scholarly journals Antifungal Activity of Hydrochloride Salts of Tylophorinidine and Tylophorinine

2012 ◽  
Vol 7 (9) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Mini Dhiman ◽  
Rajashri R. Parab ◽  
Sreedharannair L. Manju ◽  
Dattatraya C. Desai ◽  
Girish B. Mahajan
Keyword(s):  
Antifungal Activity ◽  
Candida Species ◽  
Antibacterial Activities ◽  
Antimicrobial Efficacy ◽  
Tylophora Indica ◽  
Minimum Inhibitory Concentrations ◽  
Phenanthroindolizidine Alkaloids

The antimicrobial efficacy of two phenanthroindolizidine alkaloids, tylophorinidine hydrochloride (TdnH) and tylophorinine hydrochloride (TnnH), isolated from the plant Tylophora indica (local name, Antamul) was evaluated. These were screened for in vitro antifungal and antibacterial activities. Both compounds exhibited potent antifungal activity displaying minimum inhibitory concentrations (MIC) in the range of 2-4 μg/mL for TdnH and 0.6-2.5 μg/mL for TnnH against Candida species.

scholarly journals Antifungal and Antibacterial Metabolites from a French Poplar Type Propolis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Séverine Boisard ◽  
Anne-Marie Le Ray ◽  
Anne Landreau ◽  
Marie Kempf ◽  
Viviane Cassisa ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Effect ◽  
Antibacterial Activities ◽  
Dilution Method ◽  
Agar Dilution Method ◽  
Gram Positive ◽  
Weak Activity ◽  
Agar Dilution

During this study, thein vitroantifungal and antibacterial activities of different extracts (aqueous and organic) obtained from a French propolis batch were evaluated. Antifungal activity was evaluated by broth microdilution on three pathogenic strains:Candida albicans, C. glabrata, andAspergillus fumigatus. Antibacterial activity was assayed using agar dilution method on 36 Gram-negative and Gram-positive strains includingStaphylococcus aureus. Organic extracts showed a significant antifungal activity againstC. albicansandC. glabrata(MIC80between 16 and 31 µg/mL) but only a weak activity towardsA. fumigatus(MIC80= 250 µg/mL). DCM based extracts exhibited a selective Gram-positive antibacterial activity, especially againstS. aureus(SA) and several of its methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains (MIC10030–97 µg/mL). A new and active derivative of catechin was also identified whereas a synergistic antimicrobial effect was noticed during this study.

In vitro antifungal activity of the flavonoid baicalein against Candida species

2012 ◽  
Vol 61 (12) ◽  
pp. 1704-1708 ◽  
Author(s):  
Rosana Serpa ◽  
Emanuele J. G. França ◽  
Luciana Furlaneto-Maia ◽  
Célia G. T. J. Andrade ◽  
Andréa Diniz ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Candida Species ◽  
In Vitro Antifungal Activity

scholarly journals In vitro antifungal activity against Candida species of Sri Lankan orthodox black tea (Camellia sinensis L.) belonging to different agro-climatic elevations

2017 ◽  
Vol 5 (2) ◽  
pp. 66-69 ◽  
Author(s):  
Wanigasekara Daya Ratnasooriya ◽  
◽  
Sachitra Gayanthi Ratnasooriya ◽  
Chatura Dayendra Tissa Ratnasooriya ◽  
Ranga Dissanayake ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Camellia Sinensis ◽  
Candida Species ◽  
Black Tea ◽  
Sri Lankan ◽  
In Vitro Antifungal Activity

Antifungal effect of anthraquinones against Cryptococcus neoformans: detection of synergism with amphotericin B

2020 ◽  
Author(s):  
Raimunda Sâmia Nogueira Brilhante ◽  
Géssica dos Santos Araújo ◽  
Xhaulla Maria Quariguasi Cunha Fonseca ◽  
Glaucia Morgana de Melo Guedes ◽  
Lara de Aguiar ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Cryptococcus Neoformans ◽  
Amphotericin B ◽  
Antimicrobial Properties ◽  
Pharmacological Interaction ◽  
Minimum Inhibitory Concentrations ◽  
Broth Microdilution Method ◽  
Aloe Emodin ◽  
Vitro Effect

Abstract The emergence of tolerant Cryptococcus neoformans strains to antifungals has been described. It has directed researchers to screen for new antimicrobial compounds. In this context, several plant-derived compounds, such as anthraquinones (aloe emodin, barbaloin, and chrysophanol), have been investigated for their antimicrobial properties. This study aimed to evaluate the in vitro effect of aloe emodin, barbaloin and chrysophanol on C. neoformans in vitro growth. In addition, the interaction between these anthraquinones and amphotericin B and itraconazole was evaluated. Initially, the minimum inhibitory concentrations (MIC) of these compounds were determined against 17 strains of C. neoformans by the broth microdilution method and then pharmacological interaction assays were performed with 15 strains by the checkerboard method. Aloe emodin, barbaloin, and chrysophanol showed minimum inhibitory concentrations of 236.82–473.65 μM (64–128 μg/mL), 153–306 μM (64–128 μg/ml) and ≥1007 μM (≥256 μg/ml), respectively. Furthermore, aloe emodin (11/15), barbaloin (13/15), and chrysophanol (12/15) showed pharmacological synergism (FICI < 0.5) with amphotericin B at subinhibitory concentrations (MIC/4). The itraconazole-aloe emodin interaction was additive (1/15) (0.5 < FICI < 1.0). The itraconazole-barbaloin interaction were synergistic (2/15) and additive (5/15); whereas itraconazole-chrysophanol interactions were additive (2/15). Anthraquinones, especially aloe emodin and barbaloin, present in vitro antifungal activity against C. neoformans and potentiate the antifungal activity of amphotericin B.

scholarly journals Antifungal Activity of an Original Amino-Isocyanonaphthalene (ICAN) Compound Family: Promising Broad Spectrum Antifungals

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 903
Author(s):  
Miklós Nagy ◽  
Gábor Szemán-Nagy ◽  
Alexandra Kiss ◽  
Zsolt László Nagy ◽  
László Tálas ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Candida Species ◽  
Fungal Pathogens ◽  
Clinical Strain ◽  
Control Group ◽  
Multiple Drug ◽  
Species Structure ◽  
In Vivo Experiments

Multiple drug resistant fungi pose a serious threat to human health, therefore the development of completely new antimycotics is of paramount importance. The in vitro antifungal activity of the original, 1-amino-5-isocyanonaphthalenes (ICANs) was evaluated against reference strains of clinically important Candida species. Structure-activity studies revealed that the naphthalene core and the isocyano- together with the amino moieties are all necessary to exert antifungal activity. 1,1-N-dimethylamino-5-isocyanonaphthalene (DIMICAN), the most promising candidate, was tested further in vitro against clinical isolates of Candida species, yielding a minimum inhibitory concentration (MIC) of 0.04–1.25 µg/mL. DIMICAN was found to be effective against intrinsically fluconazole resistant Candida krusei isolates, too. In vivo experiments were performed in a severly neutropenic murine model inoculated with a clinical strain of Candida albicans. Daily administration of 5 mg/kg DIMICAN intraperitoneally resulted in 80% survival even at day 13, whereas 100% of the control group died within six days. Based on these results, ICANs may become an effective clinical lead compound family against fungal pathogens.

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