scholarly journals Prevalence of Mycobacterium tuberculosis infection and rifampicin resistance among presumptive tuberculosis cases visiting tuberculosis clinic of Adare General Hospital, Southern Ethiopia

2021 ◽  
Vol 9 ◽  
pp. 205031212110455
Author(s):  
Degineh Belachew Andarge ◽  
Tariku Lambiyo Anticho ◽  
Getamesay Mulatu Jara ◽  
Musa Mohammed Ali
Keyword(s):  
Mycobacterium Tuberculosis ◽  
General Hospital ◽  
Data Entry ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Southern Ethiopia ◽  
P Value ◽  
Mycobacterium Tuberculosis Infection ◽  
Cross Sectional ◽  
Logistic Regression Models

Objective: Multidrug-resistant Mycobacterium tuberculosis is a public health threat in resource-limited countries where it is easily disseminated and difficult to control. The aim of this study was to determine the prevalence of tuberculosis, rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis, and associated factors among presumptive tuberculosis cases attending the tuberculosis clinic of Adare General Hospital located in Hawassa city. Methods: A hospital-based cross-sectional study was conducted among 321 tuberculosis suspected patients from April to July 2018. Socio-demographic, environmental, and behavioral data were collected using a structured questionnaire. Sputum specimens were analyzed using GeneXpert. Data entry was made using Epi info version 7 and analyzed by SPSS version 20. Logistic regression models were used to determine the risk factors. A p-value less than 0.05 was taken as a cut point. Results: In this study, the prevalence of Mycobacterium tuberculosis was 98 (30.5%) with 95% confidence interval (25.5–35.8), and the prevalence of rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis among the 98 Mycobacterium tuberculosis confirmed cases was 4 (4.1%). The prevalence of rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis among the tuberculosis suspected patients was 1.24%. Participants who had a history of treatment with anti-tuberculosis drugs were more likely to develop rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis. Conclusions: This study identified relatively high rifampicin-resistant/multidrug-resistant Mycobacterium tuberculosis among tuberculosis suspected patients in the study area. Early detection of drug-resistant Mycobacterium tuberculosis should be given enough attention to strengthen the management of tuberculosis cases and improve direct observation therapy short-course and eventually minimize the spread of rifampicin-resistant tuberculosis strain in the community.

scholarly journals Trends of Mycobacterium Tuberculosis and rifampicin Resistance in Adigrat General Hospital, Eastern zone of Tigrai, North Ethiopia

2020 ◽  
Author(s):  
Getachew Kahsu Abay ◽  
Bahlibi Hailay
Keyword(s):  
Mycobacterium Tuberculosis ◽  
General Hospital ◽  
Data Extraction ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Rifampicin Resistance ◽  
Drug Resistant ◽  
Cross Sectional ◽  
Eastern Zone ◽  
Previously Treated

Abstract Background: Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. The global emergence of mono- or multidrug-resistant tuberculosis and extensively drug-resistant forms of tuberculosis poses a considerable challenge to tuberculosis control programs. There has been no reliable and organized data on trends and drug Resistance of Mycobacterium tuberculosis in the study area. Therefore, this study aimed to determine the trends of Mycobacterium tuberculosis and rifampicin Resistance in the Adigrat General Hospital, eastern zone of Tigrai, North Ethiopia.Methods: A hospital-based retrospective cross-sectional study was conducted at Adigrat General Hospital from January 2015 to 2018. Data were collected retrospectively from the GenexpertTM TB registration book using a data extraction format. Data was entered into Epi-Info 3.1 and subsequently exported and analyzed using SPSS Version 20. The results were summarized using descriptive statistics, tables, and figures. Bivariate and multi-variant regression analysis were employed to measure the association between dependent and independent variables. P values < 0.05 were considered statistically significant.Result: A total of 5,944 Mycobacterium tuberculosis presumptive patients were included in the study. The majority of the study participants were male (58.1%) with participants’ median age of 40.0 (IQR 26-57) years, the majority were 30-44 years. The overall positive cases of Mycobacterium tuberculosis was 24.3% (1446) with a total of 132 (9.1%) found to be resistant to Rifampicin. Within the total Rifampicin resistant sub-group, 129/1385 (9.3 %) were newly identified cases and the rest were previously treated, tuberculosis patients. Age, the reason for diagnosis, site of presumptive tuberculosis, and/or being HIV infected showed significant association with our dependent variable; however, only age and being HIV infected were associated with Rifampicin Resistance.Conclusion: In our study, the overall trends of Mycobacterium tuberculosis and rifampicin Resistance were found to be constant. HIV co-infected and previously treated patients were more likely to develop Rifampicin Resistance. Therefore, maximizing early detection of drug-resistant Mycobacterium tuberculosis and strengthening tuberculosis infection control activities are recommended to reduce the burden of this contagious and potentially deadly disease.

