Natural History of 321 Flatfoot Reconstructions in Adult Acquired Flatfoot Deformity Over a 14-Year Period

The purpose of this study was to report the natural history, demographics, and mechanisms of requirement for additional surgery in patients undergoing flatfoot reconstruction for adult acquired flatfoot. A total of 321 consecutive patients undergoing flatfoot reconstruction over a 14-year period were included (2002-2016). All procedures were performed by a senior orthopaedic foot and ankle surgeon at our institution. Demographic data, operative reports, clinic notes, and radiographs were available for review. Statistical analysis included calculation of relative risk (RR) ratios. The majority of patients were female (83.2%,) and most patients were overweight with a body mass index greater than 25 kg/m2 (56.4%). Patient comorbidities included diabetes (13.7%) and rheumatoid arthritis (3.7%). Additional surgery was required for 54 patients (16.8%). The most common reasons for additional surgery were the following: painful calcaneal hardware (57.4%), conversion to triple arthrodesis (16.7%), and wound healing complications (9.1%). An increased risk of need for additional surgery was associated with female gender (RR = 3.4; P = .0005), smoking status (RR = 1.9; P = .0081), and age (<60 years of age; RR = 1.8; P = .042). Although retrospective, the results provide insight into the natural history of this procedure. Clinicians may use these data to appropriately counsel patients who are at increased risk of requirement for additional surgery, such as smokers, women, and patients <60 years old, regarding treatment options. Levels of Evidence: Level IV

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The spontaneous resolution of a vortex vein varix: case report

BMC Ophthalmology ◽

10.1186/s12886-021-01861-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Sara L Weidmayer ◽

Hakan Demirci

Keyword(s):

Case Report ◽

Natural History ◽

Extended Period ◽

Spontaneous Resolution ◽

Case Presentation ◽

Clinical Resolution ◽

History Of ◽

Vortex Vein ◽

Insight Into

Abstract Background The natural course of a vortex vein varix, though not well understood, has been known to remain stable. However, here we report a novel case of a vortex vein varix that resolved after an extended period of monitoring. Case presentation An asymptomatic 96-year-old Caucasian man was found to have a vortex vein varix. At his previous examination 13 months prior, his fundus was normal. At 13 months of observation, his vortex vein varix become clinically undetectable. Further follow-up confirmed continued absence of the varix. Conclusion This case demonstrates the development then clinical resolution of a vortex vein varix with no clear identifiable factors for its evolution. This case is novel and offers new insight into the natural history of some vortex vein varices, implicating venous congestion as an instigator and venous collateralization as its alleviator, suggesting that vortex vein varices are likely more common than previously reported since some may be temporary and under-identified.

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Early Airway Pathological Changes in Children: New Insights into the Natural History of Wheezing

Journal of Clinical Medicine ◽

10.3390/jcm8081180 ◽

2019 ◽

Vol 8 (8) ◽

pp. 1180 ◽

Cited By ~ 1

Author(s):

Matteo Bonato ◽

Mariaenrica Tiné ◽

Erica Bazzan ◽

Davide Biondini ◽

Marina Saetta ◽

...

Keyword(s):

Natural History ◽

Genetic Background ◽

Current Knowledge ◽

Persistent Asthma ◽

Epidemiological Studies ◽

Airflow Limitation ◽

Clinical Expression ◽

Heterogeneous Condition ◽

History Of ◽

Insight Into

Asthma is a heterogeneous condition characterized by reversible airflow limitation, with different phenotypes and clinical expressions. Although it is known that asthma is influenced by age, gender, genetic background, and environmental exposure, the natural history of the disease is still incompletely understood. Our current knowledge of the factors determining the evolution from wheezing in early childhood to persistent asthma later in life originates mainly from epidemiological studies. The underlying pathophysiological mechanisms are still poorly understood. The aim of this review is to converge epidemiological and pathological evidence early in the natural history of asthma to gain insight into the mechanisms of disease and their clinical expression.

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Prevalence of ADHD in Accident Victims: Results of the PRADA Study

Journal of Clinical Medicine ◽

10.3390/jcm8101643 ◽

2019 ◽

Vol 8 (10) ◽

pp. 1643 ◽

Cited By ~ 4

Author(s):

Kittel-Schneider ◽

Wolff ◽

Queiser ◽

Wessendorf ◽

Meier ◽

...

