scholarly journals A Facile Synthesis of (±)-Heliannuol-D

2013 ◽  
Vol 8 (9) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Tao Zhang ◽  
Liang-Zhu Huang ◽  
You-Qiang Li ◽  
Yimg-Meng Xu ◽  
Zhen-Ting Du
Keyword(s):  
Intramolecular Cyclization ◽  
Cost Effective ◽  
Synthetic Approach ◽  
Lead Compound ◽  
Facile Synthesis ◽  
New Generation

A facile synthesis of (±)-heliannuol-D 1, which serves as an allelopathic chemical in nature and a potential lead compound in the search for new herbicides, has been achieved in a linear 11 steps, together with its epimer. The synthesis commenced with 4-methoxy-3-methyl-acetophenone, through the Baeyer-Villiger reaction, lithiation and addition, epoxidation and intramolecular cyclization to give (±)-heliannuol-D (1) and its epimer (1a) in 32.6% overall yield. Our synthetic approach is cost-effective; this will be helpful in applying this kind of compound for the development of a new generation of agrochemicals.

Visible light driven metal-free intramolecular cyclization: a facile synthesis of 3-position substituted 3,4-dihydroisoquinolin-1(2H)-one

2019 ◽  
Vol 17 (2) ◽  
pp. 380-387 ◽  
Author(s):  
Shuai Zou ◽  
Shu Geng ◽  
Lina Chen ◽  
Haitao Wang ◽  
Feng Huang
Keyword(s):  
Visible Light ◽  
Intramolecular Cyclization ◽  
Facile Synthesis ◽  
Metal Free ◽  
Visible Light Driven

Visible light driven metal-free intramolecular cyclization: a facile synthesis of 3-position substituted 3,4-dihydroisoquinolin-1(2H)-one.

Facile synthesis and properties of a new generation of soluble and thermally stable polyimides

2010 ◽  
Vol 95 (12) ◽  
pp. 2603-2610 ◽  
Author(s):  
Ayesha Kausar ◽  
Sonia Zulfiqar ◽  
Zahoor Ahmad ◽  
Muhammad Ilyas Sarwar
Keyword(s):  
Thermally Stable ◽  
Facile Synthesis ◽  
New Generation

scholarly journals Modelling of new generation plasma optical devices

Nukleonika ◽  
2016 ◽  
Vol 61 (2) ◽  
pp. 207-212 ◽  
Author(s):  
Irina V. Litovko ◽  
Alexy A. Goncharov ◽  
Andrew N. Dobrovolskiy ◽  
Lily V. Naiko ◽  
Irina V. Naiko
Keyword(s):  
Low Cost ◽  
Rocket Engine ◽  
Cost Effective ◽  
Optical Devices ◽  
High Tech ◽  
Practical Applications ◽  
Plasma Accelerators ◽  
New Generation ◽  
Closed Electron ◽  
Positive Space

Abstract The paper presents new generation plasma optical devices based on the electrostatic plasma lens configuration that opens a novel attractive possibility for effective high-tech practical applications. Original approaches to use of plasma accelerators with closed electron drift and open walls for the creation of a cost-effective low-maintenance plasma lens with positive space charge and possible application for low-cost, low-energy rocket engine are described. The preliminary experimental, theoretical and simulation results are presented. It is noted that the presented plasma devices are attractive for many different applications in the state-of-the-art vacuum-plasma processing.

scholarly journals A Facile Synthesis and Characterization of Highly Crystalline Submicro-Sized BiFeO3

Materials ◽  
2020 ◽  
Vol 13 (13) ◽  
pp. 3035
Author(s):  
Dovydas Karoblis ◽  
Diana Griesiute ◽  
Kestutis Mazeika ◽  
Dalis Baltrunas ◽  
Dmitry V. Karpinsky ◽  
...  
Keyword(s):  
Bismuth Ferrite ◽  
Cost Effective ◽  
Xrd Analysis ◽  
Synthetic Approach ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Dsc Measurements ◽  
Optimal Annealing Temperature ◽  
Synthesized Materials

In this study, a highly crystalline bismuth ferrite (BFO) powder was synthesized using a novel, very simple, and cost-effective synthetic approach. It was demonstrated that the optimal annealing temperature for the preparation of highly-pure BFO is 650 °C. At lower or higher temperatures, the formation of neighboring crystal phases was observed. The thermal behavior of BFO precursor gel was investigated by thermogravimetric and differential scanning calorimetry (TG-DSC) measurements. X-ray diffraction (XRD) analysis and Mössbauer spectroscopy were employed for the investigation of structural properties. Scanning electron microscopy (SEM) was used to evaluate morphological features of the synthesized materials. The obtained powders were also characterized by magnetization measurements, which showed antiferromagnetic behavior of BFO powders.

scholarly journals Designing a new generation of expression toolkits for engineering of green microalgae; robust production of human interleukin-2

Bioimpacts ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 259-268
Author(s):  
Jaber Dehghani ◽  
Khosro Adibkia ◽  
Ali Movafeghi ◽  
Mohammad M. Pourseif ◽  
Yadollah Omidi
Keyword(s):  
Recombinant Proteins ◽  
Interleukin 2 ◽  
Cost Effective ◽  
Total Soluble Protein ◽  
Post Translational Modifications ◽  
Unstable Gene ◽  
Protein Synthesis Machinery ◽  
Wide Range ◽  
High Transformation ◽  
New Generation