scholarly journals Trends of Mycobacterium Tuberculosis and rifampicin resistance in Adigrat General Hospital, Eastern Zone of Tigrai, North Ethiopia

2020 ◽  
Author(s):  
Getachew Kahsu Abay ◽  
Bahlibi Hailay
Keyword(s):  
Drug Resistance ◽  
Mycobacterium Tuberculosis ◽  
General Hospital ◽  
Data Extraction ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Rifampicin Resistance ◽  
Drug Resistant ◽  
Cross Sectional ◽  
Eastern Zone

Abstract Background: Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. The global emergence of mono- or multidrug-resistant tuberculosis and extensively drug-resistant forms of tuberculosis pose a considerable challenge to tuberculosis control programs. There has been no reliable and organized data on trends and drug resistance of Mycobacterium tuberculosis in the study area. Therefore, this study aimed to determine the trends of Mycobacterium tuberculosis and rifampicin resistance in the Adigrat General Hospital, eastern Zone of Tigrai, North Ethiopia.Methods: A hospital-based retrospective cross-sectional study was conducted at Adigrat General Hospital from January 2015 to 2018.Data was collected retrospectively from the GeneXpertTM TB registration book using a data extraction format. Data was entered into Epi-Info 3.1 and subsequently exported and analyzed using SPSS Version 20.The results were summarized using descriptive statistics, tables, and figures. Bivariate and multi-variant regression analysis was employed to measure the association between dependent and independent variables. P values < 0.05 were considered statistically significant.Result: A total of 5,944 Mycobacterium tuberculosis presumptive patients were included in the study. The majority of the study participants were male (58.1%) with participants’ median age of 40.0 (IQR 26-57) years, the majority were 30-44 years. The overall positive cases of Mycobacterium tuberculosis was 24.3% (1446) with a total of 132 (9.1%) found to be resistant to rifampicin. Of the total confirmed positive cases 8.7 % (103/1188) and 11.2 % (29/258) were rifampicin resistance of presumptive tuberculosis and presumptive drug resistance tuberculosis patients respectively. Age, the reason for diagnosis, site of presumptive tuberculosis, and/or being HIV infected showed significant association with our dependent variable; however, only age and being HIV infected were associated with rifampicin resistance.Conclusion: In our study, the overall trends of Mycobacterium tuberculosis and rifampicin resistance were found to be high. Rifampicin resistance is more common in patients with HIV and presumptive drug resistance tuberculosis individuals. Therefore, maximizing early detection of drug-resistant and strengthening tuberculosis infection control activities are recommended to reduce the burden of this contagious and potentially deadly disease.

HUBUNGAN DUKUNGAN KELUARGA DENGAN HARGA DIRI (SELF ESTEEM) PENDERITA TUBERKULOSIS PARU DI WILAYAH EKS KAWEDANAN INDRAMAYU

2017 ◽  
Vol 5 (1) ◽  
pp. 32-39
Author(s):  
Dedeh Husnaniyah
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Self Esteem ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional

