of open- and closed-loop insulin delivery systems

2008 ◽  
Vol 60 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Terry G. Farmer ◽  
Thomas F. Edgar ◽  
Nicholas A. Peppas
Keyword(s):  
Closed Loop ◽  
Insulin Delivery ◽  
Delivery Systems ◽  
The Future

Therapeutic Advancements in the Management of Diabetes Mellitus with Special Reference to Nanotechnology

2020 ◽  
Vol 26 (38) ◽  
pp. 4909-4916
Author(s):  
Pallavi Singh Chauhan ◽  
Dhananjay Yadav ◽  
Shivam Tayal ◽  
Jun-O Jin
Keyword(s):  
Quality Of Life ◽  
Blood Glucose ◽  
Special Reference ◽  
Insulin Delivery ◽  
Delivery Systems ◽  
Glucose Sensors ◽  
Glucose Levels ◽  
Sensing Systems ◽  
Blood Glucose Levels

For improvisation of diabetic’s quality of life, nanotechnology is facilitating the development of advanced glucose sensors as well as efficient insulin delivery systems. Our prime focus of the review is to highlight the advancement in diabetic research with special reference to nanotechnology at its interface. Recent studies are more focused on enhancing sensitivity, accuracy, and response by employing metal as well as nanoparticles based glucose sensors. Moreover, the review focuses on nanoscale based approaches i.e. closed-loop insulin delivery systems, which detect any fluctuation in blood glucose levels and allow controlled release of a drug, thus are also called self-regulating insulin release system. Additionally, this review summarizes the role of nanotechnology in the diagnosis and treatment of diabetic complications through little advancement in the existing techniques. To improve health, as well as the quality of life in diabetic’s new sensing systems for blood glucose level evaluation and controlled administration of drugs through efficient drug delivery systems should be explored.

scholarly journals A boronate gel-based synthetic platform for closed-loop insulin delivery systems

2021 ◽  
Author(s):  
Akira Matsumoto ◽  
Siyuan Chen
Keyword(s):  
Closed Loop ◽  
Diabetes Management ◽  
Phenylboronic Acid ◽  
Insulin Delivery ◽  
Skin Layer ◽  
Delivery Systems ◽  
Controlled Diffusion ◽  
Number Of Patients ◽  
Life Threatening

AbstractDiabetes is one of the most devastating global diseases with an ever-increasing number of patients. Achieving persistent glycemic control in a painless and convenient way is an unmet goal for diabetes management. Insulin therapy is commonly utilized for diabetes treatment and usually relies on patient self-injection. This not only impairs a patient’s quality of life and fails to precisely control the blood glucose level but also brings the risk of life-threatening hypoglycemia. “closed-loop” insulin delivery systems could avoid these issues by providing on-demand insulin delivery. However, safety concerns limit the application of currently developed electronics-derived or enzyme-based systems. Phenylboronic acid (PBA), with the ability to reversibly bind glucose and a chemically tailored binding specificity, has attracted substantial attention in recent years. This focus review provides an overview of PBA-based versatile insulin delivery platforms developed in our group, including new PBA derivatives, glucose-responsive gels, and gel-combined medical devices, with a unique “skin layer” controlled diffusion feature.

scholarly journals Automated Insulin Delivery in Real Life (AID-IRL): Real-World User Perspectives on Commercial AID

2020 ◽  
pp. 193229682095736
Author(s):  
Dana Lewis
Keyword(s):  
Clinical Outcomes ◽  
Real World ◽  
Real Life ◽  
Insulin Delivery ◽  
Continuous Glucose Monitor ◽  
Algorithm Performance ◽  
Training Materials ◽  
Time In Range ◽  
User Perspectives

Commercial automated insulin delivery (AID) systems are usually assessed based on clinical outcomes, ignoring uptake. A qualitative study evaluated user experiences when switching to currently available commercial AID. Interview feedback was coded on key themes including the adoption experience with regards to quality of life, clinical outcomes, and users’ expectations. Most felt their learning curve was easy. Most saw reduced hypoglycemia and increased time in range, although there were outliers. Many mentioned post-meal hyperglycemia as an improvement area for commercial AID. Users with one particular continuous glucose monitor (CGM) type reported sleep disruption. Companies should consider real-world user feedback with regards to improving training materials for new users with less CGM experience and by improving target flexibility and postprandial algorithm performance, plus reducing manual interventions required by users.