Keyword(s):

General Population ◽

Incidence Rate ◽

Adult Adhd ◽

Demographic Data ◽

Trauma Surgery ◽

Self Report ◽

Stimulant Treatment ◽

Surgery Patient ◽

Increased Risk ◽

History Of

Background: Recent research has shown an increased risk of accidents and injuries in ADHD patients, which could potentially be reduced by stimulant treatment. Therefore, the first aim of our study was to evaluate the prevalence of adult ADHD in a trauma surgery population. The second aim was to investigate accident mechanisms and circumstances which could be specific to ADHD patients, in comparison to the general population. Methods: We screened 905 accident victims for ADHD using the ASRS 18-item self-report questionnaire. The basic demographic data and circumstances of the accidents were also assessed. Results: Prevalence of adult ADHD was found to be 6.18% in our trauma surgery patient sample. ADHD accident victims reported significantly higher rates of distraction, stress and overconfidence in comparison to non-ADHD accident victims. Overconfidence and being in thoughts as causal mechanisms for the accidents remained significantly higher in ADHD patients after correction for multiple comparison. ADHD patients additionally reported a history of multiple accidents. Conclusion: The majority of ADHD patients in our sample had not previously been diagnosed and were therefore not receiving treatment. The results subsequently suggest that general ADHD screening in trauma surgery patients may be useful in preventing further accidents in ADHD patients. Furthermore, psychoeducation regarding specific causal accident mechanisms could be implemented in ADHD therapy to decrease accident incidence rate.

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Management of RBC-Transfusion Dependence

Hematology ◽

10.1182/asheducation-2007.1.398 ◽

2007 ◽

Vol 2007 (1) ◽

pp. 398-404 ◽

Cited By ~ 10

Author(s):

Magda Melchert ◽

Alan F. List

Keyword(s):

Natural History ◽

Important Variable ◽

World Health ◽

Primary Therapy ◽

Endogenous Erythropoietin ◽

Fda Approval ◽

Increased Risk ◽

History Of ◽

Health Organization ◽

Rbc Transfusion

Abstract Strategies for the management of anemia in patients with myelodysplastic syndrome (MDS) have evolved following the U.S. Food and Drug Administration (FDA) approval of three new therapeutics from one of symptom amelioration with red blood cell (RBC) transfusions to one of active treatment. Most patients develop transfusion-dependent anemia over the course of their disease, however, and its adverse consequence on the natural history of disease has only recently been appreciated. Although severe anemia contributes to symptoms of fatigue and reduced quality of life, transfusion dependence increases the risk of organ complications from iron overload coupled with an increased risk of leukemia transformation. Among World Health Organization categories without elevation in bone marrow myeloblasts, an incremental rise in RBC transfusion burden is associated with a proportionate reduction in both overall survival and leukemia-free survival, implying that anemia severity is an important variable limiting the otherwise favorable natural history of patients with lower risk disease. Moreover, therapeutic strategies that successfully restore effective erythropoiesis, such as erythropoetic stimulating agents, immunomodulatory agents, immunosuppressive therapies, or hypomethylating agents, may favorably affect the natural history of this disease, creating perhaps a new urgency for the initiation of erythropoietic promoters that have durable clinical benefit. Selection of primary therapy for the management of anemia should consider four response determinants: age, RBC transfusion burden and duration, endogenous erythropoietin production, and karyotype.

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OP36.03: Review of the natural history of tetralogy of Fallot with absent pulmonary valve syndrome: does prenatal diagnosis imply increased risk?

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.8264 ◽

2010 ◽

Vol 36 (S1) ◽

pp. 156-156

Author(s):

Y. Mivelaz ◽

K. I. Lim ◽

C. Templeton ◽

C. I. Andrew ◽

J. E. Potts ◽

...

