scholarly journals Geographies of the COVID-19 pandemic

2020 ◽  
Vol 10 (2) ◽  
pp. 97-106 ◽  
Author(s):  
Reuben Rose-Redwood ◽  
Rob Kitchin ◽  
Elia Apostolopoulou ◽  
Lauren Rickards ◽  
Tyler Blackman ◽  
...  
Keyword(s):  
The Novel ◽  
Global Public Health ◽  
Special Issue ◽  
Current Crisis ◽  
Health Crisis ◽  
Global Pandemic ◽  
Theoretical Perspectives ◽  
Introductory Article ◽  
Novel Coronavirus ◽  
Political Economic

The spread of the novel coronavirus (SARS-CoV-2) has resulted in the most devastating global public health crisis in over a century. At present, over 10 million people from around the world have contracted the Coronavirus Disease 2019 (COVID-19), leading to more than 500,000 deaths globally. The global health crisis unleashed by the COVID-19 pandemic has been compounded by political, economic, and social crises that have exacerbated existing inequalities and disproportionately affected the most vulnerable segments of society. The global pandemic has had profoundly geographical consequences, and as the current crisis continues to unfold, there is a pressing need for geographers and other scholars to critically examine its fallout. This introductory article provides an overview of the current special issue on the geographies of the COVID-19 pandemic, which includes 42 commentaries written by contributors from across the globe. Collectively, the contributions in this special issue highlight the diverse theoretical perspectives, methodological approaches, and thematic foci that geographical scholarship can offer to better understand the uneven geographies of the Coronavirus/COVID-19.

scholarly journals Coronavirus Pandemic: a major public health crisis for the developed and developing world

2021 ◽  
Vol 15 (03) ◽  
pp. 366-369
Author(s):  
Rooh Ullah ◽  
Muhammad Suleman Rana ◽  
Mehmood Qadir ◽  
Muhammad Usman ◽  
Niaz Ahmed
Keyword(s):  
Public Health ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Infection ◽  
The Novel ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
The World ◽  
Novel Coronavirus ◽  
Day By Day

Pandemic of novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in China is now become global public health crisis. At present 87.64% of the world is infected by this deadly illness. The risk from this epidemic depends on the nature of the virus, including how well it transmits from person to person, and the complications resulting from this current illness. The novel coronavirus has killed thousands of people in China and other countries as well; its rate of mortality is increasing day by day. There is an urgent need to control the virus by developing vaccine or any other antiviral drugs to save the world from this deadly viral infection.

scholarly journals MicroRNAs and long non-coding RNAs as potential candidates to target specific motifs of SARS-CoV-2

2020 ◽  
Author(s):  
Lucia Natarelli ◽  
Luca Parca ◽  
Fabio Virgili ◽  
Tommaso Mazza ◽  
Christian Weber ◽  
...  
Keyword(s):  
Experimental Studies ◽  
Specific Treatment ◽  
Leader Sequence ◽  
The Novel ◽  
Health Crisis ◽  
Global Pandemic ◽  
Pulmonary Arterial ◽  
Non Coding Rnas ◽  
Novel Coronavirus

Abstract The novel Coronavirus, SARS-CoV-2 disease (COVID-19) was defined as a global pandemic and induced a severe public health crisis in 2020. Covid-19 viral infection targets the human respiratory system and, at present, no specific treatment has been identified even though certain drugs have been studied and considered apparently effective in viral progression by reducing the complications in the lung epithelium. Researchers and clinicians are still struggling to find a vaccine or a specific innovative therapeutic strategy to counter COVID-19 infection.Here we describe our study indicating that SARS-CoV-2 genome contains motif sequences in the 5´UTR leader sequence that can be selectively recognized by specific human non-coding RNAs (ncRNAs), such as micro and long non-coding RNAs (miRNAs and lncRNA). Notably, some of these ncRNAs have been already utilized as oligo-based drugs in pulmonary and virus-associated diseases. We identified three selective motifs at the 5´UTR leader sequence of SARS-CoV-2 that allow viral recognition and binding of a specific group of miRNAs, some of them characterized by “GU” seed alignments. Additionally, one seed motif within miRNAs has been found to be able to bind the 5’UTR leader sequence. Among miRNAs having thermodynamically stable binding site against leader sequence and that are able interacted with Spike transcript some are involved in pulmonary arterial hypertension and anti-viral response, i.e. miR-204, miR-3661, and miR-1343. Moreover, several miRNA candidates have been already validated in vivo and specific oligo sequence are indeed available for their inhibition or overexpression.Four lncRNAs (H19, Hotair, Fendrr, and LINC05) directly interact with spike transcript (mRNA) and viral genome.In conclusion, we suggest that specific miRNAs and lncRNAs can be potential candidates to design oligonucleotide-drugs to treat COVID-19 and that our study can provide candidate hypothesis to be eventually tested in further experimental studies.

scholarly journals Nexus between population density and COVID-19 pandemic in the south Indian states: A geo-statistical approach

