Biotransformation of (-)-(10E,15S)-10,11-Dehydrocurvularin

(-)-(10 E,15 S)-10,11-Dehydrocurvularin (1), produced from an associated-fungus of Scolopendra subspinipes mutilans on a gram scale, was microbiologically converted to curvularin (2) and 5-methoxycurvularin (3) by Antrodiella semisupina in 61% totally isolated yield. The structures of these compounds were elucidated on the basis of spectroscopic and mass spectrometric analysis. The undescribed assignments of 1H and 13C NMR spectral data for 5-methoxycurvularin (2) has now been explicitly provided. The cytotoxic activities of compounds 1-3 against four human cancer cell lines were evaluated. Dehydrocurvularin (1) showed moderate cytotoxicity against Caski and Hep-G2, and curvularin (2) was selectively cytotoxic against MDA-MB-231.

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Cytotoxic Activities of Cymbopogon citratus Extracts Three types of human cancer cell lines were tested: Lung Carcinoma (A549), Breast Cancer (MCF-7) and Hepatocellular Carcinoma (Hep G2)

Journal of Modern Research ◽

10.21608/jmr.2021.90284.1081 ◽

2022 ◽

Vol 4 (1) ◽

pp. 21-26

Author(s):

Heba sayed ◽

mohammady issa ◽

magda mahmoud ◽

hamadi ismail ◽

ahmed darwish ◽

...

Keyword(s):

Breast Cancer ◽

Hepatocellular Carcinoma ◽

Lung Carcinoma ◽

Human Cancer ◽

Cytotoxic Activities ◽

Human Cancer Cell ◽

Hep G2 ◽

Cymbopogon Citratus ◽

Human Cancer Cell Lines ◽

Mcf 7

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Cytotoxic Xanthones from the Leaves of Garcinia Urophylla

Natural Product Communications ◽

10.1177/1934578x0700200309 ◽

2007 ◽

Vol 2 (3) ◽

pp. 1934578X0700200 ◽

Cited By ~ 9

Author(s):

Rozida Mohd Khalid ◽

Md. Lip Jabit ◽

Faridah Abas ◽

Johnson Stanslas ◽

Khozirah Shaari ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cytotoxic Activities ◽

Spectroscopic Techniques ◽

Human Cancer Cell ◽

Human Cancer Cell Lines ◽

H Nmr ◽

Mcf 7 ◽

C Nmr

Two new xanthones, 7-hydroxydesoxymorellin (1) and isocaledonixanthone D (2), and four known ones, gaudichaudione H, 1,7-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone, 1,5-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone, and 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone, as well as lupeol were isolated from the leaves of Garcinia urophylla (Guttiferae). Their structures were determined using a combination of 1D (1H NMR, 13C NMR, DEPT) and 2D (COSY, gHSQC, gHMBC) NMR spectroscopic techniques. Among the isolates, 7-hydroxydesoxymorellin (1), gaudichaudione H, 1,5-dihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone, and 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone demonstrated cytotoxic activities against breast (MCF-7), prostate (DU-145), and lung (NCI-H460) human cancer cell lines.

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Synthesis of Icaritin and β-anhydroicaritin Mannich Base Derivatives and Their Cytotoxic Activities on Three Human Cancer Cell Lines

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520616666160404111210 ◽

2016 ◽

Vol 17 (1) ◽

pp. 137-142 ◽

Cited By ~ 11

Author(s):

Van-Son Nguyen ◽

Ling Shi ◽

Sheng-Chun Wang ◽

Qiu-An Wang

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Mannich Base ◽

Human Cancer ◽

Cancer Cell Lines ◽

Cytotoxic Activities ◽

Human Cancer Cell ◽

Human Cancer Cell Lines

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ent-Kaurane Diterpenes from Annona glabra and Their Cytotoxic Activities

Natural Product Communications ◽

10.1177/1934578x1400901204 ◽

2014 ◽

Vol 9 (12) ◽

pp. 1934578X1400901

Author(s):

Hoang Le Tuan Anh ◽

Nguyen Thi Thu Hien ◽

Dan Thi Thuy Hang ◽

Tran Minh Ha ◽

Nguyen Xuan Nhiem ◽

...

