The Anti-Allergic and Anti-Inflammatory Effects of Phlorotannins from the Edible Brown Algae, Ecklonia sp. and Eisenia sp

2021 ◽  
Vol 16 (12) ◽  
pp. 1934578X2110609
Author(s):  
Yoshimasa Sugiura ◽  
Hirotaka Katsuzaki ◽  
Kunio Imai ◽  
Hideomi Amano
Keyword(s):  
Phenolic Compounds ◽  
Brown Algae ◽  
Brown Alga ◽  
Research Groups ◽  
Terrestrial Plants ◽  
Large Numbers ◽  
Anti Inflammatory

Because the number of people suffering from allergies has significantly increased, improved ways of treating these conditions by medical, pharmaceutical, and dietary means are required. Large numbers of studies on allergy have been conducted, and many anti-allergic compounds have been found. Phenolic compounds from terrestrial plants, including catechins and flavonoids, possess anti-allergic properties. Although polyphenols are present in some brown algae, their anti-allergic activities were not studied in detail before the 1990s. The focus was on the algal polyphenols, collectively called phlorotannins (eg., eckol, 6,6′-bieckol, 8,8′-bieckol, dieckol, and phlorofucofuroeckol-A), and research was conducted to clarify their anti-allergic activities. This review summarizes the anti-allergic effects of phlorotannins isolated from the brown alga, Eisenia nipponica, and related reports by other research groups.

scholarly journals Oriental Hornet (Vespa orientalis) Larval Extracts Induce Antiproliferative, Antioxidant, Anti-Inflammatory, and Anti-Migratory Effects on MCF7 Cells

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3303
Author(s):  
Amina M. G. Zedan ◽  
Mohamed I. Sakran ◽  
Omar Bahattab ◽  
Yousef M. Hawsawi ◽  
Osama Al-Amer ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Aqueous Extract ◽  
Antioxidant Activities ◽  
Individual Treatment ◽  
Alcoholic Extract ◽  
Anticancer Effect ◽  
Mcf7 Cells ◽  
Vespa Orientalis ◽  
Anti Inflammatory

The use of insects as a feasible and useful natural product resource is a novel and promising option in alternative medicine. Several components from insects and their larvae have been found to inhibit molecular pathways in different stages of cancer. This study aimed to analyze the effect of aqueous and alcoholic extracts of Vespa orientalis larvae on breast cancer MCF7 cells and investigate the underlying mechanisms. Our results showed that individual treatment with 5% aqueous or alcoholic larval extract inhibited MCF7 proliferation but had no cytotoxic effect on normal Vero cells. The anticancer effect was mediated through (1) induction of apoptosis, as indicated by increased expression of apoptotic genes (Bax, caspase3, and p53) and decreased expression of the anti-apoptotic gene Bcl2; (2) suppression of intracellular reactive oxygen species; (3) elevation of antioxidant enzymes (CAT, SOD, and GPx) and upregulation of the antioxidant regulator Nrf2 and its downstream target HO-1; (4) inhibition of migration as revealed by in vitro wound healing assay and downregulation of the migration-related gene MMP9 and upregulation of the anti-migratory gene TIMP1; and (5) downregulation of inflammation-related genes (NFκB and IL8). The aqueous extract exhibited the best anticancer effect with higher antioxidant activities but lower anti-inflammatory properties than the alcoholic extract. HPLC analysis revealed the presence of several flavonoids and phenolic compounds with highest concentrations for resveratrol and naringenin in aqueous extract and rosmarinic acid in alcoholic extract. This is the first report to explain the intracellular pathway by which flavonoids and phenolic compounds-rich extracts of Vespa orientalis larvae could induce MCF7 cell viability loss through the initiation of apoptosis, activation of antioxidants, and inhibition of migration and inflammation. Therefore, these extracts could be used as adjuvants for anticancer drugs and as antioxidant and anti-inflammatory agents.

Four new phenolic compounds from the tender leaves of Eucommia ulmoides Oliv. and their anti-inflammatory activities

2021 ◽  
Vol 44 ◽  
pp. 173-177
Author(s):  
Xiao-Mei Ren ◽  
Zhu-Zhen Han ◽  
Lei-Xin Song ◽  
Zi-Yang Lv ◽  
Ying-Bo Yang ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Eucommia Ulmoides ◽  
Anti Inflammatory

Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages

2010 ◽  
Vol 48 (8-9) ◽  
pp. 2045-2051 ◽  
Author(s):  
Soo-Jin Heo ◽  
Weon-Jong Yoon ◽  
Kil-Nam Kim ◽  
Gin-Nae Ahn ◽  
Sung-Myung Kang ◽  
...  
Keyword(s):  
Brown Algae ◽  
Raw 264.7 ◽  
Raw 264.7 Macrophages ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Simultaneous determination and anti-inflammatory effects of four phenolic compounds in Dendrobii Herba

2017 ◽  
Vol 31 (24) ◽  
pp. 2923-2926 ◽  
Author(s):  
Sae-Rom Yoo ◽  
Soo-Jin Jeong ◽  
Na-Ri Lee ◽  
Hyeun-Kyoo Shin ◽  
Chang-Seob Seo
Keyword(s):  
Phenolic Compounds ◽  
Simultaneous Determination ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory effects of apo-9′-fucoxanthinone from the brown alga, Sargassum muticum