Tuberkulosis Paru merupakan penyakit menular yang disebabkan oleh Mycobacterium tuberculosis. Dampak TB Paru adalah penurunan daya tahan tubuh, kelemahan fisik, merugikan secara ekonomis dan dapat mengakibatkan isolasi sosial. Keadaan tersebut dapat mempengaruhi harga diri penderita TB Paru. Perubahan harga diri pada penderita TB Paru dapat mempengaruhi keberhasilan pengobatan, sehingga dibutuhkan adanya dukungan keluarga. Tujuan Penelitian ini adalah untuk mengidentifikasi pengaruh dukungan keluarga terhadap harga diri penderita TB Paru di Wilayah Puskesmas Eks Kawedanan Indramayu tahun 2015. Jenis penelitian ini adalah deskriptif analitik dengan rancangan penelitian cross sectional study. Pengambilan sampel dilakukan dengan tekhnik total sampling sebayak 45 responden. Hasil penelitian menunjukkan bahwa penderita TB Paru yang memiliki harga diri tinggi sebanyak 23 responden (51,1%) dan yang memiliki harga diri rendah sebanyak 22 responden (48,9%), penderita TB Paru yang mendapatkan dukungan keluarga sebanyak 26 responden (57,8 %) dan yang tidak mendapatkandukungan keluarga sebanyak 19 (42,2 %). Responden yang mendapatkan dukungan keluarga lebih banyak yang memiliki harga diri tinggi dibandingkan dengan responden yang tidak mendapatkan dukungan keluarga yaitu 69,6% dengan nilai p value = 0,047 (< 0,05). Simpulan dari penelitian ini adalah terdapat hubungandukungan keluarga denganharga diri penderita TB Paru. Hasil penelitian ini diharapkan dapat menjadi masukan bagi pemegang program TB untuk memberikan konseling terkait pentingnya dukungan keluarga bagi penderita TB Paru.

scholarly journals Perception on Management of Nursing Education Institutes among Bachelors Students in Selected Nursing Colleges at Kathmandu

2020 ◽  
Vol 7 (1) ◽  
pp. 23-36
Author(s):  
Bhuwan Kumari Dangol ◽  
Narbada Thapa
Keyword(s):  
Nursing Education ◽  
Nursing Students ◽  
Statistical Significance ◽  
Data Entry ◽  
Education Institution ◽  
Cross Sectional Study ◽  
Current Status ◽  
P Value ◽  
Cross Sectional ◽  
Organizational Goals

Management is a process of planning, decision making, organizing, leading, motivating and controlling, and an effective utilization of the resources to reach the organizational goals efficiently and effectively. Management has a crucial role in quality of work and production in any institutions. Although a rapid increase of Nursing Education Institutions in Nepal since last decade which had been trained thousands of nursing cadres, the management aspects of these institutions are not studied adequately. Thus current study intended to explore the current status of Nursing Education Institution Management as experienced and perceived by the bachelors nursing students. A descriptive cross-sectional study was conducted among the nursing institutions in Kathmandu valley. Of the total 28 in the valley, 14 were selected purposively. From the selected institutions, all 377 eligible students currently in final year of study were selected. Among them, 208were from BSN and 169 were from B Sc program.  The data was collected through the self administered structured questioners after taking informed consent. Data entry and analysis was done in SPSS version 16 software. The findings of the study show that 70% students were satisfied in institutional management (mean59.62, SD ± 3.66). In academic management (78%), (mean139.82, SD ± 6.22), followed by human resources 67%, (mean43.54, SD ± 2.79) and were in physical resources management 75% students were satisfied (mean45.02, SD ± 3.08). Analysis of variations between group (administrators, faculties, students) found statistical significance (p value <0.05). So it is concluded the perception of students, faculties and administrator were different on managing the nursing education.

scholarly journals Prevalence and Determinant of Depression among Multi-Drug Resistance Tuberculosis: Study in Dr. Kariadi General Hospital

2020 ◽  
Vol 40 (2) ◽  
pp. 88-96
Author(s):  
Mahalul Azam ◽  
Arulita Ika Fibriana ◽  
Fitri Indrawati ◽  
Indah Septiani
Keyword(s):  
Drug Resistance ◽  
General Hospital ◽  
Secondary Data ◽  
Cross Sectional Study ◽  
Multi Drug Resistance ◽  
P Value ◽  
Cross Sectional ◽  
Depression Status ◽  
Prevalence Of Depression ◽  
Mdr Tb

