scholarly journals Gallbladder adenoma in a domestic shorthair cat

2021 ◽  
Vol 7 (1) ◽  
pp. 205511692199766
Author(s):  
Catherine Broadbridge ◽  
Samantha S Taylor ◽  
Helen Renfrew ◽  
Francesco Gemignani ◽  
Veronique Livet ◽  
...  
Keyword(s):  
Total Bilirubin ◽  
Exploratory Laparotomy ◽  
Hepatic Enzymes ◽  
Abdominal Ultrasonography ◽  
Clinically Normal ◽  
Case Summary ◽  
First Case ◽  
Nodular Hyperplasia ◽  
Amoxicillin Clavulanic Acid ◽  
Gallbladder Adenoma

Case summary A 13-year-old neutered female domestic shorthair rescue cat presented asymptomatically with raised hepatic enzymes following a routine pre-anaesthetic blood test. Cholangitis was suspected, and supportive treatment with 2 weeks of amoxicillin–clavulanic acid and 4 weeks of ursodeoxycholic acid and S-adenosylmethionine was trialled, with no improvement in biochemistry parameters. Clinicopathological investigations also revealed a markedly raised total bilirubin and abnormal bile acid stimulation test. Abdominal ultrasonography revealed pathological changes in the gallbladder, hepatomegaly with increased echogenicity and markedly thickened common bile duct walls. An exploratory laparotomy was performed revealing a grossly abnormal gallbladder with a small rupture at the dorsal fundus, which was managed via cholecystectomy. Pancreatic and hepatic biopsies were collected concurrently. Histopathology from the submitted samples revealed a gallbladder adenoma, chronic neutrophilic cholangitis and nodular hyperplasia of the pancreas. Culture of the gallbladder bile was negative but may be attributable to the initial treatment with antibiosis. At the time of writing, 5 months postoperatively, the cat had recovered well and remained asymptomatic and clinically healthy, but hepatic enzymes and bilirubin were only mildly reduced from the preoperative levels, despite the cat remaining clinically normal. Relevance and novel information To our knowledge, this is the first case of a gallbladder adenoma confirmed histopathologically in a feline patient. Our findings suggest that although gallbladder neoplasia is rare in cats, this benign tumour should be considered a differential diagnosis.

scholarly journals A novel hypokalaemic polymyopathy and subsequent unrelated nutritional thiamine deficiency in a young Burmese cat

2021 ◽  
Vol 7 (2) ◽  
pp. 205511692110419
Author(s):  
Abigail Brough ◽  
Anne-Claire Duchaussoy
Keyword(s):  
Thiamine Deficiency ◽  
Subsequent Development ◽  
Serum Biochemistry ◽  
Genetic Mutation ◽  
Response To Treatment ◽  
Clinically Normal ◽  
Potassium Supplementation ◽  
Case Summary ◽  
First Case

Case summary An 8-month-old female spayed Burmese cat was referred for investigation of reduced appetite, reluctance to walk and jump and amaurosis. On serum biochemistry there was severe hypokalaemia and marked elevation of creatine kinase, suggestive of hypokalaemic polymyopathy. The neurological signs were consistent with thiamine deficiency. The cat was negative for the periodic hypokalaemic polymyopathy (PHP) of Burmese cats, and was ultimately diagnosed with a previously undescribed potassium wasting nephropathy requiring ongoing oral potassium supplementation. The response to treatment was excellent and the cat has remained clinically normal over a 12-month follow-up period. Relevance and novel information PHP in Burmese cats has been well described, but all cases to date have been shown to be secondary to a genetic mutation in WNK4, resulting in potassium wasting into the urine. This is the first case report of another potassium wasting nephropathy in a young Burmese cat, with subsequent development of nutritional thiamine deficiency.

scholarly journals Acute upper airway obstruction as a life-threatening complication of ventral bulla osteotomy: report of two consecutive cases

2021 ◽  
Vol 7 (1) ◽  
pp. 205511692110059
Author(s):  
Michal Vlasin ◽  
Richard Artingstall ◽  
Barbora Mala
Keyword(s):  
Airway Obstruction ◽  
Clinical Signs ◽  
Upper Airway ◽  
Upper Airway Obstruction ◽  
Single Session ◽  
Inflammatory Polyp ◽  
Case Summary ◽  
First Case ◽  
Life Threatening