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

2D Nmr ◽

Cancer Cell Lines ◽

Cytotoxic Activities ◽

Human Cancer Cell ◽

2D Nmr Spectroscopy ◽

Human Cancer Cell Lines ◽

Annona Glabra

A new ent-kaurane glycoside, annoglabasin H (1), and three known ent-kauranes, annoglabasin E (2), annoglabasin B (3), and 19-nor- ent-kaurent-4-ol-17-oic acid (4) were isolated from the fruits of Annona glabra. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D- and 2D-NMR spectroscopy, as well as by comparison with the NMR data reported in the literature. The cytotoxic activities of these compounds were evaluated on four human cancer cell lines, LU-1, MCF-7, SK-Mel2, and KB. Compound 1 exhibited significant cytotoxic activity on all tested human cancer cell lines with IC50 values ranging from 3.7 to 4.6 μM.

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Synthesis, Characterization, and Preliminary In Vitro Cytotoxic Evaluation of a Series of 2-Substituted Benzo [d] [1,3] Azoles

Molecules ◽

10.3390/molecules26092780 ◽

2021 ◽

Vol 26 (9) ◽

pp. 2780

Author(s):

Ozvaldo Linares-Anaya ◽

Alcives Avila-Sorrosa ◽

Francisco Díaz-Cedillo ◽

Luis Ángel Gil-Ruiz ◽

José Correa-Basurto ◽

...

Keyword(s):

Binding Site ◽

In Silico ◽

Cytotoxic Effect ◽

Human Cancer ◽

Cytotoxic Activities ◽

Human Cancer Cell ◽

Inhibitory Effects ◽

Reference Drug ◽

Human Cancer Cell Lines

A series of benzo [d] [1,3] azoles 2-substituted with benzyl- and allyl-sulfanyl groups were synthesized, and their cytotoxic activities were in vitro evaluated against a panel of six human cancer cell lines. The results showed that compounds BTA-1 and BMZ-2 have the best inhibitory effects, compound BMZ-2 being comparable in some cases with the reference drug tamoxifen and exhibiting a low cytotoxic effect against healthy cells. In silico molecular coupling studies at the tamoxifen binding site of ERα and GPER receptors revealed affinity and the possible mode of interaction of both compounds BTA-1 and BMZ-2.

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Synthesis of novel amide and Schiff’s base functionalized novel pyrido[1,2-a] pyrimidin-4-one derivatives and their anticancer activity studies.

Letters in Organic Chemistry ◽

10.2174/1570178618666210512021950 ◽

2021 ◽

Vol 18 ◽

Author(s):

Sailu Betala ◽

Chiranjeevi Abba ◽

Hanumandlu Racha

Keyword(s):

Anticancer Activity ◽

Hydrazine Hydrate ◽

Human Cancer ◽

Aromatic Aldehydes ◽

Human Cancer Cell ◽

Hep G2 ◽

Schiff’S Base ◽

Human Cancer Cell Lines ◽

Amide Derivatives ◽

Mcf 7

Abstract: A series of novel amide and Schiffs base functionalized novel pyrido[1,2-a]pyrimidin-4-one derivatives were prepared starting from 6-(thiophene-2-yl)/phenyl-4-(trifluoromethyl) pyridin-2-amine 1a and 1b. These compounds on reaction with EMME, to afford compounds 2a and 2b, followed by cyclization to afford compounds 3a and 3b. Treatment of compound 3a and 3b with hydrazine hydrate to get compounds 4a and 4b, compounds 4a and 4b on reaction with different substituted aromatic aldehydes to get Schiff’s base derivatives 5a-j, in another way compounds 3a, 3b on reaction with aliphatic amines to get amide derivatives 6a-f. All the compounds 5a-j and 6a-f were screened against four human cancer cell lines (HeLa, COLO205, Hep G2, and MCF 7), among all the derivatives, compounds 5c, 5e, 6a, and 6b showed promising anticancer activity.