Introduction: Attributable to some critical features especially the similarity of the protein synthesis machinery between humans and microalgae, these microorganisms can be utilized for the expression of many recombinant proteins. However, low and unstable gene expression levels prevent the further development of microalgae biotechnology towards protein production. Methods: Here, we designed a novel "Gained Agrobacterium-2A plasmid for microalgae expression" (named GAME plasmid) for the production of the human interleukin-2 using three model microalgae, including Chlamydomonas reinhardtii, Chlorella vulgaris, and Dunaliella salina. The GAME plasmid harbors a native chimeric hsp70/Int-1/rbcS2 promoter, the microalgae specific Kozak sequence, a novel hybrid 2A peptide, and Int-1 and Int-3 of the rbcS2 gene in its expression cassette. Results: The obtained data confirmed that the GAME plasmid can transform the microalgae with high transformation frequency. Molecular and proteomic analyses revealed the stable and robust production of the hIL-2 by the GAME plasmid in the microalgae. According to the densimetric analysis, the microalgae can accumulate the produced protein about 0.94% of the total soluble protein content. The ELISA data confirmed that the produced hIL-2 possesses the same conformation pattern with the acceptable biological activity found naturally in humans. Conclusion: Most therapeutic proteins need post-translational modifications for their correct conformation, biological function, and half-life. Accordingly, microalgae could be considered as a cost-effective and more powerful platform for the production of a wide range of recombinant proteins such as antibodies, enzymes, hormones, and vaccines.

scholarly journals Development of energy-efficient method for processing industrial waste

2019 ◽  
Vol 4 (311) ◽  
pp. 82-92
Author(s):  
B. I. Dikhanbayev ◽  
◽  
A.B. Dikhanbayev ◽  
Keyword(s):  
Rotary Kiln ◽  
Ferrous Metal ◽  
Cost Effective ◽  
Specific Productivity ◽  
Phase Layer ◽  
Industrial Sample ◽  
Ideal Displacement ◽  
Ideal Mixing ◽  
Waelz Kiln ◽  
New Generation

An energy-saving method for processing technogenic waste has been developed — a smelt layer with inversion phase as a combination of “ideal” mixing and “ideal” displacement regimes. On its basis, a new generation of melting unit was created - the “reactor inversion phase - rotary kiln”. Experimental data show that in the inversion phase layer the specific fuel consumption for processing the “poor” on zinc and “rich” on zinc slags is approximately the same. The latter provision contradicts the prevailing opinion of metallurgists that the processing of slag with a zinc concentration of less than 5% is unprofitable. Сalculation results demonstrate that in case of implementation of an industrial sample of “reactor inversion phase - rotary kiln for processing “poor” slag, compared to the Waelz kiln processing “rich” slag, the specific consumption of fuel will be reduced by 1.5-1.7 times and specific productivity will increase 1.4-1.5 times. The industrial realization of “reactor inversion phase -rotary kiln” would allow cost-effective processing of fuming slag dumps, Waelz clinker, “poor” zinc ores, enrichment tails and other non-ferrous metal wastes.

Synthesis of a Dihydroxy-Substituted Aminoxyl Spin Label and its Crown Ether and Cyclic Diester Derivatives

1993 ◽  
Vol 48 (4) ◽  
pp. 505-510 ◽  
Author(s):  
Yong-Kang Zhang ◽  
De-Kang Shen
Keyword(s):  
Crown Ether ◽  
Intramolecular Cyclization ◽  
Spin Label ◽  
Cyclic Ether ◽  
Synthetic Approach ◽  
Aminoxyl Radicals

A novel dihydroxy-substituted aminoxyl spin label, 4-hydroxy-3-(3'-hydroxypropyl)-2,2,6,6-tetramethylpiperidine-1-oxy (5), has been prepared. From this aminoxyl radical, a spin-labeled crown ether, 16,16,18,18-tetramethyl-2,5,8,11-tetraoxa-17-azabicyclo[ 13,4,0]-nonadecane-17-oxy (12), and a spin-labeled cyclic diester, 16,16,18,18-tetramethyl-3,10-dioxo-2,5,8,11-tetraoxa-17-azabicyclo[13,4,o]nonadecane-17-oxy (13), have been acquired. Other four new stable aminoxyl radicals 8,9,10, and 11 have also been obtained within the synthetic approach. It has been demonstrated that the cyclic ether compound (7) is generated by the reduction of its corresponding lactone which is sidely derived from the oxo-reduced species of 3 by intramolecular cyclization.

Diversity-Oriented Synthesis via Catalyst-Free Addition of Ketones to [e]-Fused 1H-Pyrrole-2,3-diones

Synthesis ◽  
2018 ◽  
Vol 50 (24) ◽  
pp. 4897-4904 ◽  
Author(s):  
Ekaterina Stepanova ◽  
Andrey Maslivets ◽  
Svetlana Kasatkina ◽  
Maksim Dmitriev
Keyword(s):  
Intramolecular Cyclization ◽  
Aromatic Hydrocarbons ◽  
Michael Addition ◽  
Aldol Reaction ◽  
Synthetic Approach ◽  
Reaction Conditions ◽  
Diversity Oriented Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions ◽  
Reaction Proceeds

A facile synthetic approach towards two distinct pyrrole-based heterocyclic scaffolds has been developed by the interaction of 1H-pyrrole-2,3-diones fused at the [e]-side to a 1,4-benzoxazin-2-one or quinoxalin-2(1H)-one moiety with ketones. The described interaction proceeds either as an aldol reaction or as a Michael addition/intramolecular cyclization depending on the reaction conditions. The disclosed aldol reaction proceeds with good diastereoselectivity under catalyst-free conditions when the reaction is carried out in aromatic hydrocarbons. Products of the cascade Michael addition/intramolecular cyclization reaction are predominantly formed under catalyst-free and solvent-free conditions. The proposed strategy provides facile access to pharmaceutically interesting pyrrole-based polyheterocycles.

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