Cytotoxic Activity of Cycloartane Triterpenoids from Sphaerophysa Salsula
2009 ◽
Vol 4
(1)
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pp. 1934578X0900400
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The cytotoxicity of three cycloartane triterpenoids, 9, 19-cycloart-7β, 24R, 25- triol-1-en-3-one (1), 9, 19-cycloart-7β, 24R, 25-triol-1-en-3-one 25-O-β-D-glucopynanoside (2), and 25-O-β-D-arabinopyranosyl-(1→4)- β-D-glucopyranosyl-9, 19-cycloart-7β, 24R, 25-triol-1-en-3-one (3), isolated from Sphaerophysa salsula was investigated on SF188, U87wt, MCF-7, and H460 cancer cell lines. Compound 1 showed the strongest activity. Cell cycle analysis was employed to elucidate the cytotoxicity on the tested U87wt cells, which led to G2/M arrest. In addition, from the Western blotting experiments, the expression of P21 is increased.
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2018 ◽
Vol 8
(3)
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pp. 159
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2020 ◽
Vol 19
(16)
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pp. 2010-2018
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2019 ◽
Vol 19
(15)
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pp. 1874-1886
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2017 ◽
Vol 17
(1)
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