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A New Cycloartane Glucoside from Rhizophora stylosa

Natural Product Communications ◽

10.1177/1934578x1400900909 ◽

2014 ◽

Vol 9 (9) ◽

pp. 1934578X1400900 ◽

Cited By ~ 5

Author(s):

Phan Thi Thanh Huong ◽

Chau Ngoc Diep ◽

Nguyen Van Thanh ◽

Vu Anh Tu ◽

Tran Hong Hanh ◽

...

Keyword(s):

Secondary Metabolites ◽

Lung Adenocarcinoma ◽

Cell Lines ◽

Caspase 3 ◽

Methanol Extract ◽

Human Cancer ◽

Human Cancer Cell ◽

Rhizophora Stylosa ◽

Human Cancer Cell Lines ◽

C Nmr

Nine secondary metabolites, including a new cycloartane glucoside, rhizostyloside (1), were isolated from a methanol extract of Rhizophora stylosa leaves through several chromatographic experiments. The structures of the compounds were determined on the basis of NMR spectroscopic (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, NOESY) and HR-ESI-MS data and by comparison with literature values. Compound 1 exhibited significant cytotoxicity against three human cancer cell lines: KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), and SK-Mel-2 (melanoma). In addition, 1 strongly activated caspase-3/7 in LU-1 cells.

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Cytotoxic Activities of Different Iranian Solanaceae and Lamiaceae Plants and Bioassay-Guided Study of an Active Extract from Salvia lachnocalyx

Natural Product Communications ◽

10.1177/1934578x1701201009 ◽

2017 ◽

Vol 12 (10) ◽

pp. 1934578X1701201 ◽

Cited By ~ 2

Author(s):

Hossein H. Mirzaei ◽

Omidreza Firuzi ◽

Ian T. Baldwin ◽

Amir Reza Jassbi

Keyword(s):

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Cell Lines ◽

Active Species ◽

Cytotoxic Activities ◽

Human Cancer Cell ◽

Human Cancer Cell Lines ◽

Bioassay Guided Fractionation ◽

Cytotoxic Compounds

Methanol (MeOH), dichloromethane (DCM) and 80% MeOH extractions of fourteen medicinal plants of the families Solanaceae and Lamiaceae collected from different area of Iran were tested for their cytotoxic potential against MOLT-4 human cancer cell lines. Cytotoxicity of the tested plants indicated that 11 plants had one or two active extracts (IC50 ≤50): MeOH extracts of the shoots of Thymus trautvetteri, Solanum luteum and stems of Lycium shawii; DCM extracts of the shoots of Thymus kotschyanus, Salvia persepolitana, Ballota aucheri, Nepeta glomerulosa, Hyoscyamus tenuicaulis, Salvia lachnocalyx, Salvia sharifii as well as the stems of Salvia verticillata and the roots of Salvia multicaulis and S. lachnocalyx; 80% MeOH extracts of the shoots of T. trautvetteri, S. luteum and the stems of L. shawii. The DCM extract of the aerial parts of S. lachnocalyx as one of the most active species was subjected to the cytotoxic bioassay-guided fractionation and purification using combination of chromatography methods. The bioassay-guided fractionation of DCM extract of the shoots of S. lachnocalyx led to the isolation of two cytotoxic compounds: (2 Z,6 Z,10 Z,14 E)-geranylfarnesol (1), a novel natural product, and spathulenol (2). Both of the isolated compounds, especially 1 (IC50 range: 9.6 −20.2 μg/mL), showed good cytotoxic effects against 3 human cancer cell lines, MOLT-4, MCF-7 and HT-29.

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