Case summary This paper presents two cases of acute postoperative upper airway obstruction following ventral bulla osteotomy (VBO) in cats. The first cat underwent a unilateral left-sided VBO for a suspected inflammatory polyp. The second cat underwent a single-session bilateral VBO procedure for bilateral otitis media. In the first case, immediate re-intubation and a gradual lightening of the anaesthetic plane resolved the clinical signs; in the second case, the patient deteriorated and went into acute cardiorespiratory arrest and received cardiopulmonary resuscitation. Both patients recovered well and were discharged home 3 days after surgery. Both cases were reported to show no further clinical signs on postoperative follow-up 3 weeks and 4 months after surgery, respectively. Relevance and novel information Upper airway obstruction should be regarded as a potential complication of VBO in cats.

Syncopal Episodes Associated with Cisapride and Concurrent Drugs

1998 ◽  
Vol 32 (6) ◽  
pp. 648-651 ◽  
Author(s):  
Vanessa Seals Gray
Keyword(s):  
English Language ◽  
Motor Vehicle ◽  
Concomitant Administration ◽  
Qt Prolongation ◽  
Azole Antifungals ◽  
Vehicle Accidents ◽  
Cardiac Dysrhythmias ◽  
Case Summary ◽  
First Case ◽  
Patients At Risk

OBJECTIVE: To report a case of QT prolongation and syncopal episodes resulting from concomitant use of cisapride and agents known to inhibit its metabolism. CASE SUMMARY: A 53-year-old white woman was involved in two motor vehicle accidents on the same day after experiencing syncopal episodes. Cardiac and neurologic evaluations were negative; the syncopal episodes were attributed to QT prolongation associated with the concomitant use of cisapride and agents known to inhibit its metabolism. DISCUSSION: This is the first case published in the English-language literature describing QT prolongation resulting from the concomitant use of cisapride and agents known to inhibit its metabolism. Clarithromycin inhibits CYP3A4, the isoenzyme responsible for the metabolism of cisapride. Concomitant administration of cisapride with agents known to inhibit CYP3A4 (i.e., azole antifungals, erythromycin, clarithromycin) may result in elevated cisapride concentrations. Elevated cisapride concentrations have been associated with QT prolongation, syncopal episodes, and cardiac dysrhythmias. CONCLUSIONS: Acquired QT prolongation is a well-recognized adverse effect of several drugs. Recognition of newer drugs and drug combinations that place patients at risk for this potentially fatal adverse event is imperative for appropriate monitoring and prevention.

scholarly journals Correction of hepatobiliary pathology by the complex herbal remedy

2007 ◽  
Vol 6 (4) ◽  
pp. 46-52
Author(s):  
V. S. Chuchalin ◽  
Ye. M. Teplyakova
Keyword(s):  
Total Bilirubin ◽  
Toxic Hepatitis ◽  
Herbal Remedy ◽  
The Other ◽  
Hepatic Enzymes ◽  
Active Components ◽  
Bile Acid Pool ◽  
Metabolic Functions ◽  
Experimental Toxic Hepatitis ◽  
Bile Production

The influence of complex herbal remedy on the secretary and metabolic functions of a liver was investigated in rates with experimental toxic hepatitis and hypercholesterolemia. The result obtained have shown that complex herbal remedy shortened the time of evolution and decreased hepatic enzymes (AST, ALT, and GGT), alkaline phosphates, total bilirubin, and cholesterol. It has also been shown that complex herbal remedy increased the protein synthesis of hepatocyte and hampered lipolysis processes. On the other hand, the active components of this remedy regulated the excessive bile production. During complex herbal remedy administration, the rheologycal properties of bile are normalized, bile acid pool extends, and total cholesterol in bile reduces. Along with hepatoprotective properties, remedy has the expressive choleretic and cholekinetic effects.

scholarly journals RUPTURED HEPATIC HYDATID CYST : A RARE CASE REPORT

2020 ◽  
pp. 1-3
Author(s):  
Syed Md Sharique ◽  
Mritunjay Sarawagi ◽  
Anjay Kumar
Keyword(s):  
Hydatid Cyst ◽  
Emergency Operation ◽  
Exploratory Laparotomy ◽  
Corticosteroid Treatment ◽  
Sudden Onset ◽  
Hepatic Hydatid Cyst ◽  
Cystic Hydatid Disease ◽  
Abdominal Ultrasonography ◽  
Cyst Rupture ◽  
Hepatic Hydatid