Backgrouds: Multi-drug resistance tuberculosis (MDR-TB) adds the burden of tuberculosis (TB). Depression is a common comorbidity in TB patients. Prevalence of depression among MDR-TB patients was higher, i.e. 11-70%. Prevalence of depression among TB patients in Dr. Kariadi General Hospital was 51.9%. Previous study reported the determinants related to the depression in MDR-TB patients. This study explored the prevalence of depression in MDR-TB patients and its determinants. Methods: This study was a cross-sectional study conducted from July-August 2019. Data consisted of primary and secondary data from Dr. Kariadi General Hospital patients. Sample in this study involved 72 respondents, over 16 years old from 151 registered MDR-TB patients. Depression status was determined using Depression Anxiety Stress Scales obtained from the medical record. Subjects’ characteristics and determinants were collected from primary as well as secondary data. Descriptive data were presented in proportion. Chi-square test continued by Binary logistic regression was performed to determine the association between depression status and its determinants. A P-value

Prevalence of alcohol use and associated factors among Dilla University Students, Dilla Town, Southern Ethiopia. 2018

2020 ◽  
Author(s):  
Yigrem Ali Chekole
Keyword(s):  
Alcohol Use ◽  
Undergraduate Students ◽  
Associated Factors ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Southern Ethiopia ◽  
P Value ◽  
Cross Sectional ◽  
Level Of Significance ◽  
The University

Abstract Introduction Compared to other deadly communicable diseases, Psychoactive Substance use is among the leading cause of death. Repeated use linked to addiction, dependence and predisposition for criminal and antisocial behaviors. Even though drug use in Africa relatively is short; however the abuse of drug in Africa is escalating rapidly. Substances use is also one of the most burning and growing public health problems in Ethiopia, as in many developing countries; alcohol is the most frequently used substance. Objective To Assess the Prevalence of alcohol Use and Associated factors among Dilla University undergraduate students in Southern Ethiopia. 2018. Methods An Institution based cross -sectional study was conducted at Dilla University among undergraduate regular students from January-February. Systematic random sampling technique was used to get a total of 803 samples of students from each year and department of the university. The collected data was coded, entered in to EPI-INFO version7.1 and analyzed by using SPSS version 20. Crude and adjusted OR were analyzed using logistic regression and the level of significance of association was determined at P- value <0.05. Result A total of 803 participants were interviewed with a response rate of 91.7%. Among the Participants, alcohol use was found to be 67.6%. (41.8%; n=336). Being 4 th year students (AOR =2.66, 95% CI: 1.64, 4.31), having friends who use substance (AOR=1.53, 95% CI: 1.09, 2.1), being Khat user (AOR= 1.48, 95% CI: 1.05, 2.09) and being Cigarette smoker (AOR=1.76, 95% CI: 1.09, 2.84) were found to be significantly associated with alcohol use. Conclusion Half of the participants found to have alcohol use. Therefore, early prevention, detection and alleviating of alcohol use should be implemented among students in the university.

Incidence and Pattern of Clinical Dengue Cases among Travelers and NonTravelers in a District of Bangladesh

2020 ◽  
Vol 7 (1) ◽  
pp. 3-7
Author(s):  
Syed Abdul Kader ◽  
Sonia Afrin Rob
Keyword(s):  
Endemic Area ◽  
Dengue Infection ◽  
Laboratory Data ◽  
Data Entry ◽  
Cross Sectional Study ◽  
P Value ◽  
College Hospital ◽  
Cross Sectional ◽  
Test Kit ◽  
Ns1 Antigen

