Anti-inflammatory effects of apo-9′-fucoxanthinone from the brown alga, Sargassum muticum

Because the number of people suffering from allergies has significantly increased, improved ways of treating these conditions by medical, pharmaceutical, and dietary means are required. Large numbers of studies on allergy have been conducted, and many anti-allergic compounds have been found. Phenolic compounds from terrestrial plants, including catechins and flavonoids, possess anti-allergic properties. Although polyphenols are present in some brown algae, their anti-allergic activities were not studied in detail before the 1990s. The focus was on the algal polyphenols, collectively called phlorotannins (eg., eckol, 6,6′-bieckol, 8,8′-bieckol, dieckol, and phlorofucofuroeckol-A), and research was conducted to clarify their anti-allergic activities. This review summarizes the anti-allergic effects of phlorotannins isolated from the brown alga, Eisenia nipponica, and related reports by other research groups.

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Studies on the Recently Introduced Brown Alga Sargassum muticum (Yendo) Fensholt. V. Receptacle Initiation and Growth, and Gamete Release in Laboratory Culture

Botanica Marina ◽

10.1515/botm.1990.33.3.241 ◽

1990 ◽

Vol 33 (3) ◽

Cited By ~ 28

Author(s):

J. M. Hales ◽

R. L. Fletcher

Keyword(s):

Brown Alga ◽

Laboratory Culture ◽

Sargassum Muticum ◽

Gamete Release

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Anti-inflammatory activity of edible brown alga Saccharina japonica and its constituents pheophorbide a and pheophytin a in LPS-stimulated RAW 264.7 macrophage cells

Food and Chemical Toxicology ◽

10.1016/j.fct.2013.01.054 ◽

2013 ◽

Vol 55 ◽

pp. 541-548 ◽

Cited By ~ 68

Author(s):

Md Nurul Islam ◽

Ishrat Jahan Ishita ◽

Seong Eun Jin ◽

Ran Joo Choi ◽

Chan Mee Lee ◽

...

Keyword(s):

Brown Alga ◽

Saccharina Japonica ◽

Inflammatory Activity ◽

Raw 264.7 ◽

Pheophorbide A ◽

Pheophytin A ◽

Macrophage Cells ◽

Raw 264.7 Macrophage ◽

Raw 264.7 Macrophage Cells ◽

Anti Inflammatory

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Structural Characteristics and Antitumor Activity of Fucoidans from the Brown Alga Sargassum muticum

Chemistry of Natural Compounds ◽

10.1007/s10600-017-1956-9 ◽

2017 ◽

Vol 53 (2) ◽

pp. 219-223 ◽

Cited By ~ 2

Author(s):

R. V. Usol’tseva ◽

Peipei Zhao ◽

M. I. Kusaikin ◽

Airong Jia ◽

Wenpeng Yuan ◽

...

Keyword(s):

Antitumor Activity ◽

Brown Alga ◽

Structural Characteristics ◽

Sargassum Muticum

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Antioxidant and Anti-inflammatory Meroterpenoids from the Brown Alga Cystoseira usneoides

Journal of Natural Products ◽

10.1021/np300833y ◽

2013 ◽

Vol 76 (4) ◽

pp. 621-629 ◽

Cited By ~ 28

Author(s):

Carolina de los Reyes ◽

Hanaa Zbakh ◽

Virginia Motilva ◽

Eva Zubía

Keyword(s):

Brown Alga ◽

Anti Inflammatory

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Anti-Arthritis Effect through the Anti-Inflammatory Effect of Sargassum muticum Extract in Collagen-Induced Arthritic (CIA) Mice

Molecules ◽

10.3390/molecules24020276 ◽

2019 ◽

Vol 24 (2) ◽

pp. 276 ◽

Cited By ~ 5

Author(s):

Hyelin Jeon ◽

Weon-Jong Yoon ◽

Young-Min Ham ◽

Seon-A Yoon ◽

Se Kang

Keyword(s):

Inflammatory Response ◽

Immunohistochemical Analysis ◽

Cartilage Destruction ◽

Sargassum Muticum ◽

Mice Model ◽

Articular Damage ◽

Tnf Α ◽

Anti Inflammatory ◽

Chronic Autoimmune Disease ◽

Necrosis Factor

(1) Background: Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular damage and functional loss. It is characterized by synovial inflammation that leads to progressive cartilage destruction. For this reason, research on functional foods that reduce the inflammatory response are under progress. (2) Methods: We focused on the anti-inflammatory effects of Sargassum muticum, and confirmed the effect of the extract on the collagen-induced arthritis (CIA) DBA/1J mice model. (3) Results: The extract was given at concentrations of 50, 100, and 200 mg/kg, and the arthritis score and edema volume of the experimental group were significantly different from the CIA group. The level of interleukin (IL)-6, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ were determined in serum and lymphocytes. The expression of these cytokines in the serum remarkably decreased from S. muticum extract (SME)100 mg/kg, and decreased from SME 200 mg/kg in lymphocytes. Also, immunohistochemical analysis of IL-6 and TNF-α in the joints revealed that the inflammatory response was noticeably lower when treated with S. muticum extract. (4) Conclusions: This study provides results of the experiment of S. muticum extract treatment in a mouse model. The treatment was found to contribute to the alleviation of edema and symptoms by reducing the expression of inflammatory cytokines. It was concluded that it may be a useful substance to help in the mitigation of arthritis symptoms.

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