Hydatid cyst rupture into abdomen is a serious complication in cystic hydatid disease of liver. Both microscopic or macroscopic rupture can occur and it is fatal without surgery. It is primarily caused by tapeworm (ECHINOCOCCUS GRANULOSUS) and occurs worldwide with an incidence of 200/100,000in endemic areas. This is a case of 28 yr. female presenting with sudden onset pain abdomen since 4 days. Abdominal ultrasonography demonstrates ruptured hepatic hydatid cyst with free peritoneal fluid. She was managed in emergency operation theatre due to her clinical condition and exploratory laparotomy with omentopexy and toileting were done after fluid resuscitation, antihistaminic and corticosteroid treatment. Postoperatively she received antihelminthic treatment with Albendazol. She made a good recovery following surgery.

scholarly journals A Case of Liver Abscess withDesulfovibrio desulfuricansBacteremia

2015 ◽  
Vol 2015 ◽  
pp. 1-4 ◽  
Author(s):  
Saho Koyano ◽  
Keita Tatsuno ◽  
Mitsuhiro Okazaki ◽  
Kiyofumi Ohkusu ◽  
Takashi Sasaki ◽  
...  
Keyword(s):  
Liver Abscess ◽  
Clinical Presentation ◽  
Anaerobic Bacteria ◽  
Desulfovibrio Desulfuricans ◽  
Clinical Specimens ◽  
Sulfate Reducing ◽  
Oral Amoxicillin ◽  
First Case ◽  
Causative Agents ◽  
Amoxicillin Clavulanic Acid

Desulfovibriospp. are gram-negative, sulfate-reducing, and anaerobic bacteria found in the digestive tract of humans. BecauseDesulfovibriospp. are infrequent causative agents of infectious diseases and are difficult to isolate and to identify from clinical specimens, the appropriate antibiotic therapy to infection withDesulfovibriospp. has not been determined. We report the first case of liver abscess with bacteremia due toDesulfovibrio desulfuricansto show the clinical presentation and treatment. The patient was successfully treated with intravenous piperacillin-tazobactam and oral amoxicillin-clavulanic acid.

Intestinal lymphoma in a Boxer breed dog – case report

2019 ◽  
Vol XXIV (142) ◽  
pp. 72-82
Author(s):  
Sayonara da Luz Ferro ◽  
Fernanda Jönck ◽  
Marta Cristina T. Heckler ◽  
Ewerton Cardoso ◽  
Mateus Rychescki ◽  
...  
Keyword(s):  
Weight Loss ◽  
Abdominal Cavity ◽  
Clinical Signs ◽  
Exploratory Laparotomy ◽  
Needle Aspiration ◽  
Free Fluid ◽  
Intestinal Lymphoma ◽  
Mesenteric Lymph Nodes ◽  
Abdominal Ultrasonography ◽  
Tissue Biopsy

Intestinal lymphoma is the second most common form of lymphoma in dogs. It is characterized by the presence of neoplastic lymphocytes in the gastrointestinal tract or mesenteric lymph nodes. The chief clinical signs are vomiting, diarrhea, anorexia and weight loss. The diagnosis is made through fine needle aspiration and cytology, or by tissue biopsy and histopathology, and chemotherapy is the treatment of choice. We report a case of intestinal lymphoma in a five years old Boxer, presented with history of hematochezia and lethargy of 7 days duration, and 20 days of anorexia and persistent weight loss. Abdominal ultrasonography revealed free fluid in the abdominal cavity, and an intestinal mass. Exploratory laparotomy was performed and a tissue biopsy was performed. Histopathology confirmed the diagnosis of intestinal lymphoma, but the patient died during the surgical procedure.

scholarly journals Anaphylaxis probably induced by transfer of amoxicillin via oral sex

2019 ◽  
Vol 12 (3) ◽  
pp. e227398 ◽  
Author(s):  
Nazaret Gómez Caballero ◽  
Susana Almenara ◽  
Antonia Tévar Terol ◽  
José Francisco Horga de la Parte
Keyword(s):  
Clavulanic Acid ◽  
Sexual Intercourse ◽  
Acid Treatment ◽  
Sexual Contact ◽  
Oral Drug ◽  
Oral Sex ◽  
Hypersensitivity Reactions ◽  
Drug Transfer ◽  
First Case ◽  
Amoxicillin Clavulanic Acid