2013 ◽  
Vol 21 (1) ◽  
Author(s):  
Eun-Jin Yang ◽  
Young Min Ham ◽  
Wook Jae Lee ◽  
Nam Ho Lee ◽  
Chang-Gu Hyun
Keyword(s):  
Brown Alga ◽  
Sargassum Muticum ◽  
Anti Inflammatory

ANTIULCER AND ANTI-INFLAMMATORY ACTIVITIES OF HYDROALCOHOLIC EXTRACTS OF STEM BARK AND LEAF OF ANOGEISSUS PENDULA EDGEW

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (01) ◽  
pp. 41-46
Author(s):  
Deeksha Singh ◽  
◽  
Amit Nayak ◽  
Rakesh Yadav ◽  
Uttam Singh Baghel ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Stem Bark ◽  
Inflammatory Activity ◽  
Antiulcer Activity ◽  
Paw Edema ◽  
Ulcer Index ◽  
Pylorus Ligation ◽  
Anti Inflammatory ◽  
Anogeissus Pendula

Anogeissus pendula Edgew has been reported to be used in gastric disorder even though no attempt has been made to evaluate the same. The present study was designed to evaluate the hydroalcoholic extracts of stem bark and leaves for in vivo acute antiulcer and anti-inflammatory activities. Antiulcer activity was studied by pylorus ligation induced ulcers while anti-inflammatory activities was studied by carrageenan induced paw edema. The extract of stem bark at 200 and 400 mg/kg b. w., significantly (P<0.05) reduced ulcer index whereas extracts of both stem bark and leaves significantly (P<0.001) reduced paw diameter at the fifth hour. The hydroalcholic extract of stem bark of A. pendula possesses more significant antiulcer and anti-inflammatory activity than the hydroalcholic extract of leaves may be due to the presence of higher amount of phenolic compounds.

scholarly journals Interspecific variation in total phenolic content in temperate brown algae

2017 ◽  
Vol 90 (1) ◽  
Author(s):  
Anna Maria Mannino ◽  
Valentina Vaglica ◽  
Elisabetta Oddo
Keyword(s):  
Phenolic Compounds ◽  
Brown Algae ◽  
Total Phenolic Content ◽  
Phenolic Content ◽  
Interspecific Variation ◽  
Multiple Roles ◽  
Total Phenolic ◽  
Phenolic Contents ◽  
Cystoseira Compressa ◽  
Protection Mechanisms

Marine algae synthesize secondary metabolites such as polyphenols that function as defense and protection mechanisms. Among brown algae, Fucales and Dictyotales (Phaeophyceae) contain the highest levels of phenolic compounds, mainly phlorotannins, that play multiple roles. Four temperate brown algae (Cystoseira amentacea, Cystoseira compressa, Dictyopteris polypodioides and Padina pavonica) were studied for total phenolic contents. Total phenolic content was determined colorimetrically with the Folin-Ciocalteu reagent. Significant differences in total phenolic content were observed between leathery and sheetlike algae and also within each morphological group. Among the four species, the sheet-like alga D. polypodioides, living in the upper infralittoral zone, showed the highest concentration of phenolic compounds. These results are in agreement with the hypothesis that total phenolic content in temperate brown algae is influenced by a combination of several factors, such as growth form, depth, and exposition to solar radiation.

scholarly journals The influence of brown algae alginates on phenolic compounds capability of ultraviolet radiation absorption in vitro

2007 ◽  
Vol 55 (2) ◽  
pp. 145-154 ◽  
Author(s):  
Leonardo Tavares Salgado ◽  
Rodrigo Tomazetto ◽  
Leonardo Paes Cinelli ◽  
Marcos Farina ◽  
Gilberto Menezes Amado Filho
Keyword(s):  
Phenolic Compounds ◽  
Ultraviolet Radiation ◽  
Brown Algae ◽  
Absorption Capacity ◽  
Uv Absorption ◽  
Radiation Absorption ◽  
Electromagnetic Spectrum ◽  
Cell Wall Polysaccharides ◽  
Physiological Processes

Brown algae phenolic compounds (PC) are secondary metabolites that participate in many biological processes, such as ultraviolet radiation (UV) protection, polyspermy blocking and trace metals bounding. Recently, PC has also been studied due to possible interactions with cell wall polysaccharides. However, there are few evidences of these interactions and their influence in physiological processes. The interactions between PC from the brown alga Padina gymnospora and alginates and the influence of these interactions on the UV absorption properties of PC were investigated in this work. Chromatography and spectrophotometry techniques were used to isolate, characterize and determine UV absorption capacity of studied compounds. Even after the P. gymnospora polysaccharide extraction and isolating methods, the PC was maintained linked to the alginate. The interaction of alginates with PC did not cause modifications on absorbance pattern of electromagnetic spectrum (UV-VIS-IR). The UV absorbance capability of PC linked to alginate was maintained for a longer period of time if compared with the purified PC. The obtained results reveal the strong linkage between PC and alginates and that these linkages preserve the UV absorption capability of PC along time.

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