2020 ◽  
Author(s):  
Mohammad Arif ◽  
Soumita Sengupta
Keyword(s):  
Population Density ◽  
Tamil Nadu ◽  
Spatial Relationship ◽  
The Novel ◽  
Global Public Health ◽  
Indian States ◽  
Health Crisis ◽  
South Indian ◽  
Novel Coronavirus

The unprecedented growth of the novel coronavirus (SARS-CoV-2) as a severe acute respiratory syndrome escalated to the 2019 coronavirus disease (COVID-19) pandemic. It has created an unanticipated global public health crisis. The virus is spreading rapidly in India which poses serious threat to 135 crore population. Population density poses some unforeseen challenges to control the COVID-19 contagion. In times of crisis, data is crucial to understand the spatial relationship between density and the infection. The article study the district wise transmissions of the novel coronavirus in five south Indian states until 6th June 2020 and its relationship with the respective population density. The five states are purposefully selected for better healthcare infrastructure vis-à-vis other states in India. We observed that corona virus spread depends on the spatial distribution of population density in three states especially in Tamil Nadu, Karnataka and Telangana. The results indicate that the long-term impacts of the COVID-19 crisis are likely to differ with demographic density. Policy initiatives aimed at reducing the health consequences of the COVID-19 pandemic should understand how vulnerabilities cluster together across districts.

Jordan’s Public Health and Surveillance Health Policies: During and After COVID-19 (Preprint)

2020 ◽  
Author(s):  
Raeda AlQutob ◽  
Musa Taha Ajlouni ◽  
Mohamed Majed Abu Farraj ◽  
Immanuel Azaad Moonesar
Keyword(s):  
Public Health ◽  
Health System ◽  
Health Financing ◽  
World Health Organisation ◽  
World Health ◽  
The Novel ◽  
Future Health ◽  
Health Crisis ◽  
Global Pandemic ◽  
Novel Coronavirus

UNSTRUCTURED In contemporary times, the wave of the novel Coronavirus disease (COVID-19) classified by the World Health Organisation as global pandemic has unravelled systems and processes including health, economic and social. In the case of the Kingdom of Jordan, the COVID-19 crisis illustrated for the need and ability of the policy making institutions and ministries to take many effective policies, initiatives and procedures that were met with marked approval as the opinion polls conducted by government and private institutions showed. The success of these interventions during the crisis calls upon the country’s health system to take advantage of this experience in the next stage of recovery and resilience to develop, maintain its sustainability, as well as the improvement of a number of hubs to assist the Kingdom in facing the challenges resulting from any future health crisis such as epidemics or natural disasters. The viewpoint interventions that are the most paramount given the current situation as public health evidence must inform activities in seven priority health system areas to manage during and after the pandemic includes factors on: (1) governance and management; (2) service delivery and research; (3) human resources; (4) health information systems; (5) technology and medicine; (6) health financing; and (7) citizens, refugees and communities.

scholarly journals Characterization of Nucleocapsid (N) Protein from Novel Coronavirus SARS-CoV-2

2020 ◽  
Author(s):  
Abhishek Kumar ◽  
Alisha Parveen ◽  
Narendra Kumar ◽  
Sneha Bairy ◽  
Vibha Kaushik ◽  
...  
Keyword(s):  
Nuclear Export ◽  
Structural Proteins ◽  
Global Public Health ◽  
Health Crisis ◽  
Nuclear Localization Signals ◽  
N Protein ◽  
Global Pandemic ◽  
Novel Coronavirus ◽  
Structured Proteins

Severe acute respiratory syndrome novel coronavirus 2 (SARS-CoV-2) has caused the global pandemic as COVID-19, which is the most notorious global public health crisis in the last 100 years. SARS-CoV-2 is composed of four structural proteins and several non-structured proteins. The multi-facet nucleocapsid (N) protein is the major component of structural proteins of CoVs, However, there are no dedicated genomic, sequences and structural analyses focusing on potential roles of N protein. Hence, there is an urgent requirement of a detailed study on N protein of SARS-CoV-2. Herein, we are presenting a comprehensive study on N protein from SARS-CoV-2. We have identified seven motifs conserved in the three major domains namely N-terminal domain, linker regions and the C-terminal domains. Out of seven motifs, six motifs are conserved across different members of coronaviridae, while motif4 is specific for SARS CoVs with potential amyloidogenic properties. Additionally, we report this protein has large patches of disordered regions flanking with these seven motifs. These motifs are hubs of epitopes with 67 experimentally verified epitopes from related viruses. We report the presence of three nuclear localization signals (NLS1-NLS3 mapped to 36-41, 256-26, and 363-389 residues, respectively) and two nuclear export signals (NES1-NLS2 from 151-161 and 217-230 residues, respectively) in the N protein of SARS-CoV-2. These deciphered two Q-patches as Q-patch1 and Q-patch2, mapped in the regions of 266-306, and 361-418 residues, which potentially help in the aggregation of the viral proteins along with 219LALLLLDR226 patch. Additionally, we have identified 14 antiviral drugs potentially binding to seven motifs of N-proteins using docking-based drug discovery methods.

scholarly journals SARS COV 2: Complete Review on Global Pandemic (Covid 19)