We present a case of a possible amoxicillin-induced anaphylaxis in a sensitive woman triggered by an instance of oral sexual contact with a man who was taking amoxicillin-clavulanic acid treatment.To our knowledge, this is the first case reported of a suspicion of amoxicillin-induced anaphylaxis in a woman after a sexual contact with a man who was taking the drug, we hypothesised an oral drug transfer through semen.Studies about amoxicillin concentrations achieved in semen after a drug intake are scarce. There are few cases reported of hypersensitivity reactions induced by drugs transported in semen but we have found some concern in sensitive patients about the possibility of transference of allergens via sexual intercourse. As clinicians, we consider that it is important to be aware of the existence of this possibility both in the diagnosis and in the prevention of anaphylactic reactions.

scholarly journals Renal adenocarcinoma associated with hypertrophic osteopathy in a cat

2020 ◽  
Vol 6 (2) ◽  
pp. 205511692096243
Author(s):  
Sarah Elhamiani Khatat ◽  
Rosario Vallefuoco ◽  
Meryem El Mrini ◽  
Morgane Canonne-Guibert ◽  
Dan Rosenberg
Keyword(s):  
Abdominal Mass ◽  
New Bone Formation ◽  
Abdominal Ultrasonography ◽  
Radiographic Findings ◽  
Renal Adenocarcinoma ◽  
First Case ◽  
Primary Neoplasm ◽  
The Right ◽  
Radiographic Changes

Case summary A 10-year-old neutered male domestic shorthair cat was diagnosed with renal adenocarcinoma associated with hypertrophic osteopathy. The cat was referred for chronic ambulation difficulties. The physical examination showed a painful thickening of all four limbs, a right cranial abdominal mass and a conjunctival hyperaemia. Radiographic findings were consistent with extensive periosteal new bone formation involving not only the diaphyses of the fore- and hindlimbs, but also of the pelvis, tarsus and carpus. Abdominal ultrasonography and CT revealed a mass within the right kidney and a primary neoplasm was suspected. A ureteronephrectomy of the right kidney was performed and histopathology confirmed the diagnosis of renal adenocarcinoma. Although clinical improvement of the lameness occurred after surgery, no radiographic changes of hypertrophic osteopathy lesions were observed at the 9-month follow-up. Relevance and novel information Feline cases of hypertrophic osteopathy are rarely reported in the literature and only a few of them were associated with abdominal neoplastic diseases. To our knowledge, this is the first case of renal adenocarcinoma associated with hypertrophic osteopathy in a cat.

Fatal Neutropenia and Thrombocytopenia Associated with Ticlopidine

1994 ◽  
Vol 28 (11) ◽  
pp. 1236-1238 ◽  
Author(s):  
James A. Carlson ◽  
Jon E. Maesner
Keyword(s):  
Renal Function ◽  
Absolute Neutrophil Count ◽  
Neutrophil Count ◽  
Impaired Renal Function ◽  
Healthcare Professionals ◽  
Severe Neutropenia ◽  
Gram Negative ◽  
Case Summary ◽  
First Case

OBJECTIVE: To report the first case of ticlopidine-associated neutropenia resulting in sepsis and death. CASE SUMMARY: An 83-year-old Filipino man was started on ticlopidine 250 mg bid. By the seventh week of therapy his absolute neutrophil count (ANC) had dropped to 2700 from 7600 × 106 cells/L. The ticlopidine was stopped. Six days later, he was admitted to the hospital. He died 18 hours later of gram-negative sepsis. DISCUSSION: Although ticlopidine therapy was discontinued four days after the patient's ANC was 2700 × 106 cells/L, the ANC dropped to and remained at 0 until his death eight days later. This may be associated with the patient's decreased clearance of ticlopidine given his age and impaired renal function. This is the first reported case of moderate or severe neutropenia in a nonwhite patient and the first reported case of sepsis and death caused by ticlopidine CONCLUSIONS: Healthcare professionals must be aware of the possibility of severe neutropenia and death caused by ticlopidine, even when the manufacturers' monitoring guidelines are followed.

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