Identification of anti-inflammatory effects of extract of brown algae Padina sp. in mice (Mus musculus): A pilot study

Background/Aim. The use and adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) in outpatients with rheumatic diseases has not yet been studied enough. The aim of this study was to evaluate the data about the efficacy and safety of NSAIDs obtained from the questionnaires submitted to the outpatients receiving these drugs. Methods. The patients who had been prescribed any of NSAIDs within the period from June to September, 2004 were included in the study. The answers obtained from the questionnaires were statistically analyzed by means of ?2-test. Results. At the time of the study, 150 patients had been prescribed ibuprofen or some other NSAID. Out of the total number of dispensed questionnaires (n = 150), only 45 (30%) were shown to be correctly filled-in. Their analysis showed that 64.4% of the patients had suffered from rheumatic diseases for more than five years, and had regularly used NSAIDs. The average age of these patients was about 70 years, and the number of females was double as high as that of the males. The most frequently used NSAIDs were diclofenac and ibuprofen (46.14%, and 23.24%, respectively). According to the answers given by the patients, the most often adverse reactions were gastric complaints such as nausea (11.1%), and stomach pain (8.9%). Due to this, the majority of the patients (64.4%) used some of the antiulcer drugs, most often ranitidine (31.1%). Conclusion. The results of this pilot study revealed that among the outpatients suffering from rheumatic diseases, the number of females was double as high as the number of males, that these patients were of the mean age of 70 years, and that their diseases lasted longer than five years. Gastric complains such as nausea and gastric pain of mild intensity were the most often adverse effects of NSAIDs reported by our patients. It could be the consequence of the predominant use of diclofenac and ibuprofen, NSAIDs with mild to moderate ulcerogenic potential, as well as the concomitant use of H2-receptor antagonists.

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Efecto de la inflorescencia de “coliflor” sobre síndrome caquéctico en Mus musculus var. swiss con cáncer inducido

Revista ECIPeru ◽

10.33017/reveciperu2020.0008/ ◽

2020 ◽

pp. 53-57

Keyword(s):

Body Weight ◽

Mus Musculus ◽

Redox Reactions ◽

Antioxidant Properties ◽

Body Weight Loss ◽

Progressive Increase ◽

Anticancer Properties ◽

Progressive Loss ◽

Metabolic Imbalance ◽

Anti Inflammatory

The objective was to determine the effect of Brassica oleracea var Botrytis "cauliflower" inflorescences on cachectic syndrome in Mus musculus var. swiss with induced cancer. Cachectic syndrome is characterized by progressive loss of body weight, anorexia, asthenia, immunosuppression and metabolism of carbohydrates, lipids and proteins, with loss of muscle and adipose tissue. It used dry cauliflower inflorescence extract (ESC) and male mice 35-45 g with induced cancer, divided into groups: G1 untreated control, G2 and G3 treated with ESC, doses 10 and 20mg/kg/bw/vo and G4 treated with quercitin, dose 7.14mg/Kg/bw/vo for 90 days. Some manifestations of cachectic syndrome were determined. It was observed that G1 had thinning and progressive increase in alopecia, asthenia and conjunctival xerosis due to energy and metabolic imbalance compared to G2, G3 and G4 that had higher body weight and fewer cachectic manifestations, being significant by time and treatment group (P<0.01). It has been reported that cauliflower contains flavonoids quercitin and kaemferol, with anti-inflammatory properties for its action on cyclooxygenase, lipooxygenase, interleukins and chemosins, with antioxidant properties on intracellular glutathione, in redox reactions and favoring the expression of caspases in cell apoptosis. Therefore, it is concluded that cauliflower prevents body weight loss and decreases cachectic syndrome because it contains kaempferol and quercitin that act synergistically with anti-inflammatory, antioxidant and anticancer properties.

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Evaluation of the Effect of a Single Intra-articular Injection of Allogeneic Neonatal Mesenchymal Stromal Cells Compared to Oral Non-Steroidal Anti-inflammatory Treatment on the Postoperative Musculoskeletal Status and Gait of Dogs over a 6-Month Period after Tibial Plateau Leveling Osteotomy: A Pilot Study

Frontiers in Veterinary Science ◽

10.3389/fvets.2017.00083 ◽

2017 ◽

Vol 4 ◽

Cited By ~ 7

Author(s):

Mathieu Taroni ◽

Quentin Cabon ◽

Marine Fèbre ◽

Thibaut Cachon ◽

Nathalie Saulnier ◽

...