Background: Expansion of Dengue fever caused by a mosquito borne arbovirus to new countries and, from urban to rural settings constitutes an important health problem in the world including Bangladesh. Objective: This study was conducted to evaluate spread of clinical Dengue to previously non-endemic Barisal district and get an idea of how recent this spread is by comparing proportions of non-travelers and travelers to an endemic area among the admitted patients. Methodology: The incidence of dengue infection in Barisal division with and without travel history to known endemic area was investigated in the current cross sectional study from a conveniently selected sample of patients admitted to the medicine department of Sher-e-Bangla medical College Hospital form Barisal district from July 15, through August, to September 15, 2019. Clinical and laboratory data were collected by attending doctors and checked by investigators. The primary diagnostic tool was NS1 antigen detected by SD Bioline Dengue NS1 Ag Test Kit. Data entry and analysis was done by SPSS version 24.0 software. Result: A total number of sample size was 212 admitted patents of whom 138(65.1%) were male, 74 (34.9 %) were female,116 (54.7%) of patients traveled to a known endemic zone, 96 (45.3%) did not; 206 (97.2%) were NS1 positive, 4 (1.9%) were IgM positive, 2 (0.9%) were IgM positive and IgG positive; Of travelling 116 patients, 92(79.3%) were male, 24(20.7%) were female, of travelling 96 patients 46(47.9%) were male, 50(52.1%) were female. p-value was <0.001. Conclusion: The study concluded that Dengue is becoming endemic in previously non-endemic zones like greater Barisal, though travelers still holds the major share of disease burden. Male preponderance in traveling to endemic zone was statistically significant. Bangladesh Journal of Infectious Diseases 2020;7(1):3-7

scholarly journals Trends of Mycobacterium Tuberculosis and Rifampicin resistance in Adigrat General Hospital, Eastern zone, Tigray Region, Northern Ethiopia

2020 ◽  
Author(s):  
Getachew Kahsu Abay ◽  
Bahlibi Hailay
Keyword(s):  
Mycobacterium Tuberculosis ◽  
General Hospital ◽  
Data Extraction ◽  
Multidrug Resistant ◽  
Rifampicin Resistance ◽  
Northern Ethiopia ◽  
Drug Resistant ◽  
Cross Sectional ◽  
Eastern Zone ◽  
Previously Treated

Abstract Background: Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. The global emergence of mono- or multidrug-resistant tuberculosis and extensively drug-resistant forms of tuberculosis poses a considerable challenge to tuberculosis control programs. There has been no reliable and organized data on trends and drug resistance of Mycobacterium tuberculosis in the study area. Therefore, this study aimed to determine the trends of Mycobacterium tuberculosis and Rifampicin resistance in the Adigrat General Hospital, eastern zone, Tigray, Northern Ethiopia.Methods: A hospital-based retrospective cross-sectional study was conducted at Adigrat General Hospital from January 2015 to 2018. Data were collected retrospectively from the GenexpertTM TB registration books using a data extraction format. Data was entered into Epi-Info 3.1 and subsequently exported and analyzed using SPSS Version 20. The results were summarized using descriptive statistics, tables, and figures. P values < 0.05 were considered statistically significant.Result: A total of 5,944 Mycobacterium tuberculosis presumptive patients were included in the study. The majority of the study participants were male (58.1%) with participants’ median age of 40.0 (IQR 57, 26) years, the majority were 30-44 years. The overall positive cases of Mycobacterium tuberculosis was 24.3% (1446) with a total of 132 (9.1%) found to be resistant to rifampicin. Within the total Rifampicin resistant sub-group, 129/132 (97.7 %) were newly identified cases and the rest were previously treated, tuberculosis patients. Age, the reason for diagnosis, site of presumptive tuberculosis, and/or being HIV infected showed significant association with our dependent variable; however, only age and being HIV infected were associated with rifampicin resistance.Conclusion: In our study, the overall trends of Mycobacterium tuberculosis and rifampicin resistance were found to be high and gradually increasing. HIV co-infected and previously treated patients were more likely to develop rifampicin resistance. Therefore, maximizing early detection of drug-resistant Mycobacterium tuberculosis and strengthening tuberculosis infection control activities are recommended to reduce the burden of this contagious and potentially deadly disease.

scholarly journals Under Nutrition and associated factors among lactating mothers in Southern Ethiopia: Institution Based Cross-sectional study

2019 ◽  
Author(s):  
Gemechu Kejela ◽  
Feleke Gebremeskel ◽  
Hadiya Hassen ◽  
Misgun Shewangizaw ◽  
Markos Desalegn
Keyword(s):  
Associated Factors ◽  
Cross Sectional Study ◽  
Southern Ethiopia ◽  
Systematic Sampling ◽  
P Value ◽  
Sectional Study ◽  
Quality Of Data ◽  
Cross Sectional ◽  
Under Nutrition ◽  
Lactating Mothers

