scholarly journals 5α,8α-Epidioxysterols from a Formosan Sponge, Axinyssa sp

2013 ◽  
Vol 8 (11) ◽  
pp. 1934578X1300801
Author(s):  
Tzu-Rong Su ◽  
Kai-Ju Liang ◽  
Michael Y. Chiang ◽  
Mei-Chin Lu ◽  
Yu-Jen Wu ◽  
...  
Keyword(s):  
Single Crystal ◽  
Diffraction Analysis ◽  
Cell Lines ◽  
Cancer Cell ◽  
Absolute Configuration ◽  
Cancer Cell Lines ◽  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
X Ray ◽  
First Time

One new 5α,8α-epidioxysterol, 3-acetylaxinysterol (1), along with one known sterol, axinysterol (2), were isolated from a Formosan sponge, Axinyssa sp.. The structures of the compounds were determined by spectroscopic methods and the absolute configuration of 2 was further confirmed by single-crystal X-ray diffraction analysis for the first time. Compound 2 exhibited significant cytotoxicity against K562 and Molt 4 cancer cell lines.

scholarly journals Jatroidaine A: a New Tetranortirucallane Type Triterpene from Jatropha multifida

2021 ◽  
Vol 15 (5) ◽  
pp. 408-413
Author(s):  
Fei Li ◽  
Liang Ma ◽  
Jinyuan Zhang ◽  
Xueling Qiao ◽  
Dingshan Zhang ◽  
...  
Keyword(s):  
Single Crystal ◽  
Diffraction Analysis ◽  
Absolute Configuration ◽  
Thioredoxin Reductase ◽  
Spectroscopic Methods ◽  
Significant Activity ◽  
X Ray Diffraction ◽  
X Ray ◽  
Inhibitory Activities ◽  
Jatropha Multifida

Jatroidaine A (1), a new tetranortirucallane-type triterpene, and two known analogues (2−3) were isolated from the leaves and branches of Jatropha multifida. Their structures were fully elucidated by extensive spectroscopic methods and comparison to known compounds. The absolute configuration of 1 was assigned by single-crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory and thioredoxin reductase (TrxR) inhibitory activities. Unfortunately, no significant activity was observed.

scholarly journals Structures, Chemical Conversions, and Cytotoxicity of Tricholopardins C and D, Two Tricholoma Triterpenoids from the Wild Mushroom Tricholoma pardinum

2021 ◽  
Author(s):  
Chen Shi ◽  
Yue-Ling Peng ◽  
Juan He ◽  
Zheng-Hui Li ◽  
Ji-Kai Liu ◽  
...  
Keyword(s):  
Hela Cell ◽  
Single Crystal ◽  
Cell Lines ◽  
Cell Apoptosis ◽  
Spectroscopic Methods ◽  
Wild Mushroom ◽  
X Ray Diffraction ◽  
X Ray ◽  
Hela Cell Lines ◽  
Mcf 7

AbstractTwo undescribed Tricholoma triterpenoids, namely tricholopardins C (1) and D (2), were isolated from the wild mushroom Tricholoma pardinum. Their structures with absolute configurations were elucidated by spectroscopic methods, as well as the single crystal X-ray diffraction. Compounds 1 and 2 were further obtained by chemical conversions from the known analogues. Compound 1 showed significant cytotoxicity to MCF-7 and Hela cell lines with IC50 values of 4.7 μM and 9.7 μM, respectively. Its mechanism of inducing MCF-7 cell apoptosis was studied briefly. Graphical Abstract

scholarly journals Synthesis and Anti-Proliferative Assessment of Triazolo-Thiadiazepine and Triazolo-Thiadiazine Scaffolds

Molecules ◽  
2019 ◽  
Vol 24 (24) ◽  
pp. 4471 ◽  
Author(s):  
Ahmed T. A. Boraei ◽  
Hazem A. Ghabbour ◽  
Mohamed S. Gomaa ◽  
El Sayed H. El Ashry ◽  
Assem Barakat
Keyword(s):  
Single Crystal ◽  
Cell Lines ◽  
Cancer Cell ◽  
2D Nmr ◽  
Cancer Cell Lines ◽  
Docking Studies ◽  
X Ray ◽  
Cytotoxicity Activity ◽  
Human Liver Cancer ◽  
Mcf 7