Keyword(s):

Prenatal Diagnosis ◽

Natural History ◽

Tetralogy Of Fallot ◽

Pulmonary Valve ◽

Absent Pulmonary Valve ◽

Increased Risk ◽

History Of ◽

Absent Pulmonary Valve Syndrome

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Insight into the natural history of primary biliary cirrhosis: A systemic review of data from placebo-controlled clinical trials

The Turkish Journal of Gastroenterology ◽

10.5152/tjg.2016.15535 ◽

2016 ◽

Vol 27 (4) ◽

pp. 342-348 ◽

Cited By ~ 1

Author(s):

Ping Xu ◽

Lan Li ◽

Chaohui Yu ◽

Youming Li

Keyword(s):

Clinical Trials ◽

Primary Biliary Cirrhosis ◽

Natural History ◽

Systemic Review ◽

Biliary Cirrhosis ◽

Controlled Clinical Trials ◽

History Of ◽

Insight Into

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The Sense-organs and Perceptions of Fishes; with Remarks on the Supply of Bait

Journal of the Marine Biological Association of the United Kingdom ◽

10.1017/s0025315400072118 ◽

1890 ◽

Vol 1 (3) ◽

pp. 225-256 ◽

Cited By ~ 73

Author(s):

W. Bateson

Keyword(s):

Natural History ◽

Sense Organs ◽

Marine Animals ◽

Practical Solution ◽

Biological Association ◽

Marine Biological ◽

Marine Biological Association ◽

History Of ◽

Insight Into

The Council of the Marine Biological Association appointed me, in 1889, to make observations on the perceptions of fishes, and especially on those which constitute the modes by which they hunt for and recognise their food. It was suggested that this subject should be treated in as wide a manner as possible, and in accordance with this suggestion I have endeavoured to utilize any opportunities which presented themselves of getting an insight into the natural history of marine animals. In addition to this I have also made some experiments towards the practical solution of the bait question, both by making artificial baits, and by endeavouring to preserve materials which are already in use for bait.

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The Effectiveness of Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis

Journal of Sport Rehabilitation ◽

10.1123/jsr.2013-0029 ◽

2014 ◽

Vol 23 (4) ◽

pp. 365-369 ◽

Cited By ~ 2

Author(s):

Matthew Astolfi ◽

Kelly McGuire ◽

Thomas W. Kaminski

Keyword(s):

Treatment Options ◽

Previous History ◽

Clinical Scenario ◽

Clinical Question ◽

Knee Oa ◽

Autologous Conditioned Serum ◽

Increased Risk ◽

History Of ◽

Quality Of Living

Clinical Scenario:Osteoarthritis (OA) is a debilitating degenerative disease affecting an estimated 27 million Americans. A systematic review found that patients with a previous history of traumatic knee injury are at increased risk of developing knee OA, regardless of specific injury. It is vital for the maintenance of quality of life for individuals affected with OA that the treatment options available be able to reduce symptoms and restore quality of living. The pain-relief benefits of traditional injection treatments are small to moderate and have a limited duration. It was found that at 2 wk postinjection that corticosteroids were more effective than hyaluronic acid (HA) injections. Autologous conditioned serum (ACS) injection is a novel treatment that has shown favorable results. However, many clinicians continue to use HA injections for reduction of symptoms in patients with osteoarthritis when the use of ACS may be more beneficial.Focused Clinical Question:For patients with knee OA, is an ACS injection more efficient at producing a reduction in symptoms than HA or a saline injection?

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Evolution of the treatment of cerebral vasospasm

Neurosurgical FOCUS ◽

10.3171/foc.2006.20.6.4 ◽

2006 ◽

Vol 20 (6) ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Scott Y. Rahimi ◽

John H. Brown ◽

Samuel D. Macomson ◽

Michael A. Jensen ◽

Cargill H. Alleyne

Keyword(s):

Subarachnoid Hemorrhage ◽

Natural History ◽

Cerebral Vasospasm ◽

Successful Treatment ◽

Aneurysmal Subarachnoid Hemorrhage ◽

Disease Process ◽

Acute Setting ◽

The Past ◽

History Of ◽

Insight Into

✓ Cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is a disease process for which the lack of effective treatments has plagued neurosurgeons for decades. Historically, successful treatment after SAH in the acute setting was often followed by a rapid, uncontrollable deterioration in the subacute interval. Little was known regarding the nature and progression of this condition until the mid-1800s, when the disease was first described by Gull. Insight into the origin and natural history of cerebral vasospasm came slowly over the next 100 years, until the 1950s. Over the past five decades our understanding of cerebral vasospasm has expanded exponentially. This newly discovered information has been used by neurosurgeons worldwide for successful treatment of complications associated with vasospasm. Nevertheless, although great strides have been made toward elucidating the causes of cerebral vasospasm, a lasting cure continues to elude experts and the disease continues to wreak havoc on patients after aneurysmal SAH.

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