Time In Range in Children with Type 1 Diabetes Using Treatment Strategies Based on Nonautomated Insulin Delivery Systems in the Real World

2020 ◽  
Vol 22 (7) ◽  
pp. 509-515 ◽  
Author(s):  
Valentino Cherubini ◽  
Riccardo Bonfanti ◽  
Alberto Casertano ◽  
Elena De Nitto ◽  
Antonio Iannilli ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Real World ◽  
Treatment Strategies ◽  
Insulin Delivery ◽  
Delivery Systems ◽  
The Real ◽  
Time In Range

scholarly journals Open Source Closed-Loop Insulin Delivery Systems: A Clash of Cultures or Merging of Diverse Approaches?

2018 ◽  
Vol 12 (6) ◽  
pp. 1223-1226 ◽  
Author(s):  
Katharine D. Barnard ◽  
Ralph Ziegler ◽  
David C. Klonoff ◽  
Katarina Braune ◽  
Bettina Petersen ◽  
...  
Keyword(s):  
Closed Loop ◽  
Therapeutic Option ◽  
Artificial Pancreas ◽  
Psychosocial Care ◽  
Insulin Delivery ◽  
Delivery Systems ◽  
Target Range ◽  
Related Quality ◽  
Do It Yourself ◽  
Glycemic Target

Biomedical outcomes for people with diabetes remain suboptimal for many. Psychosocial care in diabetes does not fare any better. “Artificial pancreas” (also known as “closed-loop” and “automated insulin delivery”) systems present a promising therapeutic option for people with diabetes (PWD)—simultaneously improving glycemic outcomes, reducing the burden of self-management, and improving health-related quality of life. In recent years there has emerged a growing movement of PWD innovators rallying behind the mantra #WeAreNotWaiting, developing “do-it-yourself artificial pancreas systems (DIY APS).” Self-reported results by DIY APS users show improved metabolic outcomes such as impressive stability of glucose profiles, significant reduction of A1c, and more time within their glycemic target range. However, the benefits remain unclear for the broader population of PWD beyond these highly engaged, highly tech-savvy users willing and able to engage in the demands of building and maintaining their DIY APS. We discuss the challenges faced by key stakeholder groups in terms of potential collaboration and open debate of these challenges.

Using the alveograph in developing requirements for the quality of flour for wafer sheet production

2020 ◽  
Vol 29 (12) ◽  
pp. 52-58
Author(s):  
E.P. Meleshkina ◽  
◽  
S.N. Kolomiets ◽  
A.S. Cheskidova ◽  
◽  
...  
Keyword(s):  
Rheological Properties ◽  
Quality Indicators ◽  
Wheat Flour ◽  
Mathematical Statistics ◽  
Intended Purpose ◽  
The Future ◽  
Relationship Of ◽  
The Relationship

Objectively and reliably determined indicators of rheological properties of the dough were identified using the alveograph device to create a system of classifications of wheat and flour from it for the intended purpose in the future. The analysis of the relationship of standardized quality indicators, as well as newly developed indicators for identifying them, differentiating the quality of wheat flour for the intended purpose, i.e. for finished products. To do this, we use mathematical statistics methods.

Can trust become a factor of economic growth? Dynamic changes in the level of trust of Russian youth

2020 ◽  
pp. 92-107 ◽  
Author(s):  
A. I. Bakhtigaraeva ◽  
A. A. Stavinskaya
Keyword(s):  
Institutional Environment ◽  
Negative Effects ◽  
Dynamic Changes ◽  
Generalized Trust ◽  
Level Of Education ◽  
Advantages And Disadvantages ◽  
The Future ◽  
Analysis Of Dynamics

The article considers the role of trust in the economy, the mechanisms of its accumulation and the possibility of using it as one of the growth factors in the future. The advantages and disadvantages of measuring the level of generalized trust using two alternative questions — about trusting people in general and trusting strangers — are analyzed. The results of the analysis of dynamics of the level of generalized trust among Russian youth, obtained within the study of the Institute for National Projects in 10 regions of Russia, are presented. It is shown that there are no significant changes in trust in people in general during the study at university. At the same time, the level of trust in strangers falls, which can negatively affect the level of trust in the country as a whole, and as a result have negative effects on the development of the economy in the future. Possible causes of the observed trends and the role of universities are discussed. Also the question about the connection between the level of education and generalized trust in countries with different quality of the institutional environment is raised.

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