A series of triazolo-thiadiazepines 4a–k were synthesized with excellent yields using dehydrated PTSA as a catalyst in toluene. Two triazolo-thiadiazines were obtained; 8a was formed directly by reflux in ethanol, whereas, PTSA promoted the formation of 8b. The molecular structure of the formed triazolo-thiadiazepines is identical to the imine-form 4a–k and not the enamine-tautomer 6a–k. The structures of the newly synthesized triazolo-thiadiazepines 4a–k and triazolo-thiadiazines 8a–b were elucidated using NMR (1H, and 13C), 2D NMR, HRMS, and X-ray single crystal. Furthermore, 4a was deduced using X-ray single crystal diffraction analysis. These new thiadiazepine hits represent an optimized series of previously synthesized indole-triazole derivatives for the inhibition of EGFR. The cytotoxicity activity against two cancer cell lines including human liver cancer (HEPG-2) and breast cancer (MCF-7) was promising, with IC50 between 12.9 to 44.6 µg/mL and 14.7 to 48.7 µg/mL for the tested cancer cell lines respectively, compared to doxorubicin (IC50 4.0 µg/mL). Docking studies revealed that the thiadiazepine scaffold presented a suitable anchor, allowing good interaction of the various binding groups with the enzyme binding regions and sub-pockets.

scholarly journals Anti-inflammatory Anthraquinones from the Crinoid Himerometra magnipinna

2015 ◽  
Vol 10 (2) ◽  
pp. 1934578X1501000
Author(s):  
Yen-You Lin ◽  
Su-June Tsai ◽  
Michael Y. Chiang ◽  
Zhi-Hong Wen ◽  
Jui-Hsin Su
Keyword(s):  
Single Crystal ◽  
Diffraction Analysis ◽  
Absolute Configuration ◽  
Spectroscopic Data ◽  
Test Compound ◽  
X Ray Diffraction ◽  
X Ray ◽  
Anti Inflammatory ◽  
Raw264.7 Macrophage

Chemical investigation of a crinoid Himerometra magnipinna has afforded three anthraquinones (1–3), including one new metabolite, (+)-rhodoptilometrin (1). The structures of these compounds were elucidated on the basis of their spectroscopic data and the absolute configuration of 1 was further confirmed by single-crystal X-ray diffraction analysis. In the in vitro anti-inflammatory effects test, compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells.

scholarly journals Valence self-regulation of sulfur in nanoclusters

2019 ◽  
Vol 5 (11) ◽  
pp. eaax7863 ◽  
Author(s):  
Xi Kang ◽  
Fengqing Xu ◽  
Xiao Wei ◽  
Shuxin Wang ◽  
Manzhou Zhu
Keyword(s):  
Mass Spectrometry ◽  
Single Crystal ◽  
Diffraction Analysis ◽  
Valence State ◽  
Self Regulation ◽  
X Ray Diffraction ◽  
X Ray ◽  
Capping Ligands ◽  
First Time

The valence self-regulation of sulfur from the “−2” valence state in thiols to the “−1” valence state in hydroxylated thiolates has been accomplished using the Pt1Ag28 nanocluster as a platform—the first time that the “−1” valent sulfur has been detected as S−1. Two previously unknown nanoclusters, Pt1Ag28(SR)20 and Pt1Ag28(SR)18(HO-SR)2 (where SR represents 2-adamantanethiol), have been synthesized and characterized—in the latter nanocluster, the presence of hydroxyl induces the valence regulation of two special S atoms from “−2” (in SR) to “−1” valence state in the HO-S(Ag)R. Because of the contrasting nature of the capping ligands in these two nanoclusters [i.e., only SR in Pt1Ag28(SR)20 or both SR- and HO-SR- in Pt1Ag28(SR)18(HO-SR)2], they exhibit differing shell architectures, even though their cores (Pt1Ag12) are in the same icosahedral configuration. Single-crystal x-ray diffraction analysis revealed their 1:1 cocrystallization, and mass spectrometry verified the presence of hydroxyls on Pt1Ag28(SR)18(HO-SR)2.

Deoxy-cytochalasins from a marine-derived fungus Spicaria elegans

2009 ◽  
Vol 87 (3) ◽  
pp. 486-489 ◽  
Author(s):  
Zhen-Jian Lin ◽  
Tian-Jiao Zhu ◽  
Guo-Jian Zhang ◽  
Hong-Juan Wei ◽  
Qian-Qun Gu
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Absolute Configuration ◽  
Cancer Cell Lines ◽  
Spectroscopic Methods ◽  
Ester Method ◽  
The Absolute ◽  
Cytochrome P 450

Treatment of Spicaria elegans with cytochrome P-450 inhibitor resulted in two new deoxy-cytochalasins, 7-deoxy-cytochalasin Z7 (1) and 7-deoxy-cytochalasin Z9 (2), which were recognized as plausible precursors of cytochalasins Z7 and Z9, respectively. Their structures were elucidated by spectroscopic methods and the absolute configuration of 1 was determined by the conventional Mosher ester method. Their cytotoxicities against two cancer cell lines were evaluated.