Abstract Background Maternal Nutrition contributes significantly to the long term health of mothers and their children. Despite this importance, globally, about 795 million people are undernourished and women and their children are the most vulnerable groups.Objective the main aim of this study was to assess under nutrition and associated factors among lactating mothers in Arba Minch zuria district, Southern Ethiopia.Methods institution based cross-sectional study was used. Data was collected using interview administered questionnaire from a total of 441 lactating mothers. To get the required respondents, first health centers in Arba Minch zuria district were selected by using lottery method and probability to population size was performed for each health center. Finally, eligible respondents were selected using systematic sampling method. The questionnaire was pretested and close supervision was undertaken during data collection to assure the quality of data. The collected data was entered using Epi data version 3.02 and exported to SPSS version 20.0 for analysis. Binary and multivariable logistic regression were conducted, and finally variables with p-value of <0.05 were considered as statistically significant predictors.Results Prevalence of under nutrition in this study was 26.1%. Under nutrition is higher among mothers who are unable to read and write (AOR[95%CI]= 3.931[1.700,9.091]), mothers who experienced more than five numbers of pregnancies (AOR[95%CI]= 2.453[1.051, 5.728]), those with more than four members of family size (AOR[95%CI]= 2.289[1.171, 4.472]), those who live in the household with no toilet (AOR [95%CI] = 6.407[3.556, 11.545]) and those who have less than 4 antenatal care visits (AOR[95%CI]= 2.053[1.185, 3.559]).Conclusions and Recommendations In this study, the magnitude of under nutrition among lactating women was high. So, nutrition based health information, education and communication is needed for mothers especially during pregnancy and lactation in the study area.

scholarly journals Evaluation of gene mutations in resistant strains of Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in Mazandaran and Golestan provinces of Iran - a 2-year study

2020 ◽  
Author(s):  
Ahmad Alikhani ◽  
Elnaz Amini ◽  
Mohsen Arabi ◽  
Hamid Reza Goli
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Gene Mutations ◽  
Multidrug Resistant ◽  
Cross Sectional Study ◽  
Proteinase K ◽  
Resistant Isolate ◽  
Ratio Method ◽  
Mazandaran Province ◽  
Northern Iran ◽  
Cross Sectional

Abstract Background: Due to the significant prevalence of tuberculosis (TB) in Mazandaran and Golestan provinces in northern Iran, we aimed to investigate the gene mutations in resistant Mycobacterium tuberculosis isolated from pulmonary TB patients in these provinces of Iran. Methods: In this cross-sectional study, sputum of patients with suspected tuberculosis were evaluated in the central TB laboratory of Golestan in a period of two years from 2017 to 2019. After growing the isolates on Lowenstein-Jensen medium, the antibiotic-resistant cases identified using the resistance ratio method. Then, the DNAs of the resistant isolates were extracted manually by the CTAB-Proteinase K method and investigated for gene mutations using PCR test and sequencing.Results: The mean age of 26 patients was 52 years, while smoking, addiction, and diabetes were more common risk factors. However, 4 isolates (15.38%) were resistant to antibiotics, while one (3.84%) of them was resistant to rifampin, and two isolates (7.69%) were resistant against isoniazid, whereas one other isolate (3.84%) exhibited a multidrug-resistant (MDR) phenotype. The MDR isolate had a mutation in codon 315 of the KatG gene resulting in the conversion of serine to threonine, and a mutation in the codon 450 of the rpoB gene, causing the alteration of serine to leucine. In the rifampin-resistant isolate, a mutation occurred at the same site converting serine to leucine. Conclusions: The low prevalence of antibiotic resistance in clinical isolates of Mycobacterium tuberculosis in this study indicates the appropriate treatment of the patients in this area, however, the prevalence of resistance to isoniazid was higher than rifampin. The more important point was that the single MDR isolate was identified in Mazandaran province.

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