Keyword(s):

Pilot Study ◽

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Tibial Plateau ◽

Anti Inflammatory

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Effect of cold stress on infanticide by female Swiss albino mice Mus musculus: a pilot study

Journal of Animal Science and Technology ◽

10.1186/s40781-018-0168-6 ◽

2018 ◽

Vol 60 (1) ◽

Cited By ~ 2

Author(s):

Tabassum Zafar ◽

Ab Qayoom Naik ◽

Vinoy K. Shrivastava

Keyword(s):

Pilot Study ◽

Cold Stress ◽

Mus Musculus ◽

Swiss Albino Mice ◽

Albino Mice

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The Anti-Allergic and Anti-Inflammatory Effects of Phlorotannins from the Edible Brown Algae, Ecklonia sp. and Eisenia sp

Natural Product Communications ◽

10.1177/1934578x211060924 ◽

2021 ◽

Vol 16 (12) ◽

pp. 1934578X2110609

Author(s):

Yoshimasa Sugiura ◽

Hirotaka Katsuzaki ◽

Kunio Imai ◽

Hideomi Amano

Keyword(s):

Phenolic Compounds ◽

Brown Algae ◽

Brown Alga ◽

Research Groups ◽

Terrestrial Plants ◽

Large Numbers ◽

Anti Inflammatory

Because the number of people suffering from allergies has significantly increased, improved ways of treating these conditions by medical, pharmaceutical, and dietary means are required. Large numbers of studies on allergy have been conducted, and many anti-allergic compounds have been found. Phenolic compounds from terrestrial plants, including catechins and flavonoids, possess anti-allergic properties. Although polyphenols are present in some brown algae, their anti-allergic activities were not studied in detail before the 1990s. The focus was on the algal polyphenols, collectively called phlorotannins (eg., eckol, 6,6′-bieckol, 8,8′-bieckol, dieckol, and phlorofucofuroeckol-A), and research was conducted to clarify their anti-allergic activities. This review summarizes the anti-allergic effects of phlorotannins isolated from the brown alga, Eisenia nipponica, and related reports by other research groups.

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EDEMA-REDUCING ACTIVITY OF SARGASSUM CRASSIFOLIUM Β-GLUCAN (LAMINARAN) ON EDEMA-INDUCED RATTUS NORVEGICUS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i7.18523 ◽

2017 ◽

Vol 10 (7) ◽

pp. 311 ◽

Cited By ~ 3

Author(s):

Anies Chamidah ◽

Asep A Prihanto ◽

Hardoko Hardoko

Keyword(s):

Rattus Norvegicus ◽

Brown Algae ◽

Inflammatory Activity ◽

Acid Extract ◽

Inflammatory Agent ◽

Reducing Activity ◽

Anti Inflammatory ◽

Leg Edema

Objectives: The aim of this study is to investigate anti-inflammatory activity of β-glucan (laminaran) of brown algae, Sargassum crassifolium which was extracted by using two different methods, β-glucan laminaran acid extract (LAE) and laminaran modified extract (LME).Methods: β-glucan (laminaran) of brown algae, S. crassifolium have been extracted using two different methods, namely, β-glucan LAE and LME. The edema reducing activity of the extracts was investigated with carrageenan- induced leg edema male of Rattus norvegicus as a model.Results: The swelling of edema was strongly inhibited by the treatment of LME with a percentage of 81.62% after 3rd hr. It also found that the size of edema were inhibited by all treatments with the value ranging from 25.49% to 81.68%. Smallest edema size was found on LME treatment, with a size of 0.68±0.09 mm where the control was about 0.92 mm. Furthermore, all β-glucan-treated mice showed lower edema size compared to control.Conclusion: It was obvious that all type of laminaran had anti-inflammatory activity. LME is the best method for production of β-glucan (laminaran) with high anti-inflammatory activity. Hence, in this study, we reported a new anti-inflammatory agent derived from S. crassifolium.

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