Synthesis of esters and amides of 1,4-dihydro-1,2,4,5-tetrazine-3,6-dicarboxylic acid

2009 ◽  
Vol 2009 (10) ◽  
pp. 645-648 ◽  
Author(s):  
Shi-Jie Zhang ◽  
Yi-Chun Ma ◽  
Wei Zhou ◽  
Guo-Wu Rao ◽  
Liang-Liang Chen ◽  
...  
Keyword(s):  
Diffraction Analysis ◽  
Dicarboxylic Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Elemental Analysis ◽  
X Ray Diffraction ◽  
Alkyl Esters ◽  
X Ray ◽  
H Nmr ◽  
Inhibitory Activities

Alkyl esters and alkyl amides of 1,4-dihydro-1,2,4,5-tetrazine-3,6-dicarboxylic acid were synthesised and characterised by IR, 1H NMR, EI-MS and elemental analysis. The structure of 1,4-dihydro-1,2,4,5-tetrazine-3,6-dicarboxylic was confirmed by X-ray diffraction analysis. Some selected compounds were evaluated against P-388 and A-549 cancer cell lines, but showed poor inhibitory activities.

scholarly journals Isolation and Identification of Cyclooctasulfur From the Octocoral Sinularia humilis (van Ofwegen, 2008)

2021 ◽  
Vol 16 (9) ◽  
pp. 1934578X2110406
Author(s):  
Jhao-Syuan Zeng ◽  
Yi-Hung Liu ◽  
San-Nan Yang ◽  
Su-Ying Chien ◽  
Zhi-Hong Wen ◽  
...  
Keyword(s):  
Single Crystal ◽  
Diffraction Analysis ◽  
Marine Invertebrate ◽  
X Ray Diffraction ◽  
Isolation And Identification ◽  
Chemical Examination ◽  
X Ray ◽  
First Time

Chemical examination of the octocoral Sinularia humilis, collected in the waters of Taiwan, led to the isolation of S8 (1). Its structure was determined by a single-crystal x-ray diffraction analysis and this is the first time that S8 has been reported from a marine invertebrate.

Bis(trimethylphosphan)-η5-cyclopentadienyl- tert- butylimidovanadium( III): Reaktionen mit Schwefel, Selen, Tellur und Iod

2003 ◽  
Vol 58 (4) ◽  
pp. 237-245 ◽  
Author(s):  
Martin Billen ◽  
Gabriele Hornung ◽  
Gotthelf Wolmershäuser ◽  
Fritz Preuss
Keyword(s):  
Single Crystal ◽  
Diffraction Analysis ◽  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
X Ray

The reaction of [tBuN=VCp(PMe3)2] (1) with S8, Se, Te or I2 have been studied. Via this pathway dinuclear diamagnetic tert-butylimidovanadium(IV) complexes are formed: [(μ-E)(μ- NtBu)2V2Cp2] (E=S, Se, Te), [(μ-η1−E2)(μ-NtBu)2V2Cp2] {E=Se (3), Te}, [(μ-NtBu)2V2Cp2I2]. In addition the vanadium(V) complexes [tBuN=VCp (S5)] (9a) and tBuN=VCpI2 could be isolated. The synthesis of tBuN=VCpF2 is also described. All compounds obtained have been characterized by spectroscopic methods (MS; 1H, 13C, 51V NMR), 3 and 9b by single crystal X-ray diffraction analysis.

scholarly journals HPLC-DAD-Guided Isolation of Diversified Chaetoglobosins from the Coral-Associated Fungus Chaetomium globosum C2F17

Molecules ◽  
2020 ◽  
Vol 25 (5) ◽  
pp. 1237 ◽  
Author(s):  
Xiao-Wei Luo ◽  
Cheng-Hai Gao ◽  
Hu-Mu Lu ◽  
Jia-Min Wang ◽  
Zi-Qi Su ◽  
...  
Keyword(s):  
Single Crystal ◽  
Cell Lines ◽  
Cancer Cell ◽  
Spectroscopic Analysis ◽  
Chaetomium Globosum ◽  
X Ray ◽  
X Ray Crystallography ◽  
Ic50 Values ◽  
First Time ◽  
Mcf 7

Cytochalasans have continuously aroused considerable attention among the chemistry and pharmacology communities due to their structural complexities and pharmacological significances. Sixteen structurally diverse chaetoglobosins, 10-(indol-3-yl)-[13]cytochalasans, including a new one, 6-O-methyl-chaetoglobosin Q (1), were isolated from the coral-associated fungus Chaetomium globosum C2F17. Their structures were accomplished by extensive spectroscopic analysis combined with single-crystal X-ray crystallography and ECD calculations. Meanwhile, the structures and absolute configurations of the previously reported compounds 6, 12, and 13 were confirmed by single-crystal X-ray analysis for the first time. Chaetoglobosins E (6) and Fex (11) showed significant cytotoxicity against a panel of cancer cell lines, K562, A549, Huh7, H1975, MCF-7, U937, BGC823, HL60, Hela, and MOLT-4, with the IC50 values ranging from 1.4 μM to 9.2 μM.

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