2020 ◽  
pp. 62-69
Author(s):  
Praveen Kumar Gupta ◽  
B. S. Rithu ◽  
Kauser Banu ◽  
A. Shruthi ◽  
C. Sahana
Keyword(s):  
Public Health ◽  
The Novel ◽  
Health Crisis ◽  
Public Health Crisis ◽  
Corona Virus ◽  
Global Pandemic ◽  
First Case ◽  
Life Threatening ◽  
Novel Coronavirus ◽  
Threatening Situation

SARS COV 2 (severe acute respiratory syndrome corona virus 2) has created a global health emergency worldwide due to public health crisis and life-threatening situation. According to a recent study it has been reported that the virus was found originated in animal and transmitted to humans through a food chain. First case was reported in Wuhan-china on December 2019, In this review we have enlightened on different aspects of novel coronavirus 2019 and measure to combat the battle against the novel corona virus 2019.

scholarly journals Coronavirus: Hotspot on coronavirus disease 2019 in India

2020 ◽  
Vol 72 ◽  
pp. 29-34 ◽  
Author(s):  
Rameshwar S. Cheke ◽  
Sachin Shinde ◽  
Jaya Ambhore ◽  
Vaibhav Adhao ◽  
Dnyaneshwar Cheke
Keyword(s):  
Respiratory Illness ◽  
World Health ◽  
Short Report ◽  
The Novel ◽  
Global Public Health ◽  
Health Crisis ◽  
Public Health Crisis ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

The novel coronavirus disease (COVID-19) or also known as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been recognized as the cause of respiratory infection in Wuhan, Hubei Province, China, in late December 2019. As of April 5, 2020, this epidemic had spread to worldwide with 12,03,485 confirmed cases, including 62,000 deaths. The World Health Organization has declared it a Global Public Health Crisis. Coronavirus causes respiratory illness coughing, sneezing, breathlessness, and fever including pneumonia. The disease is transmitted person to person through infected droplets. At present, the research on novel coronavirus is still in the primary stage. Based on the published study, we thoroughly summarize the history and origin, microbiology and taxonomy, mode of transmissions, target receptor, clinical features, diagnosis, prevention, and treatment about COVID-19. This short report writes in hope for providing platform to community and researcher dealings against with the novel coronavirus and providing a reference for further studies.

SARS-COV2 virus and Coronavirus disease (COVID-19)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 977-982
Author(s):  
Mohamed J. Saadh ◽  
Bashar Haj Rashid M ◽  
Roa’a Matar ◽  
Sajeda Riyad Aldibs ◽  
Hala Sbaih ◽  
...  
Keyword(s):  
Close Contact ◽  
Antiviral Agents ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Fatal Disease ◽  
Mild Disease ◽  
Life Threatening ◽  
Novel Coronavirus

SARS-COV2 virus causes Coronavirus disease (COVID-19) and represents the causative agent of a potentially fatal disease that is of great global public health concern. The novel coronavirus (2019) was discovered in 2019 in Wuhan, the market of the wet animal, China with viral pneumonia cases and is life-threatening. Today, WHO announces COVID-19 outbreak as a pandemic. COVID-19 is likely to be zoonotic. It is transmitted from bats as intermediary animals to human. Also, the virus is transmitted from human to human who is in close contact with others. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is nearly supportive; the role of antiviral agents is yet to be established. The SARS-COV2 virus spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. In this article, we aimed to summarize the transmission, symptoms, pathogenesis, diagnosis, treatment, and vaccine to control the spread of this fatal disease.

Coronavirus: Towards controlling of the pandemic - Indian scenario

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 462-468
Author(s):  
Latika kothari ◽  
Sanskruti Wadatkar ◽  
Roshni Taori ◽  
Pavan Bajaj ◽  
Diksha Agrawal
Keyword(s):  
Control Measures ◽  
The Novel ◽  
Medical Treatments ◽  
Health Crisis ◽  
The Public ◽  
Infection Control Measures ◽  
The Social ◽  
Asking Questions ◽  
The Government ◽  
Novel Coronavirus

Coronavirus disease 2019 (COVID-19) is a communicable infection caused by the novel coronavirus resulting in severe acute respiratory syndrome coronavirus 2 (SARS-CoV). It was recognized to be a health crisis for the general population of international concern on 30th January 2020 and conceded as a pandemic on 11th March 2020. India is taking various measures to fight this invisible enemy by adopting different strategies and policies. To stop the COVID-19 from spreading, the Home Affairs Ministry and the health ministry, of India, has issued the nCoV 19 guidelines on travel. Screening for COVID-19 by asking questions about any symptoms, recent travel history, and exposure. India has been trying to get testing kits available. The government of India has enforced various laws like the social distancing, Janata curfew, strict lockdowns, screening door to door to control the spread of novel coronavirus. In this pandemic, innovative medical treatments are being explored, and a proper vaccine is being hunted to deal with the situation. Infection control measures are necessary to prevent the virus from further spreading and to help control the current situation. Thus, this review illustrates and explains the criteria provided by the government of India to the awareness of the public to prevent the spread of COVID-19.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

Sign in / Sign up

Export Citation Format

Share Document