Synthetic Approach toward α-Aminomethyl-γ-butyrolactones from β-Lactam Synthons Elaborated by SmI2-mediated Reductive Coupling Reactions
2013 ◽
Vol 8
(7)
◽
pp. 1934578X1300800
Keyword(s):
A simple and straightforward synthetic approach was developed to access a biologically important class of α-aminomethyl-γ-butyrolactones via a β-lactam synthon strategy involving successive ring-opening and lactonization processes from α-hydroxyethyl-substituted β-lactams that were elaborated by SmI2-mediated reductive coupling reaction.
2020 ◽
2018 ◽
Vol 15
(7)
◽
pp. 989-994
◽